Research & Literature

Plasma-derived C1-INH for managing hereditary angioedema in pediatric patients: A systematic review.

Craig TJ, Schneider LC, MacGinnitie AJ

Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology 2015; (26(6)):537-44 doi:10.1111/pai.12425.

Urticaria and Prodromal Symptoms Including Erythema Marginatum in Danish Patients with Hereditary Angioedema.

Rasmussen ER, de Freitas PV, Bygum A

Acta dermato-venereologica 2016; (96(3)):373-6 doi:10.2340/00015555-2233.

ACE-I Angioedema: Accurate Clinical Diagnosis May Prevent Epinephrine-Induced Harm.

Curtis RM, Felder S, Borici-Mazi R, Ball I

The western journal of emergency medicine 2016; (17(3)):283-9 doi:10.5811/westjem.2016.2.29224.

HAE Pathophysiology and Underlying Mechanisms.

Zuraw BL, Christiansen SC

Clinical reviews in allergy & immunology 2016; (51(2)):216-29 doi:10.1007/s12016-016-8561-8.

Hereditary angioedema with F12 mutation: Clinical features and enzyme polymorphisms in 9 Southwestern Spanish families.

Piñero-Saavedra M, González-Quevedo T, Saenz de San Pedro B, et al.

Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 2016; (117(5)):520-526 doi:10.1016/j.anai.2016.09.001.

Histaminergic Angioedema.

Busse PJ, Smith T

Immunology and allergy clinics of North America 2017; (37(3)):467-481 doi:10.1016/j.iac.2017.03.001.

Acute Management of Hereditary Angioedema Attacks.

Katelaris CH

Immunology and allergy clinics of North America 2017; (37(3)):541-556 doi:10.1016/j.iac.2017.04.002.

Hereditary Angioedema with Normal C1 Inhibitor: Update on Evaluation and Treatment.

Magerl M, Germenis AE, Maas C, Maurer M

Immunology and allergy clinics of North America 2017; (37(3)):571-584 doi:10.1016/j.iac.2017.04.004.

Breakthrough attacks in patients with hereditary angioedema receiving long-term prophylaxis are responsive to icatibant: findings from the Icatibant Outcome Survey.

Aberer W, Maurer M, Bouillet L, et al.

Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology 2017; (13()):31 doi:10.1186/s13223-017-0203-z.

Angiotensin-converting enzyme inhibitor-induced angioedema: A review of the literature.

Brown T, Gonzalez J, Monteleone C

Journal of clinical hypertension (Greenwich, Conn.) 2017; (19(12)):1377-1382 doi:10.1111/jch.13097.

Refractory Abdominal Pain in a Patient with Chronic Lymphocytic Leukemia: Be Wary of Acquired Angioedema due to C1 Esterase Inhibitor Deficiency.

Abdulkareem A, D'Souza RS, Mundorff J, et al.

Case reports in hematology 2018; (2018()):7809535 doi:10.1155/2018/7809535.

A score for the differential diagnosis of bradykinin- and histamine-induced head and neck swellings.

Lenschow M, Bas M, Johnson F, et al.

European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery 2018; (275(7)):1767-1773 doi:10.1007/s00405-018-4989-1.

Epidemiology of Bradykinin-mediated angioedema: a systematic investigation of epidemiological studies.

Aygören-Pürsün E, Magerl M, Maetzel A, Maurer M

Orphanet journal of rare diseases 2018; (13(1)):73 doi:10.1186/s13023-018-0815-5.

Improving the Management of Hereditary Angioedema.

Giavina-Bianchi P, Kalil J

Clinics (Sao Paulo, Brazil) 2018; (73()):e354 doi:10.6061/clinics/2018/e354.

A hereditary angioedema screening on an index case: Turkey.

Ozkars MY, Keskin O, Bayram N, et al.

Asian Pacific journal of allergy and immunology 2019; (37(3)):154-161 doi:10.12932/AP-060218-0257.

[The ulm emergency algorithm for the acute treatment of drug-induced, bradykinin-mediated angioedema].

Hahn J, Bock B, Muth CM, et al.

Medizinische Klinik, Intensivmedizin und Notfallmedizin 2019; (114(8)):708-716 doi:10.1007/s00063-018-0483-1.

The physician and hereditary angioedema friend or foe: 62-year diagnostic delay and iatrogenic procedures.

Valerieva A, Cicardi M, Baraniuk J, Staevska M

Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology 2018; (14()):75 doi:10.1186/s13223-018-0275-4.

[Classification and pathophysiology of angioedema].

Buttgereit T, Maurer M

Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete 2019; (70(2)):84-91 doi:10.1007/s00105-018-4318-z.

Surgical Emphysema in a Pediatric Tertiary Referral Center.

Harrison R, Knowles S, Doherty C

Pediatric emergency care 2020; (36(1)):e21-e24 doi:10.1097/PEC.0000000000001725.

Delayed diagnosis of hereditary angioedema with C1-inhibitor deficiency in iranian children and adolescents.

