Research & Literature

When indomethacin fails: additional treatment options for "indomethacin responsive headaches".

Zhu S, McGeeney B

Current pain and headache reports 2015; (19(3)):7 doi:10.1007/s11916-015-0475-2.

Indomethacin Responsive Headaches: Exhaustive Systematic Review with Pooled Analysis and Critical Appraisal of 81 Published Clinical Studies.

Bordini EC, Bordini CA, Woldeamanuel YW, Rapoport AM

Headache 2016; (56(2)):422-35 doi:10.1111/head.12771.

Trigeminal Autonomic Cephalalgias in Children and Adolescents: Cluster Headache and Related Conditions.

Mack KJ, Goadsby P

Seminars in pediatric neurology 2016; (23(1)):23-6.

Systematic review with network meta-analysis: comparative effectiveness and safety of strategies for preventing NSAID-associated gastrointestinal toxicity.

Yuan JQ, Tsoi KK, Yang M, et al.

Alimentary pharmacology & therapeutics 2016; (43(12)):1262-75 doi:10.1111/apt.13642.

Chronic paroxysmal headache secondary to an orbital metastatic leiomyosarcoma: A case report.

Choi HA, Lee MJ, Chung CS

Cephalalgia : an international journal of headache 2018; (38(2)):389-392 doi:10.1177/0333102416687538.

"Cough Hemicrania" - An Overlapping Form of Headache: Case Reports.

Pavão Martins I, Viana P

Headache 2017; (57(5)):796-800 doi:10.1111/head.13094.

Hemicrania continua: clinical review, diagnosis and management.

Prakash S, Patel P

Journal of pain research 2017; (10()):1493-1509 doi:10.2147/JPR.S128472.

Therapeutical approaches to paroxysmal hemicrania, hemicrania continua and short lasting unilateral neuralgiform headache attacks: a critical appraisal.

Baraldi C, Pellesi L, Guerzoni S, et al.

The journal of headache and pain 2017; (18(1)):71 doi:10.1186/s10194-017-0777-3.

Occipital Nerve Stimulation for Medically Refractory Chronic Paroxysmal Hemicrania.

Miller S, Lagrata S, Watkins L, Matharu M

Headache 2017; (57(10)):1610-1613 doi:10.1111/head.13187.

Effects of gastroprotectant drugs for the prevention and treatment of peptic ulcer disease and its complications: a meta-analysis of randomised trials.

Scally B, Emberson JR, Spata E, et al.

The lancet. Gastroenterology & hepatology 2018; (3(4)):231-241 doi:10.1016/S2468-1253(18)30037-2.

Paroxysmal Hemicrania.

Osman C, Bahra A

Annals of Indian Academy of Neurology 2018; (21(Suppl 1)):S16-S22 doi:10.4103/aian.AIAN_317_17.

Overview of Trigeminal Autonomic Cephalalgias: Nosologic Evolution, Diagnosis, and Management.

Wei DY, Yuan Ong JJ, Goadsby PJ

Annals of Indian Academy of Neurology 2018; (21(Suppl 1)):S39-S44 doi:10.4103/aian.AIAN_348_17.

Functional Neuroimaging in Trigeminal Autonomic Cephalalgias.

Obermann M, Holle D, Nagel S

Annals of Indian Academy of Neurology 2018; (21(Suppl 1)):S51-S56 doi:10.4103/aian.AIAN_357_17.

Cluster Headache and Other Trigeminal Autonomic Cephalalgias.

Burish M

Continuum (Minneapolis, Minn.) 2018; (24(4, Headache)):1137-1156 doi:10.1212/CON.0000000000000625.

The Treatment of Trigeminal Autonomic Cephalalgias: An Overview.

Ramusino MC, Perini G, Antonaci F, Costa A

Journal of oral & facial pain and headache 2019; (33(1)):89-104 doi:10.11607/ofph.1922.

Multiple cranial nerve blocks for the transitional treatment of chronic headaches.

Miller S, Lagrata S, Matharu M

Cephalalgia : an international journal of headache 2019; (39(12)):1488-1499 doi:10.1177/0333102419848121.

Do paroxysmal hemicrania and hemicrania continua represent different headaches? A retrospective study.

Paliwal VK, Uniyal R, Aneez A, Singh LS

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology 2019; (40(11)):2371-2376 doi:10.1007/s10072-019-03980-7.

