Research & Literature
Explore the leading researchers and institutions driving advances in this area, and dive into the full body of literature that informs this resource.
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University of Michigan
Ann Arbor, United States
Vrije Universiteit Brussel
Brussels, Belgium
Inserm
Paris, France
University of Antwerp
Antwerp, Belgium
UNSW Sydney
Sydney, Australia
The University of Sydney
Sydney, Australia
Aarhus University
Aarhus, Denmark
University of Nottingham
Nottingham, United Kingdom
Manchester Metropolitan University
Manchester, United Kingdom
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Seattle, United States
References
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Effectiveness of Models Used to Deliver Multimodal Care for Chronic Musculoskeletal Pain: a Rapid Evidence Review.
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Patients With Chronic Spinal Pain Benefit From Pain Neuroscience Education Regardless the Self-Reported Signs of Central Sensitization: Secondary Analysis of a Randomized Controlled Multicenter Trial.
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Operant Learning Versus Energy Conservation Activity Pacing Treatments in a Sample of Patients With Fibromyalgia Syndrome: A Pilot Randomized Controlled Trial.
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Prescription of exercises for the treatment of chronic pain along the continuum of nociplastic pain: A systematic review with meta-analysis.
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Methods to discriminate between mechanism-based categories of pain experienced in the musculoskeletal system: a systematic review.
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Pruriplastic Itch-A Novel Pathogenic Concept in Chronic Pruritus.
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Frontiers in medicine 2020; (7()):615118 doi:10.3389/fmed.2020.615118.
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Short-term impact of combining pain neuroscience education with exercise for chronic musculoskeletal pain: a systematic review and meta-analysis.
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Pain 2022; (163(1)):e20-e30 doi:10.1097/j.pain.0000000000002308.
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What Influences Outcomes From Inpatient Multidisciplinary Pain Management Programs?: A Systematic Review and Meta-analysis.
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The Clinical journal of pain 2021; (37(7)):504-523 doi:10.1097/AJP.0000000000000941.
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Chronic pain: an update on burden, best practices, and new advances.
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Nociplastic pain: towards an understanding of prevalent pain conditions.
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Self-management for chronic widespread pain including fibromyalgia: A systematic review and meta-analysis.
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Nociplastic Pain Criteria or Recognition of Central Sensitization? Pain Phenotyping in the Past, Present and Future.
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Journal of clinical medicine 2021; (10(15)) doi:10.3390/jcm10153203.
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Pain, Sleep, and Health-Related Quality of Life after Multidisciplinary Intervention for Chronic Pain.
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Making exercise count: Considerations for the role of exercise in back pain treatment.
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Musculoskeletal care 2022; (20(2)):259-270 doi:10.1002/msc.1597.
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Efficacy of nonpharmacological interventions for individual features of fibromyalgia: a systematic review and meta-analysis of randomised controlled trials.
Kundakci B, Kaur J, Goh SL, et al.
Pain 2022; (163(8)):1432-1445 doi:10.1097/j.pain.0000000000002500.
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Testing a newly developed activity pacing framework for chronic pain/fatigue: a feasibility study.
Antcliff D, Keenan AM, Keeley P, et al.
BMJ open 2021; (11(12)):e045398 doi:10.1136/bmjopen-2020-045398.
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The impact of nociplastic pain features on the response to physical therapy in patients with primary myofascial pain.
Kohns DJ, Scott R, Castellanos J, et al.
Journal of back and musculoskeletal rehabilitation 2022; (35(5)):1143-1151 doi:10.3233/BMR-210244.
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Evaluation of Cognitive Behavioral Therapy on Improving Pain, Fear Avoidance, and Self-Efficacy in Patients with Chronic Low Back Pain: A Systematic Review and Meta-Analysis.
Yang J, Lo WLA, Zheng F, et al.
Pain research & management 2022; (2022()):4276175 doi:10.1155/2022/4276175.
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Comparison of Amitriptyline and US Food and Drug Administration-Approved Treatments for Fibromyalgia: A Systematic Review and Network Meta-analysis.
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JAMA network open 2022; (5(5)):e2212939 doi:10.1001/jamanetworkopen.2022.12939.
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Effects of different protocols of physical exercise on fibromyalgia syndrome treatment: systematic review and meta-analysis of randomized controlled trials.
