Research & Literature

Improved assay performance of single nucleotide polymorphism array over conventional karyotyping in analyzing products of conception.

Lin SB, Xie YJ, Chen Z, et al.

Journal of the Chinese Medical Association : JCMA 2015; (78(7)):408-13.

Surgery for Primary Proximal Hypospadias with Ventral Curvature >30°.

Snodgrass W, Bush N

Current urology reports 2015; (16(10)):69 doi:10.1007/s11934-015-0543-5.

Proximal hypospadias: A persistent challenge. Single institution outcome analysis of three surgical techniques over a 10-year period.

Pippi Salle JL, Sayed S, Salle A, et al.

Journal of pediatric urology 2016; (12(1)):28.e1-7.

Penile appearance after hypospadias correction from a parent's point of view: Comparison of the hypospadias objective penile evaluation score and parents penile perception score.

Haid B, Becker T, Koen M, et al.

Journal of pediatric urology 2016; (12(1)):33.e1-7.

Correlation of androgen receptor and SRD5A2 gene mutations with pediatric hypospadias in 46, XY DSD children.

Fu XH, Zhang WQ, Qu XS

Genetics and molecular research : GMR 2016; (15(1)):15018232 doi:10.4238/gmr.15018232.

Long-term functional outcomes after penoscrotal hypospadias repair: A retrospective comparative study of proximal TIP, Onlay, and Duckett.

Hueber PA, Salgado Diaz M, Chaussy Y, et al.

Journal of pediatric urology 2016; (12(4)):198.e1-6.

Intermediate-Term Followup of Proximal Hypospadias Repair Reveals High Complication Rate.

Long CJ, Chu DI, Tenney RW, et al.

The Journal of urology 2017; (197(3 Pt 2)):852-858 doi:10.1016/j.juro.2016.11.054.

Sexuality and fertility in men with hypospadias; improved outcome.

Örtqvist L, Fossum M, Andersson M, et al.

Andrology 2017; (5(2)):286-293 doi:10.1111/andr.12309.

Genotype-phenotype correlation and identification of two novel SRD5A2 mutations in 33 Chinese patients with hypospadias.

Yuan S, Meng L, Zhang Y, et al.

Steroids 2017; (125()):61-66 doi:10.1016/j.steroids.2017.06.010.

Posterior hypospadias: Evaluation of a paradigm shift from single to staged repair.

Badawy H, Orabi S, Hanno A, Abdelhamid H

Journal of pediatric urology 2018; (14(1)):28.e1-28.e8 doi:10.1016/j.jpurol.2017.07.007.

Proximal Hypospadias and a Novel WT1 Variant: When Should Genetic Testing Be Considered?

Dabrowski E, Armstrong AE, Leeth E, et al.

Pediatrics 2018; (141(Suppl 5)):S491-S495 doi:10.1542/peds.2017-0230.

Patients with disorders of sex development and proximal hypospadias are at high risk for reoperation.

Saltzman AF, Carrasco A, Colvin A, et al.

World journal of urology 2018; (36(12)):2051-2058 doi:10.1007/s00345-018-2350-3.

Psychosocial and Sexual Outcomes in Adolescents following Surgery for Proximal Hypospadias in Childhood.

Andersson M, Sjöström S, Wängqvist M, et al.

The Journal of urology 2018; (200(6)):1362-1370 doi:10.1016/j.juro.2018.06.032.

Incidence and diagnoses of disorders of sex development in proximal hypospadias.

Wong YS, Tam YH, Pang KKY, Yau HC

Journal of pediatric surgery 2018; (53(12)):2498-2501 doi:10.1016/j.jpedsurg.2018.08.010.

Staged transverse preputial island flap urethroplasty for proximal hypospadias: a single-center experience.

Wang C, Song H, Zhang W

Pediatric surgery international 2019; (35(7)):823-827 doi:10.1007/s00383-019-04480-7.

Yield of modern genetic evaluation for patients with proximal hypospadias and descended gonads.

Rowe CK, Adam MP, Ahn JJ, et al.

Journal of pediatric urology 2019; (15(5)):527.e1-527.e6 doi:10.1016/j.jpurol.2019.07.017.

