Research & Literature

Incidence, Trends, and Survival of Children With Embryonal Tumors.

Tulla M, Berthold F, Graf N, et al.

Pediatrics 2015; (136(3)):e623-32 doi:10.1542/peds.2015-0224.

Medulloblastoma.

Millard NE, De Braganca KC

Journal of child neurology 2016; (31(12)):1341-53 doi:10.1177/0883073815600866.

Targeting the Sonic Hedgehog Signaling Pathway: Review of Smoothened and GLI Inhibitors.

Rimkus TK, Carpenter RL, Qasem S, et al.

Cancers 2016; (8(2)).

Medulloblastoma Genotype Dictates Blood Brain Barrier Phenotype.

Phoenix TN, Patmore DM, Boop S, et al.

Cancer cell 2016; (29(4)):508-522 doi:10.1016/j.ccell.2016.03.002.

Childhood medulloblastoma.

Massimino M, Biassoni V, Gandola L, et al.

Critical reviews in oncology/hematology 2016; (105()):35-51.

Preradiation Chemotherapy for Adult High-risk Medulloblastoma: A Trial of the ECOG-ACRIN Cancer Research Group (E4397).

Moots PL, O'Neill A, Londer H, et al.

American journal of clinical oncology 2018; (41(6)):588-594 doi:10.1097/COC.0000000000000326.

Posterior fossa syndrome-a narrative review.

Wahab SS, Hettige S, Mankad K, Aquilina K

Quantitative imaging in medicine and surgery 2016; (6(5)):582-590 doi:10.21037/qims.2016.10.12.

The anti-neoplastic activity of Vandetanib against high-risk medulloblastoma variants is profoundly enhanced by additional PI3K inhibition.

Craveiro RB, Ehrhardt M, Velz J, et al.

Oncotarget 2017; (8(29)):46915-46927 doi:10.18632/oncotarget.14911.

Molecular Proteomic Characterization of a Pediatric Medulloblastoma Xenograft.

Tsangaris GT, Dimas K, Malamou A, et al.

Cancer genomics & proteomics 2017; (14(4)):267-275 doi:10.21873/cgp.20037.

Multiple pilomatrixomas in a survivor of WNT-activated medulloblastoma leading to the discovery of a germline APC mutation and the diagnosis of familial adenomatous polyposis.

Bendelsmith CR, Skrypek MM, Patel SR, et al.

Pediatric blood & cancer 2018; (65(1)) doi:10.1002/pbc.26756.

Predicted Rate of Secondary Malignancies Following Adjuvant Proton Versus Photon Radiation Therapy for Thymoma.

Vogel J, Lin L, Litzky LA, et al.

International journal of radiation oncology, biology, physics 2017; (99(2)):427-433 doi:10.1016/j.ijrobp.2017.04.022.

Differential patterns of metastatic dissemination across medulloblastoma subgroups.

Zapotocky M, Mata-Mbemba D, Sumerauer D, et al.

Journal of neurosurgery. Pediatrics 2018; (21(2)):145-152.

Medulloblastoma with extensive nodularity (SHH medulloblastoma).

Fudyma IA, Wadhwani NR

Polish journal of pathology : official journal of the Polish Society of Pathologists 2017; (68(4)):364-366 doi:10.5114/pjp.2017.73934.

Susceptibility-weighted magnetic resonance imaging of cerebrovascular sequelae after radiotherapy for pediatric brain tumors.

Neu MA, Tanyildizi Y, Wingerter A, et al.

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 2018; (127(2)):280-286 doi:10.1016/j.radonc.2018.03.010.

Meta-analysis of the incidence and patterns of second neoplasms after photon craniospinal irradiation in children with medulloblastoma.

Bavle A, Tewari S, Sisson A, et al.

Pediatric blood & cancer 2018; (65(8)):e27095 doi:10.1002/pbc.27095.

