Research & Literature

Effectiveness and Safety of rhIGF-1 Therapy in Children: The European Increlex® Growth Forum Database Experience.

Bang P, Polak M, Woelfle J, et al.

Hormone research in paediatrics 2015; (83(5)):345-57 doi:10.1159/000371798.

GH Receptor Deficiency in Ecuadorian Adults Is Associated With Obesity and Enhanced Insulin Sensitivity.

Guevara-Aguirre J, Rosenbloom AL, Balasubramanian P, et al.

The Journal of clinical endocrinology and metabolism 2015; (100(7)):2589-96 doi:10.1210/jc.2015-1678.

Growth hormone insensitivity: diagnostic and therapeutic approaches.

Kurtoğlu S, Hatipoglu N

Journal of endocrinological investigation 2016; (39(1)):19-28 doi:10.1007/s40618-015-0327-2.

Fifty seven years of follow-up of the Israeli cohort of Laron Syndrome patients-From discovery to treatment.

Laron Z, Kauli R

Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society 2016; (28()):53-6.

LESSONS FROM 50 YEARS OF STUDY OF LARON SYNDROME.

Laron Z

Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists 2015; (21(12)):1395-402 doi:10.4158/EP15939.RA.

Growth hormone signaling pathways.

Carter-Su C, Schwartz J, Argetsinger LS

Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society 2016; (28()):11-5.

Short and tall stature: a new paradigm emerges.

Baron J, Sävendahl L, De Luca F, et al.

Nature reviews. Endocrinology 2015; (11(12)):735-46 doi:10.1038/nrendo.2015.165.

STAT5B deficiency: Impacts on human growth and immunity.

Hwa V

Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society 2016; (28()):16-20.

Insulin-Like Growth Factor-I is a Marker for the Nutritional State.

Hawkes CP, Grimberg A

Pediatric endocrinology reviews : PER 2015; (13(2)):499-511.

Clinical and Molecular Features of Laron Syndrome, A Genetic Disorder Protecting from Cancer.

Janecka A, Kołodziej-Rzepa M, Biesaga B

In vivo (Athens, Greece) 2016; (30(4)):375-81.

Short Stature in a Boy with Multiple Early-Onset Autoimmune Conditions due to a STAT3 Activating Mutation: Could Intracellular Growth Hormone Signalling Be Compromised?
.

Sediva H, Dusatkova P, Kanderova V, et al.

Hormone research in paediatrics 2017; (88(2)):160-166 doi:10.1159/000456544.

Clinical, Endocrine, and Molecular Genetic Analysis of a Large Cohort of Saudi Arabian Patients with Laron Syndrome.

Al-Ashwal AA, Al-Sagheir A, Ramzan K, et al.

Hormone research in paediatrics 2017; (88(2)):119-126 doi:10.1159/000475991.

Whole-exome sequencing gives additional benefits compared to candidate gene sequencing in the molecular diagnosis of children with growth hormone or IGF-1 insensitivity.

Shapiro L, Chatterjee S, Ramadan DG, et al.

European journal of endocrinology 2017; (177(6)):485-501.

Compound heterozygosity for two GHR missense mutations in a patient affected by Laron Syndrome: a case report.

Moia S, Tessaris D, Einaudi S, et al.

Italian journal of pediatrics 2017; (43(1)):94 doi:10.1186/s13052-017-0411-7.

Growth hormone insensitivity: Mexican case report.

Castilla-Cortazar I, De Ita JR, Aguirre GA, et al.

Endocrinology, diabetes & metabolism case reports 2017; (2017()) doi:10.1530/EDM-17-0126.

Same Phenotype in Children with Growth Hormone Deficiency and Resistance.

Ioimo I, Guarracino C, Meazza C, et al.

Case reports in pediatrics 2018; (2018()):5902835 doi:10.1155/2018/5902835.

Diagnosis and management of pseudohypoparathyroidism and related disorders: first international Consensus Statement.

Mantovani G, Bastepe M, Monk D, et al.

Nature reviews. Endocrinology 2018; (14(8)):476-500 doi:10.1038/s41574-018-0042-0.

Sequential measurements of IGF-I serum concentrations in adolescents with Laron syndrome treated with recombinant human IGF-I (rhIGF-I).

Breil T, Kneppo C, Bettendorf M, et al.

Journal of pediatric endocrinology & metabolism : JPEM 2018; (31(8)):895-902 doi:10.1515/jpem-2018-0139.

Treatment of severe primary IGF-1 deficiency using rhIGF-1 preparation - first three years of Polish experience.

Petriczko E, Jackowski T, Horodnicka-Józwa A, et al.

Endokrynologia Polska 2019; (70(1)):20-27 doi:10.5603/EP.a2018.0074.

Idiopathic short stature and growth hormone sensitivity in prepubertal children.

Derraik JGB, Miles HL, Chiavaroli V, et al.

Clinical endocrinology 2019; (91(1)):110-117 doi:10.1111/cen.13976.

A 42-Year-Old Woman with Untreated Growth Hormone Insensitivity, Diabetic Retinopathy, and Gene Sequencing Identifies a Variant of Laron Syndrome.

