Research & Literature

Early Diagnosis and Monitoring of Neurodegenerative Langerhans Cell Histiocytosis.

Sieni E, Barba C, Mortilla M, et al.

PloS one 2015; (10(7)):e0131635 doi:10.1371/journal.pone.0131635.

Vemurafenib Use in an Infant for High-Risk Langerhans Cell Histiocytosis.

Héritier S, Jehanne M, Leverger G, et al.

JAMA oncology 2015; (1(6)):836-8 doi:10.1001/jamaoncol.2015.0736.

A case of bilateral sensorineural hearing loss from Langerhans cell histiocytosis.

Henderson AH, Khan AA, Good C, Baer ST

BMJ case reports 2015; (2015()).

Genomic Alterations in Langerhans Cell Histiocytosis.

Rollins BJ

Hematology/oncology clinics of North America 2015; (29(5)):839-51.

Clinical Characteristics and Treatment of Langerhans Cell Histiocytosis.

Monsereenusorn C, Rodriguez-Galindo C

Hematology/oncology clinics of North America 2015; (29(5)):853-73.

Diverse Cutaneous Presentations of Langerhans Cell Histiocytosis in Children: A Retrospective Cohort Study.

Morren MA, Vanden Broecke K, Vangeebergen L, et al.

Pediatric blood & cancer 2016; (63(3)):486-92 doi:10.1002/pbc.25834.

18F-Fluorodeoxyglucose PET/CT in Langerhans cell histiocytosis: spectrum of manifestations.

Agarwal KK, Seth R, Behra A, et al.

Japanese journal of radiology 2016; (34(4)):267-76 doi:10.1007/s11604-016-0517-7.

MRI and clinical features of Langerhans cell histiocytosis (LCH) in the pelvis and extremities: can LCH really look like anything?

Samet J, Weinstein J, Fayad LM

Skeletal radiology 2016; (45(5)):607-13 doi:10.1007/s00256-016-2330-x.

Langerhans Cell Histiocytosis: Emerging Insights and Clinical Implications.

Zinn DJ, Chakraborty R, Allen CE

Oncology (Williston Park, N.Y.) 2016; (30(2)):122-32, 139.

Multinucleated giant cells in Langerhans cell histiocytosis.

Yanagisawa R, Ogiso Y, Miyairi Y, et al.

British journal of haematology 2016; (174(1)):7 doi:10.1111/bjh.14124.

Langerhans cell histiocytosis: therapeutic strategy and outcome in a 30-year nationwide cohort of 1478 patients under 18 years of age.

Rigaud C, Barkaoui MA, Thomas C, et al.

British journal of haematology 2016; (174(6)):887-98 doi:10.1111/bjh.14140.

Hydroxyurea: a new old therapy for Langerhans cell histiocytosis.

Zinn DJ, Grimes AB, Lin H, et al.

Blood 2016; (128(20)):2462-2465 doi:10.1182/blood-2016-06-721993.

Insights into the pathogenesis of Langerhans cell histiocytosis: the development of targeted therapies.

Hutter C, Minkov M

ImmunoTargets and therapy 2016; (5()):81-91 doi:10.2147/ITT.S91058.

18F-FDG PET/CT in follow-up evaluation in pediatric patients with Langerhans histiocytosis.

Garcia JR, Riera E, Bassa P, et al.

Revista espanola de medicina nuclear e imagen molecular 2017; (36(5)):325-328 doi:10.1016/j.remn.2017.01.007.

Late outcomes in children with Langerhans cell histiocytosis.

Chow TW, Leung WK, Cheng FWT, et al.

Archives of disease in childhood 2017; (102(9)):830-835 doi:10.1136/archdischild-2016-312185.

Langerhans cell histiocytosis of the maxillae in a child treated only with chemotherapy: a case report.

Cazzolla AP, Troiano G, Zhurakivska K, et al.

Journal of medical case reports 2017; (11(1)):130 doi:10.1186/s13256-017-1286-3.

Vinblastine chemotherapy in adult patients with langerhans cell histiocytosis: a multicenter retrospective study.

Tazi A, Lorillon G, Haroche J, et al.

Orphanet journal of rare diseases 2017; (12(1)):95 doi:10.1186/s13023-017-0651-z.

Perianal Langerhans cell histiocytosis: a rare presentation in an adult male.

Abdou AG, MaherTaie D

Autopsy & case reports 2017; (7(3)):38-43 doi:10.4322/acr.2017.028.

