Research & Literature

Polyneuropathy improvement following autologous stem cell transplantation for POEMS syndrome.

Karam C, Klein CJ, Dispenzieri A, et al.

Neurology 2015; (84(19)):1981-7 doi:10.1212/WNL.0000000000001565.

Ventriculoperitoneal shunt placement for POEMS syndrome.

Alvarez-Breckenridge CA, Attiah MA, Zachariah M, et al.

Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 2015; (22(10)):1672-4.

Renal impairment in patients with polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy and skin changes syndrome: incidence, treatment and outcome.

Ye W, Wang C, Cai QQ, et al.

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2016; (31(2)):275-83 doi:10.1093/ndt/gfv261.

POEMS syndrome: update on diagnosis, risk-stratification, and management.

Dispenzieri A

American journal of hematology 2015; (90(10)):951-62 doi:10.1002/ajh.24171.

Vascular endothelial growth factor as a predictive marker for POEMS syndrome treatment response: retrospective cohort study.

Misawa S, Sato Y, Katayama K, et al.

BMJ open 2015; (5(11)):e009157 doi:10.1136/bmjopen-2015-009157.

Polyneuropathy, organomegaly, endocrinopathy, M-protein and skin changes (POEMS syndrome): a paraneoplastic syndrome.

Kumar S, Sharma S

Oxford medical case reports 2015; (2015(3)):237-40 doi:10.1093/omcr/omv023.

Risk factors for and outcomes of patients with POEMS syndrome who experience progression after first-line treatment.

Kourelis TV, Buadi FK, Gertz MA, et al.

Leukemia 2016; (30(5)):1079-85 doi:10.1038/leu.2015.344.

Prognostic study for overall survival in patients with newly diagnosed POEMS syndrome.

Wang C, Huang XF, Cai QQ, et al.

Leukemia 2017; (31(1)):100-106 doi:10.1038/leu.2016.168.

Diffuse large B-cell non-Hodgkin's lymphoma and osteosclerotic myeloma with features of POEMS syndrome.

Ngamdu KS, Torabi A, Badri N, et al.

Proceedings (Baylor University. Medical Center) 2016; (29(3)):306-8 doi:10.1080/08998280.2016.11929446.

Bone lesions in Chinese POEMS syndrome patients: imaging characteristics and clinical implications.

Wang F, Huang X, Zhang Y, et al.

PeerJ 2016; (4()):e2294 doi:10.7717/peerj.2294.

Remarkable expression of vascular endothelial growth factor in bone marrow plasma cells of patients with POEMS syndrome.

Wang C, Huang XF, Cai QQ, et al.

Leukemia research 2016; (50()):78-84 doi:10.1016/j.leukres.2016.09.017.

POEMS Syndrome: an Enigma.

Warsame R, Yanamandra U, Kapoor P

Current hematologic malignancy reports 2017; (12(2)):85-95 doi:10.1007/s11899-017-0367-0.

Diagnostic challenges in POEMS syndrome presenting with polyneuropathy: A case series.

Li Y, Valent J, Soltanzadeh P, et al.

Journal of the neurological sciences 2017; (378()):170-174 doi:10.1016/j.jns.2017.05.019.

POEMS syndrome: 2017 Update on diagnosis, risk stratification, and management.

Dispenzieri A

American journal of hematology 2017; (92(8)):814-829 doi:10.1002/ajh.24802.

POEMS SYNDROME: an Update.

Nozza A

Mediterranean journal of hematology and infectious diseases 2017; (9(1)):e2017051 doi:10.4084/MJHID.2017.051.

POEMS syndrome presentation with progressive weakness in upper and lower limbs: A case report.

Cao CJ, Dou CY, Zhou KH, et al.

Oncology letters 2017; (14(5)):5197-5202 doi:10.3892/ol.2017.6904.

POEMS Syndrome: Therapeutic Options.

Jaccard A

Hematology/oncology clinics of North America 2018; (32(1)):141-151 doi:10.1016/j.hoc.2017.09.011.

