Research & Literature

Serum alpha-1 antitrypsin: a noninvasive marker of pouchitis.

Matalon S, Elad H, Brazowski E, et al.

Inflammatory bowel diseases 2015; (21(3)):589-95 doi:10.1097/MIB.0000000000000308.

Pouch Inflammation Is Associated With a Decrease in Specific Bacterial Taxa.

Reshef L, Kovacs A, Ofer A, et al.

Gastroenterology 2015; (149(3)):718-27.

The therapeutic potential of antibiotics and probiotics in the treatment of pouchitis.

Gionchetti P, Calabrese C, Lauri A, Rizzello F

Expert review of gastroenterology & hepatology 2015; (9(9)):1175-81 doi:10.1586/17474124.2015.1072046.

Review article: the pathogenesis of pouchitis.

Schieffer KM, Williams ED, Yochum GS, Koltun WA

Alimentary pharmacology & therapeutics 2016; (44(8)):817-35 doi:10.1111/apt.13780.

Fecal microbiota in pouchitis and ulcerative colitis.

Li KY, Wang JL, Wei JP, et al.

World journal of gastroenterology 2016; (22(40)):8929-8939 doi:10.3748/wjg.v22.i40.8929.

[Restorative proctocolectomy for ulcerative colitis : Long-term functional results and quality of life].

Rijcken E, Senninger N, Mennigen R

Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen 2017; (88(7)):566-573 doi:10.1007/s00104-017-0441-0.

Crohn's Disease of the Pouch: A True Diagnosis or an Oversubscribed Diagnosis of Exclusion?

Lightner AL, Fletcher JG, Pemberton JH, et al.

Diseases of the colon and rectum 2017; (60(11)):1201-1208 doi:10.1097/DCR.0000000000000918.

Comparative genomic analysis of the multispecies probiotic-marketed product VSL#3.

Douillard FP, Mora D, Eijlander RT, et al.

PloS one 2018; (13(2)):e0192452 doi:10.1371/journal.pone.0192452.

MRI defecography of the ileal pouch-anal anastomosis-contributes little to the understanding of functional outcome.

Sunde ML, Negård A, Øresland T, et al.

International journal of colorectal disease 2018; (33(5)):609-617 doi:10.1007/s00384-018-3011-0.

Computed tomography-guided endoscopic sinusotomy for an ileal pouch presacral sinus.

El Ouali S, Veniero JC, Shen B

Endoscopy 2018; (50(7)):730-731 doi:10.1055/a-0596-7107.

Complications Related to J-Pouch Surgery.

Freeha K, Bo S

Gastroenterology & hepatology 2018; (14(10)):571-576.

Mucosa-Associated Microbiota in Ileoanal Pouches May Contribute to Clinical Symptoms, Particularly Stool Frequency, Independent of Endoscopic Disease Activity.

Turpin W, Kelly O, Borowski K, et al.

Clinical and translational gastroenterology 2019; (10(5)):1-7 doi:10.14309/ctg.0000000000000038.

Ustekinumab Is Effective for the Treatment of Chronic Antibiotic-Refractory Pouchitis.

Ollech JE, Rubin DT, Glick L, et al.

Digestive diseases and sciences 2019; (64(12)):3596-3601 doi:10.1007/s10620-019-05697-1.

Prevention and Medical Treatment of Pouchitis In Ulcerative Colitis.

Benlice C, Shen B, Steele SR

Current drug targets 2019; (20(13)):1399-1408 doi:10.2174/1389450120666190723130137.

Ileal-anal pouches: A review of its history, indications, and complications.

Ng KS, Gonsalves SJ, Sagar PM

World journal of gastroenterology 2019; (25(31)):4320-4342 doi:10.3748/wjg.v25.i31.4320.

Effectiveness of vedolizumab treatment in two different anti-tumor necrosis factor alpha refractory pouchitis: A case report.

Cakir OO

World journal of clinical cases 2019; (7(16)):2316-2321 doi:10.12998/wjcc.v7.i16.2316.

Endoscopic activity in asymptomatic patients with an ileal pouch is associated with an increased risk of pouchitis.

Kayal M, Plietz M, Radcliffe M, et al.