Congenital Langerhans cell histiocytosis: a good prognosis disease?

Frade AP, Godinho MM, Batalha ABW, Bueno APS

Anais brasileiros de dermatologia 2017; (92(5 Suppl 1)):40-42 doi:10.1590/abd1806-4841.20175308.

A 12-Month-Old Healthy Girl with a New Oral Ulcer and Chronic Diaper Rash.

Song H, Song JS, Wallace EB, et al.

Dermatopathology (Basel, Switzerland) 2017; (4(1-4)):24-30 doi:10.1159/000481308.

The multiple faces of Langerhans cell histiocytosis in childhood: A gentle reminder.

Papadopoulou M, Panagopoulou P, Papadopoulou A, et al.

Molecular and clinical oncology 2018; (8(3)):489-492 doi:10.3892/mco.2017.1539.

Intensification of induction therapy and prolongation of maintenance therapy did not improve the outcome of pediatric Langerhans cell histiocytosis with single-system multifocal bone lesions: results of the Japan Langerhans Cell Histiocytosis Study Group-02 Protocol Study.

Morimoto A, Shioda Y, Imamura T, et al.

International journal of hematology 2018; (108(2)):192-198 doi:10.1007/s12185-018-2444-0.

CNS Langerhans cell histiocytosis: Common hematopoietic origin for LCH-associated neurodegeneration and mass lesions.

McClain KL, Picarsic J, Chakraborty R, et al.

Cancer 2018; (124(12)):2607-2620 doi:10.1002/cncr.31348.

Cutaneous Langerhans cell histiocytosis presenting with hypopigmented lesions: Report of two cases and review of literature.

Mori S, Adar T, Kazlouskaya V, et al.

Pediatric dermatology 2018; (35(4)):502-506 doi:10.1111/pde.13509.

Langerhans cell histiocytosis in children: History, classification, pathobiology, clinical manifestations, and prognosis.

Krooks J, Minkov M, Weatherall AG

Journal of the American Academy of Dermatology 2018; (78(6)):1035-1044 doi:10.1016/j.jaad.2017.05.059.

Langerhans cell histiocytosis in children: Diagnosis, differential diagnosis, treatment, sequelae, and standardized follow-up.

Krooks J, Minkov M, Weatherall AG

Journal of the American Academy of Dermatology 2018; (78(6)):1047-1056 doi:10.1016/j.jaad.2017.05.060.

Successful management of multiple-systemic Langerhans cell histiocytosis involving endocrine organs in an adult: A case report and review of literature.

Xie J, Li Z, Tang Y

Medicine 2018; (97(26)):e11215 doi:10.1097/MD.0000000000011215.

Long-term disease control of Langerhans cell histiocytosis using combined BRAF and MEK inhibition.

Awada G, Seremet T, Fostier K, et al.

Blood advances 2018; (2(16)):2156-2158 doi:10.1182/bloodadvances.2018021782.

The multidisciplinary pediatric psycho-oncology workforce: A national report on supervision for staff and training opportunities.

Kazak AE, Scialla MA, Patenaude AF, et al.

Psycho-oncology 2018; (27(12)):2802-2808 doi:10.1002/pon.4892.

Clinical responses and persistent BRAF V600E+ blood cells in children with LCH treated with MAPK pathway inhibition.

Eckstein OS, Visser J, Rodriguez-Galindo C, et al.

Blood 2019; (133(15)):1691-1694 doi:10.1182/blood-2018-10-878363.

Langerhans cell histiocytosis presenting as eosinophilic granuloma of the bilateral forearms in an 8-year-old girl: a case report.

Idrissa S, Cherrabi H, Efared B, et al.

Journal of medical case reports 2019; (13(1)):67 doi:10.1186/s13256-019-2011-1.

Langerhans' cell histiocytosis of the temporal bone in an adult with central diabetes insipidus.

Allen A, Matrova E, Ozgen B, et al.

Radiology case reports 2019; (14(7)):847-850 doi:10.1016/j.radcr.2019.03.040.

Endocrine manifestations in a cohort of 63 adulthood and childhood onset patients with Langerhans cell histiocytosis.

Sagna Y, Courtillot C, Drabo JY, et al.

European journal of endocrinology 2019; (181(3)):275-285.

Childhood Langerhans cell histiocytosis: a disease with many faces.

Leung AKC, Lam JM, Leong KF

World journal of pediatrics : WJP 2019; (15(6)):536-545 doi:10.1007/s12519-019-00304-9.

