Research & Literature

Valproate in the treatment of epilepsy in girls and women of childbearing potential.

Tomson T, Marson A, Boon P, et al.

Epilepsia 2015; (56(7)):1006-19 doi:10.1111/epi.13021.

Dose-dependent teratogenicity of valproate in mono- and polytherapy: an observational study.

Tomson T, Battino D, Bonizzoni E, et al.

Neurology 2015; (85(10)):866-72 doi:10.1212/WNL.0000000000001772.

A definition and classification of status epilepticus--Report of the ILAE Task Force on Classification of Status Epilepticus.

Trinka E, Cock H, Hesdorffer D, et al.

Epilepsia 2015; (56(10)):1515-23 doi:10.1111/epi.13121.

Psychiatric disorders among 165 patients with juvenile myoclonic epilepsy in India and association with clinical and sociodemographic variables.

Somayajula S, Vooturi S, Jayalakshmi S

Epilepsy & behavior : E&B 2015; (53()):37-42.

Valproic acid after five decades of use in epilepsy: time to reconsider the indications of a time-honoured drug.

Tomson T, Battino D, Perucca E

The Lancet. Neurology 2016; (15(2)):210-218 doi:10.1016/S1474-4422(15)00314-2.

Pharmacological outcomes in juvenile myoclonic epilepsy: Support for sodium valproate.

Chowdhury A, Brodie MJ

Epilepsy research 2016; (119()):62-6.

Focal EEG features and therapeutic response in patients with juvenile absence and myoclonic epilepsy.

Japaridze G, Kasradze S, Lomidze G, et al.

Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology 2016; (127(2)):1182-1187 doi:10.1016/j.clinph.2015.11.048.

Differential improvement of the sleep quality among patients with juvenile myoclonic epilepsy with valproic acid: A longitudinal sleep questionnaire-based study.

Nayak C, Sinha S, Ramachandraiah CT, et al.

Annals of Indian Academy of Neurology 2015; (18(4)):403-7 doi:10.4103/0972-2327.165472.

Optical coherence tomography parameters in patients with photosensitive juvenile myoclonic epilepsy.

Gomceli YB, Dogan B, Genc F, et al.

Seizure 2016; (35()):36-40.

Treatment of Convulsive Status Epilepticus.

Grover EH, Nazzal Y, Hirsch LJ

Current treatment options in neurology 2016; (18(3)):11 doi:10.1007/s11940-016-0394-5.

Modern management of juvenile myoclonic epilepsy.

Brodie MJ

Expert review of neurotherapeutics 2016; (16(6)):681-8 doi:10.1080/14737175.2016.1179113.

[Pharmacological treatment of women with epilepsy before and during pregnancy].

Müffelmann B, Bien CG

Der Nervenarzt 2016; (87(10)):1115-1126 doi:10.1007/s00115-016-0210-1.

Juvenile myoclonic epilepsy: Challenges on its 60th anniversary.

Yacubian EM

Seizure 2017; (44()):48-52 doi:10.1016/j.seizure.2016.09.005.

Women with epilepsy initiating a progestin IUD: A prospective pilot study of safety and acceptability.

Davis AR, Saadatmand HJ, Pack A

Epilepsia 2016; (57(11)):1843-1848 doi:10.1111/epi.13559.

Status epilepticus in patients with juvenile myoclonic epilepsy: Frequency, precipitating factors and outcome.

Oğuz-Akarsu E, Aydin-Özemir Z, Bebek N, et al.

Epilepsy & behavior : E&B 2016; (64(Pt A)):127-132 doi:10.1016/j.yebeh.2016.07.038.

Juvenile Myoclonic Epilepsy in Rural Western India: Not Yet a Benign Syndrome.

Desai D, Desai S, Jani T

Epilepsy research and treatment 2016; (2016()):1435150 doi:10.1155/2016/1435150.

Monotherapy treatment of epilepsy in pregnancy: congenital malformation outcomes in the child.

Weston J, Bromley R, Jackson CF, et al.

The Cochrane database of systematic reviews 2016; (11()):CD010224 doi:10.1002/14651858.CD010224.pub2.

Prevalence of juvenile myoclonic epilepsy in people <30 years of age-A population-based study in Norway.

Syvertsen M, Hellum MK, Hansen G, et al.

Epilepsia 2017; (58(1)):105-112 doi:10.1111/epi.13613.

The topographical distribution of epileptic spikes in juvenile myoclonic epilepsy with and without photosensitivity.

Bauer PR, Gorgels K, Spetgens W, et al.

Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology 2017; (128(1)):176-182 doi:10.1016/j.clinph.2016.10.098.