Alimentary pharmacology & therapeutics 2019; (50(11-12)):1189-1194 doi:10.1111/apt.15505.

Predominantly Antibiotic-resistant Intestinal Microbiome Persists in Patients With Pouchitis Who Respond to Antibiotic Therapy.

Dubinsky V, Reshef L, Bar N, et al.

Gastroenterology 2020; (158(3)):610-624.e13 doi:10.1053/j.gastro.2019.10.001.

Recommendations of the Spanish Working Group on Crohn's Disease and Ulcerative Colitis (GETECCU) on pouchitis in ulcerative colitis. Part 1: Epidemiology, diagnosis and prognosis.

Barreiro-de Acosta M, Gutierrez A, Rodríguez-Lago I, et al.

Gastroenterologia y hepatologia 2019; (42(9)):568-578 doi:10.1016/j.gastrohep.2019.08.001.

Probiotic mixture VSL#3: An overview of basic and clinical studies in chronic diseases.

Cheng FS, Pan D, Chang B, et al.

World journal of clinical cases 2020; (8(8)):1361-1384 doi:10.12998/wjcc.v8.i8.1361.

IBD Microbial Metabolome: The Good, Bad, and Unknown.

Sidebottom AM, Chang EB

Trends in endocrinology and metabolism: TEM 2020; (31(11)):807-809 doi:10.1016/j.tem.2020.05.001.

Pouch failures following restorative proctocolectomy in ulcerative colitis.

Helavirta I, Lehto K, Huhtala H, et al.

International journal of colorectal disease 2020; (35(11)):2027-2033 doi:10.1007/s00384-020-03680-1.

Surveillance pouchoscopy for dysplasia: Cleveland Clinic Ileoanal Pouch Anastomosis Database.

Lightner AL, Vaidya P, Vogler S, et al.

The British journal of surgery 2020; (107(13)):1826-1831 doi:10.1002/bjs.11811.

Determinants of Pouch-Related Symptoms, a Common Outcome of Patients With Adenomatous Polyposis Undergoing Ileoanal Pouch Surgery.

Gilad O, Gluck N, Brazowski E, et al.

Clinical and translational gastroenterology 2020; (11(10)):e00245 doi:10.14309/ctg.0000000000000245.

Pouchitis in inflammatory bowel disease: a review of diagnosis, prognosis, and treatment.

Akiyama S, Rai V, Rubin DT

Intestinal research 2021; (19(1)):1-11 doi:10.5217/ir.2020.00047.

Crohn's Disease of the Pouch: Convinced It's Truly De Novo Crohn's Disease?

Lightner AL

Diseases of the colon and rectum 2021; (64(2)):143-144 doi:10.1097/DCR.0000000000001780.

Transanal proctocolectomy and ileal pouch-anal anastomosis (TaIPAA) for ulcerative colitis: medium term functional outcomes in a single centre.

Capolupo GT, Carannante F, Mascianà G, et al.

BMC surgery 2021; (21(1)):17 doi:10.1186/s12893-020-01007-z.

A pragmatic stepwise approach to the diagnosis and management of refractory acute pouchitis.

Ardalan ZS, Sparrow MP

Expert opinion on pharmacotherapy 2021; (22(5)):531-533 doi:10.1080/14656566.2021.1882422.

Systematic Review and Meta-analysis of Outcomes After Ileal Pouch-anal Anastomosis in Primary Sclerosing Cholangitis and Ulcerative Colitis.

Barnes EL, Holubar SD, Herfarth HH

Journal of Crohn's & colitis 2021; (15(8)):1272-1278 doi:10.1093/ecco-jcc/jjab025.

Surgical results and quality of life of patients submitted to restorative proctocolectomy and ileal pouch-anal anastomosis.

Cherem-Alves A, Lacerda-Filho A, Alves PF, et al.

Revista do Colegio Brasileiro de Cirurgioes 2021; (48()):e20202791 doi:10.1590/0100-6991e-20202791.

Medical treatment of pouchitis: a guide for the clinician.

Rabbenou W, Chang S

Therapeutic advances in gastroenterology 2021; (14()):17562848211023376 doi:10.1177/17562848211023376.