[Status of Langerhans cell histiocytosis in children and adults].

Kudo K

[Rinsho ketsueki] The Japanese journal of clinical hematology 2019; (60(9)):1308-1316 doi:10.11406/rinketsu.60.1308.

FDG PET-CT in pediatric Langerhans cell histiocytosis.

Jessop S, Crudgington D, London K, et al.

Pediatric blood & cancer 2020; (67(1)):e28034 doi:10.1002/pbc.28034.

Altered cerebral perfusion in children with Langerhans cell histiocytosis after chemotherapy.

Han M, Kim LH, Shpanskaya K, et al.

Pediatric blood & cancer 2020; (67(3)):e28104 doi:10.1002/pbc.28104.

Isolated Langerhans cell histiocytosis in the hypothalamic-pituitary region: a case report.

Zhou W, Rao J, Li C

BMC endocrine disorders 2019; (19(1)):143 doi:10.1186/s12902-019-0474-0.

A case of multisystem Langerhans cell histiocytosis presenting as central diabetes insipidus.

Nicholas PD, Garrahy I

Journal of community hospital internal medicine perspectives 2019; (9(6)):515-517 doi:10.1080/20009666.2019.1698231.

Ratio and index of Neurofilament light chain indicate its origin in Guillain-Barré Syndrome.

Körtvelyessy P, Kuhle J, Düzel E, et al.

Annals of clinical and translational neurology 2020; (7(11)):2213-2220 doi:10.1002/acn3.51207.

Long-term complications in uniformly treated paediatric Langerhans histiocytosis patients disclosed by 12 years of follow-up of the JLSG-96/02 studies.

Sakamoto K, Morimoto A, Shioda Y, et al.

British journal of haematology 2021; (192(3)):615-620 doi:10.1111/bjh.17243.

Eosinophilic Granuloma of the Skull Presenting as Non-Traumatic Extradural Haematoma in Children.

Al-Mousa A, Altarawneh M, Alqatawneh O, et al.

International journal of general medicine 2020; (13()):1229-1234 doi:10.2147/IJGM.S288512.

Langerhans cell histiocytosis in a 5-month-old baby.

Chanchlani N, Parke SC, Hart JW

CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne 2021; (193(1)):E23 doi:10.1503/cmaj.201151.

Discrepancies between F-18-FDG PET/CT findings and conventional imaging in Langerhans cell histiocytosis.

Ferrell J, Sharp S, Kumar A, et al.

Pediatric blood & cancer 2021; (68(4)):e28891 doi:10.1002/pbc.28891.

BRAFV600E-induced senescence drives Langerhans cell histiocytosis pathophysiology.

Bigenwald C, Le Berichel J, Wilk CM, et al.

Nature medicine 2021; (27(5)):851-861 doi:10.1038/s41591-021-01304-x.

Paediatric Langerhans Cell Histiocytosis Disease: Long-Term Sequelae in the Hypothalamic Endocrine System.

Vaiani E, Felizzia G, Lubieniecki F, et al.

Hormone research in paediatrics 2021; (94(1-2)):9-17 doi:10.1159/000517040.

Neuroendocrine manifestations of Langerhans cell histiocytosis.

Yavropoulou MP, Tsoli M, Kaltsas G

Handbook of clinical neurology 2021; (181()):127-135 doi:10.1016/B978-0-12-820683-6.00009-9.

Diagnostic challenges in fine-needle aspiration of a jaw lesion.

Allen C, Nodit L

Diagnostic cytopathology 2021; (49(10)):1141-1143 doi:10.1002/dc.24857.

Evaluation of Cheek Edema in an Infant Reveals Langerhans Cell Histiocytosis.

Asimakopoulos AD, Panosetti E, Papoudou-Bai A, Sioka C

Ethiopian journal of health sciences 2022; (32(1)):217-220 doi:10.4314/ejhs.v32i1.24.

Infantile-Onset Isolated Neurohypophyseal Langerhans Cell Histiocytosis with Central Diabetes Insipidus: A Case Report.

Tani M, Hiroshima S, Sato H, et al.

Children (Basel, Switzerland) 2022; (9(5)) doi:10.3390/children9050716.

New biomarker paves the way for a clinical trial for neurodegeneration in Langerhans cell histiocytosis.

Shioda Y, Sakamoto K, Morimoto A

British journal of haematology 2022; (198(4)):623-624 doi:10.1111/bjh.18308.

