Research & Literature

Prolonged release melatonin for improving sleep in totally blind subjects: a pilot placebo-controlled multicenter trial.

Roth T, Nir T, Zisapel N

Nature and science of sleep 2015; (7()):13-23 doi:10.2147/NSS.S71838.

Clinical assessment of drug-drug interactions of tasimelteon, a novel dual melatonin receptor agonist.

Ogilvie BW, Torres R, Dressman MA, et al.

Journal of clinical pharmacology 2015; (55(9)):1004-11 doi:10.1002/jcph.507.

Caffeine does not entrain the circadian clock but improves daytime alertness in blind patients with non-24-hour rhythms.

St Hilaire MA, Lockley SW

Sleep medicine 2015; (16(6)):800-4.

Safety profile of tasimelteon, a melatonin MT1 and MT2 receptor agonist: pooled safety analyses from six clinical studies.

Leger D, Quera-Salva MA, Vecchierini MF, et al.

Expert opinion on drug safety 2015; (14(11)):1673-85 doi:10.1517/14740338.2015.1093112.

Clinical Practice Guideline for the Treatment of Intrinsic Circadian Rhythm Sleep-Wake Disorders: Advanced Sleep-Wake Phase Disorder (ASWPD), Delayed Sleep-Wake Phase Disorder (DSWPD), Non-24-Hour Sleep-Wake Rhythm Disorder (N24SWD), and Irregular Sleep-Wake Rhythm Disorder (ISWRD). An Update for 2015: An American Academy of Sleep Medicine Clinical Practice Guideline.

Auger RR, Burgess HJ, Emens JS, et al.

Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine 2015; (11(10)):1199-236 doi:10.5664/jcsm.5100.

Tasimelteon for non-24-hour sleep-wake disorder in totally blind people (SET and RESET): two multicentre, randomised, double-masked, placebo-controlled phase 3 trials.

Lockley SW, Dressman MA, Licamele L, et al.

Lancet (London, England) 2015; (386(10005)):1754-64.

Non-24-Hour Sleep-Wake Rhythm Disorder in Sighted and Blind Patients.

Uchiyama M, Lockley SW

Sleep medicine clinics 2015; (10(4)):495-516.

Architecture of retinal projections to the central circadian pacemaker.

Fernandez DC, Chang YT, Hattar S, Chen SK

Proceedings of the National Academy of Sciences of the United States of America 2016; (113(21)):6047-52 doi:10.1073/pnas.1523629113.

Circadian Melatonin and Temperature Taus in Delayed Sleep-wake Phase Disorder and Non-24-hour Sleep-wake Rhythm Disorder Patients: An Ultradian Constant Routine Study.

Micic G, Lovato N, Gradisar M, et al.

Journal of biological rhythms 2016; (31(4)):387-405 doi:10.1177/0748730416650069.

Estimating the dim light melatonin onset of adolescents within a 6-h sampling window: the impact of sampling rate and threshold method.

Crowley SJ, Suh C, Molina TA, et al.

Sleep medicine 2016; (20()):59-66.

Prevalence of Circadian Rhythm Sleep-Wake Disorders and Associated Factors in Euthymic Patients with Bipolar Disorder.

Takaesu Y, Inoue Y, Murakoshi A, et al.

PloS one 2016; (11(7)):e0159578 doi:10.1371/journal.pone.0159578.

Diagnosis and Treatment of Non-24-h Sleep-Wake Disorder in the Blind.

Emens JS, Eastman CI

Drugs 2017; (77(6)):637-650 doi:10.1007/s40265-017-0707-3.

Daily Light Exposure Patterns Reveal Phase and Period of the Human Circadian Clock.

Woelders T, Beersma DGM, Gordijn MCM, et al.

Journal of biological rhythms 2017; (32(3)):274-286 doi:10.1177/0748730417696787.

Effect of aripiprazole on non-24-hour sleep-wake rhythm disorder comorbid with major depressive disorder: a case report.

Matsui K, Takaesu Y, Inoue T, et al.

Neuropsychiatric disease and treatment 2017; (13()):1367-1371 doi:10.2147/NDT.S136628.

Non-24-Hour Sleep-Wake Rhythm Disorder in the Totally Blind: Diagnosis and Management.

Quera Salva MA, Hartley S, Léger D, Dauvilliers YA

Frontiers in neurology 2017; (8()):686 doi:10.3389/fneur.2017.00686.

