Research & Literature
Explore the leading researchers and institutions driving advances in this area, and dive into the full body of literature that informs this resource.
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Mayo Clinic
Rochester, United States
Inserm
Paris, France
Harvard University
Cambridge, United States
University of California, San Francisco
San Francisco, United States
Icahn School of Medicine at Mount Sinai
New York, United States
Centre Hospitalier Universitaire Amiens-Picardie
Amiens, France
Centre National de la Recherche Scientifique
Paris, France
Leiden University Medical Center
Leiden, The Netherlands
Oslo University Hospital
Oslo, Norway
University of Michigan
Ann Arbor, United States
References
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A Comparative Assessment of Echocardiographic Parameters for Determining Primary Mitral Regurgitation Severity Using Magnetic Resonance Imaging as a Reference Standard.
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Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography 2018; (31(9)):992-999 doi:10.1016/j.echo.2018.04.006.
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Long-Term Outcome of Active Surveillance in Severe But Asymptomatic Primary Mitral Regurgitation.
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JACC. Cardiovascular imaging 2018; (11(9)):1213-1221 doi:10.1016/j.jcmg.2018.05.014.
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Isolated Flailed P3 Scallop of the Mitral Valve Leaflet in the Setting of Newly Diagnosed Heart Failure With Preserved Ejection Fraction.
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Cureus 2020; (12(8)):e9919 doi:10.7759/cureus.9919.
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Replacement Myocardial Fibrosis in Patients With Mitral Valve Prolapse: Relation to Mitral Regurgitation, Ventricular Remodeling, and Arrhythmia.
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Mitral valve prolapse with ventricular arrhythmias: does it carries a worse prognosis?
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Gender differences in primary mitral regurgitant volumes at specific regurgitant fractions as assessed by magnetic resonance imaging.
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Cardiac and Obstetric Outcomes Associated With Mitral Valve Prolapse.
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Cardiac Arrest in a Patient With Arrhythmic Mitral Valve Prolapse Syndrome: Multiple Possible Etiologies.
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Starting A New Robotic Surgery Program for Mitral Valve Repair. Lessons Learned from The First Nine Months.
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Journal of clinical medicine 2021; (10(22)) doi:10.3390/jcm10225439.
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Dark-blood late gadolinium enhancement CMR improves detection of papillary muscle fibrosis in patients with mitral valve prolapse.
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The Outcome of Ventricular Arrhythmias Associated With Mitral Valve Prolapse After Catheter Ablation: A Systematic Review and Meta-Analysis.
Wibawa K, Ivan I, Jessica G, Ridjab D
Cureus 2021; (13(12)):e20310 doi:10.7759/cureus.20310.
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Complex sympathetic regulation in adolescent mitral valve prolapse.
Bona Olexova L, Visnovcova Z, Ferencova N, et al.
Physiological research 2021; (70(S3)):S317-S325 doi:10.33549/physiolres.934830.
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Genetic background of mitral valve prolapse.
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Reviews in cardiovascular medicine 2022; (23(3)):96 doi:10.31083/j.rcm2303096.
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Valvular Heart Disease in Athletes.
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Current treatment options in cardiovascular medicine 2021; (23(11)) doi:10.1007/s11936-021-00950-1.
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The Role of Transforming Growth Factor-β Signaling in Myxomatous Mitral Valve Degeneration.
Tang Q, McNair AJ, Phadwal K, et al.
Frontiers in cardiovascular medicine 2022; (9()):872288 doi:10.3389/fcvm.2022.872288.
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Clinical features and complications of Loeys-Dietz syndrome: A systematic review.
Gouda P, Kay R, Habib M, et al.
International journal of cardiology 2022; (362()):158-167 doi:10.1016/j.ijcard.2022.05.065.
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Pharmacologic Management for Ventricular Arrhythmias: Overview of Anti-Arrhythmic Drugs.
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Journal of clinical medicine 2022; (11(11)) doi:10.3390/jcm11113233.
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Characterization of ventricular arrhythmias and sudden cardiac death in subjects with mitral valve prolapse and mitral annular disjunction.
Raina A, Gersh BJ, Asirvatham SJ, Del-Carpio Munoz F
Heart rhythm 2023; (20(1)):112-121 doi:10.1016/j.hrthm.2022.09.008.
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Ventricular arrhythmias in arrhythmic mitral valve syndrome-a prospective continuous long-term cardiac monitoring study.
Aabel EW, Chivulescu M, Lie ØH, et al.
Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology 2023; (25(2)):506-516 doi:10.1093/europace/euac182.
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Research Opportunities in the Treatment of Mitral Valve Prolapse: JACC Expert Panel.
Delling FN, Noseworthy PA, Adams DH, et al.
Journal of the American College of Cardiology 2022; (80(24)):2331-2347 doi:10.1016/j.jacc.2022.09.044.
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Is there a role for biomarkers in asymptomatic severe chronic primary mitral regurgitation?