Efficacy and Long-Term Outcomes of Autologous Stem Cell Transplantation in POEMS Syndrome: A Nationwide Survey in Japan.

Kawajiri-Manako C, Sakaida E, Ohwada C, et al.

Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 2018; (24(6)):1180-1186 doi:10.1016/j.bbmt.2018.01.026.

POEMS neuropathy: optimising diagnosis and management.

Keddie S, D'Sa S, Foldes D, et al.

Practical neurology 2018; (18(4)):278-290 doi:10.1136/practneurol-2017-001792.

A prospective phase II study of low dose lenalidomide plus dexamethasone in patients with newly diagnosed polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes (POEMS) syndrome.

Li J, Huang XF, Cai QQ, et al.

American journal of hematology 2018; (93(6)):803-809 doi:10.1002/ajh.25100.

Atypical central retinal artery occlusion as the first presentation of POEMS syndrome: a case report.

Jindahra P, Dejthevaporn C, Niparuck P, et al.

BMC neurology 2018; (18(1)):64 doi:10.1186/s12883-018-1071-y.

Raised VEGF: High sensitivity and specificity in the diagnosis of POEMS syndrome.

Pihan M, Keddie S, D'Sa S, et al.

Neurology(R) neuroimmunology & neuroinflammation 2018; (5(5)):e486 doi:10.1212/NXI.0000000000000486.

Prevalence and Course of Endocrinopathy in POEMS Syndrome.

Caimari F, Keddie S, Lunn MP, et al.

The Journal of clinical endocrinology and metabolism 2019; (104(6)):2140-2146 doi:10.1210/jc.2018-01516.

Proposal of new clinical diagnostic criteria for POEMS syndrome.

Suichi T, Misawa S, Sato Y, et al.

Journal of neurology, neurosurgery, and psychiatry 2019; (90(2)):133-137 doi:10.1136/jnnp-2018-318514.

POEMS syndrome: clinical update.

Brown R, Ginsberg L

Journal of neurology 2019; (266(1)):268-277 doi:10.1007/s00415-018-9110-6.

What is the best first-line treatment for POEMS syndrome: autologous transplantation, melphalan and dexamethasone, or lenalidomide and dexamethasone?

Zhao H, Huang XF, Gao XM, et al.

Leukemia 2019; (33(4)):1023-1029 doi:10.1038/s41375-019-0391-2.

Correlation of changes in serum level of VEGF and peripapillary retinal thickness in patients with POEMS syndrome.

Yokouchi H, Baba T, Misawa S, et al.

The British journal of ophthalmology 2020; (104(1)):33-38 doi:10.1136/bjophthalmol-2018-313703.

POEMS Syndrome: 2019 Update on diagnosis, risk-stratification, and management.

Dispenzieri A

American journal of hematology 2019; (94(7)):812-827 doi:10.1002/ajh.25495.

Clinical and electrophysiological profiles in early recognition of polyneuropathy, organomegaly, endocrinopathy, M-protein, and skin changes syndrome.

Wang Q, Liu P, Ji LL, et al.

Chinese medical journal 2019; (132(14)):1666-1672 doi:10.1097/CM9.0000000000000318.

Prevalence, clinical profiles, and prognosis of POEMS syndrome in Japanese nationwide survey.

Suichi T, Misawa S, Beppu M, et al.

Neurology 2019; (93(10)):e975-e983 doi:10.1212/WNL.0000000000008062.

Living with Polyneuropathy Organomegaly Endocrinopathy Monoclonal gammopathy Skin changes (POEMS) syndrome: a case study of healthcare experiences and quality of life.

Twigg J, Methley A, Lavin T, et al.

Disability and rehabilitation 2021; (43(17)):2502-2510 doi:10.1080/09638288.2019.1700563.

POEMS syndrome: a rare cause of adrenal insufficiency in a young male.

Prokop J, Estorninho J, Marote S, et al.

