Research & Literature

Epidemiology of Mixed Connective Tissue Disease, 1985-2014: A Population-Based Study.

Ungprasert P, Crowson CS, Chowdhary VR, et al.

Arthritis care & research 2016; (68(12)):1843-1848 doi:10.1002/acr.22872.

Can SLE classification rules be effectively applied to diagnose unclear SLE cases?

Mesa A, Fernandez M, Wu W, et al.

Lupus 2017; (26(2)):150-162 doi:10.1177/0961203316655212.

U1-RNP and TLR receptors in the pathogenesis of mixed connective tissue diseasePart I. The U1-RNP complex and its biological significance in the pathogenesis of mixed connective tissue disease.

Paradowska-Gorycka A

Reumatologia 2015; (53(2)):94-100 doi:10.5114/reum.2015.51509.

U1-RNP and Toll-like receptors in the pathogenesis of mixed connective tissue diseasePart II. Endosomal TLRs and their biological significance in the pathogenesis of mixed connective tissue disease.

Paradowska-Gorycka A

Reumatologia 2015; (53(3)):143-51 doi:10.5114/reum.2015.53136.

Mixed connective tissue disease.

Gunnarsson R, Hetlevik SO, Lilleby V, Molberg Ø

Best practice & research. Clinical rheumatology 2016; (30(1)):95-111.

Treatment of Vasodilator-resistant Mixed Connective Tissue Disease-associated Pulmonary Arterial Hypertension with Glucocorticoid and Cyclophosphamide.

Sugawara E, Kato M, Hisada R, et al.

Internal medicine (Tokyo, Japan) 2017; (56(4)):445-448 doi:10.2169/internalmedicine.56.7668.

Facts and controversies in mixed connective tissue disease.

Martínez-Barrio J, Valor L, López-Longo FJ

Medicina clinica 2018; (150(1)):26-32 doi:10.1016/j.medcli.2017.06.066.

Predictors of Favorable Responses to Immunosuppressive Treatment in Pulmonary Arterial Hypertension Associated With Connective Tissue Disease.

Yasuoka H, Shirai Y, Tamura Y, et al.

Circulation journal : official journal of the Japanese Circulation Society 2018; (82(2)):546-554 doi:10.1253/circj.CJ-17-0351.

Scleroderma Renal Crisis in Mixed Connective Tissue Disease With Full Renal Recovery Within 3 Months: A Case Report With Expanding Treatment Modalities to Treat Each Clinical Sign as an Independent Entity.

Cheta J, Rijhwani S, Rust H

Journal of investigative medicine high impact case reports 2017; (5(4)):2324709617734012 doi:10.1177/2324709617734012.

Disease evolution in mixed connective tissue disease: results from a long-term nationwide prospective cohort study.

Reiseter S, Gunnarsson R, Corander J, et al.

Arthritis research & therapy 2017; (19(1)):284 doi:10.1186/s13075-017-1494-7.

Clinical and immunological profile in patients with mixed connective tissue disease.

Ahsan T, Erum U, Dahani A, Khowaja D

JPMA. The Journal of the Pakistan Medical Association 2018; (68(6)):959-962.

Mixed connective tissue disease: state of the art on clinical practice guidelines.

Chaigne B, Scirè CA, Talarico R, et al.

RMD open 2018; (4(Suppl 1)):e000783 doi:10.1136/rmdopen-2018-000783.

A Rare Cause of Dysphagia and Weight Loss.

Gyorffy JB, Marowske J, Gancayco J

Case reports in gastroenterology 2018; (12(3)):640-645 doi:10.1159/000493919.

Interstitial Lung Disease and Other Pulmonary Manifestations in Connective Tissue Diseases.

Mira-Avendano I, Abril A, Burger CD, et al.

Mayo Clinic proceedings 2019; (94(2)):309-325 doi:10.1016/j.mayocp.2018.09.002.