Albuquerque MLL, Monteiro D, Marinho DA, et al.
Rheumatology international 2022; (42(11)):1893-1908 doi:10.1007/s00296-022-05140-1.
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Central sensitization in opioid use disorder: a novel application of the American College of Rheumatology Fibromyalgia Survey Criteria.
Hall OT, Teater J, Rood KM, et al.
Pain reports 2022; (7(4)):e1016 doi:10.1097/PR9.0000000000001016.
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On the superiority of a combination of aerobic and resistance exercise for fibromyalgia syndrome: A network meta-analysis.
Chen J, Han B, Wu C
Frontiers in psychology 2022; (13()):949256 doi:10.3389/fpsyg.2022.949256.
PMID: 36248603 - 53
Phenotyping Post-COVID Pain as a Nociceptive, Neuropathic, or Nociplastic Pain Condition.
Fernández-de-Las-Peñas C, Nijs J, Neblett R, et al.
Biomedicines 2022; (10(10)) doi:10.3390/biomedicines10102562.
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The role of mind body interventions in the treatment of irritable bowel syndrome and fibromyalgia.
Islam Z, D'Silva A, Raman M, Nasser Y
Frontiers in psychiatry 2022; (13()):1076763 doi:10.3389/fpsyt.2022.1076763.
PMID: 36620663 - 55
Pain assessment 3 × 3: a clinical reasoning framework for healthcare professionals.
Bäckryd E
Scandinavian journal of pain 2023; (23(2)):268-272 doi:10.1515/sjpain-2023-0007.
PMID: 36869594 - 56
Association Between Nociplastic Pain and Pain Severity and Impact in Women With Chronic Pelvic Pain.
Till SR, Schrepf A, Clauw DJ, et al.
The journal of pain 2023; (24(8)):1406-1414 doi:10.1016/j.jpain.2023.03.004.
PMID: 36958459 - 57
A Call for Improving Research on Pain Neuroscience Education and Chronic Pain: An Overview of Systematic Reviews.
Martinez-Calderon J, Ho EK, Ferreira PH, et al.
The Journal of orthopaedic and sports physical therapy 2023; (53(6)):353–368 doi:10.2519/jospt.2023.11833.
PMID: 37161889 - 58
How to treat chronic pain in rheumatic and musculoskeletal diseases (RMDs) - A pharmacological review.
Gérard B, Bailly F, Trouvin AP
Joint bone spine 2024; (91(1)):105624 doi:10.1016/j.jbspin.2023.105624.
PMID: 37495074 - 59
Application of a Clinical Approach to Diagnosing Primary Pain: Prevalence and Correlates of Primary Back and Neck Pain in a Community Physiatry Clinic.
Schubiner H, Lowry WJ, Heule M, et al.
The journal of pain 2024; (25(3)):672-681 doi:10.1016/j.jpain.2023.09.019.
PMID: 37777033 - 60
Comparative effectiveness of non-pharmacological interventions on sleep in individuals with chronic musculoskeletal pain: A systematic review with network meta-analysis.
Chang JR, Cheung YK, Sharma S, et al.
Sleep medicine reviews 2024; (73()):101867 doi:10.1016/j.smrv.2023.101867.
PMID: 37897843 - 61
The optimal dose of pain neuroscience education added to an exercise programme for patients with chronic spinal pain: a systematic review and dose-response meta-analysis.
Núñez-Cortés R, Salazar-Méndez J, Calatayud J, et al.
Pain 2024; (165(6)):1196-1206 doi:10.1097/j.pain.0000000000003126.
PMID: 38047772 - 62
Pain neuroscience education in patients with chronic musculoskeletal pain: an umbrella review.
Cuenca-Martínez F, Suso-Martí L, Calatayud J, et al.
Frontiers in neuroscience 2023; (17()):1272068 doi:10.3389/fnins.2023.1272068.
PMID: 38075271 - 63
Rethinking neck-related arm pain: hypothetical clinical scenarios to differentiate the underlying IASP-defined pain mechanisms.
Hage R, Roussel N, Dierick F, et al.
The Journal of manual & manipulative therapy 2024; (32(4)):378-389 doi:10.1080/10669817.2023.2292909.
PMID: 38087995 - 64
Cauda equina syndrome.
