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PubMed This is a summary of 2 peer-reviewed journal articles Updated
Dermatology

Your Guide to Mal de Meleda

At a Glance

Mal de Meleda (MDM) is a rare genetic skin condition that causes severe thickening of the skin on the palms and soles. Management focuses on daily skincare to address moisture and functional mobility, often requiring a dermatologist experienced in rare orphan skin diseases.

Receiving a diagnosis of Mal de Meleda (MDM) can feel overwhelming, especially because it is an “orphan” disease—a condition so rare that many doctors may never encounter it in their entire careers. MDM is a genetic skin condition that primarily affects the palms of the hands and the soles of the feet, but its impact is more than just skin deep [1].

While your journey with MDM is unique, understanding the mechanics of the condition and the landscape of care can help you navigate the path ahead with confidence. This guide is broken down into four sections to help you better understand and manage your diagnosis:

01

Understanding Mal de Meleda

Learn about Mal de Meleda (MDM), a rare genetic skin condition. Understand SLURP1 mutations, symptoms like thickened skin, and modern treatment options.

02

Symptoms and Complications

Learn about the symptoms and complications of Mal de Meleda (MDM). Understand skin thickening, excessive sweating, odor, nail changes, and secondary infections.

03

The Biology of Your Diagnosis

Understand the biology of Mal de Meleda (MDM). Learn how the SLURP1 gene mutation causes thickened skin and how genetic testing confirms your diagnosis.

04

Treatment and Daily Management

Learn about Mal de Meleda (MDM) treatment options, including oral retinoids like acitretin, topical keratolytics, orthotics, and daily skin management.

Common questions in this guide

What is Mal de Meleda?
Mal de Meleda is a rare genetic skin condition, often called an orphan disease, that causes abnormal thickening of the skin primarily on the palms of the hands and soles of the feet.
Should I see a genetic counselor for Mal de Meleda?
Consulting a genetic counselor can help you and your family understand how this condition is inherited and the potential genetic risks for future generations.
What are the main complications of Mal de Meleda?
Complications can include significantly thickened skin that affects your hand and foot mobility, along with challenges managing skin moisture and odor.
How is Mal de Meleda treated?
Treatment typically focuses on daily symptom management, specialized skin care routines, and sometimes surgical interventions to improve comfort and daily function.

Questions to Ask Your Doctor

Curated prompts to bring to your next appointment.

  1. 1.What is the most important first step we should take in managing my condition?
  2. 2.Can you recommend a genetic counselor who can help me and my family understand the risks for future generations?
  3. 3.How many other patients with palmoplantar keratodermas have you treated, and do we need to consult a specialist in orphan skin diseases?

Questions For You

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References

References (1)
  1. 1

    Mal de Meleda: A Focused Review.

    Perez C, Khachemoune A

    American journal of clinical dermatology 2016; (17(1)):63-70 doi:10.1007/s40257-015-0157-1.

    PMID: 26445964

This guide provides educational information about Mal de Meleda. It does not replace professional medical advice, and you should always consult your dermatologist or genetic counselor for personalized care.

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