Two-stage repair of proximal hypospadias with moderate to severe chordee using inner preputial skin graft: prospective evaluation of functional and cosmetic outcomes.

Al-Adl AM, Abdel Aal AM, El-Karamany TM, Noureldin YA

World journal of urology 2020; (38(11)):2873-2879 doi:10.1007/s00345-020-03075-5.

Use of Acellular Dermal Matrix for Urethroplasty Coverage in Proximal Hypospadias Repair: a Pilot Study.

Lin D, Wang G, Song H, et al.

Advances in therapy 2020; (37(4)):1425-1435 doi:10.1007/s12325-020-01254-9.

Proximal Hypospadias-Isolated Genital Condition or Marker of More?

Johnson EK, Jacobson DL, Finlayson C, et al.

The Journal of urology 2020; (204(2)):345-352 doi:10.1097/JU.0000000000000810.

Urological results and patient satisfaction in adolescents after surgery for proximal hypospadias in childhood.

Andersson M, Sjöström S, Doroszkiewicz M, et al.

Journal of pediatric urology 2020; (16(5)):660.e1-660.e8 doi:10.1016/j.jpurol.2020.07.005.

45,X/46,X,psu idic(Y)(q11.2) in a phenotypically normal male with short stature: a case report.

Kawabe Y, Yamaguchi M, Miyagaki S, et al.

Clinical pediatric endocrinology : case reports and clinical investigations : official journal of the Japanese Society for Pediatric Endocrinology 2020; (29(4)):189-193 doi:10.1297/cpe.29.189.

The learning curve in proximal hypospadias repair.

Hisamatsu E, Sugita Y, Haruna A, et al.

Journal of pediatric urology 2021; (17(3)):330.e1-330.e6 doi:10.1016/j.jpurol.2021.01.005.

Parental Concerns of Boys with Hypospadias.

Snodgrass P, Snodgrass W, Bush N

Research and reports in urology 2021; (13()):73-77 doi:10.2147/RRU.S285626.

Spongiosum-combined glanuloplasty reduces glans complications after proximal hypospadias repair.

Lyu YQ, Yu L, Xie H, et al.

Asian journal of andrology 2021; (23(5)):532-536 doi:10.4103/aja.aja_19_21.

Time to event analysis for post-hypospadias repair complications: a single-surgeon experience.

Kim JK, Shiff M, Chua ME, et al.

World journal of urology 2021; (39(10)):3913-3919 doi:10.1007/s00345-021-03689-3.

Meta-analysis comparing the outcomes of single stage (foreskin pedicled tube) versus two stage (foreskin free graft & foreskin pedicled flap) repair for proximal hypospadias in the last decade.

Babu R, Chandrasekharam VVS

Journal of pediatric urology 2021; (17(5)):681-689 doi:10.1016/j.jpurol.2021.05.014.

New mutation in WT1 gene in a boy with an incomplete form of Denys-Drash syndrome: A CARE-compliant case report.

Akramov NR, Shavaliev RF, Osipova IV

Medicine 2021; (100(19)):e25864 doi:10.1097/MD.0000000000025864.

Does parental opinion differ from the health care team regarding cosmesis after hypospadias repair?

Costa E, Fraga JC, Salle JP, Rosito N

Revista da Associacao Medica Brasileira (1992) 2021; (67(1)):33-38 doi:10.1590/1806-9282.67.01.20200062.

An Enlarged and Infected Prostatic Utricle as a Rare Cause of Lower Urinary Tract Symptoms in Adolescent Males.

Shakir R, Packer MG, Balsara ZR

Case reports in pediatrics 2021; (2021()):5516232 doi:10.1155/2021/5516232.

Variants in 46,XY DSD-Related Genes in Syndromic and Non-Syndromic Small for Gestational Age Children with Hypospadias.

Leitao Braga B, Lisboa Gomes N, Nishi MY, et al.

Sexual development : genetics, molecular biology, evolution, endocrinology, embryology, and pathology of sex determination and differentiation 2022; (16(1)):27-33 doi:10.1159/000518091.