Prognostic factors in patients with refractory idiopathic generalized epilepsy.

Gomez-Ibañez A, McLachlan RS, Mirsattari SM, et al.

Epilepsy research 2017; (130()):69-73 doi:10.1016/j.eplepsyres.2017.01.011.

Photosensitivity in generalized epilepsies.

Poleon S, Szaflarski JP

Epilepsy & behavior : E&B 2017; (68()):225-233 doi:10.1016/j.yebeh.2016.10.040.

Unmasking of myoclonus by lacosamide in generalized epilepsy.

Birnbaum D, Koubeissi M

Epilepsy & behavior case reports 2017; (7()):28-30 doi:10.1016/j.ebcr.2016.09.006.

Photosensitivity and epilepsy: Current concepts and perspectives-A narrative review.

Martins da Silva A, Leal B

Seizure 2017; (50()):209-218 doi:10.1016/j.seizure.2017.04.001.

Sleep abnormalities in juvenile myoclonic epilepsy-A sleep questionnaire and polysomnography based study.

Roshan S, Puri V, Chaudhry N, et al.

Seizure 2017; (50()):194-201 doi:10.1016/j.seizure.2017.06.021.

NREM Sleep and Antiepileptic Medications Modulate Epileptiform Activity by Altering Cortical Synchrony.

Nayak CS, Mariyappa N, Majumdar KK, et al.

Clinical EEG and neuroscience 2018; (49(6)):417-424 doi:10.1177/1550059417747436.

Impact of sleep disorders on the risk of seizure recurrence in juvenile myoclonic epilepsy.

Buratti L, Natanti A, Viticchi G, et al.

Epilepsy & behavior : E&B 2018; (80()):21-24 doi:10.1016/j.yebeh.2017.11.023.

Comparative risk of major congenital malformations with eight different antiepileptic drugs: a prospective cohort study of the EURAP registry.

Tomson T, Battino D, Bonizzoni E, et al.

The Lancet. Neurology 2018; (17(6)):530-538 doi:10.1016/S1474-4422(18)30107-8.

Relapse after treatment withdrawal of antiepileptic drugs for Juvenile Absence Epilepsy and Juvenile Myoclonic Epilepsy.

Healy L, Moran M, Singhal S, et al.

Seizure 2018; (59()):116-122 doi:10.1016/j.seizure.2018.05.015.

Praxis-induced myoclonia: From the neurophysiologist to the patient perspective.

Abarrategui B, De Marchi LR, Guaranha MSB, Yacubian EMT

Seizure 2018; (60()):184-189 doi:10.1016/j.seizure.2018.06.022.

Refractory juvenile myoclonic epilepsy: a meta-analysis of prevalence and risk factors.

Stevelink R, Koeleman BPC, Sander JW, et al.

European journal of neurology 2019; (26(6)):856-864 doi:10.1111/ene.13811.

Treatment of Juvenile Myoclonic Epilepsy in Patients of Child-Bearing Potential.

Serafini A, Gerard E, Genton P, et al.

CNS drugs 2019; (33(3)):195-208 doi:10.1007/s40263-018-00602-2.

Pharmacokinetic changes and therapeutic drug monitoring of lamotrigine during pregnancy.

Ding Y, Tan X, Zhang S, Guo Y

Brain and behavior 2019; (9(7)):e01315 doi:10.1002/brb3.1315.

The Timing, Nature, and Range of Neurobehavioral Comorbidities in Juvenile Myoclonic Epilepsy.

Almane DN, Jones JE, McMillan T, et al.

Pediatric neurology 2019; (101()):47-52 doi:10.1016/j.pediatrneurol.2019.03.011.

Clinical features and treatment outcomes of Juvenile myoclonic epilepsy patients.

Zhang Y, Chen J, Ren J, et al.

Epilepsia open 2019; (4(2)):302-308 doi:10.1002/epi4.12321.

Generalized epilepsies.

Guerrini R, Marini C, Barba C

Handbook of clinical neurology 2019; (161()):3-15 doi:10.1016/B978-0-444-64142-7.00038-2.

Levetiracetam in genetic generalized epilepsy: A prospective unblinded active-controlled trial.

Tabrizi N, Zarvani A, Rezaei P, et al.

Epilepsy research 2019; (157()):106214 doi:10.1016/j.eplepsyres.2019.106214.

Bidirectional interaction between oral contraception and lamotrigine in women with epilepsy - Role of progestins.

Rauchenzauner M, Deichmann S, Pittschieler S, et al.

Seizure 2020; (74()):89-92 doi:10.1016/j.seizure.2019.11.011.