Oral vancomycin in the treatment of primary sclerosing cholangitis-associated pouchitis.

Shen B

Gastroenterology report 2021; (9(3)):274-275 doi:10.1093/gastro/goab004.

Pouchitis: Clinical Features, Diagnosis, and Treatment.

Gionchetti P, Calabrese C, Laureti S, et al.

International journal of general medicine 2021; (14()):3871-3879 doi:10.2147/IJGM.S306039.

Treatment of pouchitis, Crohn's disease, cuffitis, and other inflammatory disorders of the pouch: consensus guidelines from the International Ileal Pouch Consortium.

Shen B, Kochhar GS, Rubin DT, et al.

The lancet. Gastroenterology & hepatology 2022; (7(1)):69-95 doi:10.1016/S2468-1253(21)00214-4.

Fecal Calprotectin Is Increased in Pouchitis and Progressively Increases With More Severe Endoscopic and Histologic Disease.

Ollech JE, Bannon L, Maharshak N, et al.

Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 2022; (20(8)):1839-1846.e2 doi:10.1016/j.cgh.2021.11.012.

Prevalence of 'pouch failure' of the ileoanal pouch in ulcerative colitis: a systematic review and meta-analysis.

Alsafi Z, Snell A, Segal JP

International journal of colorectal disease 2022; (37(2)):357-364 doi:10.1007/s00384-021-04067-6.

A Multi-Disciplinary Approach to Perianal Fistulizing Crohn's Disease.

Wiseman J, Chawla T, Morin F, et al.

Clinics in colon and rectal surgery 2022; (35(1)):51-57 doi:10.1055/s-0041-1740038.

Defining normal pouch function in patients with ileal pouch-anal anastomosis: a pilot study.

Quinn KP, Busciglio IA, Burton DD, et al.

Alimentary pharmacology & therapeutics 2022; (55(12)):1560-1568 doi:10.1111/apt.16859.

Laparoscopic Restorative Proctocolectomy for Ulcerative Colitis - How I Do It?

Stanciulea O, Eftimie MA, Mosteanu I, et al.

Chirurgia (Bucharest, Romania : 1990) 2022; (117(3)):328-340.

Management of pouch neoplasia: consensus guidelines from the International Ileal Pouch Consortium.

Kiran RP, Kochhar GS, Kariv R, et al.

The lancet. Gastroenterology & hepatology 2022; (7(9)):871-893 doi:10.1016/S2468-1253(22)00039-5.

Disease Monitoring of the Ileoanal Pouch: How to Utilize Biomarkers, Imaging, and Pouchoscopy.

Barnes EL, Darlington K, Herfarth HH

Current gastroenterology reports 2022; (24(11)):127-136 doi:10.1007/s11894-022-00850-9.

Inflammatory bowel disease-specific findings are common morphological changes in the ileal pouch with ulcerative colitis.

Toritani K, Kimura H, Otani M, et al.

Scientific reports 2022; (12(1)):20361 doi:10.1038/s41598-022-24708-2.

Biologic Therapies for the Treatment of Post-ileal Pouch Anal Anastomosis Surgery Chronic Inflammatory Disorders: Systematic Review and Meta-analysis.

Shehab M, Alrashed F, Charabaty A, Bessissow T

Journal of the Canadian Association of Gastroenterology 2022; (5(6)):287-296 doi:10.1093/jcag/gwac026.

Risk Factors and Quality of Life in Patients with Diffuse Pouchitis After Ileal Pouch Anal Anastomosis According to the Chicago Classification for J Pouch: a Retrospective Multicenter Cohort Study in China.

Xu W, Wang Y, Hua Z, et al.

Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract 2023; (27(4)):766-776 doi:10.1007/s11605-022-05563-y.

The Incidence of Pouch Neoplasia Following Ileal Pouch-Anal Anastomosis in Patients With Inflammatory Bowel Disease.

Urquhart SA, Comstock BP, Jin MF, et al.

Inflammatory bowel diseases 2024; (30(2)):183-189 doi:10.1093/ibd/izad021.

Restorative pouch surgery following proctocolectomy for inflammatory bowel disease: past experience and future direction.