Miller J, West J, Khawar H, Middleton R
British journal of hospital medicine (London, England : 2005) 2023; (84(11)):1-7 doi:10.12968/hmed.2023.0012.
PMID: 38186331 - 65
The Role of Physical Exercise in Chronic Musculoskeletal Pain: Best Medicine-A Narrative Review.
De la Corte-Rodriguez H, Roman-Belmonte JM, Resino-Luis C, et al.
Healthcare (Basel, Switzerland) 2024; (12(2)) doi:10.3390/healthcare12020242.
PMID: 38255129 - 66
Guideline No. 445: Management of Chronic Pelvic Pain.
Allaire C, Yong PJ, Bajzak K, et al.
Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstetrique et gynecologie du Canada : JOGC 2024; (46(1)):102283 doi:10.1016/j.jogc.2023.102283.
PMID: 38341225 - 67
Current understanding of nociplastic pain.
Yoo YM, Kim KH
The Korean journal of pain 2024; (37(2)):107-118 doi:10.3344/kjp.23326.
PMID: 38504389 - 68
Is the Central Sensitization Inventory (CSI) associated with quantitative sensory testing (QST)? A systematic review and meta-analysis.
Neblett R, Sanabria-Mazo JP, Luciano JV, et al.
Neuroscience and biobehavioral reviews 2024; (161()):105612 doi:10.1016/j.neubiorev.2024.105612.
PMID: 38604015 - 69
Neuropathic and Nociplastic Pain Profiles are Common in Adult Chronic Nonbacterial Osteitis (CNO).
Leerling AT, Niesters M, Flendrie M, et al.
Calcified tissue international 2024; (114(6)):603-613 doi:10.1007/s00223-024-01214-3.
PMID: 38627292 - 70
Deciphering nociplastic pain: clinical features, risk factors and potential mechanisms.
Kaplan CM, Kelleher E, Irani A, et al.
Nature reviews. Neurology 2024; (20(6)):347-363 doi:10.1038/s41582-024-00966-8.
PMID: 38755449 - 71
From fibrositis to fibromyalgia to nociplastic pain: how rheumatology helped get us here and where do we go from here?
Clauw DJ
Annals of the rheumatic diseases 2024; (83(11)):1421-1427 doi:10.1136/ard-2023-225327.
PMID: 39107083 - 72
Efficacy of antidepressants in the treatment of chronic nonspecific low back pain: a systematic review and meta-analysis.
Leão Nunes Filho MJ, Barreto ESR, Antunes Júnior CR, et al.
Pain management 2024; (14(8)):437-451 doi:10.1080/17581869.2024.2408215.
PMID: 39377458 - 73
Chronic Widespread Pain.
Kissoon NR
Continuum (Minneapolis, Minn.) 2024; (30(5)):1427-1446 doi:10.1212/CON.0000000000001470.
PMID: 39445928 - 74
Quantitative sensory testing and exercise-induced hypoalgesia protocols in low back pain: A scoping review.
Goodman LR, Dass R, Daniel E, et al.
The journal of pain 2025; (28()):104725 doi:10.1016/j.jpain.2024.104725.
PMID: 39532209 - 75
The concept of nociplastic pain-where to from here?
Kosek E
Pain 2024; (165(11S)):S50-S57 doi:10.1097/j.pain.0000000000003305.
PMID: 39560415 - 76
Quantitative Sensory Testing - From bench to bedside.
Hughes S, Vollert J, Freeman R, Forstenpointner J
International review of neurobiology 2024; (179()):67-90 doi:10.1016/bs.irn.2024.10.011.
PMID: 39580222 - 77
Nociplastic pain: controversy of the concept.
Macionis V
The Korean journal of pain 2025; (38(1)):4-13 doi:10.3344/kjp.24257.
PMID: 39743317 - 78
The effect of psychological manipulations on the development of secondary hyperalgesia: a critical review.
Meyers E, Della Porta D, Torta DM, van den Broeke EN
Pain reports 2025; (10(4)):e1291 doi:10.1097/PR9.0000000000001291.
PMID: 40444022 - 79
Effects of pharmacological and non-pharmacological interventions for the management of sleep problems in people with fibromyalgia: a multi-methods evidence synthesis.
Imamura M, Robertson C, Hudson J, et al.
Health technology assessment (Winchester, England) 2025; (29(20)):1-228 doi:10.3310/GTBR7561.