Circadian Rhythm Sleep-Wake Disorders in Older Adults.

Kim JH, Duffy JF

Sleep medicine clinics 2018; (13(1)):39-50 doi:10.1016/j.jsmc.2017.09.004.

Delayed sleep-wake phase disorder.

Nesbitt AD

Journal of thoracic disease 2018; (10(Suppl 1)):S103-S111 doi:10.21037/jtd.2018.01.11.

Diagnostic and Treatment Challenges of Sighted Non-24-Hour Sleep-Wake Disorder.

Malkani RG, Abbott SM, Reid KJ, Zee PC

Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine 2018; (14(4)):603-613 doi:10.5664/jcsm.7054.

Use of Actigraphy for the Evaluation of Sleep Disorders and Circadian Rhythm Sleep-Wake Disorders: An American Academy of Sleep Medicine Clinical Practice Guideline.

Smith MT, McCrae CS, Cheung J, et al.

Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine 2018; (14(7)):1231-1237 doi:10.5664/jcsm.7230.

Circadian Rhythm Disturbances in the Blind.

Hartley S, Dauvilliers Y, Quera-Salva MA

Current neurology and neuroscience reports 2018; (18(10)):65 doi:10.1007/s11910-018-0876-9.

[Diagnosis and comorbidities of Circadian Rhythm Sleep Disorders].

Ruppert E, Kilic-Huck U,

Presse medicale (Paris, France : 1983) 2018; (47(11-12 Pt 1)):969-976 doi:10.1016/j.lpm.2018.10.016.

[Treating circadian sleep-wake disorders by light].

Leger D, Duforez F, Gronfier C,

Presse medicale (Paris, France : 1983) 2018; (47(11-12 Pt 1)):1003-1009 doi:10.1016/j.lpm.2018.10.013.

Tasimelteon for treating non-24-h sleep-wake rhythm disorder.

Nishimon S, Nishimon M, Nishino S

Expert opinion on pharmacotherapy 2019; (20(9)):1065-1073 doi:10.1080/14656566.2019.1603293.

Refractory Insomnia in an Adolescent with Total Blindness.

Tubbs AS, Grandner MA, Combs D

The Yale journal of biology and medicine 2019; (92(2)):201-204.

Non-24-hour Sleep-Wake Rhythm Disorder.

Abbott SM

Neurologic clinics 2019; (37(3)):545-552 doi:10.1016/j.ncl.2019.03.002.

Clinical neurophysiology of circadian rhythm sleep-wake disorders.

Saeed Y, Zee PC, Abbott SM

Handbook of clinical neurology 2019; (161()):369-380 doi:10.1016/B978-0-444-64142-7.00061-8.

No evidence for an S cone contribution to acute neuroendocrine and alerting responses to light.

Spitschan M, Lazar R, Yetik E, Cajochen C

Current biology : CB 2019; (29(24)):R1297-R1298 doi:10.1016/j.cub.2019.11.031.

Advances in the pharmacological management of non-24-h sleep-wake disorder.

Nishimon S, Nishino N, Nishino S

Expert opinion on pharmacotherapy 2021; (22(8)):1039-1049 doi:10.1080/14656566.2021.1876665.

Sleep deprivation therapy to reset the circadian pacemaker in a non-24-hour sleep-wake disorder: a case report.

Guichard K, Micoulaud-Franchi JA, Philip P, Taillard J

Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine 2021; (17(7)):1503-1506 doi:10.5664/jcsm.9294.

Comparative Neurology of Circadian Photoreception: The Retinohypothalamic Tract (RHT) in Sighted and Naturally Blind Mammals.

Hannibal J

Frontiers in neuroscience 2021; (15()):640113 doi:10.3389/fnins.2021.640113.

Behaviorally and environmentally induced non-24-hour sleep-wake rhythm disorder in sighted patients.

Emens JS, St Hilaire MA, Klerman EB, et al.

Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine 2022; (18(2)):453-459 doi:10.5664/jcsm.9612.

Restoring the Molecular Clockwork within the Suprachiasmatic Hypothalamus of an Otherwise Clockless Mouse Enables Circadian Phasing and Stabilization of Sleep-Wake Cycles and Reverses Memory Deficits.