Risk-adapted therapy for young children with medulloblastoma (SJYC07): therapeutic and molecular outcomes from a multicentre, phase 2 trial.

Robinson GW, Rudneva VA, Buchhalter I, et al.

The Lancet. Oncology 2018; (19(6)):768-784 doi:10.1016/S1470-2045(18)30204-3.

The clinical importance of medulloblastoma extent of resection: a systematic review.

Thompson EM, Bramall A, Herndon JE, et al.

Journal of neuro-oncology 2018; (139(3)):523-539 doi:10.1007/s11060-018-2906-5.

Advances in the classification of pediatric brain tumors through DNA methylation profiling: From research tool to frontline diagnostic.

Kumar R, Liu APY, Orr BA, et al.

Cancer 2018; (124(21)):4168-4180 doi:10.1002/cncr.31583.

Prospective, longitudinal comparison of neurocognitive change in pediatric brain tumor patients treated with proton radiotherapy versus surgery only.

Kahalley LS, Douglas Ris M, Mahajan A, et al.

Neuro-oncology 2019; (21(6)):809-818 doi:10.1093/neuonc/noz041.

Medulloblastoma: optimizing care with a multidisciplinary approach.

Thomas A, Noël G

Journal of multidisciplinary healthcare 2019; (12()):335-347 doi:10.2147/JMDH.S167808.

Medulloblastoma genomics in the modern molecular era.

Kumar R, Liu APY, Northcott PA

Brain pathology (Zurich, Switzerland) 2020; (30(3)):679-690 doi:10.1111/bpa.12804.

Effects of the growth pattern of medulloblastoma on short-term neurological impairments after surgery: results from the prospective multicenter HIT-SIOP PNET 4 study.

Schepke E, Tisell M, Kennedy C, et al.

Journal of neurosurgery. Pediatrics 2020; (25(4)):425-433 doi:10.3171/2019.11.PEDS19349.

Pathology, diagnostics, and classification of medulloblastoma.

Orr BA

Brain pathology (Zurich, Switzerland) 2020; (30(3)):664-678 doi:10.1111/bpa.12837.

Bridging the treatment gap in infant medulloblastoma: molecularly informed outcomes of a globally feasible regimen.

Baroni LV, Sampor C, Gonzalez A, et al.

Neuro-oncology 2020; (22(12)):1873-1881 doi:10.1093/neuonc/noaa122.

Vismodegib as First-Line Treatment of Mutated Sonic Hedgehog Pathway in Adult Medulloblastoma.

Kian W, Roisman LC, Goldstein IM, et al.

JCO precision oncology 2020; (4()) doi:10.1200/PO.19.00264.

Safety and efficacy of concurrent carboplatin during full-dose craniospinal irradiation for high-risk/metastatic medulloblastoma in a resource-limited setting.

Gupta T, Sinha S, Chinnaswamy G, et al.

Pediatric blood & cancer 2021; (68(5)):e28925 doi:10.1002/pbc.28925.

Proton beam therapy for children and adolescents and young adults (AYAs): JASTRO and JSPHO Guidelines.

Mizumoto M, Fuji H, Miyachi M, et al.

Cancer treatment reviews 2021; (98()):102209 doi:10.1016/j.ctrv.2021.102209.

Overview and recent advances in the targeting of medulloblastoma cancer stem cells.

Paul MR, Zage PE

Expert review of anticancer therapy 2021; (21(9)):957-974 doi:10.1080/14737140.2021.1932472.

Efficacy of Carboplatin and Isotretinoin in Children With High-risk Medulloblastoma: A Randomized Clinical Trial From the Children's Oncology Group.

Leary SES, Packer RJ, Li Y, et al.

JAMA oncology 2021; (7(9)):1313-1321 doi:10.1001/jamaoncol.2021.2224.

Long non-coding RNAs as a predictive markers of group 3 medulloblastomas.

Mutlu M, Tekin C, Ak Aksoy S, et al.