PMID: 40454897 - 80
CENTRAL SENSITIZATION IN PATIENTS WITH CHRONIC MUSCULOSKELETAL PAIN.
Tomašević-Todorović S, Spasojević T
Acta clinica Croatica 2023; (62(Suppl4)):102-106 doi:10.20471/acc.2023.62.s4.15.
PMID: 40463460 - 81
Pain Science Education, Stress Management, and Cognition-Targeted Exercise Therapy in Chronic Whiplash Disorders: A Randomized Clinical Trial.
Malfliet A, Lenoir D, Murillo C, et al.
JAMA network open 2025; (8(8)):e2526674 doi:10.1001/jamanetworkopen.2025.26674.
PMID: 40794407 - 82
Brain signatures of nociplastic pain: Fibromyalgia Index and descending modulation at population level.
Kelleher EM, Lange F, Wanigasekera V, et al.
Brain : a journal of neurology 2026; (149(4)):1365-1380 doi:10.1093/brain/awaf307.
PMID: 40819274 - 83
Pain Science in Practice (Part 8): Nociceptive, Neuropathic, and Nociplastic Pain.
Hoegh M, Hodges P
The Journal of orthopaedic and sports physical therapy 2025; (55(9)):555-560 doi:10.2519/jospt.2025.13335.
PMID: 40875589 - 84
Association of nociplastic pain with executive function decline in a longitudinal cohort of middle-age adults: a prospective cohort study.
Kelleher EM, Tai XY, Schrepf A, et al.
British journal of anaesthesia 2025; (135(6)):1717-1729 doi:10.1016/j.bja.2025.08.002.
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Vulvodynia: still a dramatically neglected condition. A position statement on pathogenetic mechanisms from the Italian Society of Andrology and Sexual Medicine (SIAMS).
Cangiano B, Cipriani S, Federici S, et al.
Journal of endocrinological investigation 2026; (49(2)):241-254 doi:10.1007/s40618-025-02707-0.
PMID: 41026403 - 86
Nociplastic pain: an introduction.
Roecker CB, Schut SM
The Journal of the Canadian Chiropractic Association 2025; (69(2)):131-144.
PMID: 41098639 - 87
Diagnostic Utility of Red Flags for Detecting Spinal Malignancies in Patients with Low Back Pain: A Scoping Review.
Notarangelo G, Margelli M, Giovannico G, et al.
Journal of clinical medicine 2025; (14(20)) doi:10.3390/jcm14207174.
PMID: 41156041 - 88
Nociplastic Pain: Facts, Controversies and Future Tasks.
Häuser W, Kosek E
European journal of pain (London, England) 2026; (30(1)):e70175 doi:10.1002/ejp.70175.
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[Cognitive-Behavioral therapy for patients with disability associated with chronic pain: systematic review of clinical trials]
Granizo Lara L, Carvajal Granizo V, Reyes Izurieta Á
Revista de la Facultad de Ciencias Medicas (Cordoba, Argentina) 2025; (82(4)):882-901 doi:10.31053/1853.0605.v82.n4.48710.
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Nociplastic pain: the prominent role of non-neuronal cells in central and peripheral sensitization.
Lai W, Tang X, Chen S, et al.
Frontiers in immunology 2026; (17()):1677310 doi:10.3389/fimmu.2026.1677310.
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Evidence-Based Self-Management Strategies for Fibromyalgia: Foundations for Digital Therapeutic Applications.
Lebeau Foustoukos T, Leclercq I, Blanchard M, Hügle T
Interactive journal of medical research 2026; (15()):e67523 doi:10.2196/67523.
PMID: 41701966 - 92
A Self-Reported Electronic Body Map Identifies Distinct Clinical Pain Phenotypes in Chronic Pancreatitis.
Machicado JD, Guevara-Lazo D, Troost JP, et al.
Clinical and translational gastroenterology 2026; (17(5)):e00998 doi:10.14309/ctg.0000000000000998.
PMID: 41718453 - 93
Nociplastic Pain and Central Sensitization in Hip and Knee Arthroplasty: A Practical Primer for Arthroplasty Surgeons.
Carender CN, Kheir MM, Dailey EA, Clauw DJ
Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews 2026; (10(3)) doi:e25.00471.
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