Maywood ES, Chesham JE, Winsky-Sommerer R, Hastings MH

The Journal of neuroscience : the official journal of the Society for Neuroscience 2021; (41(41)):8562-8576 doi:10.1523/JNEUROSCI.3141-20.2021.

Beyond the limits of circadian entrainment: Non-24-h sleep-wake disorder, shift work, and social jet lag.

Diekman CO, Bose A

Journal of theoretical biology 2022; (545()):111148 doi:10.1016/j.jtbi.2022.111148.

Desynchronizing the sleep---wake cycle from circadian timing to assess their separate contributions to physiology and behaviour and to estimate intrinsic circadian period.

Wang W, Yuan RK, Mitchell JF, et al.

Nature protocols 2023; (18(2)):579-603 doi:10.1038/s41596-022-00746-y.

Continuous positive airway pressure as an accurate marker for non-24-hour sleep-wake rhythm disorder.

Bazin B, Geoffroy PA, Benzaquen H, et al.

Journal of sleep research 2023; (32(4)):e13859 doi:10.1111/jsr.13859.

Objective Diagnosis of Circadian Rhythm Disorders.

Giordano A, Duffy J, Epstein LJ, Pavlova MK

Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society 2023; (40(3)):230-235 doi:10.1097/WNP.0000000000000951.

Neuroprotective effects of melatonin in neurodegenerative and autoimmune central nervous system diseases.

Shin JW

Encephalitis (Seoul, Korea) 2023; (3(2)):44-53 doi:10.47936/encephalitis.2022.00094.

Case report: Diagnosis and intervention of a non-24-h sleep-wake disorder in a sighted child with a psychiatric disorder.

Estivill-Domènech C, Rodriguez-Morilla B, Estivill E, Madrid JA

Frontiers in psychiatry 2023; (14()):1129153 doi:10.3389/fpsyt.2023.1129153.

Improvement in non-24-h sleep-wake rhythm disorder in a sighted individual treated with a melatonin receptor agonist.

Connolly PJ, Quigg M, Davis EM

Sleep medicine 2024; (116()):41-42 doi:10.1016/j.sleep.2023.10.041.

A Protocol to Determine Circadian Phase by At-Home Salivary Dim Light Melatonin Onset Assessment.

Murray JM, Stone JE, Abbott SM, et al.

Journal of pineal research 2024; (76(5)):e12994 doi:10.1111/jpi.12994.

Locus coeruleus microstructural integrity is associated with vigilance vulnerability to sleep deprivation.

Quan P, Mao T, Zhang X, et al.

Human brain mapping 2024; (45(13)):e70013 doi:10.1002/hbm.70013.

Clinical significance criteria in the ICSD and DSM sleep disorder classifications: a content overlap analysis using the Jaccard index.

Gauld C, Martin VP, Quilès C, et al.

Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine 2025; (21(6)):1109-1121 doi:10.5664/jcsm.11570.

Circadian rhythm disorders in the blind.

Quera-Salva MA, Hartley S, Uscamaita K

Handbook of clinical neurology 2025; (206()):113-123 doi:10.1016/B978-0-323-90918-1.00007-1.

Irregular sleep-wake rhythm disorder: From the pathophysiologic perspective to the treatment.

Videnovic A, Cai A

Handbook of clinical neurology 2025; (206()):71-87 doi:10.1016/B978-0-323-90918-1.00006-X.

Retinal light perception and biological rhythms: The role of light in sleep and mood from an ophthalmic perspective (Review).

Yuan M, Liu H, Zhu R, et al.

Molecular medicine reports 2026; (33(1)).

Non-24-Hour Sleep-Wake Disorder in Children and Adolescents: A Case Series.

Chen RY, Grewal G, Lee J, Xiao L

Behavioral sleep medicine 2026; 1-11 doi:10.1080/15402002.2026.2678880.

Practical tips for paediatricians: implementing cognitive behavioural therapy for adolescent insomnia.

Youssef T, Valji R

Paediatrics & child health 2026; (31(5)):447-450 doi:10.1093/pch/pxag029.

Multimodal circadian phenotyping reveals distinct mechanisms of photic entrainment failure in two sighted patients with non-24-hour sleep-wake disorder.

Kilic Huck Ü, Vasseur F, Braun Hughes S, et al.

Sleep medicine 2026; (148()):109204 doi:10.1016/j.sleep.2026.109204.