Therapeutic Drug Monitoring of Antiepileptic Drugs in Women with Epilepsy Before, During, and After Pregnancy.

Arfman IJ, Wammes-van der Heijden EA, Ter Horst PGJ, et al.

Clinical pharmacokinetics 2020; (59(4)):427-445 doi:10.1007/s40262-019-00845-2.

Pharmacological Management of the Genetic Generalised Epilepsies in Adolescents and Adults.

Stephen LJ, Brodie MJ

CNS drugs 2020; (34(2)):147-161 doi:10.1007/s40263-020-00698-5.

Meta-analysis of response inhibition in juvenile myoclonic epilepsy.

Smith A, Syvertsen M, Pal DK

Epilepsy & behavior : E&B 2020; (106()):107038 doi:10.1016/j.yebeh.2020.107038.

The impact and challenges of the 2018 MHRA statement on the use of sodium valproate in women of childbearing age during the first year of implementation, in a UK epilepsy centre.

Davies P, Reuber M, Grunewald R, et al.

Seizure 2020; (79()):8-13 doi:10.1016/j.seizure.2020.03.015.

Contraceptive vaginal ring reduces lamotrigine levels.

King A, Bachman E, Macken MP, et al.

Epilepsy & behavior : E&B 2020; (111()):107162 doi:10.1016/j.yebeh.2020.107162.

Do interictal EEG findings reflect cognitive function in juvenile myoclonic epilepsy?

Balcik ZE, Senadim S, Tekin B, et al.

Epilepsy & behavior : E&B 2020; (111()):107281 doi:10.1016/j.yebeh.2020.107281.

Association of Prenatal Exposure to Valproate and Other Antiepileptic Drugs With Intellectual Disability and Delayed Childhood Milestones.

Daugaard CA, Pedersen L, Sun Y, et al.

JAMA network open 2020; (3(11)):e2025570 doi:10.1001/jamanetworkopen.2020.25570.

Alternatives to valproate in girls and women of childbearing potential with Idiopathic Generalized Epilepsies: state of the art and guidance for the clinician proposed by the Epilepsy and Gender Commission of the Italian League Against Epilepsy (LICE).

Mostacci B, Ranzato F, Giuliano L, et al.

Seizure 2021; (85()):26-38 doi:10.1016/j.seizure.2020.12.005.

Risk factors of paradoxical reactions to anti-seizure medication in genetic generalized epilepsy.

Gesche J, Hjalgrim H, Rubboli G, Beier CP

Epilepsy research 2021; (170()):106547 doi:10.1016/j.eplepsyres.2020.106547.

Response to levetiracetam or lamotrigine in subjects with Juvenile Myoclonic Epilepsy previously treated with valproic acid: A single center retrospective study.

Milano C, Turco F, Pizzanelli C, et al.

Epilepsy & behavior : E&B 2021; (115()):107706 doi:10.1016/j.yebeh.2020.107706.

Juvenile Myoclonic Epilepsy: Myoclonic Status Epilepticus without Coma - Report of Three Cases.

Murthy JMK

Journal of epilepsy research 2020; (10(2)):92-95 doi:10.14581/jer.20015.

Juvenile myoclonic epilepsy: Long-term prognosis and risk factors.

Pietrafusa N, La Neve A, de Palma L, et al.

Brain & development 2021; (43(6)):688-697 doi:10.1016/j.braindev.2021.02.005.

Diagnostic and therapeutic approach to drug-resistant juvenile myoclonic epilepsy.

Ascoli M, Mastroianni G, Gasparini S, et al.

Expert review of neurotherapeutics 2021; (21(11)):1265-1273 doi:10.1080/14737175.2021.1931126.

Reconsidering the role of selective sodium channel blockers in genetic generalized epilepsy.

Cerulli Irelli E, Morano A, Fanella M, et al.

Acta neurologica Scandinavica 2021; (144(6)):647-654 doi:10.1111/ane.13509.

Prolonged and short epileptiform discharges have an opposite relationship with the sleep-wake cycle in patients with JME: Implications for EEG recording protocols.

Turco F, Giorgi FS, Maestri M, et al.

Epilepsy & behavior : E&B 2021; (122()):108226 doi:10.1016/j.yebeh.2021.108226.

Seizure outcome trajectories in a well-defined cohort of newly diagnosed juvenile myoclonic epilepsy patients.

Cerulli Irelli E, Morano A, Orlando B, et al.

Acta neurologica Scandinavica 2022; (145(3)):314-321 doi:10.1111/ane.13556.