Rituximab in connective tissue disease-associated interstitial lung disease.

Duarte AC, Cordeiro A, Fernandes BM, et al.

Clinical rheumatology 2019; (38(7)):2001-2009 doi:10.1007/s10067-019-04557-7.

2019 Diagnostic criteria for mixed connective tissue disease (MCTD): From the Japan research committee of the ministry of health, labor, and welfare for systemic autoimmune diseases.

Tanaka Y, Kuwana M, Fujii T, et al.

Modern rheumatology 2021; (31(1)):29-33 doi:10.1080/14397595.2019.1709944.

"Mixed connective tissue disease": a condition in search of an identity.

Alves MR, Isenberg DA

Clinical and experimental medicine 2020; (20(2)):159-166 doi:10.1007/s10238-020-00606-7.

Clinical features and outcome of mixed connective tissue disease in developmental age - observational study from one center.

Rutkowska-Sak L, Gietka P

Reumatologia 2019; (57(6)):315-319 doi:10.5114/reum.2019.91275.

Clinical and Immunological Profile of Mixed Connective Tissue Disease and a Comparison of Four Diagnostic Criteria.

John KJ, Sadiq M, George T, et al.

International journal of rheumatology 2020; (2020()):9692030 doi:10.1155/2020/9692030.

Mixed connective tissue disease: Not always an obvious diagnosis.

Rahmouni S, Maatallah K, Ferjani H, et al.

Clinical case reports 2020; (8(10)):1979-1983 doi:10.1002/ccr3.3045.

Capillaroscopy as a diagnostic tool in the diagnosis of mixed connective tissue disease (MCTD): a case report.

Radić M, Overbury RS

BMC rheumatology 2021; (5(1)):9 doi:10.1186/s41927-021-00179-2.

Incidence and Clinical Pattern of Mixed Connective Tissue Disease in Sudanese Patients at Omdurman Military Hospital: Hospital-Based Study.

Abdelgalil Ali Ahmed S, Adam Essa ME, Ahmed AF, et al.

Open access rheumatology : research and reviews 2021; (13()):333-341 doi:10.2147/OARRR.S335206.

Nailfold microvascular abnormalities are associated with a higher prevalence of pulmonary arterial hypertension in patients with MCTD.

Todoroki Y, Kubo S, Nakano K, et al.

Rheumatology (Oxford, England) 2022; (61(12)):4875-4884 doi:10.1093/rheumatology/keac165.

The diagnostic challenge of patients with anti-U1-RNP antibodies.

Elhani I, Khoy K, Mariotte D, et al.

Rheumatology international 2023; (43(3)):509-521 doi:10.1007/s00296-022-05161-w.

Delphi-Based Consensus on Interstitial Lung Disease Screening in Patients with Connective Tissue Diseases (Croatian National-Based Study).

Radić M, Novak S, Barešić M, et al.

Biomedicines 2022; (10(12)) doi:10.3390/biomedicines10123291.

In-depth characterization of pulmonary arterial hypertension in mixed connective tissue disease: a French national multicentre study.

Chaigne B, Chevalier K, Boucly A, et al.

Rheumatology (Oxford, England) 2023; (62(10)):3261-3267 doi:10.1093/rheumatology/kead055.

Challenging diagnosis of renal failure associated with severe neurological symptoms in a patient with mixed connective tissue disease.

Gros C, Fogel O, Boudhabhay I, et al.

Journal of scleroderma and related disorders 2023; (8(1)):NP6-NP10 doi:10.1177/23971983221099847.

A Case of Mixed Connective Tissue Disease That Transformed Into Systemic Lupus Erythematosus After a Long Clinical Course.

Sato F, Sato M, Yamano T, et al.

Cureus 2023; (15(4)):e38201 doi:10.7759/cureus.38201.

An Unusual Case of Telangiectasias.