Case Report: Shortest Course of Pediatric Paroxysmal Hemicrania.

Ishii R, Fukazawa R, Takezawa H, Fujii A

Headache 2019; (59(7)):1084-1087 doi:10.1111/head.13580.

Managing cluster headache.

Wei DY, Khalil M, Goadsby PJ

Practical neurology 2019; (19(6)):521-528 doi:10.1136/practneurol-2018-002124.

Non-steroidal anti-inflammatory drug (NSAID) therapy in patients with hypertension, cardiovascular, renal or gastrointestinal comorbidities: joint APAGE/APLAR/APSDE/APSH/APSN/PoA recommendations.

Szeto CC, Sugano K, Wang JG, et al.

Gut 2020; (69(4)):617-629 doi:10.1136/gutjnl-2019-319300.

Cluster headache and TACs: state of the art.

Giani L, Proietti Cecchini A, Leone M

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology 2020; (41(Suppl 2)):367-375 doi:10.1007/s10072-020-04639-4.

Paroxysmal hemicrania masquerading as a stroke in an elderly gentleman: case report.

Tan BH, Suantio AM, Koh YH

BMC geriatrics 2020; (20(1)):392 doi:10.1186/s12877-020-01768-5.

Long-Term Outcome of Indomethacin Treatment in Pediatric Patients with Paroxysmal Hemicrania-A Case Series.

Mauritz MD, Enninger A, Wamsler C, et al.

Children (Basel, Switzerland) 2021; (8(2)) doi:10.3390/children8020101.

Lipid Formulations and Bioconjugation Strategies for Indomethacin Therapeutic Advances.

Gliszczyńska A, Nowaczyk M

Molecules (Basel, Switzerland) 2021; (26(6)) doi:10.3390/molecules26061576.

Paroxysmal Hemicrania: An Update.

Paliwal VK, Uniyal R

Neurology India 2021; (69(Supplement)):S135-S143 doi:10.4103/0028-3886.315982.

SUNCT and SUNA: An Update.

Duggal AK, Chowdhury D

Neurology India 2021; (69(Supplement)):S144-S159 doi:10.4103/0028-3886.315990.

Hemicrania continua: Indomethacin induced myoclonus.

Chan TLH, Hindiyeh N

Clinical neurology and neurosurgery 2021; (206()):106703 doi:10.1016/j.clineuro.2021.106703.

Metabolomic Studies for Metabolic Alterations Induced by Non-Steroidal Anti-Inflammatory Drugs: Mini Review.

Ghosh S

Biomolecules 2021; (11(10)) doi:10.3390/biom11101456.

Indomethacin-Induced Hypertensive Crisis.

Dhungana B, Kansakar S, Paudel P, et al.

Cureus 2021; (13(9)):e18043 doi:10.7759/cureus.18043.

[Autonomic Disorders in Trigeminal Autonomic Cephalalgias: An Update].

Kowa H

Brain and nerve = Shinkei kenkyu no shinpo 2022; (74(3)):263-270 doi:10.11477/mf.1416202022.

Etoricoxib and celecoxib sensitive indomethacin-responsive headache disorders.

Farag M, Bahra A

Headache 2022; (62(3)):383-388 doi:10.1111/head.14282.

The spectrum of indomethacin-responsive headaches in children and adolescents.

Myers KA, Barmherzig R, Raj NR, et al.

Cephalalgia : an international journal of headache 2022; (42(8)):793-797 doi:10.1177/03331024221076483.

Incidence, risk and risk factors for acute kidney injury associated with the use of intravenous indomethacin in neonatal patent ductus arteriosus: A 16-year retrospective cohort study.

Raknoo T, Janjindamai W, Sitaruno S, et al.

Pharmacy practice 2021; (19(4)):2409 doi:10.18549/PharmPract.2021.4.2409.

Paroxysmal hemicrania in children and adolescents: A systematic review.

Bemanalizadeh M, Baghaei Oskouei H, Hadizadeh A, et al.

Headache 2022; (62(8)):952-966 doi:10.1111/head.14354.

Management of Trigeminal Autonomic Cephalalgias Including Chronic Cluster: A Review.

Diener HC, Tassorelli C, Dodick DW

JAMA neurology 2023; (80(3)):308-319 doi:10.1001/jamaneurol.2022.4804.

Symptomatic trigeminal autonomic cephalalgias in neuromyelitis optica spectrum disorders.