Endocrinology, diabetes & metabolism case reports 2019; (2019()).

Thrombosis revealing POEMS syndrome. About a case.

Dumas C, Bienvenu FH, Hicks J, et al.

Annales de biologie clinique 2020; (78(2)):195-197 doi:10.1684/abc.2020.1534.

Immunoglobulin variable domain high-throughput sequencing reveals specific novel mutational patterns in POEMS syndrome.

Bender S, Javaugue V, Saintamand A, et al.

Blood 2020; (135(20)):1750-1758 doi:10.1182/blood.2019004197.

Skin and Nerve Neovascularization in POEMS Syndrome: Insights From a Small Cohort.

Guibert C, Richard L, Durand S, et al.

Journal of neuropathology and experimental neurology 2020; (79(5)):542-550 doi:10.1093/jnen/nlaa021.

High rates of venous and arterial thrombotic events in patients with POEMS syndrome: results from the UCLH (UK) POEMS Registry.

Sayar Z, Weatherill A, Keddie S, et al.

Blood advances 2020; (4(10)):2139-2142 doi:10.1182/bloodadvances.2020001492.

Clinical characteristics, risk factors, and outcomes of POEMS syndrome: A longitudinal cohort study.

Keddie S, Foldes D, Caimari F, et al.

Neurology 2020; (95(3)):e268-e279 doi:10.1212/WNL.0000000000009940.

Ischemic stroke in patients with POEMS syndrome.

Feng J, Gao XM, Zhao H, et al.

Blood advances 2020; (4(14)):3427-3434 doi:10.1182/bloodadvances.2020001865.

POEMS syndrome: A multisystem clonal disorder.

Ali T, Qazilbash MH

European journal of haematology 2021; (106(1)):14-18 doi:10.1111/ejh.13514.

Skin Responses in Newly Diagnosed Polyneuropathy, Organomegaly, Endocrinopathy, Monoclonal Gammopathy, and Skin Changes (POEMS) Syndrome After Therapy With Low-Dose Lenalidomide Plus Dexamethasone.

Gao Y, Zhang S, Yang L, et al.

Frontiers in immunology 2021; (12()):681360 doi:10.3389/fimmu.2021.681360.

Update on the Diagnosis and Treatment of POEMS (Polyneuropathy, Organomegaly, Endocrinopathy, Monoclonal Gammopathy, and Skin Changes) Syndrome: A Review.

Khouri J, Nakashima M, Wong S

JAMA oncology 2021; (7(9)):1383-1391 doi:10.1001/jamaoncol.2021.0586.

Effective treatment of polyneuropathy, organomegaly, endocrinopathy, M-protein, and skin changes syndrome with congestive heart failure: A case report.

Fu LY, Zhang HB

World journal of clinical cases 2021; (9(25)):7504-7511 doi:10.12998/wjcc.v9.i25.7504.

Characteristics and risk factors for thrombosis in POEMS syndrome: A retrospective evaluation of 230 patients.

Mellors PW, Kourelis T, Go RS, et al.

American journal of hematology 2022; (97(2)):209-215 doi:10.1002/ajh.26422.

Development of Polyneuropathy, Organomegaly, Endocrinopathy, M Protein, and Skin Changes Syndrome after Conversion from Plasmacytoma of Bone to Multiple Myeloma.

Hatano K, Orimo K, Ogura M, et al.

Internal medicine (Tokyo, Japan) 2023; (62(3)):475-479 doi:10.2169/internalmedicine.9101-21.

POEMS Syndrome: Clinical and Laboratory Approach Towards Diagnosis.

Mahto M, Kumar T, Kumar M, et al.

Indian journal of clinical biochemistry : IJCB 2022; (37(3)):370-374 doi:10.1007/s12291-020-00940-3.

Combined Therapy with Ixazomib, Lenalidomide, and Dexamethasone for Polyneuropathy, Organomegaly, Endocrinopathy, Monoclonal Gammopathy, and Skin Changes Syndrome.