Castilla-Cortazar I, De Ita JR, García-Magariño M, et al.

The American journal of case reports 2019; (20()):689-696 doi:10.12659/AJCR.913178.

Genome-Wide Profiling of Laron Syndrome Patients Identifies Novel Cancer Protection Pathways.

Werner H, Lapkina-Gendler L, Achlaug L, et al.

Cells 2019; (8(6)) doi:10.3390/cells8060596.

Branding of subjects affected with genetic syndromes of severe short stature in developing countries.

Guevara-Aguirre J, Guevara C, Guevara A, Gavilanes AA

BMJ case reports 2020; (13(2)) doi:10.1136/bcr-2019-231737.

Marjolin's Ulcer in Laron Syndrome - an Unexpected Combination: A Case Report.

de la Paz EM

Malaysian orthopaedic journal 2020; (14(1)):78-80 doi:10.5704/MOJ.2003.012.

Cognitive Functioning in Turner Syndrome: Addressing Deficits Through Academic Accommodation.

Reimann GE, Comis LE, Bernad Perman MM

Women's health reports (New Rochelle, N.Y.) 2020; (1(1)):143-149 doi:10.1089/whr.2019.0019.

Effect of recombinant human insulin-like growth factor 1 therapy in a child with 3-M syndrome-1 with CUL7 gene mutation.

Yang M, Patni N

Journal of pediatric endocrinology & metabolism : JPEM 2020; (33(12)):1609-1612 doi:10.1515/jpem-2020-0278.

Genetic causes of growth hormone insensitivity beyond GHR.

Hwa V, Fujimoto M, Zhu G, et al.

Reviews in endocrine & metabolic disorders 2021; (22(1)):43-58 doi:10.1007/s11154-020-09603-3.

Insights from the clinical phenotype of subjects with Laron syndrome in Ecuador.

Guevara-Aguirre J, Bautista C, Torres C, et al.

Reviews in endocrine & metabolic disorders 2021; (22(1)):59-70 doi:10.1007/s11154-020-09602-4.

Laron Syndrome Research Paves the Way for New Insights in Oncological Investigation.

Werner H, Sarfstein R, Nagaraj K, Laron Z

Cells 2020; (9(11)) doi:10.3390/cells9112446.

Effectiveness and safety of rhIGF1 therapy in patients with or without Laron syndrome.

Bang P, Woelfle J, Perrot V, et al.

European journal of endocrinology 2021; (184(2)):267-276.

Genetic Characterization of Short Stature Patients With Overlapping Features of Growth Hormone Insensitivity Syndromes.

Andrews A, Maharaj A, Cottrell E, et al.

The Journal of clinical endocrinology and metabolism 2021; (106(11)):e4716-e4733 doi:10.1210/clinem/dgab437.

Role of the GH-IGF1 axis on the hypothalamus-pituitary-testicular axis function: lessons from Laron syndrome.

Cannarella R, Crafa A, La Vignera S, et al.

Endocrine connections 2021; (10(9)):1006-1017.

Laron syndrome in three female siblings with the development of subclinical hypothyroidism and dyslipidemia in one case: first report of a Syrian family.

Chreitah A, Hijazia K, Doya LJ

Oxford medical case reports 2021; (2021(9)):omab079 doi:10.1093/omcr/omab079.

Pubertal Timing and Growth Dynamics in Children With Severe Primary IGF-1 Deficiency: Results From the European Increlex® Growth Forum Database Registry.

Bang P, Polak M, Perrot V, et al.

Frontiers in endocrinology 2022; (13()):812568 doi:10.3389/fendo.2022.812568.

Exploratory study of the provision of academic and health-related accommodations to transition-age adolescents and emerging adults with spina bifida.

Betz CL, Hudson SM, Skura AL, et al.

Journal of pediatric rehabilitation medicine 2022; (15(4)):593-605 doi:10.3233/PRM-210116.

Health-related quality of life in boys with constitutional delay of growth and puberty.

Kariola L, Varimo T, Huopio H, et al.

Frontiers in endocrinology 2022; (13()):1028828 doi:10.3389/fendo.2022.1028828.

Treatment for Infertility in Laron Syndrome: A Case Report.

Alhazidou E, Vlachadis N, Androulaki M, et al.

Cureus 2022; (14(12)):e33090 doi:10.7759/cureus.33090.

Cancer in Ecuadorian subjects with Laron syndrome (ELS).

Guevara-Aguirre J, Peña G, Pazmiño G, et al.

Endocrine-related cancer 2023; (30(6)).

Caregiving burden and special needs of parents in the care of their short-statured children - a qualitative approach.

Lackner L, Quitmann JH, Witt S

Frontiers in endocrinology 2023; (14()):1093983 doi:10.3389/fendo.2023.1093983.

Short stature related to Growth Hormone Insensitivity (GHI) in childhood.

Mastromauro C, Giannini C, Chiarelli F

Frontiers in endocrinology 2023; (14()):1141039 doi:10.3389/fendo.2023.1141039.

Reporting a novel growth hormone receptor gene variant in an Iranian consanguineous pedigree with Laron syndrome: a case report.

