Research & Literature

MEN1, MEN4, and Carney Complex: Pathology and Molecular Genetics.

Schernthaner-Reiter MH, Trivellin G, Stratakis CA

Neuroendocrinology 2016; (103(1)):18-31 doi:10.1159/000371819.

Pasireotide in Acromegaly: An Overview of Current Mechanistic and Clinical Data.

Samson SL

Neuroendocrinology 2015; (102(1-2)):8-17 doi:10.1159/000381460.

60 YEARS OF NEUROENDOCRINOLOGY: Acromegaly.

Capatina C, Wass JA

The Journal of endocrinology 2015; (226(2)):T141-60 doi:10.1530/JOE-15-0109.

Landscape of Familial Isolated and Young-Onset Pituitary Adenomas: Prospective Diagnosis in AIP Mutation Carriers.

Hernández-Ramírez LC, Gabrovska P, Dénes J, et al.

The Journal of clinical endocrinology and metabolism 2015; (100(9)):E1242-54 doi:10.1210/jc.2015-1869.

Clinical and genetic characterization of pituitary gigantism: an international collaborative study in 208 patients.

Rostomyan L, Daly AF, Petrossians P, et al.

Endocrine-related cancer 2015; (22(5)):745-57 doi:10.1530/ERC-15-0320.

Histological criteria for atypical pituitary adenomas - data from the German pituitary adenoma registry suggests modifications.

Miermeister CP, Petersenn S, Buchfelder M, et al.

Acta neuropathologica communications 2015; (3()):50 doi:10.1186/s40478-015-0229-8.

Acromegaly.

Dineen R, Stewart PM, Sherlock M

QJM : monthly journal of the Association of Physicians 2017; (110(7)):411-420 doi:10.1093/qjmed/hcw004.

Genetic and clinical characteristics of Japanese patients with sporadic somatotropinoma.

Matsumoto R, Izawa M, Fukuoka H, et al.

Endocrine journal 2016; (63(11)):953-963 doi:10.1507/endocrj.EJ16-0075.

Cavernous Sinus Invasion in Pituitary Adenomas: Systematic Review and Pooled Data Meta-Analysis of Radiologic Criteria and Comparison of Endoscopic and Microscopic Surgery.

Dhandapani S, Singh H, Negm HM, et al.

World neurosurgery 2016; (96()):36-46 doi:10.1016/j.wneu.2016.08.088.

A pediatric case of pituitary macroadenoma presenting with pituitary apoplexy and cranial nerve involvement: case report.

Özçetin M, Karacı M, Toroslu E, Edebali N

Turk pediatri arsivi 2016; (51(3)):162-165 doi:10.5152/TurkPediatriArs.2016.1945.

Acromegaly: clinical features at diagnosis.

Vilar L, Vilar CF, Lyra R, et al.

Pituitary 2017; (20(1)):22-32 doi:10.1007/s11102-016-0772-8.

Germline variants in familial pituitary tumour syndrome genes are common in young patients and families with additional endocrine tumours.

De Sousa SMC, McCabe MJ, Wu K, et al.

European journal of endocrinology 2017; (176(5)):635-644.

Young adult patient with headache, fever and blurred vision.

Paschou SA, Tzioras K, Trianti V, et al.

Hormones (Athens, Greece) 2016; (15(4)):548-550 doi:10.14310/horm.2002.1701.

Body mass index and insulin-like growth factor 1 as risk factors for discordant growth hormone and insulin-like growth factor 1 levels following pituitary surgery in acromegaly.

Zhang S, Li Y, Guo X, et al.

Journal of the Formosan Medical Association = Taiwan yi zhi 2018; (117(1)):34-41 doi:10.1016/j.jfma.2017.02.014.

Pituitary apoplexy - A single center retrospective study from the neurosurgical perspective and review of the literature.

Grzywotz A, Kleist B, Möller LC, et al.

Clinical neurology and neurosurgery 2017; (163()):39-45 doi:10.1016/j.clineuro.2017.10.006.

Clinical characteristics and ophthalmologic findings of pituitary adenoma in Korean patients.

Kim TG, Jin KH, Kang J

International ophthalmology 2019; (39(1)):21-31 doi:10.1007/s10792-017-0778-x.

Pediatric Pituitary Adenoma: Case Series, Review of the Literature, and a Skull Base Treatment Paradigm.

Perry A, Graffeo CS, Marcellino C, et al.

Journal of neurological surgery. Part B, Skull base 2018; (79(1)):91-114 doi:10.1055/s-0038-1625984.

Dermatologic manifestations of acromegaly: A case in point and a focused review.