Results of the one-stage proximal hypospadias repair with modified Koyanagi technique: A prospective cohort study in a single Vietnam centre.

Vu TH, Viet Nguyen H, Quy Hong Q, et al.

Annals of medicine and surgery (2012) 2021; (71()):103012 doi:10.1016/j.amsu.2021.103012.

A meta-analysis comparing dorsal plication and ventral lengthening for chordee correction during primary proximal hypospadias repair.

Babu R, Chandrasekharam VVS

Pediatric surgery international 2022; (38(3)):389-398 doi:10.1007/s00383-022-05065-7.

Spectrum of Clinical Manifestations in Children With WT1 Mutation: Case Series and Literature Review.

Arroyo-Parejo Drayer P, Seeherunvong W, Katsoufis CP, et al.

Frontiers in pediatrics 2022; (10()):847295 doi:10.3389/fped.2022.847295.

Defining the role of pre-operative hormonal therapy in hypospadias.

Taghavi K, O'Hagan LA, Hewitt JK, Mouriquand P

Journal of paediatrics and child health 2022; (58(9)):1508-1519 doi:10.1111/jpc.16087.

The effect of staged TIP urethroplasty on proximal hypospadias with severe chordee.

Xie Q, Liu Y, Zhao X, et al.

Frontiers in surgery 2022; (9()):892048 doi:10.3389/fsurg.2022.892048.

Utility of genetic work-up for 46, XY patients with severe hypospadias.

Srivastava P, Tenney J, Lodish M, et al.

Journal of pediatric urology 2023; (19(3)):261-272 doi:10.1016/j.jpurol.2022.11.023.

Role of epigenetics in the etiology of hypospadias through penile foreskin DNA methylation alterations.

Kaefer M, Rink R, Misseri R, et al.

Scientific reports 2023; (13(1)):555 doi:10.1038/s41598-023-27763-5.

Targeted Next-Generation Sequencing for the Diagnosis of Gene Variants in Patients with 46,XY Disorder of Sex Development.

Guo Q, Zhong WW, Lai HJ, et al.

Sexual development : genetics, molecular biology, evolution, endocrinology, embryology, and pathology of sex determination and differentiation 2023; (17(1)):26-31 doi:10.1159/000528916.

Post-pubertal functional outcomes of one-stage anatomical reconstruction of the corpus spongiosum, bulbo-spongiosus muscle and dartos in 46 children with proximalhypospadias.

S H, F A, A A, A B

Journal of pediatric urology 2023; (19(4)):383-390 doi:10.1016/j.jpurol.2023.03.024.

Advanced maternal age: copy number variations and pregnancy outcomes.

Cao L, Dong W, Wu Q, et al.

Frontiers in genetics 2023; (14()):1206855 doi:10.3389/fgene.2023.1206855.

Effectiveness of penile ventral curvature correction and the trend of hypospadias repair: a prospective study of the national center in China.

Yang Z, Li J, Liu P, et al.

BMJ paediatrics open 2023; (7(1)) doi:10.1136/bmjpo-2023-001984.

Male refractory hypospadias with sexual reversal: a case report.

Zhao J, Chen G, Chen J, Qian L

Journal of medical case reports 2023; (17(1)):494 doi:10.1186/s13256-023-04230-3.

What should be next in lifelong posterior hypospadias: Conclusions from the 2023 ERN eUROGEN and EJP-RD networking meeting.

Lammers RJM, Tsachouridis G, Andersson MK, et al.

Neurourology and urodynamics 2024; (43(5)):1097-1103 doi:10.1002/nau.25305.

The impact of audiovisual information on parental anxiety levels prior to hypospadias surgery: A prospective single center cohort study.

Karaburun MC, Akıncı A, Kubilay E, et al.

Journal of pediatric urology 2024; (20(4)):746.e1-746.e7 doi:10.1016/j.jpurol.2024.06.012.

Time to complication after primary pediatric hypospadias repair with transverse preputial island flap urethroplasty.

Zhao J, Sun N, Zhang W, Song H

Translational andrology and urology 2024; (13(8)):1364-1371 doi:10.21037/tau-24-135.