Suichi T, Misawa S, Sekiguchi Y, et al.

Internal medicine (Tokyo, Japan) 2022; (61(17)):2567-2572 doi:10.2169/internalmedicine.8786-21.

Comprehensive Diagnosis and Management of POEMS Syndrome.

D'Sa S, Khwaja J, Keddie S, et al.

HemaSphere 2022; (6(11)):e796 doi:10.1097/HS9.0000000000000796.

Recent Advances in the Treatment and Supportive Care of POEMS Syndrome.

Bou Zerdan M, George TI, Bunting ST, Chaulagain CP

Journal of clinical medicine 2022; (11(23)) doi:10.3390/jcm11237011.

[POEMS-syndrome].

Arkhipov IE, Vergunova IY, Malkova NA, Korobko DS

Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 2023; (123(7. Vyp. 2)):15-21 doi:10.17116/jnevro202312307215.

Regular assessment of serum vascular endothelial growth factor levels to monitor POEMS syndrome.

Gentile F, Terenghi F, Doneddu PE, et al.

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology 2024; (45(2)):727-733 doi:10.1007/s10072-023-07064-5.

Long-Term Outcomes of Autologous Stem Cell Transplantation in Patients with Newly Diagnosed POEMS Syndrome.

Li AA, Gao XM, Zhao H, et al.

Transplantation and cellular therapy 2024; (30(2)):207.e1-207.e7 doi:10.1016/j.jtct.2023.11.001.

Pulmonary manifestations of POEM syndrome: a retrospective analysis of 282 cases.

Huang Y, Luo Y, Hou H, Gao J

BMC pulmonary medicine 2023; (23(1)):465 doi:10.1186/s12890-023-02741-9.

A Multicenter Analysis of Clinical Features and Long-Term Outcomes of POEMS Syndrome in Korea.

Kook HW, Jang JE, Min CK, et al.

Journal of Korean medical science 2024; (39(2)):e5 doi:10.3346/jkms.2024.39.e5.

Efficacy of bortezomib, cyclophosphamide, and dexamethasone for newly diagnosed POEMS syndrome patients.

Fang F, Lan XX, Hu RH, et al.

Therapeutic advances in neurological disorders 2024; (17()):17562864231219151 doi:10.1177/17562864231219151.

Detection of clonal plasma cells in POEMS syndrome using multiparameter flow cytometry.

Ishii A, Tsukamoto S, Mimura N, et al.

Scientific reports 2024; (14(1)):10362 doi:10.1038/s41598-024-61034-1.

[POEMS Syndrome].

Suichi T, Misawa S

Brain and nerve = Shinkei kenkyu no shinpo 2024; (76(5)):547-554 doi:10.11477/mf.1416202642.

Paraproteinemic neuropathies.

Traub R, Qarni T, Cohen AD, Karam C

Muscle & nerve 2024; (70(2)):173-179 doi:10.1002/mus.28164.

POEMS syndrome with undetectable M-protein: a case report and literature review.

Xue HY, Zhou L, Yuan QZ, et al.

Diagnostic pathology 2024; (19(1)):74 doi:10.1186/s13000-024-01502-4.

Requirement of Repeated Serum VEGF Measurements in POEMS Syndrome.

Nomura T, Iwata I, Eguchi K, et al.

Internal medicine (Tokyo, Japan) 2025; (64(5)):769-773 doi:10.2169/internalmedicine.4086-24.

Dramatically elevated plasma vascular endothelial growth factor levels from influenza A infection in polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes syndrome: A case report.

Kannan A, Zhuo Y, Banerjee R

EJHaem 2024; (5(4)):842-844 doi:10.1002/jha2.965.

POEMS Syndrome.

Jaccard A, Pascal V, Magy L, Roussel M

Presse medicale (Paris, France : 1983) 2025; (54(1)):104270 doi:10.1016/j.lpm.2025.104270.