Neurological research 2022; (44(3)):232-241 doi:10.1080/01616412.2021.1975223.

Estimated Risk of Radiation-Induced Cancer after Thymoma Treatments with Proton- or X-ray Beams.

Lideståhl A, Johansson G, Siegbahn A, Lind PA

Cancers 2021; (13(20)) doi:10.3390/cancers13205153.

High-Dose Chemotherapy in Children with Newly Diagnosed Medulloblastoma.

Lafay-Cousin L, Dufour C

Cancers 2022; (14(3)) doi:10.3390/cancers14030837.

Risk Stratification of Childhood Medulloblastoma Using Integrated Diagnosis: Discrepancies with Clinical Risk Stratification.

Cho HW, Lee H, Ju HY, et al.

Journal of Korean medical science 2022; (37(7)):e59 doi:10.3346/jkms.2022.37.e59.

Targeting AKT and CK2 represents a novel therapeutic strategy for SMO constitutive activation-driven medulloblastoma.

Yao YL, Wang YX, Yang FC, et al.

CNS neuroscience & therapeutics 2022; (28(7)):1033-1044 doi:10.1111/cns.13835.

New Developments in the Pathogenesis, Therapeutic Targeting, and Treatment of Pediatric Medulloblastoma.

Fang FY, Rosenblum JS, Ho WS, Heiss JD

Cancers 2022; (14(9)) doi:10.3390/cancers14092285.

Adult medulloblastoma in an Australian population.

Parakh S, Davies A, Westcott K, et al.

Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 2022; (102()):65-70 doi:10.1016/j.jocn.2022.06.008.

Adult Medulloblastoma: Updates on Current Management and Future Perspectives.

Franceschi E, Giannini C, Furtner J, et al.

Cancers 2022; (14(15)) doi:10.3390/cancers14153708.

Endocrinopathy After Treatment for Medulloblastoma: Results From the SJMB03 Trial of Risk-Adapted Radiation Therapy.

Merchant TE, Wu S, Onar-Thomas A, et al.

International journal of radiation oncology, biology, physics 2023; (116(3)):560-568 doi:10.1016/j.ijrobp.2022.12.016.

"I Wish There had been Resources": A Photo-Elicitation Study of Rectal Cancer Survivorship Care Needs.

Rivard SJ, Vitous CA, Bamdad MC, et al.

Annals of surgical oncology 2023; (30(6)):3530-3537 doi:10.1245/s10434-022-13042-6.

Scanxiety among Adults with Cancer: A Scoping Review to Guide Research and Interventions.

Derry-Vick HM, Heathcote LC, Glesby N, et al.

Cancers 2023; (15(5)) doi:10.3390/cancers15051381.

The diagnostic significance of cerebrospinal fluid cytology and circulating tumor DNA in meningeal carcinomatosis.

Di WY, Chen YN, Cai Y, et al.

Frontiers in neurology 2023; (14()):1076310 doi:10.3389/fneur.2023.1076310.

Spatial transcriptomic analysis of Sonic hedgehog medulloblastoma identifies that the loss of heterogeneity and promotion of differentiation underlies the response to CDK4/6 inhibition.

Vo T, Balderson B, Jones K, et al.

Genome medicine 2023; (15(1)):29 doi:10.1186/s13073-023-01185-4.

Cytopathological differential diagnosis of malignant tumor cells in the cerebrospinal fluid: A retrospective analysis.

Ruotolo R, Maffei E, Sabbatino F, et al.

Diagnostic cytopathology 2023; (51(12)):751-757 doi:10.1002/dc.25217.

Late effects of medulloblastoma treatment: multidisciplinary approach of survivors.

Aktekin EH, Kütük MÖ, Sangün Ö, et al.

Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery 2024; (40(2)):417-425 doi:10.1007/s00381-023-06146-1.