Prevalence of disorders of sex development in patients with hypospadias and cryptorchidism.

Lavoie C, Chun B, Au M, et al.

Journal of pediatric urology 2025; (21(1)):71-77 doi:10.1016/j.jpurol.2024.09.017.

Comparative study of modified Koyanagi and staged Duckett for proximal hypospadias.

Ji F, Chen J, Tang H, et al.

BMC urology 2024; (24(1)):218 doi:10.1186/s12894-024-01608-3.

Mental health and health-related quality of life in adolescents surgically treated for hypospadias in childhood.

Gulseth E, Urdal A, Andersen MH, et al.

Journal of pediatric urology 2025; (21(1)):59-70 doi:10.1016/j.jpurol.2024.09.031.

Usefulness topical di-hydro testosterone prior to proximal hypospadias repair in testosterone non-responders.

Babu R, Chandrasekharam VVS

Journal of pediatric urology 2025; (21(3)):633-638 doi:10.1016/j.jpurol.2025.01.020.

Investigation of Y chromosome microdeletions in algerian children with hypospadias.

Laouar R, Chellat-Rezgoune D, Touabti S, et al.

Journal of pediatric urology 2025; (21(3)):644-650 doi:10.1016/j.jpurol.2025.01.027.

Failure of Prenatal Ultrasonography to Identify Classic Bladder Exstrophy in a Heavily Screened Population.

Dekalo A, Friedman M, Ben-Chaim J, Bar-Yosef Y

Urology 2025; (200()):166-169 doi:10.1016/j.urology.2025.02.028.

Practice patterns in the care of proximal hypospadias among pediatric urologists.

Rague JT, Rosoklija I, Chu DI, et al.

Journal of pediatric urology 2025; (21(5)):1195-1202 doi:10.1016/j.jpurol.2025.03.002.

Preliminary Experience with Transdermal Preoperative Hormonal Treatment Before Severe Hypospadias Repair: Synergy Between Pediatric Surgeons and Endocrinologists.

Lucaccioni L, Ghidini F, Repetto P, et al.

Children (Basel, Switzerland) 2025; (12(3)) doi:10.3390/children12030296.

Urethral plate transection for chordee release in severe proximal hypospadias cases.

Demirtas G, Ekberli G, Tagcı S, et al.

Scientific reports 2025; (15(1)):15269 doi:10.1038/s41598-025-00079-2.

Bulbospongiosus Muscle Reconstruction in Proximal Hypospadias: Post Pubertal Function and Patient Satisfaction.

Hennayake S, Marei MM, De Silva A, et al.

Journal of pediatric surgery 2025; (60(8)):162385 doi:10.1016/j.jpedsurg.2025.162385.

Application of glanular decompression and expansion surgery in proximal hypospadias with hypoplastic glans penis.

Wang Y, Gu S, Ding Y, et al.

Pediatric surgery international 2025; (41(1)):237 doi:10.1007/s00383-025-06141-4.

Wilms Tumor, Version 2.2025, NCCN Clinical Practice Guidelines In Oncology.

Balis F, Green DM, Armstrong A, et al.

Journal of the National Comprehensive Cancer Network : JNCCN 2025; (23(8)):319-342 doi:10.6004/jnccn.2025.0037.

Impact of an integrated disease-specific nursing care model on parental anxiety and depression in severe hypospadias patients in China: a randomized controlled trial.

Wu R, Jia L, Ding B, et al.

Journal of Korean Academy of Nursing 2025; (55(3)):327-341 doi:10.4040/jkan.24147.

The Impact of Postoperative Urinary Diversion on Surgical Outcomes of Hypospadias Repair: A Systematic Review and Meta-Analysis of Pediatric Literature.

Escolino M, Caracò MS, Mazzone V, et al.

Medicina (Kaunas, Lithuania) 2025; (61(9)) doi:10.3390/medicina61091659.

Unraveling the Androgen Receptor's Role in Hypospadias: A Systematic Review and Meta-Analysis.

Ko S, Malm-Buatsi E, Amato CM

International journal of molecular sciences 2026; (27(2)) doi:10.3390/ijms27020718.