Research & Literature

Both tumor depth and diameter are predictive of sentinel lymph node status and survival in Merkel cell carcinoma.

Smith FO, Yue B, Marzban SS, et al.

Cancer 2015; (121(18)):3252-60 doi:10.1002/cncr.29452.

Merkel Cell Carcinoma Analysis of Outcomes: A 30-Year Experience.

Liang E, Brower JV, Rice SR, et al.

PloS one 2015; (10(6)):e0129476 doi:10.1371/journal.pone.0129476.

Merkel cell carcinoma incidence is increasing in Sweden.

Zaar O, Gillstedt M, Lindelöf B, et al.

Journal of the European Academy of Dermatology and Venereology : JEADV 2016; (30(10)):1708-1713 doi:10.1111/jdv.13698.

SATB2 is expressed in Merkel cell carcinoma.

Fukuhara M, Agnarsdóttir M, Edqvist PH, et al.

Archives of dermatological research 2016; (308(6)):449-54 doi:10.1007/s00403-016-1655-6.

Avelumab in patients with chemotherapy-refractory metastatic Merkel cell carcinoma: a multicentre, single-group, open-label, phase 2 trial.

Kaufman HL, Russell J, Hamid O, et al.

The Lancet. Oncology 2016; (17(10)):1374-1385 doi:10.1016/S1470-2045(16)30364-3.

Merkel Cell Polyomavirus Exhibits Dominant Control of the Tumor Genome and Transcriptome in Virus-Associated Merkel Cell Carcinoma.

Starrett GJ, Marcelus C, Cantalupo PG, et al.

mBio 2017; (8(1)) doi:10.1128/mBio.02079-16.

Impact of total radiotherapy dose on survival for head and neck Merkel cell carcinoma after resection.

Patel SA, Qureshi MM, Mak KS, et al.

Head & neck 2017; (39(7)):1371-1377 doi:10.1002/hed.24776.

Talimogene laherparepvec for regionally advanced Merkel cell carcinoma: A report of 2 cases.

Blackmon JT, Dhawan R, Viator TM, et al.

JAAD case reports 2017; (3(3)):185-189 doi:10.1016/j.jdcr.2017.02.003.

Prognostic factors in Merkel cell carcinoma patients undergoing sentinel node biopsy.

Mattavelli I, Patuzzo R, Torri V, et al.

European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology 2017; (43(8)):1536-1541 doi:10.1016/j.ejso.2017.05.013.

Insulinoma-associated 1: A novel nuclear marker in Merkel cell carcinoma (cutaneous neuroendocrine carcinoma).

Rush PS, Rosenbaum JN, Roy M, et al.

Journal of cutaneous pathology 2018; (45(2)):129-135 doi:10.1111/cup.13079.

Demographics and outcomes of stage I and II Merkel cell carcinoma treated with Mohs micrographic surgery compared with wide local excision in the National Cancer Database.

Singh B, Qureshi MM, Truong MT, Sahni D

Journal of the American Academy of Dermatology 2018; (79(1)):126-134.e3 doi:10.1016/j.jaad.2018.01.041.

PD-L1 inhibition with avelumab for metastatic Merkel cell carcinoma.

Gaiser MR, Bongiorno M, Brownell I

Expert review of clinical pharmacology 2018; (11(4)):345-359 doi:10.1080/17512433.2018.1445966.

Merkel cell carcinoma with seborrheic keratosis: A unique association.

Anand MS, Krishnamurthy S, Ravindranath S, Ranganathan J

Indian journal of pathology & microbiology 2018; (61(1)):101-102 doi:10.4103/IJPM.IJPM_659_16.

Merkel cell carcinoma: Clinical outcome and prognostic factors in 351 patients.

van Veenendaal LM, van Akkooi ACJ, Verhoef C, et al.

Journal of surgical oncology 2018; (117(8)):1768-1775 doi:10.1002/jso.25090.

Merkel Cell Carcinoma, Version 1.2018, NCCN Clinical Practice Guidelines in Oncology.

Bichakjian CK, Olencki T, Aasi SZ, et al.

Journal of the National Comprehensive Cancer Network : JNCCN 2018; (16(6)):742-774 doi:10.6004/jnccn.2018.0055.

Systematic review of sentinel lymph node biopsy in Merkel cell carcinoma of the head and neck.