Eye movement abnormalities in neurodegenerative langerhans cell histiocytosis.

Autier L, Gaymard B, Bayen E, et al.

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology 2022; (43(11)):6539-6546 doi:10.1007/s10072-022-06180-y.

Pediatric Langerhans Cell Histiocytosis: An Aggressive Presentation.

Suthersan S, Ong FM, Maruthamuthu T, et al.

Cureus 2022; (14(6)):e25684 doi:10.7759/cureus.25684.

Dissemination of an evidence-based behavioral intervention to alleviate distress in caregivers of children recently diagnosed with cancer: Bright IDEAS.

Voll M, Fairclough DL, Morrato EH, et al.

Pediatric blood & cancer 2022; (69(10)):e29904 doi:10.1002/pbc.29904.

Changing the name of diabetes insipidus: a position statement of the working group to consider renaming diabetes insipidus.

Arima H, Cheetham T, Christ-Crain M, et al.

Clinical endocrinology 2024; (101(5)):443-445 doi:10.1111/cen.14819.

Langerhans cell histiocytosis (LCH). Overview of symptoms of LCH, which may lead the patients to any of these medical specialists.

Adam Z, Pour L, Tomíška M, et al.

Vnitrni lekarstvi 2022; (68(E-2)):11-21.

Signaling pathways, microenvironment, and targeted treatments in Langerhans cell histiocytosis.

Gao XM, Li J, Cao XX

Cell communication and signaling : CCS 2022; (20(1)):195 doi:10.1186/s12964-022-00917-0.

Success of Trametinib in the Treatment of Langerhans Cell Histiocytosis With Novel MAPK Pathway Mutations.

Orr K, Hustak S, Beaudoin R, Ray A

Journal of pediatric hematology/oncology 2023; (45(4)):e534-e538 doi:10.1097/MPH.0000000000002599.

Clinical Profile and Outcome of 806 Pediatric Oncology Patients Treated With Radiotherapy at the Serbian National Cancer Center.

Bokun J, Popović-Vuković M, Stanić D, et al.

Journal of pediatric hematology/oncology 2023; (45(3)):116-122 doi:10.1097/MPH.0000000000002589.

Incidental Detection of Ilium Langerhans Cell Histiocytosis on 99m Tc-DTPA Renal Dynamic Scintigraphy.

Deng Y, He J, He L, et al.

Clinical nuclear medicine 2023; (48(7)):633-634 doi:10.1097/RLU.0000000000004683.

Successful treatment of Langerhans cell histiocytosis in an infant with vemurafenib: a case report and literature review.

Li Q

The Journal of dermatological treatment 2023; (34(1)):2279901 doi:10.1080/09546634.2023.2279901.

Intestinal Langerhans cell histiocytosis presenting with symptoms similar to inflammatory bowel disease: a case report.

Liu Y, Chen Z, Wang L, Li B

Pathology oncology research : POR 2024; (30()):1611705 doi:10.3389/pore.2024.1611705.

Nationwide Study of Factors Impacting Survival Outcome and Consequences in Children with Reactivation/Refractory Langerhans Cell Histiocytosis.

Monsereenusorn C, Suwannaying K, Buaboonnam J, et al.

Asian Pacific journal of cancer prevention : APJCP 2024; (25(5)):1831-1839 doi:10.31557/APJCP.2024.25.5.1831.

Multisystem Langerhans Cell Histiocytosis following Treatment of Initially Presumed Atopic Dermatitis with Dupilumab: A Case Report of an Extremely Confusing Scenario.

Cheng W, Ren H, Hu W

Case reports in dermatology 2024; (16(1)):181-185 doi:10.1159/000539704.

Targeted Therapy With Vemurafenib in Brazilian Children With Refractory Langerhans Cell Histiocytosis: Two Case Reports and Review of Literature.

Silva KAS, Magalhães IMQS, Benincasa DER, et al.

Cancer reports (Hoboken, N.J.) 2024; (7(8)):e2142 doi:10.1002/cnr2.2142.

68 Ga-FAPI and 18 F-FDG PET/CT Imaging in Langerhans Cell Histiocytosis for Recurrence and Therapeutic Response Assessment.

Liu M, Tang R, Chen X, et al.

Clinical nuclear medicine 2024; (49(11)):1027-1030 doi:10.1097/RLU.0000000000005476.