Subtyping of Group 3/4 medulloblastoma as a potential prognostic biomarker among patients treated with reduced dose of craniospinal irradiation: a Japanese Pediatric Molecular Neuro-Oncology Group study.

Fukuoka K, Kurihara J, Shofuda T, et al.

Acta neuropathologica communications 2023; (11(1)):153 doi:10.1186/s40478-023-01652-4.

Verschlimmbesserung: Craniospinal Radiotherapy Is Essential in WNT Medulloblastoma Patients.

Gottardo NG, Gajjar A

Clinical cancer research : an official journal of the American Association for Cancer Research 2023; (29(24)):4996-4998 doi:10.1158/1078-0432.CCR-23-2331.

Proton Therapy Mediates Dose Reductions to Brain Structures Associated With Cognition in Children With Medulloblastoma.

Sienna J, Kahalley LS, Mabbott D, et al.

International journal of radiation oncology, biology, physics 2024; (119(1)):200-207 doi:10.1016/j.ijrobp.2023.11.035.

Evolution of neurosurgical advances and nuances in medulloblastoma therapy.

Rechberger JS, Power EA, DeCuypere M, Daniels DJ

Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery 2024; (40(4)):1031-1044 doi:10.1007/s00381-023-06239-x.

Spinal Ependymomas: An Updated WHO Classification and a Narrative Review.

Villanueva-Castro E, Meraz-Soto JM, Hernández-Dehesa IA, et al.

Cureus 2023; (15(11)):e49086 doi:10.7759/cureus.49086.

Scanxiety and quality of life around follow-up imaging in patients with unruptured intracranial aneurysms: a prospective cohort study.

Kamphuis MJ, van der Kamp LT, van Eijk RPA, et al.

European radiology 2024; (34(9)):6018-6025 doi:10.1007/s00330-024-10602-0.

Medical management for cerebellar mutism syndrome following posterior fossa surgery: A systematic review.

Turkistani AN, Alsharif TH, Aldhafeeri WF, et al.

Clinical neurology and neurosurgery 2024; (242()):108352 doi:10.1016/j.clineuro.2024.108352.

Risk factors for domain-specific neurocognitive outcome in pediatric survivors of a brain tumor in the posterior fossa-Results of the HIT 2000 trial.

Mynarek M, Rossius A, Guiard A, et al.

Neuro-oncology 2024; (26(11)):2113-2124 doi:10.1093/neuonc/noae092.

Neurocognitive outcomes and functional independence in adult survivors of childhood medulloblastoma diagnosed over 3 decades.

Papini C, Mirzaei S, Xing M, et al.

Neuro-oncology 2025; (27(1)):254-266 doi:10.1093/neuonc/noae119.

Arrested development: the dysfunctional life history of medulloblastoma.

Tao R, Han K, Wu SC, et al.

Genes & development 2025; (39(1-2)):4-17 doi:10.1101/gad.351936.124.

The Pediatric Physiatric Posterior Fossa Symptoms scale: Impairments and outcome in pediatric inpatient rehabilitation for posterior fossa brain tumors.

Wu J, Wishart BD, Cohen SE, et al.

Neuro-oncology 2025; (27(2)):508-516 doi:10.1093/neuonc/noae199.

Clinical and Molecular Characteristics and Outcome of Adult Medulloblastoma at a Tertiary Cancer Center.

Almousa A, Erjan A, Sarhan N, et al.

Cancers 2024; (16(21)) doi:10.3390/cancers16213609.

Scanxiety and Fear of Recurrence in Young Adult Female Breast and Gynaecological Cancer Survivors: Investigating Shared Mechanisms.

Patel DS, Webster SN, Dowling EJ, et al.

Psycho-oncology 2024; (33(12)):e70050 doi:10.1002/pon.70050.

Advancing medulloblastoma therapy: strategies and survival insights.

Pan Z, Bao J, Wei S

Clinical and experimental medicine 2025; (25(1)):119 doi:10.1007/s10238-025-01648-5.