Karunaratne YG, Gunaratne DA, Veness MJ

Head & neck 2018; (40(12)):2704-2713 doi:10.1002/hed.25345.

Immunohistochemical profiles of different subsets of Merkel cell carcinoma.

Pasternak S, Carter MD, Ly TY, et al.

Human pathology 2018; (82()):232-238 doi:10.1016/j.humpath.2018.07.022.

Neurofilament is superior to cytokeratin 20 in supporting cutaneous origin for neuroendocrine carcinoma.

Stanoszek LM, Chan MP, Palanisamy N, et al.

Histopathology 2019; (74(3)):504-513 doi:10.1111/his.13758.

Usefulness of ulceration and hyperkeratosis as clinical predictors of Merkel cell polyomavirus-negative and combined Merkel cell carcinoma: A retrospective study.

Nagase K, Kimura-Kaku H, Inoue T, et al.

The Journal of dermatology 2019; (46(2)):103-109 doi:10.1111/1346-8138.14743.

Sentinel lymph node biopsy in clinically node-negative Merkel cell carcinoma: the Westmead Hospital experience.

Jenkins LN, Howle JR, Veness MJ

ANZ journal of surgery 2019; (89(5)):520-523 doi:10.1111/ans.15228.

Merkel Cell Carcinoma: Updates on Staging and Management.

Cornejo C, Miller CJ

Dermatologic clinics 2019; (37(3)):269-277 doi:10.1016/j.det.2019.03.001.

Morphologic and immunophenotypical features distinguishing Merkel cell polyomavirus-positive and negative Merkel cell carcinoma.

Kervarrec T, Tallet A, Miquelestorena-Standley E, et al.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2019; (32(11)):1605-1616 doi:10.1038/s41379-019-0288-7.

Qualitative study: patients' and parents' views on brain tumour MRIs.

Tyldesley-Marshall N, Greenfield S, Neilson S, et al.

Archives of disease in childhood 2020; (105(2)):166-172 doi:10.1136/archdischild-2019-317306.

Updates on Merkel Cell Carcinoma.

Emge DA, Cardones AR

Dermatologic clinics 2019; (37(4)):489-503 doi:10.1016/j.det.2019.06.002.

Optimal adjuvant radiotherapy dose for stage I, II or III Merkel cell carcinoma: an analysis of the National Cancer Database.

Yusuf M, Gaskins J, Wall W, et al.

Japanese journal of clinical oncology 2020; (50(2)):175-184 doi:10.1093/jjco/hyz153.

Immune checkpoint inhibitors for the management of advanced non-small-cell lung carcinoma: a meta-analysis.

Lai LT, Zhan ZY, Feng M, et al.

Anti-cancer drugs 2020; (31(6)):637-645 doi:10.1097/CAD.0000000000000921.

Management Recommendations for Merkel Cell Carcinoma-A Danish Perspective.

Naseri S, Steiniche T, Ladekarl M, et al.

Cancers 2020; (12(3)) doi:10.3390/cancers12030554.

A Rare Cause of Acute Liver Failure: Diffuse Liver Metastization of Merkel Cell Carcinoma.

Santos AL, Magno Pereira V, Coelho R, et al.

GE Portuguese journal of gastroenterology 2020; (27(3)):203-206 doi:10.1159/000503150.

Effect of Sentinel Lymph Node Biopsy and LVI on Merkel Cell Carcinoma Prognosis and Treatment.

Harounian JA, Molin N, Galloway TJ, et al.

The Laryngoscope 2021; (131(3)):E828-E835 doi:10.1002/lary.28866.

Current concepts and approaches to merkel cell carcinoma.

Babadzhanov M, Doudican N, Wilken R, et al.

Archives of dermatological research 2021; (313(3)):129-138 doi:10.1007/s00403-020-02107-9.

Structure of Merkel Cell Polyomavirus Capsid and Interaction with Its Glycosaminoglycan Attachment Receptor.

Bayer NJ, Januliene D, Zocher G, et al.

Journal of virology 2020; (94(20)) doi:10.1128/JVI.01664-19.

Treatment of primary Merkel cell carcinoma: Radiotherapy can be an effective, less morbid alternative to surgery.

Hong AM, Stretch JR, Thompson JF

European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology 2021; (47(2)):483-485 doi:10.1016/j.ejso.2020.05.013.