Cohen D, Silvestri C, Schwartzberg DM

Translational gastroenterology and hepatology 2023; (8()):27 doi:10.21037/tgh-23-28.

A Systematic Review and Meta-analysis of Randomized Clinical Trials on the Prevention and Treatment of Pouchitis after Ileoanal Pouch Anastomosis.

Emile SH, Horesh N, Freund MR, et al.

Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract 2023; (27(11)):2650-2660 doi:10.1007/s11605-023-05841-3.

Effectiveness of Oral Tofacitinib in Chronic Pouchitis: A Prospective, Open-Label Pilot Study.

Syal G, Mishkin DS, Banty A, et al.

Inflammatory bowel diseases 2024; (30(10)):1907-1910 doi:10.1093/ibd/izad191.

Treatment of Antibiotic Refractory Chronic Pouchitis With JAK Inhibitors and S1P Receptor Modulators: An ECCO CONFER Multicentre Case Series.

Ribaldone DG, Testa G, Verstockt B, et al.

Journal of Crohn's & colitis 2024; (18(5)):720-726 doi:10.1093/ecco-jcc/jjad194.

Altered Bile Acid and Pouch Microbiota Composition in Patients With Chronic Pouchitis.

Santiago P, Quinn KP, Chen J, et al.

Inflammatory bowel diseases 2024; (30(7)):1062-1070 doi:10.1093/ibd/izad288.

A specific phenotype of pouchitis was associated with worst prognosis in patients with ulcerative colitis according to Chicago classification.

Wang Z, Wang J, Yang Z, et al.

Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 2024; (56(6)):1007-1013 doi:10.1016/j.dld.2023.11.035.

AGA Clinical Practice Guideline on the Management of Pouchitis and Inflammatory Pouch Disorders.

Barnes EL, Agrawal M, Syal G, et al.

Gastroenterology 2024; (166(1)):59-85 doi:10.1053/j.gastro.2023.10.015.

Pouchitis Is Associated with Paneth Cell Dysfunction and Ameliorated by Exogenous Lysosome in a Rat Model Undergoing Ileal Pouch Anal Anastomosis.

Xu Y, Yu Z, Li S, et al.

Microorganisms 2023; (11(12)) doi:10.3390/microorganisms11122832.

Position statement of the Spanish Working Group on Crohn's Disease and Ulcerative Colitis on sexuality and inflammatory bowel disease.

Calvo Moya M, Mesonero Gismero F, Suarez Ferrer C, et al.

Gastroenterologia y hepatologia 2024; (47(7)):774-792 doi:10.1016/j.gastrohep.2023.12.013.

Endoscopic Evaluation of the Ileal Pouch.

Shen B

Diseases of the colon and rectum 2024; (67(S1)):S52-S69 doi:10.1097/DCR.0000000000003269.

Management of Primary Sclerosing Cholangitis and Extraintestinal Disorders in Patients With Ileal Pouches: A Systematic Review.

Shen B, Yao Q, Scherl EJ

Diseases of the colon and rectum 2024; (67(S1)):S106-S114 doi:10.1097/DCR.0000000000003231.

Histopathological Evaluation of Pouch Neoplasia in IBD and Familial Adenomatous Polyposis.

Ko HM

Diseases of the colon and rectum 2024; (67(S1)):S91-S98 doi:10.1097/DCR.0000000000003320.

Pouchitis: pathophysiology and management.

Shen B

Nature reviews. Gastroenterology & hepatology 2024; (21(7)):463-476 doi:10.1038/s41575-024-00920-5.

Endoscopic assessment of the J pouch in ulcerative colitis: A narrative review.

Akiyama S, Barnes EL, Onoda T, et al.

DEN open 2025; (5(1)):e373 doi:10.1002/deo2.373.

Influence of hospital-level and surgeon factors on the outcomes after ileo-anal pouch surgery for inflammatory bowel disease: systematic review.

Giddings HL, Yang PF, Steffens D, et al.

The British journal of surgery 2024; (111(5)) doi:10.1093/bjs/znae088.

The aetiology of pouchitis in patients with inflammatory bowel disease.