Dabadghao VS, Sharma SK, Malik SK, Khese VB

The Journal of the Association of Physicians of India 2023; (71(4)):11-12 doi:10.5005/japi-11001-0223.

The phenotype of mixed connective tissue disease patients having associated interstitial lung disease.

Boleto G, Reiseter S, Hoffmann-Vold AM, et al.

Seminars in arthritis and rheumatism 2023; (63()):152258 doi:10.1016/j.semarthrit.2023.152258.

Clinical presentation, course, and prognosis of patients with mixed connective tissue disease: A multicenter retrospective cohort.

Chevalier K, Thoreau B, Michel M, et al.

Journal of internal medicine 2024; (295(4)):532-543 doi:10.1111/joim.13752.

Childhood mixed connective tissue disease at disease onset: Evidence from a systematic review.

Terminiello A, Marrani E, Pagnini I, et al.

Autoimmunity reviews 2024; (23(4)):103513 doi:10.1016/j.autrev.2023.103513.

Mixed Connective Tissue Disease: The Two Cases Representing the Range of this Illness.

Parrey AH, Koka M, Ismail M

Current rheumatology reviews 2024; (20(5)):569-573 doi:10.2174/0115733971263972231124111042.

Naifold capillaroscopy in mixed connective tissue disease patients.

Ornowska S, Wudarski M, Dziewięcka E, Olesińska M

Clinical rheumatology 2024; (43(5)):1703-1709 doi:10.1007/s10067-024-06879-7.

Connective tissue disease-associated interstitial lung disease.

Storrer KM, Müller CS, Pessoa MCA, Pereira CAC

Jornal brasileiro de pneumologia : publicacao oficial da Sociedade Brasileira de Pneumologia e Tisilogia 2024; (50(1)):e20230132 doi:10.36416/1806-3756/e20230132.

To Test or Not to Test: A Case Report on Hereditary Hemorrhagic Telangiectasia.

Chadalavada B, Baddam R

Cureus 2024; (16(2)):e55118 doi:10.7759/cureus.55118.

Anti-U1RNP antibodies are associated with a distinct clinical phenotype and a worse survival in patients with systemic sclerosis.

Chevalier K, Chassagnon G, Leonard-Louis S, et al.

Journal of autoimmunity 2024; (146()):103220 doi:10.1016/j.jaut.2024.103220.

Interstitial Lung Disease in Patients with Mixed Connective Tissue Disease: A Retrospective Study.

Shan X, Ge Y

International journal of general medicine 2024; (17()):2091-2099 doi:10.2147/IJGM.S464704.

Deciphering the Reactivity of Autoantibodies Directed against the RNP-A, -C and 70 kDa Components of the U1-snRNP Complex: "Double or Nothing"?

Bertin D, Babacci B, Brodovitch A, et al.

Biomedicines 2024; (12(7)) doi:10.3390/biomedicines12071552.

Interstitial lung disease in rheumatic diseases: an update of the 2018 review.

Atzeni F, Alciati A, Gozza F, et al.

Expert review of clinical immunology 2025; (21(2)):209-226 doi:10.1080/1744666X.2024.2407536.

Treatment of mixed connective tissue disease: A multicenter retrospective study.

Chevalier K, Thoreau B, Michel M, et al.

Journal of autoimmunity 2025; (153()):103420 doi:10.1016/j.jaut.2025.103420.

Unravelling IPAF, VEDOSS and connective tissue diseases classifications through the mixed connective tissue disease spectrum.

Chevalier K, Thoreau B, Michel M, et al.

RMD open 2025; (11(4)) doi:10.1136/rmdopen-2025-006145.

Acute Hypoxemic Respiratory Failure Caused by Nonspecific Interstitial Pneumonia in Mixed Connective Tissue Disease: A Case Report.

Naqvi SM, Nadeem AUR, Liu J, et al.

Cureus 2025; (17(12)):e99922 doi:10.7759/cureus.99922.