Research & Literature
Explore the leading researchers and institutions driving advances in this area, and dive into the full body of literature that informs this resource.
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National and Kapodistrian University of Athens
Athens, Greece
Chinese Academy of Medical Sciences & Peking Union Medical College
Beijing, China
Yeditepe University
Istanbul, Türkiye
Erciyes University
Kayseri, Türkiye
Jichi Medical University
Shimotsuke, Japan
Post Graduate Institute of Medical Education and Research
Chandigarh, India
Inserm
Paris, France
Johns Hopkins University
Baltimore, United States
Università Cattolica del Sacro Cuore
Milan, Italy
University of California, San Francisco
San Francisco, United States
References
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[Autoimmune hypophysitis associated with new anti-cancer immunotherapies].
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Utility of serum IGF-1 for diagnosis of growth hormone deficiency following traumatic brain injury and sport-related concussion.
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BMC endocrine disorders 2018; (18(1)):20 doi:10.1186/s12902-018-0247-1.
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Idiopathic granulomatous hypophysitis: A report of an uncommon disorder.
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Nivolumab Induced Adrenal Insufficiency: Rare Side-effect of a New Anti-cancer Therapy - Immune-checkpoint Inhibitors.
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A Case Series of Patients with Isolated IgG4-related Hypophysitis Treated with Rituximab.
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A Remarkable Response of Granulomatous Hypophysitis to Infliximab in a Patient With a Background of Crohn's Disease-A Case Report.
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A Novel Etiology of Hypophysitis: Immune Checkpoint Inhibitors.
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MRI Findings of Immune Checkpoint Inhibitor-Induced Hypophysitis: Possible Association with Fibrosis.
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Surgical treatment of a 72-year-old patient with headache, hyponatremia and oculomotor nerve palsy: a case report and literature review.
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Early Pulse Glucocorticoid Therapy and Improved Hormonal Outcomes in Primary Hypophysitis.
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Neuroendocrinology 2022; (112(2)):186-195 doi:10.1159/000516006.
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Th17 Cells Contribute to the Pathology of Autoimmune Hypophysitis.
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Hypophysitis from immune checkpoint inhibitors: challenges in diagnosis and management.
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Adrenal crisis and mortality rate in adrenal insufficiency and congenital adrenal hyperplasia.
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Archives of endocrinology and metabolism 2021; (65(4)):488-494.
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Hypophysitis, the Growing Spectrum of a Rare Pituitary Disease.
Langlois F, Varlamov EV, Fleseriu M
The Journal of clinical endocrinology and metabolism 2022; (107(1)):10-28 doi:10.1210/clinem/dgab672.
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Outcomes of Initial Management Strategies in Patients With Autoimmune Lymphocytic Hypophysitis: A Systematic Review and Meta-analysis.
Donegan D, Saeed Z, Delivanis DA, et al.
The Journal of clinical endocrinology and metabolism 2022; (107(4)):1170-1190 doi:10.1210/clinem/dgab839.
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[Emergency card, emergency medication, and information leaflet for the prevention and treatment of adrenal crisis (Addison crisis): an Austrian consensus document].
Pilz S, Krebs M, Bonfig W, et al.
Journal fur klinische Endokrinologie und Stoffwechsel 2022; (15(1)):5-27 doi:10.1007/s41969-022-00155-2.
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[Pituitary immune-related adverse events induced by programmed cell death protein 1 inhibitors in advanced lung cancer patients: A report of 3 cases].
Gu YC, Liu Y, Xie C, Cao BS
Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences 2022; (54(2)):369-375.
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Differential diagnosis of pituitary enlargement.
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Vnitrni lekarstvi 2022; (68(1)):58-63.
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Clinical Usefulness of the Growth Hormone-Releasing Peptide-2 Test for Hypothalamic-Pituitary Disorder.
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Journal of the Endocrine Society 2022; (6(8)):bvac088 doi:10.1210/jendso/bvac088.
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Isolated ACTH deficiency following immunization with the BNT162b2 SARS-CoV-2 vaccine: a case report.
Morita S, Tsuji T, Kishimoto S, et al.
BMC endocrine disorders 2022; (22(1)):185 doi:10.1186/s12902-022-01095-3.
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Delayed Vasospasm in Endoscopic Transsphenoidal Pituitary Surgery: Two Case Reports and Reviews.
S Birua GJ, Tyagi G, Beniwal M, et al.
Neurology India 2022; (70(3)):996-1003 doi:10.4103/0028-3886.349613.