Bitarafan F, Khodaeian M, Garrousi F, et al.

BMC endocrine disorders 2023; (23(1)):155 doi:10.1186/s12902-023-01388-1.

Frequency and Predictive Factors of Hypoglycemia in Patients Treated With rhIGF-1: Data From the Eu-IGFD Registry.

Bang P, Polak M, Bossowski A, et al.

The Journal of clinical endocrinology and metabolism 2023; (109(1)):46-56 doi:10.1210/clinem/dgad479.

Recombinant Human Insulin-Like Growth Factor-1 Treatment of Severe Growth Failure in Three Siblings with STAT5B Deficiency.

Muthuvel G, Al Remeithi SS, Foley C, et al.

Hormone research in paediatrics 2024; (97(2)):195-202 doi:10.1159/000531491.

Functional hypogonadism in adolescence: an overlooked cause of secondary hypogonadism.

Esquivel-Zuniga R, Rogol AD

Endocrine connections 2023; (12(11)).

A Recurrent Mutation in Growth Hormone Receptor (GHR) Gene Underlying Laron-type Dwarfism in a Pakistani Family.

Shabbir RMK, Nalbant G, Zaman Q, et al.

The Yale journal of biology and medicine 2023; (96(3)):313-325 doi:10.59249/TCAA2040.

Challenges in the care of individuals with severe primary insulin-like growth factor-I deficiency (SPIGFD): an international, multi-stakeholder perspective.

Backeljauw PF, Andrews M, Bang P, et al.

Orphanet journal of rare diseases 2023; (18(1)):312 doi:10.1186/s13023-023-02928-7.

Laron Syndrome: A Tale of Two Siblings.

Das N, Tarenia SS, Saha S, et al.

Journal of the ASEAN Federation of Endocrine Societies 2023; (38(2)):124-127 doi:10.15605/jafes.038.02.22.

Approach to the Peripubertal Patient With Short Stature.

Torres-Santiago L, Mauras N

The Journal of clinical endocrinology and metabolism 2024; (109(7)):e1522-e1533 doi:10.1210/clinem/dgae011.

Normal or improved cardiovascular risk factors in IGF-I-deficient adults with growth hormone receptor deficiency.

Guevara-Aguirre J, Mishra A, Canepa M, et al.

Med (New York, N.Y.) 2024; (5(7)):816-825.e4 doi:10.1016/j.medj.2024.03.022.

Adult patients with Laron syndrome tend to develop the metabolic syndrome.

Laron Z, Kauli R, Silbergeld A

Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society 2024; (78()):101605 doi:10.1016/j.ghir.2024.101605.

Long-Term Treatment for Laron Syndrome with IGF-1 Injection over 22 Years in Saudi Arabia: A Cohort Study.

Alashwal AA, Al-Fattani A, Ramzan K, et al.

Hormone research in paediatrics 2026; (99(4)):469-479 doi:10.1159/000543047.

Near-adult height outcomes in patients treated with rhIGF-1 for severe growth failure: real-world IGFD Registry data.

Ramon-Krauel M, Polak M, Maghnie M, et al.

The Journal of clinical endocrinology and metabolism 2025; doi:10.1210/clinem/dgaf390.

A Systematic Review of School-Based Behavioral Interventions and the Symbolic Labor of Inclusion for Children with Chronic Illness.

Efthymiou E, Katsarou DV, Sofologi M, et al.

Healthcare (Basel, Switzerland) 2025; (13(16)) doi:10.3390/healthcare13161968.

Growth hormone deficiency, bullying victimization, and associations with treatment status: a pediatric case-control study.

Kocabey Sutcu Z, Caliskan Y, Aytaç Kaplan EH

Journal of pediatric psychology 2026; (51(7)):612-620 doi:10.1093/jpepsy/jsag022.

Low or Low-Normal Insulin-Like Growth Factor 1 After Traumatic Brain Injury: Interpretation and Implications.

Mishra V, Martinez M, Weppner J

Journal of neurotrauma 2026; (43(21-22)):1728-1734 doi:10.1177/08977151261434917.

Impact of idiopathic short stature on children's well-being: a nationwide study of short Danish children.

Juul A, Linglart A, Højby M, et al.

Journal of the Endocrine Society 2026; (10(5)):bvag038 doi:10.1210/jendso/bvag038.

Real world data on rhIGF-1 therapy in children with severe primary IGF-I deficiency - The European experience.

Saavedra J, Bang P

Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society 2026; (85()):101719 doi:10.1016/j.ghir.2026.101719.

LARON SYNDROME. (Growth Hormone Insensitivity) Geographical distribution and relationship to the genetic defects in the growth hormone receptor gene.

Rabin T, Shinar Y, Laron Z

The Journal of clinical endocrinology and metabolism 2026; doi:10.1210/clinem/dgag253.

Managing growth and puberty concerns in individuals with Duchenne muscular dystrophy: Updated guidance and future directions.

Rutter MM, Crane JL, Babalola F, et al.

Journal of neuromuscular diseases 2026; 22143602261486896 doi:10.1177/22143602261486896.