Ayazi M, Fazlollahi MR, Mohammadzadeh I, et al.

Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology 2019; (30(3)):395-398 doi:10.1111/pai.13028.

Hereditary angioedema: examining the landscape of therapies and preclinical therapeutic targets.

Farkas H

Expert opinion on therapeutic targets 2019; (23(6)):457-459 doi:10.1080/14728222.2019.1608949.

A review of kallikrein inhibitor lanadelumab in hereditary angioedema.

Hwang G, Johri A, Ng S, Craig T

Immunotherapy 2019; (11(11)):937-944 doi:10.2217/imt-2018-0197.

The functional promoter F12-46C/T variant predicts the asymptomatic phenotype of C1-INH-HAE.

Rijavec M, Košnik M, Andrejević S, et al.

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2019; (49(11)):1520-1522 doi:10.1111/cea.13470.

Evidence for bradykinin release in chronic spontaneous urticaria.

Hofman ZLM, van den Elzen MT, Kuijpers J, et al.

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2020; (50(3)):343-351 doi:10.1111/cea.13558.

Update on bradykinin-mediated angioedema in 2020.

Lepelley M, Bernardeau C, Defendi F, et al.

Therapie 2020; (75(2)):195-205 doi:10.1016/j.therap.2020.02.011.

ACE inhibitor angioedema: characterization and treatment versus non-ACE angioedema in acute hospitalized patients.

Weisman DS, Arnouk N, Asghar MB, et al.

Journal of community hospital internal medicine perspectives 2020; (10(1)):16-18 doi:10.1080/20009666.2020.1711641.

US HAEA Medical Advisory Board 2020 Guidelines for the Management of Hereditary Angioedema.

Busse PJ, Christiansen SC, Riedl MA, et al.

The journal of allergy and clinical immunology. In practice 2021; (9(1)):132-150.e3 doi:10.1016/j.jaip.2020.08.046.

Novel Use of Fresh Frozen Plasma in Treating Hereditary Angioedema: A Success Story From Pakistan.

Sabeen Ahmed A, Fayyaz S

Cureus 2020; (12(8)):e9669 doi:10.7759/cureus.9669.

Hereditary angioedema: Pathophysiology (HAE type I, HAE type II, and HAE nC1-INH).

Wedner HJ

Allergy and asthma proceedings 2020; (41(Suppl 1)):S14-S17 doi:10.2500/aap.2020.41.200081.

A follow-up survey of patients with acquired angioedema due to C1-inhibitor deficiency.

Pólai Z, Balla Z, Andrási N, et al.

Journal of internal medicine 2021; (289(4)):547-558 doi:10.1111/joim.13182.

Differences and Similarities in the Mechanisms and Clinical Expression of Bradykinin-Mediated vs. Mast Cell-Mediated Angioedema.

Maurer M, Magerl M

Clinical reviews in allergy & immunology 2021; (61(1)):40-49 doi:10.1007/s12016-021-08841-w.

Real-world off-label use of icatibant for acute management of non-hereditary angioedema.

Le TA, Smith W, Hissaria P

Internal medicine journal 2021; (51(3)):419-423 doi:10.1111/imj.15241.

Hereditary angioedema: how to approach it at the emergency department?

Serpa FS, Mansour E, Aun MV, et al.

Einstein (Sao Paulo, Brazil) 2021; (19()):eRW5498 doi:10.31744/einstein_journal/2021RW5498.

Medical algorithm: Management of C1 inhibitor hereditary angioedema.

Caballero T, Cabañas R, Pedrosa M

Allergy 2022; (77(3)):1060-1063 doi:10.1111/all.15115.

Emerging drugs for the treatment of hereditary angioedema due to C1-inhibitor deficiency.

Zanichelli A, Montinaro V, Triggiani M, et al.

Expert opinion on emerging drugs 2022; (27(2)):103-110 doi:10.1080/14728214.2022.2105834.

A review of berotralstat for the treatment of hereditary angioedema.

Farkas H, Balla Z

Expert review of clinical immunology 2023; (19(2)):145-153 doi:10.1080/1744666X.2023.2150611.

Hereditary angio-oedema with normal C1-INH, developing recurrent acute abdomen after taking low-dose oestrogen-progestin: A case report.

Nakayama T, Tamimoto Y, Shimomura Y, Tsukamoto H

Modern rheumatology case reports 2023; (7(2)):491-494 doi:10.1093/mrcr/rxad017.

Angioedema in the Absence of C1 Esterase Inhibitor Deficiency in a Young Patient With Anti-dsDNA Negative Lupus Nephritis.

Nadeem I, Khan D, Huang J, et al.

Cureus 2023; (15(5)):e39141 doi:10.7759/cureus.39141.

Hereditary Angioedema.

Banerjee A, Bermudez N, Gould MB, et al.

Cureus 2023; (15(7)):e42088 doi:10.7759/cureus.42088.