Degirmentepe EN, Gungor S, Kocaturk E, et al.

Dermatology online journal 2017; (23(8)).

Interaction of AIP with protein kinase A (cAMP-dependent protein kinase).

Schernthaner-Reiter MH, Trivellin G, Stratakis CA

Human molecular genetics 2018; (27(15)):2604-2613 doi:10.1093/hmg/ddy166.

Emergence of Pituitary Adenoma in a Child during Surveillance: Clinical Challenges and the Family Members' View in an AIP Mutation-Positive Family.

Marques P, Barry S, Ronaldson A, et al.

International journal of endocrinology 2018; (2018()):8581626 doi:10.1155/2018/8581626.

Resistant Paediatric Somatotropinomas due to AIP Mutations: Role of Pegvisomant.

Joshi K, Daly AF, Beckers A, Zacharin M

Hormone research in paediatrics 2018; (90(3)):196-202 doi:10.1159/000488856.

Germline and mosaic mutations causing pituitary tumours: genetic and molecular aspects.

Pepe S, Korbonits M, Iacovazzo D

The Journal of endocrinology 2019; (240(2)):R21-R45.

The efficacy of microperimetry and contrast sensitivity test in the diagnosis of optic chiasm compression due to pituitary adenomas.

Sarnat-Kucharczyk M, Kos-Kudła B, Kajdaniuk D, Mrukwa-Kominek E

Endokrynologia Polska 2019; (70(3)):241-247 doi:10.5603/EP.a2019.0003.

AIP and MEN1 mutations and AIP immunohistochemistry in pituitary adenomas in a tertiary referral center.

Daly AF, Cano DA, Venegas-Moreno E, et al.

Endocrine connections 2019; (8(4)):338-348.

AIP-mutated acromegaly resistant to first-generation somatostatin analogs: long-term control with pasireotide LAR in two patients.

Daly AF, Rostomyan L, Betea D, et al.

Endocrine connections 2019; (8(4)):367-377.

Surgery, Octreotide, Temozolomide, Bevacizumab, Radiotherapy, and Pegvisomant Treatment of an AIP Mutation‒Positive Child.

Dutta P, Reddy KS, Rai A, et al.

The Journal of clinical endocrinology and metabolism 2019; (104(8)):3539-3544 doi:10.1210/jc.2019-00432.

Modern imaging of pituitary adenomas.

Bashari WA, Senanayake R, Fernández-Pombo A, et al.

Best practice & research. Clinical endocrinology & metabolism 2019; (33(2)):101278 doi:10.1016/j.beem.2019.05.002.

Pituitary gigantism: a case series from Hospital de San José (Bogotá, Colombia).

García WR, Cortes HT, Romero AF

Archives of endocrinology and metabolism 2019; (63(4)):385-393 doi:10.20945/2359-3997000000150.

Current perspectives on recurrent pituitary adenoma: The role and timing of surgery vs adjuvant treatment.

Hayhurst C, Taylor PN, Lansdown AJ, et al.

Clinical endocrinology 2020; (92(2)):89-97 doi:10.1111/cen.14127.

Clinical Relevance of Genetic Analysis in Patients With Pituitary Adenomas: A Systematic Review.

van den Broek MFM, van Nesselrooij BPM, Verrijn Stuart AA, et al.

Frontiers in endocrinology 2019; (10()):837 doi:10.3389/fendo.2019.00837.

Significant Benefits of AIP Testing and Clinical Screening in Familial Isolated and Young-onset Pituitary Tumors.

Marques P, Caimari F, Hernández-Ramírez LC, et al.

The Journal of clinical endocrinology and metabolism 2020; (105(6)) doi:10.1210/clinem/dgaa040.

HEREDITARY ENDOCRINE TUMOURS: CURRENT STATE-OF-THE-ART AND RESEARCH OPPORTUNITIES: The roles of AIP and GPR101 in familial isolated pituitary adenomas (FIPA).

Vasilev V, Daly AF, Trivellin G, et al.

Endocrine-related cancer 2020; (27(8)):T77-T86.

Pituitary adenomas in the setting of multiple endocrine neoplasia type 1: a single-institution experience.

Cohen-Cohen S, Brown DA, Himes BT, et al.

Journal of neurosurgery 2021; (134(3)):1132-1138.

Phenotypic and genotypic features of a large kindred with a germline AIP variant.

Dal J, Nielsen EH, Klose M, et al.

Clinical endocrinology 2020; (93(2)):146-153 doi:10.1111/cen.14207.

Pituitary adenoma presenting as acute onset isolated complete third cranial nerve palsy without vision changes.

