Research & Literature

Poor thiamin and riboflavin status is common among women of childbearing age in rural and urban Cambodia.

Whitfield KC, Karakochuk CD, Liu Y, et al.

The Journal of nutrition 2015; (145(3)):628-33 doi:10.3945/jn.114.203604.

Association study of methylenetetrahydrofolate reductase C677T mutation with cerebral venous thrombosis in an Iranian population.

Ghaznavi H, Soheili Z, Samiei S, Soltanpour MS

Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 2015; (26(8)):869-73 doi:10.1097/MBC.0000000000000292.

Supplementation with Riboflavin (Vitamin B2) for Migraine Prophylaxis in Adults and Children: A Review.

Namazi N, Heshmati J, Tarighat-Esfanjani A

International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition 2015; (85(1-2)):79-87 doi:10.1024/0300-9831/a000225.

Riboflavin status, MTHFR genotype and blood pressure: current evidence and implications for personalised nutrition.

McAuley E, McNulty H, Hughes C, et al.

The Proceedings of the Nutrition Society 2016; (75(3)):405-14 doi:10.1017/S0029665116000197.

Disruption of Slc52a3 gene causes neonatal lethality with riboflavin deficiency in mice.

Yoshimatsu H, Yonezawa A, Yamanishi K, et al.

Scientific reports 2016; (6()):27557 doi:10.1038/srep27557.

Riboflavin, MTHFR genotype and blood pressure: A personalized approach to prevention and treatment of hypertension.

McNulty H, Strain JJ, Hughes CF, Ward M

Molecular aspects of medicine 2017; (53()):2-9 doi:10.1016/j.mam.2016.10.002.

Associations of Milk Consumption and Vitamin B₂ and Β12 Derived from Milk with Fitness, Anthropometric and Biochemical Indices in Children. The Healthy Growth Study.

Moschonis G, van den Heuvel EG, Mavrogianni C, et al.

Nutrients 2016; (8(10)).

Riboflavin deficiency induces a significant change in proteomic profiles in HepG2 cells.

Xin Z, Pu L, Gao W, et al.

Scientific reports 2017; (7()):45861 doi:10.1038/srep45861.

Dietary Intake and Food Sources of Niacin, Riboflavin, Thiamin and Vitamin B₆ in a Representative Sample of the Spanish Population. The Anthropometry, Intake, and Energy Balance in Spain (ANIBES) Study †.

Mielgo-Ayuso J, Aparicio-Ugarriza R, Olza J, et al.

Nutrients 2018; (10(7)) doi:10.3390/nu10070846.

Suboptimal Biochemical Riboflavin Status Is Associated with Lower Hemoglobin and Higher Rates of Anemia in a Sample of Canadian and Malaysian Women of Reproductive Age.

Aljaadi AM, How RE, Loh SP, et al.

The Journal of nutrition 2019; (149(11)):1952-1959 doi:10.1093/jn/nxz151.

Impact of the MTHFR C677T polymorphism on one-carbon metabolites: Evidence from a randomised trial of riboflavin supplementation.

Rooney M, Bottiglieri T, Wasek-Patterson B, et al.

Biochimie 2020; (173()):91-99 doi:10.1016/j.biochi.2020.04.004.

The Homozygous Hemoglobin EE Variant Is Associated with Poorer Riboflavin Status in Cambodian Women of Reproductive Age.

Williams BA, Cochrane KM, Fischer JAJ, et al.

The Journal of nutrition 2020; (150(7)):1943-1950 doi:10.1093/jn/nxaa119.

Dietary Reference Values for riboflavin.

, Turck D, Bresson JL, et al.

EFSA journal. European Food Safety Authority 2017; (15(8)):e04919 doi:10.2903/j.efsa.2017.4919.

Vitamin B2 concentration in cow milk: Quantification by a new UHPLC method and prediction by visible and near-infrared spectral analysis.

Laverroux S, Picard F, Andueza D, Graulet B

Food chemistry 2021; (342()):128310 doi:10.1016/j.foodchem.2020.128310.