Screening for type II hereditary angioedema-the "poor man's c1-inhibitor function".

Jindal AK, Chiang V, Barman P, et al.

The journal of allergy and clinical immunology. Global 2024; (3(1)):100179 doi:10.1016/j.jacig.2023.100179.

The Occurrence of Atopy in Patients with Isolated Spontaneous Mast Cell (or Nonallergic) Angioedema.

Zajac M, Bozek A, Grzanka A

Journal of clinical medicine 2024; (13(2)) doi:10.3390/jcm13020477.

Hereditary angioedema with normal C1-inhibitor: Clinical and genetic characterization of 15 Portuguese unrelated families.

Dias de Castro E, Pinhal AL, Bragança M, et al.

Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 2024; (132(6)):730-736 doi:10.1016/j.anai.2024.01.027.

Repeated attacks of hereditary angioedema in pediatric female.

Abass MK, Dabosy A, Walid Khawaja K, Fischer PR

Paediatrics and international child health 2024; (44(1)):39-41 doi:10.1080/20469047.2024.2317488.

Acquired Angioedema Associated with Lymphoproliferative Disorders.

Ng JY, Ooi M, Bennett SK, et al.

Case reports in oncology 2024; (17(1)):329-336 doi:10.1159/000536458.

Five-Membered Nitrogen Heterocycles Angiotensin-Converting Enzyme (ACE) Inhibitors Induced Angioedema: An Underdiagnosed Condition.

Papapostolou N, Gregoriou S, Katoulis A, Makris M

Pharmaceuticals (Basel, Switzerland) 2024; (17(3)) doi:10.3390/ph17030360.

Isolated Laryngeal Angioedema in a Patient with Long-term ACE Inhibitor Use: A Case Report.

Flinn C, Massaro I

Clinical practice and cases in emergency medicine 2024; (8(1)):18-21 doi:10.5811/cpcem.1565.

The future of therapeutic options for hereditary angioedema.

Smith TD, Riedl MA

Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 2024; (133(4)):380-390 doi:10.1016/j.anai.2024.04.029.

Current and Emerging Therapeutics in Hereditary Angioedema.

Do T, Riedl MA

Immunology and allergy clinics of North America 2024; (44(3)):561-576 doi:10.1016/j.iac.2024.03.009.

Physician- and patient-reported outcomes by hereditary angioedema type: Data from a real-world study.

Anderson J, Soteres D, Mellor J, et al.

Allergy and asthma proceedings 2024; (45(4)):247-254 doi:10.2500/aap.2024.45.240021.

Acute Abdominal Pain as the Initial Presentation of an Acquired C1 Inhibitor Deficiency.

Pinto AR, Carolino F

GE Portuguese journal of gastroenterology 2024; (31(4)):273-277 doi:10.1159/000533179.

Hereditary angioedema (HAE) in children and adolescents: New treatment options.

Fasshauer M, Wedi B

Allergologie select 2024; (8()):336-345 doi:10.5414/ALX02532E.

Angioedema.

Lacuesta G, Betschel SD, Tsai E, Kim H

Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology 2024; (20(Suppl 3)):65 doi:10.1186/s13223-024-00934-3.

Angioedema without urticaria: Diagnosis and management.

Young MC, Banerji A

Allergy and asthma proceedings 2025; (46(3)):185-191 doi:10.2500/aap.2025.46.250013.

An Atypical Case of Angioedema With Normal C1-Inhibitor Responding to Both C1-Inhibitor Concentrate and Omalizumab.

Miyahara K, Matsumoto M, Kunihiro M, et al.

The Journal of dermatology 2025; doi:10.1111/1346-8138.17838.

Expanding the Genetic and Clinical Spectrum of Hereditary Angioedema with Normal C1 Inhibitor: Novel Variants and Treatment Insights.

Gao H, Zhao Y, Chen S, et al.

Journal of clinical immunology 2025; (45(1)):124.

C1 Esterase Inhibitor Deficiency in an Indian Female: A Rare Case Report and a Review of Literature with Treatment Update.

Singh J, Kumar N, Kumar K, et al.

Current drug targets 2026; (27(3)):211-216 doi:10.2174/0113894501411809251001113142.

Barely There But Existent: Angiotensin-Converting Enzyme Inhibitor-Induced Angioedema.

Butt MA, Kumar S, Sarwer SM, Manna D

Cureus 2025; (17(10)):e94104 doi:10.7759/cureus.94104.

Patient Preferences for Long-Term Prophylactic Treatment in Hereditary Angioedema: A Discrete-Choice Experiment.

Villa KF, Mansfield C, Yarlas A, et al.

The patient 2026; (19(3)):481-495 doi:10.1007/s40271-025-00798-8.

A Treat-to-Target approach in hereditary angioedema: expert consensus from a European committee.

Cancian M, Caballero T, Boccon-Gibod I, et al.

Frontiers in immunology 2026; (17()):1773279 doi:10.3389/fimmu.2026.1773279.