Pembrolizumab and other immune checkpoint inhibitors in locally advanced or metastatic Merkel Cell Carcinoma: safety and efficacy.

Marchand A, Kervarrec T, Bhatia S, Samimi M

Expert review of anticancer therapy 2020; (20(12)):1093-1106 doi:10.1080/14737140.2021.1835477.

Assessment of Age, Period, and Birth Cohort Effects and Trends in Merkel Cell Carcinoma Incidence in the United States.

Jacobs D, Huang H, Olino K, et al.

JAMA dermatology 2021; (157(1)):59-65 doi:10.1001/jamadermatol.2020.4102.

Merkel Cell Carcinoma: New Trends.

Zwijnenburg EM, Lubeek SFK, Werner JEM, et al.

Cancers 2021; (13(7)) doi:10.3390/cancers13071614.

International Increases in Merkel Cell Carcinoma Incidence Rates between 1997 and 2016.

Olsen CM, Pandeya N, Whiteman DC

The Journal of investigative dermatology 2021; (141(11)):2596-2601.e1 doi:10.1016/j.jid.2021.04.007.

New Insights into the Biological and Clinical Aspects of Merkel Cell Carcinoma.

Koljonen V, Lui WO, Becker JC

Cancers 2021; (13(9)) doi:10.3390/cancers13092259.

Response to "Mohs surgery for early-stage Merkel cell carcinoma (MCC) achieves local control better than wide local excision +/- radiation therapy with no increase in MCC-specific death".

Nguyen KA, Maloney NJ, Fonseca A, et al.

International journal of dermatology 2022; (61(4)):e143-e144 doi:10.1111/ijd.15723.

T-Cell Responses in Merkel Cell Carcinoma: Implications for Improved Immune Checkpoint Blockade and Other Therapeutic Options.

Gehrcken L, Sauerer T, Schaft N, Dörrie J

International journal of molecular sciences 2021; (22(16)) doi:10.3390/ijms22168679.

Merkel Cell Carcinoma: From Pathobiology to Clinical Management.

Farooq Baba PU, Rasool Z, Younas Khan I, et al.

Biology 2021; (10(12)) doi:10.3390/biology10121293.

Merkel cell carcinoma: An updated review of pathogenesis, diagnosis, and treatment options.

Hernandez LE, Mohsin N, Yaghi M, et al.

Dermatologic therapy 2022; (35(3)):e15292 doi:10.1111/dth.15292.

Merkel cell carcinoma in the hand. Report of two cases.

Mesa F, Cardona M, Mesa C, et al.

Case reports in plastic surgery & hand surgery 2022; (9(1)):41-45 doi:10.1080/23320885.2021.2025378.

Merkel cell carcinoma.

Mistry K, Levell NJ, Craig P, et al.

Skin health and disease 2021; (1(4)):e55 doi:10.1002/ski2.55.

Diagnosis and treatment of Merkel cell carcinoma: European consensus-based interdisciplinary guideline - Update 2022.

Gauci ML, Aristei C, Becker JC, et al.

European journal of cancer (Oxford, England : 1990) 2022; (171()):203-231 doi:10.1016/j.ejca.2022.03.043.

Merkel Cell Carcinoma Display PIEZO2 Immunoreactivity.

García-Mesa Y, Martín-Sanz R, García-Piqueras J, et al.

Journal of personalized medicine 2022; (12(6)) doi:10.3390/jpm12060894.

The impact of merkel cell polyomavirus positivity on prognosis of merkel cell carcinoma: A systematic review and meta-analysis.

Yang A, Wijaya WA, Yang L, et al.

Frontiers in oncology 2022; (12()):1020805 doi:10.3389/fonc.2022.1020805.

Merkel Cell Carcinoma.

Lewis DJ, Sobanko JF, Etzkorn JR, et al.

Dermatologic clinics 2023; (41(1)):101-115 doi:10.1016/j.det.2022.07.015.

Scanxiety among Adults with Cancer: A Scoping Review to Guide Research and Interventions.

Derry-Vick HM, Heathcote LC, Glesby N, et al.

Cancers 2023; (15(5)) doi:10.3390/cancers15051381.

S2k Guideline - Merkel cell carcinoma (MCC, neuroendocrine carcinoma of the skin) - Update 2022.

