Research & Literature

Neurocutaneous melanosis and congenital melanocytic naevi: a retrospective review of clinical and radiological characteristics.

Sibbald C, Randhawa H, Branson H, Pope E

The British journal of dermatology 2015; (173(6)):1522-4 doi:10.1111/bjd.13949.

Amplification of mutated NRAS leading to congenital melanoma in neurocutaneous melanocytosis.

Salgado CM, Basu D, Nikiforova M, et al.

Melanoma research 2015; (25(5)):453-60 doi:10.1097/CMR.0000000000000188.

Neurocutaneous melanocytosis presenting in a teenager: A case report and review of the literature.

Monica I, Kumar LP, Uppin MS, Jagannath Rao Naidu KV

Journal of cancer research and therapeutics 2015; (11(3)):649 doi:10.4103/0973-1482.138201.

Mutation in NRAS in familial Noonan syndrome--case report and review of the literature.

Ekvall S, Wilbe M, Dahlgren J, et al.

BMC medical genetics 2015; (16()):95 doi:10.1186/s12881-015-0239-1.

Increase in NRAS mutant allele percentage during metastatic melanoma progression.

Funck-Brentano E, Hélias-Rodzewicz Z, Longvert C, et al.

Experimental dermatology 2016; (25(6)):472-4 doi:10.1111/exd.13001.

Primary Amelanotic Leptomeningeal Melanomatosis in a Child: A Rare but Severe Disease.

Szathmari A, Perbet R, Hermier M, et al.

World neurosurgery 2016; (92()):581.e15-581.e20 doi:10.1016/j.wneu.2016.06.039.

Age related changes in brain MR appearance in the course of neurocutaneous melanosis.

Bekiesińska-Figatowska M, Sawicka E, Żak K, Szczygielski O

European journal of radiology 2016; (85(8)):1427-31.

Melanocytic Nevi in Children: A Review.

Levy R, Lara-Corrales I

Pediatric annals 2016; (45(8)):e293-8 doi:10.3928/19382359-20160720-07.

Diagnostic and therapeutic approach for neurocutaneous melanosis in a young adult.

Alessandro L, Blaquier JB, Bártoli J, Diez B

Neurologia 2019; (34(5)):336-338 doi:10.1016/j.nrl.2016.09.008.

Copy number variations as potential diagnostic and prognostic markers for CNS melanocytic neoplasms in neurocutaneous melanosis.

van Engen-van Grunsven AC, Rabold K, Küsters-Vandevelde HV, et al.

Acta neuropathologica 2017; (133(2)):333-335 doi:10.1007/s00401-016-1654-x.

Melanoma in congenital melanocytic naevi.

Kinsler VA, O'Hare P, Bulstrode N, et al.

The British journal of dermatology 2017; (176(5)):1131-1143 doi:10.1111/bjd.15301.

Congenital Melanocytic Nevus Syndrome: A Case Series.

Recio A, Sánchez-Moya AI, Félix V, Campos Y

Actas dermo-sifiliograficas 2017; (108(9)):e57-e62 doi:10.1016/j.ad.2016.07.025.

MEK inhibition appears to improve symptom control in primary NRAS-driven CNS melanoma in children.

Kinsler VA, O'Hare P, Jacques T, et al.

British journal of cancer 2017; (116(8)):990-993 doi:10.1038/bjc.2017.49.

Targeted therapy for infants with diencephalic syndrome: A case report and review of management strategies.

Wagner LM, Myseros JS, Lukins DE, et al.

Pediatric blood & cancer 2018; (65(5)):e26917 doi:10.1002/pbc.26917.

Primary Central Nervous System Malignant Melanoma in Children: A Case Series and Review of the Literature.

Choi DK, Pillay-Smiley N, Marzec S, et al.

Journal of pediatric hematology/oncology 2018; (40(8)):616-619 doi:10.1097/MPH.0000000000001092.

Spectrum of Clinical, Neuroimaging, and Cerebrospinal Fluid Features of Adult Neurocutaneous Melanocytosis.

Qian M, Ren H, Qu T, et al.

European neurology 2018; (80(1-2)):1-6 doi:10.1159/000488687.

New insights into neurocutaneous melanosis.

Jakchairoongruang K, Khakoo Y, Beckwith M, Barkovich AJ

Pediatric radiology 2018; (48(12)):1786-1796 doi:10.1007/s00247-018-4205-x.

Shunt Surgery for Neurocutaneous Melanosis with Hydrocephalus: Case Report and Review of the Literature.

Omar AT, Bagnas MAC, Del Rosario-Blasco KAR, et al.