Natarajan D, Tatineni S, Ponnapalli SP, Sachdeva V

BMJ case reports 2020; (13(6)) doi:10.1136/bcr-2019-232490.

Pituitary Disease in AIP Mutation-Positive Familial Isolated Pituitary Adenoma (FIPA): A Kindred-Based Overview.

Bilbao Garay I, Daly AF, Egaña Zunzunegi N, Beckers A

Journal of clinical medicine 2020; (9(6)) doi:10.3390/jcm9062003.

Germinal defects of SDHx genes in patients with isolated pituitary adenoma.

Mougel G, Lagarde A, Albarel F, et al.

European journal of endocrinology 2020; (183(4)):369-379.

miR-34a is upregulated in AIP-mutated somatotropinomas and promotes octreotide resistance.

Bogner EM, Daly AF, Gulde S, et al.

International journal of cancer 2020; (147(12)):3523-3538 doi:10.1002/ijc.33268.

AIP variant causing familial prolactinoma.

Carty DM, Harte R, Drummond RS, et al.

Pituitary 2021; (24(1)):48-52 doi:10.1007/s11102-020-01085-5.

Thin-Slice Pituitary MRI with Deep Learning-based Reconstruction: Diagnostic Performance in a Postoperative Setting.

Kim M, Kim HS, Kim HJ, et al.

Radiology 2021; (298(1)):114-122 doi:10.1148/radiol.2020200723.

Outcomes of pituitary apoplexy: a comparison of microadenomas and macroadenomas.

Nakhleh A, Assaliya Naffa M, Sviri G, et al.

Pituitary 2021; (24(4)):492-498 doi:10.1007/s11102-020-01124-1.

Aggressive Pituitary Adenoma Not Fulfilling the New High-Risk Criteria with Progression after 18-Year Stable Clinical Course: Case Report.

Kawaguchi T, Ogawa Y, Watanabe M, Tominaga T

Journal of neurological surgery. Part A, Central European neurosurgery 2022; (83(4)):391-395 doi:10.1055/s-0040-1722195.

Clinical Implications of the New WHO Classification 2017 for Pituitary Tumors.

Saeger W, Koch A

Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association 2021; (129(3)):146-156 doi:10.1055/a-1310-7900.

Development and Evaluation of Deep Learning-based Automated Segmentation of Pituitary Adenoma in Clinical Task.

Wang H, Zhang W, Li S, et al.

The Journal of clinical endocrinology and metabolism 2021; (106(9)):2535-2546 doi:10.1210/clinem/dgab371.

An Update on Pituitary Neuroendocrine Tumors Leading to Acromegaly and Gigantism.

Asa SL, Ezzat S

Journal of clinical medicine 2021; (10(11)) doi:10.3390/jcm10112254.

Medical guidelines for Li-Fraumeni syndrome 2019, version 1.1.

Kumamoto T, Yamazaki F, Nakano Y, et al.

International journal of clinical oncology 2021; (26(12)):2161-2178 doi:10.1007/s10147-021-02011-w.

Diagnosis and Treatment of Acromegaly: An Update.

Ershadinia N, Tritos NA

Mayo Clinic proceedings 2022; (97(2)):333-346 doi:10.1016/j.mayocp.2021.11.007.

Prognostic Factors for Recurrence in Pituitary Adenomas: Recent Progress and Future Directions.

Lu L, Wan X, Xu Y, et al.

Diagnostics (Basel, Switzerland) 2022; (12(4)) doi:10.3390/diagnostics12040977.

Complicated Clinical Course in Incipient Gigantism Due to Treatment-resistant Aryl Hydrocarbon Receptor-Interacting Protein-mutated Pediatric Somatotropinoma.

van Santen SS, Daly AF, Buchfelder M, et al.

AACE clinical case reports 2022; (8(3)):119-123 doi:10.1016/j.aace.2021.12.003.

An altered state of consciousness while using anticoagulants and the incidental discovery of a pituitary lesion: considering pituitary apoplexy.

Viola N, Urbani C, Cosottini M, et al.

Endocrinology, diabetes & metabolism case reports 2022; (2022()).

Overview of the 2022 WHO Classification of Pituitary Adenomas/Pituitary Neuroendocrine Tumors: Clinical Practices, Controversies, and Perspectives.

Wan XY, Chen J, Wang JW, et al.

Current medical science 2022; (42(6)):1111-1118 doi:10.1007/s11596-022-2673-6.

Novel AIP mutation in exon 6 causing acromegaly in a German family.

Detomas M, Altieri B, Flitsch J, et al.

Journal of endocrinological investigation 2023; (46(8)):1705-1709 doi:10.1007/s40618-023-02031-5.