Diagnostic Challenges of Polyneuropathy, Organomegaly, Endocrinopathy, M-protein, and Skin Changes (POEMS) Syndrome: A Rare Case Report and Review of the Literature.

Kumar K, Daga R, Singh J, et al.

Cardiovascular & hematological disorders drug targets 2025; (25(2)):133-138 doi:10.2174/011871529X352283250305042317.

Daratumumab (anti-CD38)- and elotuzumab (anti-SLAMF7)-based treatments for refractory POEMS syndrome: a single-center case series.

Suichi T, Misawa S, Shibuya K, et al.

Hematology (Amsterdam, Netherlands) 2025; (30(1)):2519896 doi:10.1080/16078454.2025.2519896.

POEMS Syndrome Without a Detectable Monoclonal Peak: The Critical Role of VEGF and Bone Marrow Biopsy in Diagnosis.

J Pecorin P, A MM, Olson G, et al.

Case reports in hematology 2025; (2025()):5530850 doi:10.1155/crh/5530850.

Neurological Peculiarities of POEMS Syndrome: Experience From a Brazilian University Center.

Rosenstein RF, Soares Baima JP, Meneguin Pereira TD, et al.

Muscle & nerve 2026; (73(3)):421-426 doi:10.1002/mus.70114.

Efficacy of radiotherapy and role of adjunctive immunochemotherapy in POEMS syndrome with solitary plasmacytoma.

Lau G, Vivekananthan C, Tomkins O, et al.

Blood advances 2026; (10(6)):2074-2081 doi:10.1182/bloodadvances.2025018944.

Pachymeningeal Involvement in POEMS Syndrome: Longitudinal Follow-Up Study and Correlation With Therapeutic Response.

Briani C, Massarotti L, Branca A, et al.

Journal of the peripheral nervous system : JPNS 2026; (31(1)):e70098 doi:10.1111/jns.70098.

POEMS syndrome: a neuromuscular perspective.

Gonçalves TAP, Donadel CD, Frezatti RSS, et al.

Journal of neurology, neurosurgery, and psychiatry 2026; (97(4)):293-301 doi:10.1136/jnnp-2025-336633.

When Foot Drop Tells a Bigger Story: POEMS (Polyneuropathy, Organomegaly, Endocrinopathy, Monoclonal Plasma Cell Disorder, and Skin Changes) Syndrome Revealed by Femoral Plasmacytoma.

Al-Anbagi U, Ahmed S, Telfah H, et al.

Cureus 2026; (18(2)):e103751 doi:10.7759/cureus.103751.

[Recent advances in pathogenesis, diagnosis, and therapeutic strategies for POEMS syndrome].

Tsukamoto S

[Rinsho ketsueki] The Japanese journal of clinical hematology 2026; (67(5)):453-461 doi:10.11406/rinketsu.67.453.

Polyneuropathy, Organomegaly, Endocrinopathy, Monoclonal Protein, and Skin Changes (POEMS) Syndrome Presenting With Superior Mesenteric and Portal Vein Thrombosis: A Case Report.

El Aoufir C, Slimani S, Ait Sahel O, et al.

Cureus 2026; (18(5)):e109591 doi:10.7759/cureus.109591.

POEMS Syndrome: 2026 Update on Diagnosis, Risk-Stratification, and Management.

Dispenzieri A

American journal of hematology 2026; (101(10)):2632-2651 doi:10.1002/ajh.70438.

Detection of M-protein by iMS-IP and iMS-FLC assays redefines previously non-secretory POEMS syndrome.

Huang Y, Li A, Yang Z, et al.

Clinical chemistry and laboratory medicine 2026; (64(11)):2556-2563 doi:10.1515/cclm-2026-0489.

Polyneuropathy, Organomegaly, Endocrinopathy, M-Protein, and Skin Changes (POEMS) Syndrome With Characteristic Muscle Biopsy Findings and Without M-Protein.

Yalovitser J, Seyam M, DeWitt J, et al.

The neurologist 2026; doi:10.1097/NRL.0000000000000688.