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Diagnosis and Management of Adrenal Insufficiency and Adrenal Crisis in the Emergency Department.
Lentz S, Collier KC, Willis G, Long B
The Journal of emergency medicine 2022; (63(2)):212-220 doi:10.1016/j.jemermed.2022.06.005.
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Isolated adrenocorticotropic hormone deficiency associated with sintilimab therapy in a patient with advanced lung adenocarcinoma: a case report and literature review.
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BMC endocrine disorders 2022; (22(1)):239 doi:10.1186/s12902-022-01151-y.
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Approach to the Patient: A Case With an Unusual Cause of Hypopituitarism.
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The Journal of clinical endocrinology and metabolism 2023; (108(6)):1488-1504 doi:10.1210/clinem/dgac747.
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Spectrum of Clinical Presentations, Imaging Findings, and HLA Types in Immune Checkpoint Inhibitor-Induced Hypophysitis.
Quandt Z, Kim S, Villanueva-Meyer J, et al.
Journal of the Endocrine Society 2023; (7(4)):bvad012 doi:10.1210/jendso/bvad012.
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Diagnostic criteria and proposed management of immune-related endocrinopathies following immune checkpoint inhibitor therapy for cancer.
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Endocrine connections 2023; (12(5)).
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Executive summary of the consensus document on hypophysitis of the Neuroendocrinology Area of Knowledge of the Spanish Society of Endocrinology and Nutrition.
Iglesias P, Biagetti B, Guerrero-Pérez F, et al.
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Diagnosis and management of adrenal insufficiency.
Lewis A, Thant AA, Aslam A, et al.
Clinical medicine (London, England) 2023; (23(2)):115-118 doi:10.7861/clinmed.2023-0067.
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Pituitary and adrenal disorders induced by immune checkpoint inhibitors.
Albarel F, Brue T, Castinetti F
Annales d'endocrinologie 2023; (84(3)):339-345 doi:10.1016/j.ando.2023.03.014.
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Neuroimaging of hypophysitis: etiologies and imaging mimics.
Kurokawa R, Kurokawa M, Baba A, et al.
Japanese journal of radiology 2023; (41(9)):911-927 doi:10.1007/s11604-023-01417-y.
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A rare case of isolated IgG4-related hypophysitis with Rathke's cleft cyst presenting as panhypopituitarism.
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Endocrinology, diabetes & metabolism case reports 2023; (2023(2)).
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Characteristics of inflammatory and infectious diseases of the pituitary gland in patients undergoing transsphenoidal surgery.
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Pituitary 2023; (26(4)):451-460 doi:10.1007/s11102-023-01333-4.
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Clinical presentation and magnetic resonance imaging characteristics of lymphocytic hypophysitis: a systematic review with meta-analysis.
Ju JS, Cui T, Zhao J, et al.
Archives of medical science : AMS 2023; (19(4)):976-986 doi:10.5114/aoms/144628.
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Iatrogenic Pituitary Shutdown: A Rare Adverse Event of Programmed Cell Death-Ligand 1 Inhibitor.
Al-Hiari M, Workman A, Ezeh E, Teka S
JCEM case reports 2024; (2(1)):luad157 doi:10.1210/jcemcr/luad157.
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Unique case of lymphocytic hypophysitis with normal pituitary hormone serology mimicking a non-functioning pituitary adenoma.
Shen K, Cadang C, Phillips D, Babu V
BMC endocrine disorders 2024; (24(1)):20 doi:10.1186/s12902-024-01546-z.
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Diagnosis and management of secondary adrenal crisis.
Martel-Duguech L, Poirier J, Bourdeau I, Lacroix A
Reviews in endocrine & metabolic disorders 2024; (25(3)):619-637 doi:10.1007/s11154-024-09877-x.
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Effects of glucocorticoid replacement therapy in patients with pituitary disease: A new perspective for personalized replacement therapy.
Chiloiro S, Vicari A, Mongelli G, et al.
Reviews in endocrine & metabolic disorders 2024; (25(5)):855-873 doi:10.1007/s11154-024-09898-6.
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Evaluation and follow-up of patients diagnosed with hypophysitis: a cohort study.
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European journal of endocrinology 2024; (191(3)):312-322 doi:10.1093/ejendo/lvae101.
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Deciphering the Presentation and Etiologies of Hypophysitis Highlights the Need for Repeated Systematical Investigation.
Miquel L, Testud B, Albarel F, et al.