Alenzi M, Schildkraut T, Hartley I, et al.

Therapeutic advances in gastroenterology 2024; (17()):17562848241249449 doi:10.1177/17562848241249449.

Types, behaviour and therapeutic requirements of inflammatory pouch disorders: Results from the RESERVO study of GETECCU.

Mesonero F, Zabana Y, Fernández-Clotet A, et al.

Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 2025; (57(2)):566-573 doi:10.1016/j.dld.2024.09.023.

Prevalence of Active Pouch Symptoms and Patient Perception of Symptom Control and Quality of Life in an Outpatient Practice.

Kirsch P, Rauch J, Delau O, et al.

Gastro hep advances 2024; (3(8)):1069-1078 doi:10.1016/j.gastha.2024.07.019.

Ileal Pouch-Anal Anastomosis for Ulcerative Colitis: Predictors of Early and Late Complications.

Sarangi Y, Kumar A, Malage S, et al.

Cureus 2024; (16(12)):e75086 doi:10.7759/cureus.75086.

Medical, Endoscopic, and Surgical Treatments for Rectal Cuffitis in IBD Patients with an Ileal Pouch-Anal Anastomosis: A Narrative Review.

Powers JC, Dester E, Schleicher M, et al.

Digestive diseases and sciences 2025; (70(3)):943-963 doi:10.1007/s10620-024-08822-x.

Navigating Chronic Pouchitis: Pathogenesis, Diagnosis, and Management.

Hill R, Travis S, Ardalan Z

Gastroenterology & hepatology 2025; (21(1)):46-58.

Comparative Effectiveness of Bile Acid Sequestrants and Antibiotics in the Management of Acute Pouchitis: A Matched Cohort Study from the United States.

Alsakarneh S, Camilleri M, Farraye FA, Hashash JG

Digestive diseases and sciences 2025; (70(8)):2760-2767 doi:10.1007/s10620-025-09039-2.

Optimal Approaches to Treating and Preventing Acute and Chronic Pouchitis by Altering Microbial Profiles.

Kallumkal G, Barnes EL

Gastroenterology clinics of North America 2025; (54(2)):469-483 doi:10.1016/j.gtc.2024.12.007.

ECCO Topical Review on Pouch Disorders.

Kayal M, Bislenghi G, Adamina M, et al.

Journal of Crohn's & colitis 2025; (19(7)) doi:10.1093/ecco-jcc/jjaf103.

[Pouchitis].

Thomsen L, Jacobsen S, Tøttrup A

Ugeskrift for laeger 2025; (187(27)) doi:10.61409/V01250033.

Efficacy and Safety of Ustekinumab and Vedolizumab for Crohn's Disease of the Pouch.

Park S, Keyashian K, Ho A, et al.

Inflammatory bowel diseases 2025; (31(11)):3142-3148 doi:10.1093/ibd/izaf146.

Impaired Quality of Life in Croatian IBD Patients in the Era of Advanced Treatment Options.

Bišćanin A, Palac L, Dorosulić Z, et al.

Healthcare (Basel, Switzerland) 2025; (13(14)) doi:10.3390/healthcare13141681.

A narrative review of the ileal pouch in pediatric inflammatory bowel disease and familial adenomatous polyposis.

Philip A, Wyatt A, Rodriguez JR, et al.

Journal of pediatric gastroenterology and nutrition 2025; (81(4)):913-921 doi:10.1002/jpn3.70175.

Pouch excision, dysplasia and polypectomy in familial adenomatous polyposis ileal pouch anal anastomosis: a retrospective analysis.

Blake I, Aslam H, Ahmed S, et al.

BMJ open gastroenterology 2025; (12(1)) doi:10.1136/bmjgast-2025-001758.

Development of a convolutional neural network for the endoscopic classification of pouchitis in patients after restorative proctocolectomy.

Saifi M, Eisenmann U, Ringwald F, et al.

Techniques in coloproctology 2026; (30(1)).

Optimal Antibiotic Selection for the Treatment of Pouchitis After Ileal Pouch-Anal Anastomosis.

Bronze S, Kayal M

Journal of inflammation research 2026; (19()):546274 doi:10.2147/JIR.S546274.