Gray Matter Changes in Juvenile Myoclonic Epilepsy. A Voxel-Wise Meta-Analysis.

Kazis D, Petridis F, Chatzikonstantinou S, et al.

Medicina (Kaunas, Lithuania) 2021; (57(11)) doi:10.3390/medicina57111136.

Analysis of Clinical Characteristics, Background, and Paroxysmal Activity in EEG of Patients with Juvenile Myoclonic Epilepsy.

Santiago-Rodríguez E, Zaldívar-Uribe E

Brain sciences 2021; (12(1)) doi:10.3390/brainsci12010029.

Comparative analysis of background EEG activity in juvenile myoclonic epilepsy during valproic acid treatment: a standardized, low-resolution, brain electromagnetic tomography (sLORETA) study.

Moon JU, Lee JY, Kim KY, et al.

BMC neurology 2022; (22(1)):48 doi:10.1186/s12883-022-02577-6.

Sex-specific disease modifiers in juvenile myoclonic epilepsy.

Shakeshaft A, Panjwani N, Collingwood A, et al.

Scientific reports 2022; (12(1)):2785 doi:10.1038/s41598-022-06324-2.

A case of juvenile myoclonic epilepsy in which a disease-specific question led to the diagnosis.

Maita H, Kobayashi T, Akimoto T, et al.

Journal of general and family medicine 2022; (23(2)):107-109 doi:10.1002/jgf2.496.

Recurrence rates and risk factors for seizure recurrence following antiseizure medication withdrawal in adolescent patients with genetic generalized epilepsy.

Komatsubara T, Kobayashi Y, Hiraiwa A, et al.

Epilepsia open 2022; (7(2)):332-343 doi:10.1002/epi4.12603.

ILAE definition of the Idiopathic Generalized Epilepsy Syndromes: Position statement by the ILAE Task Force on Nosology and Definitions.

Hirsch E, French J, Scheffer IE, et al.

Epilepsia 2022; (63(6)):1475-1499 doi:10.1111/epi.17236.

Can Disruption of Basal Ganglia-Thalamocortical Circuit in Wilson Disease Be Associated with Juvenile Myoclonic Epilepsy Phenotype?

Rossi J, Cavallieri F, Giovannini G, et al.

Brain sciences 2022; (12(5)) doi:10.3390/brainsci12050553.

Association of Prenatal Exposure to Antiseizure Medication With Risk of Autism and Intellectual Disability.

Bjørk MH, Zoega H, Leinonen MK, et al.

JAMA neurology 2022; (79(7)):672-681 doi:10.1001/jamaneurol.2022.1269.

Treatment and care of women with epilepsy before, during, and after pregnancy: a practical guide.

Nucera B, Brigo F, Trinka E, Kalss G

Therapeutic advances in neurological disorders 2022; (15()):17562864221101687 doi:10.1177/17562864221101687.

Sleep quality and architecture in Idiopathic generalized epilepsy: A systematic review and meta-analysis.

Lehner J, Frueh JS, Datta AN

Sleep medicine reviews 2022; (65()):101689 doi:10.1016/j.smrv.2022.101689.

Rescue Treatments for Seizure Clusters.

Kotloski RJ, Gidal BE

Neurologic clinics 2022; (40(4)):927-937 doi:10.1016/j.ncl.2022.03.016.

Individualised prediction of drug resistance and seizure recurrence after medication withdrawal in people with juvenile myoclonic epilepsy: A systematic review and individual participant data meta-analysis.

Stevelink R, Al-Toma D, Jansen FE, et al.

EClinicalMedicine 2022; (53()):101732 doi:10.1016/j.eclinm.2022.101732.

Duration of epileptic seizure types: A data-driven approach.

Meritam Larsen P, Wüstenhagen S, Terney D, et al.

Epilepsia 2023; (64(2)):469-478 doi:10.1111/epi.17492.

Neurophysiology of Juvenile and Progressive Myoclonic Epilepsy.

Acharya JN, Acharya VJ

Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society 2023; (40(2)):100-108 doi:10.1097/WNP.0000000000000913.

Prevalence, nature, and severity of the psychiatric comorbidities and their impact on quality of life in adolescents with Juvenile myoclonic epilepsy.

Panda PK, Ramachandran A, Tomar A, et al.

Epilepsy & behavior : E&B 2023; (142()):109216 doi:10.1016/j.yebeh.2023.109216.

Variation in prognosis and treatment outcome in juvenile myoclonic epilepsy: a Biology of Juvenile Myoclonic Epilepsy Consortium proposal for a practical definition and stratified medicine classifications.

Rubboli G, Beier CP, Selmer KK, et al.