Becker JC, Beer AJ, DeTemple VK, et al.

Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG 2023; (21(3)):305-320 doi:10.1111/ddg.14930.

Feasibility and preliminary efficacy of a virtual reality intervention targeting distress and anxiety in primary brain tumor patients at the time of clinical evaluation: Study protocol for a phase 2 clinical trial.

King AL, Acquaye-Mallory AA, Vera E, et al.

BMC cancer 2023; (23(1)):262 doi:10.1186/s12885-023-10671-2.

Scanxiety Conversations on Twitter: Observational Study.

Bui KT, Li Z, Dhillon HM, et al.

JMIR cancer 2023; (9()):e43609 doi:10.2196/43609.

No difference in survival for primary cutaneous Merkel cell carcinoma after Mohs micrographic surgery and wide local excision.

Moore KJ, Thakuria M, Ruiz ES

Journal of the American Academy of Dermatology 2023; (89(2)):254-260 doi:10.1016/j.jaad.2023.04.042.

Expression of Genes Associated With Epithelial-Mesenchymal Transition in Merkel Cell Polyomavirus-Negative Merkel Cell Carcinoma.

Karpinski P, Rosales I, Laczmanski L, et al.

Laboratory investigation; a journal of technical methods and pathology 2023; (103(8)):100177 doi:10.1016/j.labinv.2023.100177.

Merkel cell carcinoma: a review of clinical management with focus on Asian patients.

Nakano E, Ogata D, Namikawa K, Yamazaki N

Japanese journal of clinical oncology 2023; (53(8)):673-679 doi:10.1093/jjco/hyad059.

Adjuvant immunotherapy with nivolumab versus observation in completely resected Merkel cell carcinoma (ADMEC-O): disease-free survival results from a randomised, open-label, phase 2 trial.

Becker JC, Ugurel S, Leiter U, et al.

Lancet (London, England) 2023; (402(10404)):798-808 doi:10.1016/S0140-6736(23)00769-9.

Case report: Metastatic Merkel cell carcinoma presenting seven years after loco-regional disease resection of primary tumor with interval in-transit and nodal metastases.

Rusheen J, Clune J, Ariyan S, et al.

Frontiers in oncology 2023; (13()):1217816 doi:10.3389/fonc.2023.1217816.

Scan-Associated Distress in People Affected by Cancer: A Qualitative Systematic Review.

Hussain M, Chau S, Turner M, Paterson C

Seminars in oncology nursing 2023; (39(5)):151502 doi:10.1016/j.soncn.2023.151502.

Modern diagnostics and treatment of Merkel cell carcinoma.

Weilandt J, Peitsch WK

Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG 2023; (21(12)):1524-1546 doi:10.1111/ddg.15214.

SATB2, CKAE1/AE3, and synaptophysin as a sensitive immunohistochemical panel for the detection of lymph node metastases of Merkel cell carcinoma.

Szumera-Cieckiewicz A, Massi D, Cassisa A, et al.

Virchows Archiv : an international journal of pathology 2024; (484(4)):629-636 doi:10.1007/s00428-023-03691-7.

Color Analysis of Merkel Cell Carcinoma: A Comparative Study with Cherry Angiomas, Hemangiomas, Basal Cell Carcinomas, and Squamous Cell Carcinomas.

Koumaki D, Manios G, Papadakis M, et al.

Diagnostics (Basel, Switzerland) 2024; (14(2)) doi:10.3390/diagnostics14020230.

Scanxiety and quality of life around follow-up imaging in patients with unruptured intracranial aneurysms: a prospective cohort study.

Kamphuis MJ, van der Kamp LT, van Eijk RPA, et al.

European radiology 2024; (34(9)):6018-6025 doi:10.1007/s00330-024-10602-0.

Merkel Cell Carcinoma on the Face: Case Report.

Alhaj SS, Qaderi FA, Ibrahim T, Almohammad M

JMIR dermatology 2024; (7()):e56658 doi:10.2196/56658.

Rare but Still There: An Interesting Case of Cytokeratin 20-Negative Merkel Cell Carcinoma.

Zahid A, Sheikh A

Cureus 2024; (16(3)):e55612 doi:10.7759/cureus.55612.