Case report and review of the literature regarding management of primary uterine primitive neuroectodermal tumors (PNET).

Weinstein S, Walker AR, Barr K, et al.

Gynecologic oncology reports 2025; (59()):101775 doi:10.1016/j.gore.2025.101775.

Targeting synthetic lethality between non-homologous end joining and radiation in very-high-risk medulloblastoma.

DeCarlo A, MacLeod G, Fernandes da Silva C, et al.

Cell reports. Medicine 2025; (6(7)):102202 doi:10.1016/j.xcrm.2025.102202.

MYC promotes group 3 medulloblastoma cell proliferation and alleviates ROS-induced cell death by upregulating transketolase.

Wang S, Zhang D, Wang C, Liu Y

Acta neuropathologica communications 2025; (13(1)):139 doi:10.1186/s40478-025-02051-7.

Systematic Review and Meta-Analysis of Proton Beam Therapy Versus Photon Radiotherapy for Medulloblastoma: TRP-Medulloblastoma 2025.

Li Y, Mizumoto M, Oshiro Y, et al.

Cancers 2025; (17(13)) doi:10.3390/cancers17132191.

Molecular subtypes, prognostic factors, and treatment optimization in pediatric medulloblastoma: a real-world study from China.

Liu J, Sun Y, Li H, et al.

Frontiers in oncology 2025; (15()):1597123 doi:10.3389/fonc.2025.1597123.

The role of DNA methylation in directing treatment in medulloblastoma.

Alsaedi MAH, Strathdee G

Epigenomics 2025; (17(16)):1189-1199 doi:10.1080/17501911.2025.2554570.

Genome-wide methylation and copy number variation analysis of medulloblastoma in a Saudi Arabian pediatric population.

AlKofide A, Arabi T, Ahmed AA, et al.

Annals of medicine and surgery (2012) 2025; (87(10)):6265-6271 doi:10.1097/MS9.0000000000003643.

"You Always Worry": Scan-Related Anxiety Among Patients With Metastatic Lung Cancer.

Derry-Vick H, Prigerson HG, Hahne J, et al.

Journal of the American College of Radiology : JACR 2025; (22(12)):1572-1577 doi:10.1016/j.jacr.2025.08.021.

Dual primary cancers of skin cancer and lung cancer: a case report.

He B, Zhang H, Guo Y, Song Y

Journal of cardiothoracic surgery 2026; (21(1)):71 doi:10.1186/s13019-025-03793-0.

Children's outcomes in medulloblastoma proton versus photon craniospinal radiotherapy (CURE): meta-analysis.

Viani GA, Hamamura AC, Arruda CV, et al.

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 2026; 111367 doi:10.1016/j.radonc.2026.111367.

Stepwise Craniospinal Irradiation: A Practical Approach to Urgent Palliative Focal Radiation Therapy as a "Bridge" to the Definitive Management of Acute Leptomeningeal Disease.

Ninia JG, Wallington DG, Chon BH, et al.

Practical radiation oncology 2026; (16(4)):e301-e305 doi:10.1016/j.prro.2026.01.003.

Long-Term Outcomes Associated With Posterior Fossa Syndrome in Survivors of Childhood Medulloblastoma.

Sarvode S, Dhaduk R, Chen Y, et al.

JAMA network open 2026; (9(2)):e2559376 doi:10.1001/jamanetworkopen.2025.59376.

Late-onset vascular and tumor complications after childhood brain radiotherapy: A rare case of dual sequelae.

Ly QH, Garrel S, Kanamalla K, et al.

Radiology case reports 2026; (21(5)):1821-1826 doi:10.1016/j.radcr.2026.01.063.

High-dose chemotherapy with autologous stem cell rescue in children under 5 years of age with central nervous system embryonal tumors: results from a prospective cohort in an upper-middle-income country.

Cappellano AM, Dassi N, Gamba FT, et al.

Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery 2026; (42(1)).