Verma R, Bisleri G, Ong G, Connelly KA
Current opinion in cardiology 2023; (38(2)):68-74 doi:10.1097/HCO.0000000000001016.
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Percutaneous MitraClip Device or Surgical Mitral Valve Repair in Patients With Primary Mitral Regurgitation Who Are Candidates for Surgery: Design and Rationale of the REPAIR MR Trial.
McCarthy PM, Whisenant B, Asgar AW, et al.
Journal of the American Heart Association 2023; (12(4)):e027504 doi:10.1161/JAHA.122.027504.
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The evolving role of cardiovascular magnetic resonance in the assessment of mitral valve prolapse.
Vermes E, Altes A, Iacuzio L, et al.
Frontiers in cardiovascular medicine 2023; (10()):1093060 doi:10.3389/fcvm.2023.1093060.
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Quantification of primary mitral regurgitation by echocardiography: A practical appraisal.
Altes A, Vermes E, Levy F, et al.
Frontiers in cardiovascular medicine 2023; (10()):1107724 doi:10.3389/fcvm.2023.1107724.
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Arrhythmic mitral valve prolapse in 2023: Evidence-based update.
Kubala M, Essayagh B, Michelena HI, et al.
Frontiers in cardiovascular medicine 2023; (10()):1130174 doi:10.3389/fcvm.2023.1130174.
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Transcatheter Mitral Valve Repair for Degenerative Mitral Regurgitation.
Makkar RR, Chikwe J, Chakravarty T, et al.
JAMA 2023; (329(20)):1778-1788 doi:10.1001/jama.2023.7089.
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Mitral Valve Prolapse-The Role of Cardiac Imaging Modalities.
Adabifirouzjaei F, Hsiao A, DeMaria AN
Structural heart : the journal of the Heart Team 2022; (6(2)):100024 doi:10.1016/j.shj.2022.100024.
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High-risk phenotypes of arrhythmic mitral valve prolapse: a systematic review and meta-analysis.
Benjanuwattra J, Kewcharoen J, Phinyo P, et al.
Acta cardiologica 2023; (78(9)):1012-1019 doi:10.1080/00015385.2023.2227487.
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Effectiveness of the risk stratification proposed by the 2022 European Heart Rhythm Association Expert Consensus statement on arrhythmic mitral valve prolapse.
L'Hoyes W, Robyns T, Moura-Fereira S, et al.
American heart journal 2023; (266()):48-60 doi:10.1016/j.ahj.2023.08.004.
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Genetic mechanisms underlying arrhythmogenic mitral valve prolapse: Current and future perspectives.
Levy S, Sharaf Dabbagh G, Giudicessi JR, et al.
Heart rhythm O2 2023; (4(9)):581-591 doi:10.1016/j.hroo.2023.08.003.
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Arrhythmic risk profile in mitral valve prolapse: A systematic review and metanalysis of 1715 patients.
Pistelli L, Vetta G, Parlavecchio A, et al.
Journal of cardiovascular electrophysiology 2024; (35(2)):290-300 doi:10.1111/jce.16149.
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Mitral Annular Disjunction: Review of an Increasingly Recognized Mitral Valve Entity.
Gulati A, Gulati V, Hu R, et al.
Radiology. Cardiothoracic imaging 2023; (5(6)):e230131 doi:10.1148/ryct.230131.
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Early and Late Results after Surgical Mitral Valve Repair: A High-Volume Center Experience.
Götte J, Zittermann A, Deutsch MA, et al.
The Thoracic and cardiovascular surgeon 2024; (72(8)):624-630 doi:10.1055/a-2266-7677.
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Frequency of Cardiac Valvulopathies in Patients With Marfan Syndrome: A Systematic Review and Meta-Analysis.
Sama C, Fongwen NT, Chobufo MD, et al.
Cureus 2024; (16(2)):e54141 doi:10.7759/cureus.54141.
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Are children with mitral valve prolapse more anxious?
Beyazal M, Orun UA, Sayici IU
Annals of pediatric cardiology 2023; (16(5)):331-336 doi:10.4103/apc.apc_126_23.
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Survival loss linked to guideline-based indications for degenerative mitral regurgitation surgery.
Vancraeynest D, Pouleur AC, de Meester C, et al.
European heart journal. Cardiovascular Imaging 2024; (25(12)):1703-1711 doi:10.1093/ehjci/jeae176.
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Arrhythmogenic Mitral Valve Prolapse: Can We Risk Stratify and Prevent Sudden Cardiac Death?
Cameron JN, Kadhim KI, Kamsani SH, et al.
Arrhythmia & electrophysiology review 2024; (13()):e11 doi:10.15420/aer.2023.26.
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Floppy Mitral Valve/Mitral Valve Prolapse and Manifestations Not Related to Mitral Regurgitation: Time to Search the Dark Side of the Moon.
Boudoulas KD, Pitsis A, Iliescu C, et al.
Cardiology 2025; (150(3)):283-293 doi:10.1159/000541179.
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Prevalence of Diastolic and Systolic Mitral Annular Disjunction in Patients With Mitral Valve Prolapse.