Quantitative proteomics identified a novel invasion biomarker associated with EMT in pituitary adenomas.

Zhang Y, Li L, Ma X, et al.

Frontiers in endocrinology 2023; (14()):1137648 doi:10.3389/fendo.2023.1137648.

Multidisciplinary management of difficult/aggressive growth-hormone pituitary neuro-endocrine tumors.

Bianchi A, Chiloiro S, Giampietro A, et al.

Frontiers in endocrinology 2023; (14()):1123267 doi:10.3389/fendo.2023.1123267.

Pituitary Adenoma With Apoplexy Presenting As Unilateral Third Nerve Palsy.

Waqar F, Arif A, Muazzam A, Khan A

Cureus 2023; (15(6)):e40555 doi:10.7759/cureus.40555.

The clinical and therapeutic profiles of prolactinomas associated with germline pathogenic variants in the aryl hydrocarbon receptor interacting protein (AIP) gene.

Vroonen L, Beckers A, Camby S, et al.

Frontiers in endocrinology 2023; (14()):1242588 doi:10.3389/fendo.2023.1242588.

Cancer worry at higher-risk sample of hereditary cancer in Spain.

Costa-Requena G, Richart-Aznar P, Segura-Huerta Á

European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) 2024; (33(4)):293-298 doi:10.1097/CEJ.0000000000000862.

Case report: Complete restoration of the HPA axis function in Cushing's disease with drug treatment.

Nguyen JT, Ferrière A, Tabarin A

Frontiers in endocrinology 2024; (15()):1337741 doi:10.3389/fendo.2024.1337741.

Challenges and opportunities for Lynch syndrome cascade testing in the United States.

Passero LE, Roberts MC

Familial cancer 2024; (23(2)):147-154 doi:10.1007/s10689-024-00374-3.

Pituitary gigantism due to a novel AIP germline splice-site variant.

Lamback E, Miranda RL, Chimelli L, et al.

Endocrine oncology (Bristol, England) 2024; (4(1)):e240003 doi:10.1530/EO-24-0003.

Pituitary adenomas: biology, nomenclature and clinical classification.

Ho KKY, Melmed S

Reviews in endocrine & metabolic disorders 2025; (26(2)):137-146 doi:10.1007/s11154-025-09944-x.

Reassessing the role of the p.(Arg304Gln) missense AIP variant in pituitary tumorigenesis.

Loughrey PB, Mothojakan NB, Iacovazzo D, et al.

European journal of endocrinology 2025; (192(4)):385-397 doi:10.1093/ejendo/lvaf044.

BRCA cascade counselling and testing in Italy: current position and future directions.

Costanzo S, Godino L, De Summa S, et al.

BMC cancer 2025; (25(1)):1044 doi:10.1186/s12885-025-14419-y.

Practical approach to managing pituitary gigantism.

Andrews A, Korbonits M, Dias RP

Archives of disease in childhood 2026; doi:10.1136/archdischild-2025-329283.

Living with a Hereditary Cancer Syndrome: Personal Perspectives and Implications for Oncology Nurses.

Diez de Los Rios de la Serna C, Kavanaugh S, Magalhães D, et al.

Seminars in oncology nursing 2026; (42(2)):152151 doi:10.1016/j.soncn.2026.152151.

Gigantism.

Donato S, Regala C, Marques P

Vitamins and hormones 2026; (131()):195-234 doi:10.1016/bs.vh.2025.10.005.

A novel pathogenic AIP variant associated with familial isolated pituitary adenoma.

Marino Picciola V, Crociara A, Piacentini S, et al.

Pituitary 2026; (29(3)).

The germline landscape of pituitary adenomas: established and emerging predisposition genes.

Mignone E, Sorvina A, Torpy DJ, et al.

The Journal of clinical endocrinology and metabolism 2026; (111(8)):e1926-e1936 doi:10.1210/clinem/dgag195.

Genetic testing in pituitary adenomas: a Pituitary Society International Consensus Statement.

De Sousa SMC, Andoniadou CL, Daly AF, et al.

Nature reviews. Endocrinology 2026; doi:10.1038/s41574-026-01291-4.

Uncertainty and information management for Lynch syndrome in a genomic screening cohort: Connections to clinical engagement.

Hallquist ML, Bakhsh RI, Delehoy BN, Campbell-Salome G

Patient education and counseling 2026; (153()):109838 doi:10.1016/j.pec.2026.109838.

Clinical and Genetic Spectrum of Large AIP Deletions.

Kolnikaj TS, Ruka M, Xhumari A, et al.

Human mutation 2026; (2026()):4212742 doi:10.1155/humu/4212742.