Merkel Cell Carcinoma Case Reports With Merkel Cell Polyomavirus Test and Review of the Literature.

Chai J, Tang Y, Chen Y, Liu Y

The American Journal of dermatopathology 2024; (46(11)):784-787 doi:10.1097/DAD.0000000000002837.

The Role of the Large T Antigen in the Molecular Pathogenesis of Merkel Cell Carcinoma.

Myrda J, Bremm F, Schaft N, Dörrie J

Genes 2024; (15(9)) doi:10.3390/genes15091127.

Surveillance-Associated Anxiety After Curative-Intent Cancer Surgery: A Systematic Review.

Khatri R, Quinn PL, Wells-Di Gregorio S, et al.

Annals of surgical oncology 2025; (32(1)):47-62 doi:10.1245/s10434-024-16287-5.

A Comparative Study of Merkel Cell Carcinoma and Melanoma Incidence and Survival in the United States, 2000-2021.

Tribble JT, Brownell I, Cahoon EK, et al.

The Journal of investigative dermatology 2025; (145(8)):1979-1986.e3 doi:10.1016/j.jid.2024.12.014.

Importance of Surgical Margins in Patients with Early-Stage Merkel Cell Carcinoma.

Cowman AW, Lourdault K, Hanes D, et al.

Dermatology and therapy 2025; (15(3)):733-746 doi:10.1007/s13555-025-01345-x.

[Merkel cell carcinoma: An update].

Toumelin L, Kervarrec T, Mortier L, et al.

Bulletin du cancer 2025; (112(10)):1193-1207 doi:10.1016/j.bulcan.2024.11.013.

Patient Characteristics and Outcomes in Clinically Misdiagnosed Patients With Merkel Cell Carcinoma.

Li Y, Tran T, Lee BA, et al.

The Journal of surgical research 2025; (309()):71-79 doi:10.1016/j.jss.2025.03.005.

Phase II study of retifanlimab in patients with recurrent locally advanced or metastatic Merkel cell carcinoma (POD1UM-201).

Grignani G, Rutkowski P, Lebbé C, et al.

Journal for immunotherapy of cancer 2025; (13(8)) doi:10.1136/jitc-2025-012478.

A Rare Case of Rapidly Progressing Merkel Cell Carcinoma.

Jain DST, Riyadh O, Tran K, et al.

Cureus 2025; (17(7)):e88816 doi:10.7759/cureus.88816.

Prevalence, severity, and modifiable predictors of scanxiety in patients undergoing routine oncologic imaging: a prospective longitudinal study.

Shah MS, Memon JA, Malik U, et al.

Clinical imaging 2025; (128()):110634 doi:10.1016/j.clinimag.2025.110634.

Immune Checkpoint Inhibitors in Merkel Cell Carcinoma of the Skin: A 2025 Comprehensive Review.

Tai P, Alqaisi O, Al-Ghabeesh S, et al.

Cancers 2025; (17(19)) doi:10.3390/cancers17193272.

Recurrence and Survival Outcomes in Patients with Primary Merkel Cell Carcinoma with Positive, Negative, or Not Performed Sentinel Lymph Node Biopsy.

Dugan MM, Balsay-Patel C, Chin N, et al.

Annals of surgical oncology 2026; (33(1)):389-396 doi:10.1245/s10434-025-18618-6.

Outcomes of Patients Undergoing Sentinel Lymph Node Biopsy for Merkel Cell Carcinoma.

Bartlett EK, Kalvin HL, Barker CA, et al.

Annals of surgical oncology 2025; doi:10.1245/s10434-025-18792-7.

Tumor virus-induced lineage survival circuit drives Merkel cell carcinogenesis.

Shuda M

The Journal of clinical investigation 2025; (135(24)).

Updates for Management of Merkel Cell Carcinoma of the Head and Neck: A Systematic Review.

Kimball KM, Pember BJ, Soliman NM, Nemer KM

Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.] 2026; (52(6)):513-520 doi:10.1097/DSS.0000000000004967.

Accuracy of Sentinel Lymph Node Biopsy to Predict Nodal Metastasis in Head and Neck Merkel Cell Carcinoma.

Wang SY, Turner G, Valdes-Morales KL, et al.

JAMA otolaryngology-- head & neck surgery 2026; (152(3)):313-322 doi:10.1001/jamaoto.2025.5211.