Dynamic endoscopic progression of gastrointestinal tract involvement in Langerhans cell histiocytosis: A pediatric case report.

Pan J, Liu B, Zhang H, Li Z

DEN open 2025; (5(1)):e70023 doi:10.1002/deo2.70023.

[Characteristics of long-term complications in Langerhans cell histiocytosis].

Shioda Y, Sakamoto K, Ono R, et al.

[Rinsho ketsueki] The Japanese journal of clinical hematology 2024; (65(9)):1216-1226 doi:10.11406/rinketsu.65.1216.

Isolated Langerhans cell histiocytosis of the stomach in adults: An analysis of clinicopathologic characteristics and molecular genetics.

Wu R, Zhao Y, Wu X, et al.

Medicine 2024; (103(51)):e40950 doi:10.1097/MD.0000000000040950.

The Great Mimicker: Langerhans Cell Histiocytosis Mimicking Autoimmune Polyendocrinopathy Candidiasis Ectodermal Dystrophy.

Jha T, Gupta P, Garg V, Dewan V

Fetal and pediatric pathology 2025; (44(3)):265-272 doi:10.1080/15513815.2025.2476463.

Langerhans Cell Histiocytosis With MAP2K1 Mutation Successfully Treated With Trametinib.

Lang M, Chang L, Cao XX

EJHaem 2025; (6(3)):e70067 doi:10.1002/jha2.70067.

Pediatric Langerhans Cell Histiocytosis: Unifocal Localization in the Frontal Bone Presenting With Periorbital Swelling.

Gorica A, Zeroli C, Franzini G, et al.

Case reports in pediatrics 2025; (2025()):8892923 doi:10.1155/crpe/8892923.

Quantitative Brain MRI Analysis in Neurodegenerative Langerhans Cell Histiocytosis.

Baek C, de la Rosa LR, Aliouat I, et al.

European journal of neurology 2025; (32(6)):e70249 doi:10.1111/ene.70249.

Lincoln Sign in a Case of Langerhans Cell Histiocytosis on Bone Scintigraphy.

Liang H, Dong Z, Chen F, et al.

Clinical nuclear medicine 2025; (50(10)):943-945 doi:10.1097/RLU.0000000000006065.

A clinical study incorporating multimodal 18F-FDG PET/CT metabolic parameters, genetic markers, and clinical characteristics for the evaluation and prediction of treatment efficacy and prognosis in Langerhans cell histiocytosis.

Huang Z, Qi W, Rao T, et al.

Frontiers in medicine 2025; (12()):1619967 doi:10.3389/fmed.2025.1619967.

Pulmonary Langerhans Cell Histiocytosis.

Benattia A, Jouenne F, Tazi A

Clinics in chest medicine 2025; (46(4)):605-618 doi:10.1016/j.ccm.2025.07.003.

Ear Discharge and Destructive Postauricular Mass: An ENT Manifestation of Langerhans Cell Histiocytosis.

Chishty F, Bonduelle Q

British journal of hospital medicine (London, England : 2005) 2025; (86(10)):1-10 doi:10.12968/hmed.2024.0498.

Efficacy and safety of dabrafenib-targeted therapy for pediatric langerhans cell histiocytosis: a systematic review and meta-analysis.

Lu Y, Ye Y, Ren W, et al.

Translational pediatrics 2025; (14(10)):2606-2616 doi:10.21037/tp-2025-464.

Advances in the diagnosis and management of pediatric Langerhans cell histiocytosis and Rosai-Dorfman disease: therapies, biomarkers, and response assessment.

Eckstein OS, Gulati N

Hematology. American Society of Hematology. Education Program 2025; (2025(1)):215-228 doi:10.1182/hematology.2025000708.

Prognostic factor analysis of oral and maxillofacial Langerhans cell histiocytosis based on clinical findings and tumour microenvironment.

Ogawa M, Yokoo S, Saitou E, et al.

BMC oral health 2026; (26(1)):255 doi:10.1186/s12903-025-07638-z.

Neurodegeneration in Langerhans Cell Histiocytosis: beyond a Sequela.

Santa-María López V, Gutiérrez-Carrasco I, Pérez-Martínez A, et al.

Anales de pediatria 2026; (104(2)):504058 doi:10.1016/j.anpede.2026.504058.

Successful Treatment of Histiocytic Sarcoma in Childhood.

Tsipou H, Avgerinou G, Glentis S, et al.

Cureus 2026; (18(2)):e103409 doi:10.7759/cureus.103409.