World neurosurgery 2018; (120()):583-589.e3 doi:10.1016/j.wneu.2018.09.002.

Neurocutaneous Melanosis with Bilateral Temporal Lobe Lesions without Leptomeningeal Enhancement: A Distinct Entity or Subtype.

Kumar S, Dey S, Pimpalwar Y, Rao A

Journal of pediatric neurosciences 2018; (13(3)):331-333 doi:10.4103/JPN.JPN_53_18.

Neurocutaneous Melanosis with Leptomeningeal Melanoma Involving Supratentorium and Infratentorium.

Thomas S, Patel B, Varghese SS, Backianathan S

Cureus 2018; (10(9)):e3275 doi:10.7759/cureus.3275.

Giant Congenital Melanocytic Nevus Treated With Trametinib.

Mir A, Agim NG, Kane AA, et al.

Pediatrics 2019; (143(3)) doi:10.1542/peds.2018-2469.

Neurocutaneous Melanosis in Association With Large Congenital Melanocytic Nevi in Children: A Report of 2 Cases With Clinical, Radiological, and Pathogenetic Evaluation.

Chen L, Zhai L, Al-Kzayer LFY, et al.

Frontiers in neurology 2019; (10()):79 doi:10.3389/fneur.2019.00079.

Skin-related quality of life in children and adolescents with congenital melanocytic naevi - an analysis of self- and parent reports.

Neuhaus K, Landolt MA, Theiler M, et al.

Journal of the European Academy of Dermatology and Venereology : JEADV 2020; (34(5)):1105-1111 doi:10.1111/jdv.16131.

Serial 18F-FDG PET/CT findings in a patient with neurocutaneous melanosis.

Deng Y, Shen X, Zhang W

Neurology. Clinical practice 2020; (10(2)):e14-e16 doi:10.1212/CPJ.0000000000000700.

Trametinib-associated Hyponatremia in a Child With Low-grade Glioma is Not Seen Following Treatment With Alternative MEK Inhibitor.

Lazow MA, Lawson SA, Salloum R, et al.

Journal of pediatric hematology/oncology 2021; (43(4)):e550-e553 doi:10.1097/MPH.0000000000001859.

Congenital melanocytic nevi.

Moustafa D, Blundell AR, Hawryluk EB

Current opinion in pediatrics 2020; (32(4)):491-497 doi:10.1097/MOP.0000000000000924.

Risk factors for MEK-associated retinopathy in patients with advanced melanoma treated with combination BRAF and MEK inhibitor therapy.

Booth AEC, Hopkins AM, Rowland A, et al.

Therapeutic advances in medical oncology 2020; (12()):1758835920944359 doi:10.1177/1758835920944359.

Neurocutaneous melanocytosis (melanosis).

Ruggieri M, Polizzi A, Catanzaro S, et al.

Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery 2020; (36(10)):2571-2596 doi:10.1007/s00381-020-04770-9.

Malignant Melanoma Arising From a Giant Congenital Melanocytic Nevus in a 3-Year Old: Review of Diagnosis and Management.

Kugar M, Akhavan A, Ndem I, et al.

The Journal of craniofacial surgery 2021; (32(4)):e342-e345 doi:10.1097/SCS.0000000000007115.

Symptomatic neurocutaneous melanosis: mild clinical onset in a teenager.

Vanood A, Lee YA, Leleszi E, Krishnan A

BMJ case reports 2020; (13(11)) doi:10.1136/bcr-2020-235772.

Congenital melanocytic naevi: An up-to-date overview.

Farabi B, Akay BN, Goldust M, et al.

The Australasian journal of dermatology 2021; (62(2)):e178-e191 doi:10.1111/ajd.13535.

Imaging and Clinical Features of Neurocutaneous Melanosis in the Pediatric Population.

Mormina E, Granata F, Vinci SL, et al.

Current medical imaging 2021; (17(12)):1391-1402 doi:10.2174/1573405617666210527091109.

Nonsyndromic Primary Diffuse Leptomeningeal Melanomatosis in a Child.

Tavana Rad S, Ashrafzadeh F, Golmakani H, Ganjeifar B

Iranian journal of child neurology 2021; (15(3)):153-157 doi:10.22037/ijcn.v15i2.20159.

Neurocutaneous melanocytosis-associated malignant melanoma presenting with peritoneal seeding.

Sener U, Elmore K, Jayaseelan K, et al.

Pediatric dermatology 2021; (38(5)):1298-1301 doi:10.1111/pde.14789.

The retrospective molecular analysis of large or giant congenital melanocytic nevi in a group of Polish children.