Brain communications 2023; (5(3)):fcad182 doi:10.1093/braincomms/fcad182.

The Roles of Cystatin B in the Brain and Pathophysiological Mechanisms of Progressive Myoclonic Epilepsy Type 1.

Singh S, Hämäläinen RH

Cells 2024; (13(2)) doi:10.3390/cells13020170.

Dose Monitoring of Lamotrigine Monotherapy in Pregnancy: Are Pregnant Women with Epilepsy Currently Optimally Managed? A Systematic Review.

Goo Y, der Nederlanden AM, Bleasel A, et al.

Therapeutic drug monitoring 2024; (46(2)):181-194 doi:10.1097/FTD.0000000000001186.

Risk of Autism after Prenatal Topiramate, Valproate, or Lamotrigine Exposure.

Hernández-Díaz S, Straub L, Bateman BT, et al.

The New England journal of medicine 2024; (390(12)):1069-1079 doi:10.1056/NEJMoa2309359.

A systematic review and meta-analysis of factors related to first line drugs refractoriness in patients with juvenile myoclonic epilepsy (JME).

Fayad C, Saad K, Kahwagi GJ, et al.

PloS one 2024; (19(4)):e0300930 doi:10.1371/journal.pone.0300930.

Immediate Treatment of Seizure Clusters: A Conceptual Roadmap to Expedited Seizure Management.

Wheless JW, Becker DA, Benbadis SR, et al.

Neuropsychiatric disease and treatment 2024; (20()):2255-2265 doi:10.2147/NDT.S481758.

Awareness and driving safety during awake interictal epileptiform discharges in idiopathic generalised epilepsies: A systematic review.

Arnaout B, Nurse ES, Cook MJ

Epilepsy & behavior : E&B 2025; (163()):110197 doi:10.1016/j.yebeh.2024.110197.

[Absence status epilepticus in adults].

Kozhokaru AB, Vlasov PN, Karlov VA, et al.

Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 2024; (124(12)):47-56 doi:10.17116/jnevro202412412147.

Clarithromycin-induced myoclonic status epilepticus.

Biçimveren MS

Practical neurology 2025; (25(5)):455-457 doi:10.1136/pn-2024-004464.

Long-term outcomes of treatment with levetiracetam and valproate in idiopathic generalized epilepsy.

Tabrizi N, Cheraghmakani H, Samadi F, Alizadeh-Navaei R

Seizure 2025; (127()):66-70 doi:10.1016/j.seizure.2025.03.004.

Levetiracetam for myoclonic seizures in idiopathic generalized epilepsy: A systematic review and meta-analysis.

Pereira ARO, Leão IA, Dias LA, Moura RF

Epilepsy & behavior : E&B 2025; (171()):110512 doi:10.1016/j.yebeh.2025.110512.

Juvenile Myoclonic Epilepsy in Children and Adolescents: The Effect of Antiseizure Medications on Cognitive Functions.

Mertoglu S, Kafadar I

Journal of child neurology 2026; (41(6)):812-821 doi:10.1177/08830738251389081.

Dosing Optimization of Lamotrigine in Peripregnancy Epilepsy Through PopPK Modelling and Simulation.

Huo J, Liu Y, Yang J, et al.

Drug design, development and therapy 2025; (19()):10243-10258 doi:10.2147/DDDT.S541597.

Dose adjustment of the anti-seizure medications levetiracetam and lamotrigine during the postpartum period. Schedule plan, safety and efficacy.

Khmelev N, Fahoum F, Goldstein L

Epilepsy & behavior : E&B 2026; (175()):110858 doi:10.1016/j.yebeh.2025.110858.

Recommendations for the community-based management of prolonged convulsive seizures in children in Europe.

Vigevano F, Arzimanoglou A, Auvin S, et al.

BMC pediatrics 2026; (26(1)):135.

Lamotrigine, Contraceptives, and Psychiatry: A Narrative Review.

Costa I, Esteves-Sousa D

Cureus 2025; (17(12)):e100392 doi:10.7759/cureus.100392.

Do generalized epilepsies exhibit more attentional or executive disorders?

Lacour B, Heintz V, Forthoffer N, et al.

Epilepsy & behavior reports 2026; (33()):100843 doi:10.1016/j.ebr.2025.100843.

How are we doing? The electroclinical diagnosis of status epilepticus in idiopathic generalized epilepsy in a tertiary referral center: A case series and scoping review of 40 years of literature.

Peña-Ceballos J, Moloney PB, Kinney MO, et al.

Journal of the neurological sciences 2026; (484()):125864 doi:10.1016/j.jns.2026.125864.