The Journal of clinical endocrinology and metabolism 2025; (110(6)):e1767-e1775 doi:10.1210/clinem/dgae664.
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18 F-FDG PET/CT for Detection of Immunotherapy-Induced Hypophysitis-A Case-Control Study.
Fischer A, Martínez-Gómez JM, Mangana J, et al.
Clinical nuclear medicine 2024; (49(12)):e656-e663 doi:10.1097/RLU.0000000000005440.
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Immune checkpoint inhibitor induced hypophysitis: a specific disease of corticotrophs?
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Endocrine connections 2024; (13(11)).
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Treatment and Prevention of Adrenal Crisis and Family Education
Çamtosun E, Sangün Ö
Journal of clinical research in pediatric endocrinology 2025; (17(Suppl 1)):80-92 doi:10.4274/jcrpe.galenos.2024.2024-6-12-S.
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Clinical features of Rathke's cleft cyst with secondary hypophysitis and outcomes of endoscopic transnasal surgery versus features of common Rathke's cleft cysts: a single-center retrospective cohort study.
Ehara T, Fukuhara N, Ito S, et al.
Journal of neurosurgery 2025; (143(2)):423-430 doi:10.3171/2025.1.JNS24892.
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Lymphocytic Hypophysitis Presenting as Acute-onset Arginine Vasopressin Deficiency and Pituitary Stalk Thickening: A Case Report.
Yang LZ, Velaiutham S
Journal of the ASEAN Federation of Endocrine Societies 2025; (40(1)):121-125 doi:10.15605/jafes.040.01.08.
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Risk of Pituitary Immune-Related Adverse Events Caused by Immune Checkpoint Inhibitors: A Systematic Review and Meta-Analysis.
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Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists 2025; (31(9)):1177-1184 doi:10.1016/j.eprac.2025.06.008.
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Rare secondary pituitary abscess arising in a craniopharyngioma: A case report and literature review.
Fan R, Zhao R, Zhong Y, Wan W
Experimental and therapeutic medicine 2025; (30(2)):158 doi:10.3892/etm.2025.12908.
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Adrenal Insufficiency: A Case Study.
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Advanced emergency nursing journal 2025; (47(3)):186-192 doi:10.1097/TME.0000000000000575.
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Retrospective analysis of clinical characteristics and treatment of patients with immune checkpoint inhibitors-induced adrenal insufficiency.
Huang X, Zhang L, Zhang C, et al.
Frontiers in oncology 2025; (15()):1614223 doi:10.3389/fonc.2025.1614223.
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Normal adrenocorticotropic hormone levels do not exclude adrenal insufficiency during immune checkpoint inhibitor therapy: evidence from clinical, steroid, and structural analyses.
Ishibashi Y, Baba R, Okada A, et al.
Frontiers in endocrinology 2025; (16()):1683546 doi:10.3389/fendo.2025.1683546.
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Magnetic resonance imaging features of hypophysitis in patients with cancer treated with immune checkpoint inhibitors.
Angelousi A, Asimakopoulou S, Bourgioti C, et al.
Journal of neuroendocrinology 2026; (38(1)):e70116 doi:10.1111/jne.70116.
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Progression From Isolated Posterior Pituitary Dysfunction to Combined Anterior Hormone Deficiencies With Pituitary Stalk Enlargement in Suspected Lymphocytic Hypophysitis: A Case Report.
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Cureus 2025; (17(12)):e98595 doi:10.7759/cureus.98595.
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Immune Checkpoint Inhibitor-Related Hypophysitis and Pituitary Dysfunction: A Systematic Review of Diagnosis and Management.
SirDeshpande P, Hegde SBS, Akhtar H
Cureus 2025; (17(12)):e98717 doi:10.7759/cureus.98717.
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Lymphocytic panhypophysitis with clival extension and positive anti-rabphilin-3A antibodies: illustrative case.
Kato T, Ochiai H, Hasegawa M, et al.
Journal of neurosurgery. Case lessons 2025; (10(24)).
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The Diagnostic Challenge of Hypophysitis vs. Non-Functioning Pituitary Macroadenomas: An Updated Review and Comparative Analysis of Distinguishing Criteria.
Ach T, Bouzaouech I, Gasmi A, et al.
Diagnostics (Basel, Switzerland) 2026; (16(2)) doi:10.3390/diagnostics16020328.
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Clinical characteristics and management of PD-1/PD-L1 inhibitor-induced secondary adrenal insufficiency.
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