Wertheim-Tysarowska K, Szczygielski O, Seliga K, et al.

Journal of mother and child 2021; (25(1)):19-24 doi:10.34763/jmotherandchild.20212501.d-21-00007.

Combinatorial effects of azacitidine and trametinib on NRAS-mutated melanoma.

Hanft KM, Hamed E, Kaiser M, et al.

Pediatric blood & cancer 2022; (69(4)):e29468 doi:10.1002/pbc.29468.

Risk of Malignant Transformation Arising From Giant Congenital Melanocytic Nevi: A 20-year Single-center Study.

Kim JY, Jeon JH, Choi TH, Kim BJ

Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.] 2022; (48(2)):171-175 doi:10.1097/DSS.0000000000003341.

Neurocutaneous Melanosis with Hydrocephalus and Dandy-Walker Variant.

Sarwar M, Tripathy L, Jain H, et al.

Asian journal of neurosurgery 2021; (16(4)):876-880 doi:10.4103/ajns.AJNS_542_20.

Neurosurgical management of patients with neurocutaneous melanosis: a systematic review.

Rahman RK, Majmundar N, Ghani H, et al.

Neurosurgical focus 2022; (52(5)):E8 doi:10.3171/2022.2.FOCUS21791.

Neurocutaneous melanosis with an intracranial cystic-solid meningeal melanoma in an adult: A case report and review of literature.

Liu BC, Wang YB, Liu Z, et al.

World journal of clinical cases 2022; (10(15)):5025-5035 doi:10.12998/wjcc.v10.i15.5025.

Incidence of neurocutaneous melanosis in Japanese pediatric patients with congenital melanocytic nevi.

Takiya M, Fushimi Y, Sakamoto M, et al.

Scientific reports 2023; (13(1)):16442 doi:10.1038/s41598-023-43829-w.

Missense mutation of NRAS is associated with malignant progression in neurocutaneous melanosis.

Takahashi H, Natsumeda M, Hara N, et al.

Acta neuropathologica communications 2024; (12(1)):14 doi:10.1186/s40478-024-01723-0.

Spinal melanoma with optic neuropathy -rare manifestation of Neurocutaneous melanosis and PET-MRI findings.

Baskar D, Vengalil S, Chakkera P, et al.

eNeurologicalSci 2024; (35()):100504 doi:10.1016/j.ensci.2024.100504.

Regulation of brain fluid volumes and pressures: basic principles, intracranial hypertension, ventriculomegaly and hydrocephalus.

Hladky SB, Barrand MA

Fluids and barriers of the CNS 2024; (21(1)):57 doi:10.1186/s12987-024-00532-w.

Primary Malignant Meningeal Melanoma Complicated by Cerebral Venous Sinus Thrombosis: An Illustrative Case With a Systematic Review of the Literature.

Mann JA, Bhatt D, Tso MK

Cureus 2024; (16(8)):e66710 doi:10.7759/cureus.66710.

Congenital melanocytic nevi and risk of melanoma.

Pastore LM, Valentini R, Marghoob AA

Clinics in dermatology 2025; (43(3)):378-384 doi:10.1016/j.clindermatol.2024.09.004.

Neurocutaneous Melanocytosis-Associated Hydrocephalus: The Memorial Sloan Kettering Experience from 2001 to 2022.

Rodriguez S, DeIeso-Frechette F, Umeasor C, et al.

Pediatric blood & cancer 2025; (72(1)):e31434 doi:10.1002/pbc.31434.

Central Nervous System Involvement and Neuroradiological Imaging Insights of Neurocutaneous Melanocytosis in Congenital Melanocytic Nevi.

Ruff C, Gohla G, Nägele T, Batra M

Diagnostics (Basel, Switzerland) 2024; (14(21)) doi:10.3390/diagnostics14212345.

A Review of the Clinical Presentation, Causes, and Diagnostic Evaluation of Increased Intracranial Pressure in the Emergency Department.

Olaru C, Langberg S, McCoin NS

The western journal of emergency medicine 2024; (25(6)):1003-1010 doi:10.5811/westjem.18500.

Congenital Melanocytic Nevi.

Nathan S, Smetona J, Naran S, Bauer BS

Clinics in plastic surgery 2025; (52(2)):259-269 doi:10.1016/j.cps.2024.09.003.

Sudden death associated with primary leptomeningeal melanocytosis without features of neurocutaneous melanosis syndrome.

Doğan M, Buğra A, Karayel F, Üzün İ

Journal of forensic and legal medicine 2025; (115()):102953 doi:10.1016/j.jflm.2025.102953.