Effect of riboflavin deficiency on development of the cerebral cortex in Slc52a3 knockout mice.

Jin C, Yonezawa A, Yoshimatsu H, et al.

Scientific reports 2020; (10(1)):18443 doi:10.1038/s41598-020-75601-9.

Impact of the common MTHFR 677C→T polymorphism on blood pressure in adulthood and role of riboflavin in modifying the genetic risk of hypertension: evidence from the JINGO project.

Ward M, Hughes CF, Strain JJ, et al.

BMC medicine 2020; (18(1)):318 doi:10.1186/s12916-020-01780-x.

Effect of Vitamin B2 supplementation on migraine prophylaxis: a systematic review and meta-analysis.

Chen YS, Lee HF, Tsai CH, et al.

Nutritional neuroscience 2022; (25(9)):1801-1812 doi:10.1080/1028415X.2021.1904542.

Riboflavin Inhibits Histamine-Dependent Itch by Modulating Transient Receptor Potential Vanilloid 1 (TRPV1).

Lee K, Choi YI, Im ST, et al.

Frontiers in molecular neuroscience 2021; (14()):643483 doi:10.3389/fnmol.2021.643483.

Abnormal VLCADD newborn screening resembling MADD in four neonates with decreased riboflavin levels and VLCAD activity.

Hagemeijer MC, Oussoren E, Ruijter GJG, et al.

JIMD reports 2021; (61(1)):12-18 doi:10.1002/jmd2.12223.

Riboflavin (Vitamin B2) Deficiency Induces Apoptosis Mediated by Endoplasmic Reticulum Stress and the CHOP Pathway in HepG2 Cells.

Zhang B, Cao JT, Wu YB, et al.

Nutrients 2022; (14(16)) doi:10.3390/nu14163356.

Riboflavin intake and status and relationship to anemia.

Aljaadi AM, Devlin AM, Green TJ

Nutrition reviews 2022; (81(1)):114-132 doi:10.1093/nutrit/nuac043.

Vitamin B-6 and riboflavin, their metabolic interaction, and relationship with MTHFR genotype in adults aged 18-102 years.

Jarrett H, McNulty H, Hughes CF, et al.

The American journal of clinical nutrition 2022; (116(6)):1767-1778 doi:10.1093/ajcn/nqac240.

Normal Outcome With Prenatal Intervention for Riboflavin Transporter Defect.

Elks N, Wilmshurst JM, Raga SV

Pediatric neurology 2023; (144()):16-18 doi:10.1016/j.pediatrneurol.2023.04.004.

Premature farrowing and stillbirths in two organic sow farms due to riboflavin deficiency.

Torreggiani C, Maes D, Franchi L, et al.

Porcine health management 2023; (9(1)):12 doi:10.1186/s40813-023-00308-y.

Anemia: Microcytic Anemia.

Rampon K

FP essentials 2023; (530()):12-16.

Benefit of high-dose oral riboflavin therapy in riboflavin transporter deficiency.

Fennessy JR, Cornett KMD, Burns J, Menezes MP

Journal of the peripheral nervous system : JPNS 2023; (28(3)):308-316 doi:10.1111/jns.12587.

The influence of a maternal vegan diet on carnitine and vitamin B2 concentrations in human milk.

Juncker HG, van den Akker CHP, Meerdink PL, et al.

Frontiers in nutrition 2023; (10()):1107768 doi:10.3389/fnut.2023.1107768.

Causes and Clinical Sequelae of Riboflavin Deficiency.

McNulty H, Pentieva K, Ward M

Annual review of nutrition 2023; (43()):101-122 doi:10.1146/annurev-nutr-061121-084407.

Riboflavin bio-enrichment of soy beverage by selected roseoflavin-resistant and engineered lactic acid bacteria.

Langa S, Peirotén Á, Rodríguez S, et al.

International journal of food microbiology 2024; (411()):110547 doi:10.1016/j.ijfoodmicro.2023.110547.

Brown-Vialetto-Van Laere syndrome.

Imannezhad S, Ghayoor Karimiani E, Sezavar M, et al.