Fiore G, Rizza V, Ingallina G, et al.
Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography 2025; (38(1)):1-11 doi:10.1016/j.echo.2024.10.004.
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Echocardiographic Assessment of Mitral Valve Prolapse Prevalence before and after the Year 1999: A Systematic Review.
Sonaglioni A, Nicolosi GL, Bruno A, et al.
Journal of clinical medicine 2024; (13(20)) doi:10.3390/jcm13206160.
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Imminent risk of LVEF decline in asymptomatic patients with primary mitral regurgitation.
Zheng J, Huang SW, Ahmed MI, et al.
Frontiers in cardiovascular medicine 2024; (11()):1410859 doi:10.3389/fcvm.2024.1410859.
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Asymptomatic severe degenerative mitral regurgitation.
Björn R, Strom JB, Lloyd G, Bhattacharyya S
Heart (British Cardiac Society) 2024; (111(2)):47-54 doi:10.1136/heartjnl-2024-324739.
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Cardiovascular magnetic resonance in patients with mitral valve prolapse.
Figliozzi S, Di Maio S, Georgiopoulos G, et al.
Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance 2025; (27(1)):101137 doi:10.1016/j.jocmr.2024.101137.
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A 23-Year-Old Man With Multilobar Consolidation.
Kundu A, Gupta N, Kumar R, et al.
Chest 2025; (167(1)):e5-e8 doi:10.1016/j.chest.2024.03.049.
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Characteristics of Patients With the Arrhythmogenic Mitral Valve Prolapse Syndrome and Sudden Cardiac Arrest and Sustained Ventricular Arrhythmias.
Chakrabarti A, Giudicessi JR, Ezzeddine FM, et al.
Circulation. Arrhythmia and electrophysiology 2025; (18(3)):e013099 doi:10.1161/CIRCEP.124.013099.
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Prevalence, progression, and clinical outcomes of mitral valve prolapse: a systematic review and meta-analysis.
Melamed T, Badiani S, Harlow S, et al.
European heart journal. Quality of care & clinical outcomes 2025; (11(5)):631-641 doi:10.1093/ehjqcco/qcaf016.
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Clinical and Phenotypic Correlates of Mitral Valve Prolapse in Marfan Syndrome: The Cornell Aortic Aneurysm Registry.
Narula N, Schwartz Y, Devereux RB, et al.
Journal of the American Heart Association 2025; (14(10)):e040947 doi:10.1161/JAHA.125.040947.
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Complex Ventricular Arrhythmias in Patients with Mitral Annular Disjunction: A Systematic Review and Meta-Analysis.
Gonçalves LS, Tanus LMA, Queiroz LA, et al.
Echocardiography (Mount Kisco, N.Y.) 2025; (42(6)):e70211 doi:10.1111/echo.70211.
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Multiparametric Approach to Arrhythmic Mitral Valve Prolapse: Novel and Recognized Markers of Increased Sudden Cardiac Arrest Risk.
Jaworski K, Kowalik I, Firek B, et al.
Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography 2026; (39(1)):1-14 doi:10.1016/j.echo.2025.07.011.
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Echocardiographic and Pathophysiologic Insights Into Mitral Regurgitation, Mitral Annular Disjunction, and Ventricular Arrhythmias in Patients with Mitral Valve Prolapse.
Silbiger JJ, Marchenko O, Safi L, Panday P
Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography 2026; (39(1)):107-119 doi:10.1016/j.echo.2025.08.014.
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Case Report: From multimodality imaging to catheter ablation of ventricular arrhythmias in arrhythmogenic mitral valve prolapse.
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Frontiers in physiology 2025; (16()):1654085 doi:10.3389/fphys.2025.1654085.
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Ventricular arrhythmias during exercise in patients with mitral valve prolapse.
van Wijngaarden AL, de Riva M, Sabbag A, et al.
Heart (British Cardiac Society) 2026; (112(14)):781-788 doi:10.1136/heartjnl-2025-326395.
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The Burden of Cardiac Arrhythmias in Loeys-Dietz Syndrome: Prevalence, Etiology, and Therapeutic Interventions.
Nabi HA, Bcharah G, Bcharah H, et al.
JACC. Advances 2025; (4(11 Pt 1)):102269 doi:10.1016/j.jacadv.2025.102269.
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Acquired Gerbode Defect Diagnosed Seven Years After Surgical Mitral Valve Repair for Severe Primary Mitral Valve Regurgitation: A Case Report.
Kazma H, Iskandar S, Hitti J, et al.
Cureus 2025; (17(10)):e94436 doi:10.7759/cureus.94436.
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Characterizing Sustained Arrhythmias in Patients With Arrhythmic Mitral Valve Prolapse: Insights From the SAVE-MVP collaboration.
Sabbag A, Ajmone-Marsan N, Ezzeddine F, et al.
JACC. Clinical electrophysiology 2026; (12(3)):540-551 doi:10.1016/j.jacep.2025.10.004.
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