Liu J, Xiao S, Yang F, et al.

Multiple sclerosis and related disorders 2023; (74()):104722 doi:10.1016/j.msard.2023.104722.

Use of non-steroidal anti-inflammatory drugs in renal transplant patients: A retrospective study.

Sridharan K, Shah S

The International journal of risk & safety in medicine 2023; (34(4)):379-386 doi:10.3233/JRS-220065.

Protective effects of Saccharomyces boulardii CNCM I-745 in an experimental model of NSAID-induced enteropathy.

Simon O'Brien E, Robert A, Gauthier D, et al.

Beneficial microbes 2023; (14(3)):239-253 doi:10.3920/BM2023.0003.

Efficacy of Occipital Nerve Stimulation in Trigeminal Autonomic Cephalalgias: A Systematic Review.

Veilleux C, Khousakoun D, Kwon CS, et al.

Neurosurgery 2023; (93(4)):755-763 doi:10.1227/neu.0000000000002490.

Paroxysmal hemicrania and hemicrania continua: Review on pathophysiology, clinical features and treatment.

Bahra A

Cephalalgia : an international journal of headache 2023; (43(11)):3331024231214239 doi:10.1177/03331024231214239.

Epidemiology and clinical features of paroxysmal hemicrania: A systematic review and meta-analysis.

Henningsen MJ, Larsen JG, Karlsson WK, et al.

Headache 2024; (64(1)):5-15 doi:10.1111/head.14658.

SUNCT, SUNA and short-lasting unilateral neuralgiform headache attacks: Debates and an update.

Kang MK, Cho SJ

Cephalalgia : an international journal of headache 2024; (44(2)):3331024241232256 doi:10.1177/03331024241232256.

One-year prevalence of cluster headache, hemicrania continua, paroxysmal hemicrania and SUNCT in Norway: a population-based nationwide registry study.

Hagen K

The journal of headache and pain 2024; (25(1)):30 doi:10.1186/s10194-024-01738-x.

Indomethacin-Responsive Headache Disorders.

Goadsby PJ

Continuum (Minneapolis, Minn.) 2024; (30(2)):488-497 doi:10.1212/CON.0000000000001409.

How can you manage an indomethacin-responsive headache in someone who cannot take indomethacin?

Osiowski A, Stolarz K, Taterra D

Current opinion in neurology 2025; (38(3)):254-261 doi:10.1097/WCO.0000000000001347.

Co-morbid Indomethacin-Responsive Headaches in a Woman in Her Late 60s With Paroxysmal Hemicrania and Hypnic Headache: A Case Report.

Brown A, Evans RW, Carrizo C, Burish M

Cureus 2025; (17(1)):e77243 doi:10.7759/cureus.77243.

Proton pump inhibitors for the prevention of non-steroidal anti-inflammatory drug-induced ulcers and dyspepsia.

Garegnani L, Oltra G, Burgos MA, et al.

The Cochrane database of systematic reviews 2025; (5()):CD014585 doi:10.1002/14651858.CD014585.pub2.

Prevalence, demographics, comorbidities, and treatment patterns of patients with the trigeminal autonomic cephalalgias: a retrospective analysis of United States electronic health records.

Moskatel LS, Ogunlaja O, Zhang N

BMC neurology 2025; (25(1)):299 doi:10.1186/s12883-025-04314-1.

Neuromodulation in trigeminal autonomic cephalalgias: 11-year experience of non-invasive vagus nerve stimulation.

Fernandes CS, Ashraf U, Goadsby PJ

Cephalalgia : an international journal of headache 2025; (45(9)):3331024251370339 doi:10.1177/03331024251370339.

Paroxysmal hemicrania: A diagnostic challenge presenting as orofacial pain: A case series.

Al-Taee A, Botros J, Groenke BR, Nixdorf DR

Cranio : the journal of craniomandibular practice 2026; (44(4)):721-728 doi:10.1080/08869634.2025.2610489.

From paroxysmal hemicrania to SUNCT: a unique presentation of herpetic zoster ophthalmicus: a case report.

Tsai PY, Su HC, Chang YM

Frontiers in ophthalmology 2025; (5()):1628665 doi:10.3389/fopht.2025.1628665.

Menstruation-triggered paroxysmal hemicrania.

Patel S, Shah H, Prakash S

BMJ case reports 2026; (19(8)) doi:10.1136/bcr-2026-274651.