Iranian journal of child neurology 2024; (18(2)):141-146 doi:10.22037/ijcn.v18i2.37314.

Case Report: A rare treatable metabolic syndrome (Brown-Vialetto-Van Laere syndrome) masquerading as chronic inflammatory demyelinating polyneuropathy from Saudi Arabia.

Kentab AY, Alsalloum Y, Labani M, et al.

Frontiers in pediatrics 2024; (12()):1377515 doi:10.3389/fped.2024.1377515.

Atypical presentations in an RTD patient and report of novel SLC52A3 and SLC52A2 mutations.

Sabeghi D, InanlooRahatloo K, Mirzadeh HS, et al.

Acta neurologica Belgica 2024; (124(4)):1363-1370 doi:10.1007/s13760-024-02598-7.

Recommendations for diagnosis, treatment, and prevention of iron deficiency and iron deficiency anemia.

Iolascon A, Andolfo I, Russo R, et al.

HemaSphere 2024; (8(7)):e108 doi:10.1002/hem3.108.

Riboflavin for women's health and emerging microbiome strategies.

Dricot CEMK, Erreygers I, Cauwenberghs E, et al.

NPJ biofilms and microbiomes 2024; (10(1)):107 doi:10.1038/s41522-024-00579-5.

Riboflavin Deficiency and Apoptosis: A Review.

Zhang B, Hou S, Tang J

The Journal of nutrition 2025; (155(1)):27-36 doi:10.1016/j.tjnut.2024.10.053.

Anaemia during pregnancy: could riboflavin deficiency be implicated?

Duffy B, McNulty H, Ward M, Pentieva K

The Proceedings of the Nutrition Society 2026; (85(1)):74-81 doi:10.1017/S0029665124007468.

Determination of red blood cell parameters for signs of iron deficiency anemia in patients with oral diseases.

Rajasekaran K, Renu K, Sankaran K, et al.

Minerva dental and oral science 2026; (75(4)):257-262 doi:10.23736/S2724-6329.24.04907-6.

Transient neonatal multiple acyl-CoA dehydrogenase deficiency due to riboflavin deficiency in an infant on total parenteral nutrition.

Panichsillaphakit E, Laohathai P, Dhachpramuk D, Vatanavicharn N

BMJ case reports 2025; (18(5)) doi:10.1136/bcr-2025-265089.

Characterization of riboflavin-overproducing Bifidobacterium longum subsp. infantis strains selected by roseoflavin treatment.

Tamés H, Cuesta I, Vázquez X, et al.

Food microbiology 2025; (131()):104799 doi:10.1016/j.fm.2025.104799.

The relationship between riboflavin and hypertension with MTHFR C677T in older adults in northern China: a case-control study.

Zhang L, Wang Z, Wu T, et al.

Asia Pacific journal of clinical nutrition 2025; (34(4)):619-626 doi:10.6133/apjcn.202508_34(4).0013.

Impact of Maternal Riboflavin Deficiency on the Growth and Development of Offspring Rats.

Gomathi S, Radha H, Reddy GB, Reddy SS

Birth defects research 2026; (118(1)):e70013 doi:10.1002/bdr2.70013.

Riboflavin Deficiency Is Highly Prevalent in Females and Children across High and Low/Middle Income Countries Worldwide.

McAnena L, Ward M, McCann A, et al.

The Journal of nutrition 2026; (156(3)):101277 doi:10.1016/j.tjnut.2025.101277.

Can riboflavin offer a novel personalised strategy for maintaining healthy blood pressure in pregnancy in populations globally?

Duffy B, Patted A, Boelig RC, et al.

BMJ nutrition, prevention & health 2025; (8(2)):e001212 doi:10.1136/bmjnph-2025-001212.

An Updated Review on Iron Deficiency Anemia: From Epidemiology to Diagnosis, Etiology, Prevention and Treatment.

Ahmad AMR, Ashraf Z, Awan MA, et al.

Journal of blood medicine 2026; (17()):612806 doi:10.2147/JBM.S612806.