Research & Literature

Long-term outcome of patients with acquired chronic pure red cell aplasia (PRCA) following immunosuppressive therapy: a final report of the nationwide cohort study in 2004/2006 by the Japan PRCA collaborative study group.

Hirokawa M, Sawada K, Fujishima N, et al.

British journal of haematology 2015; (169(6)):879-86 doi:10.1111/bjh.13376.

Good syndrome: an adult-onset immunodeficiency remarkable for its high incidence of invasive infections and autoimmune complications.

Malphettes M, Gérard L, Galicier L, et al.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2015; (61(2)):e13-9 doi:10.1093/cid/civ269.

Human parvovirus B19 infection induced pure red cell aplasia in liver transplant recipients.

Zhang M, Zhong X, Zhang W, et al.

International journal of clinical practice. Supplement 2015; 29-34 doi:10.1111/ijcp.12664.

Endocrine Dysfunction in Diamond-Blackfan Anemia (DBA): A Report from the DBA Registry (DBAR).

Lahoti A, Harris YT, Speiser PW, et al.

Pediatric blood & cancer 2016; (63(2)):306-12 doi:10.1002/pbc.25780.

Fanconi Syndrome Secondary to Deferasirox in Diamond-Blackfan Anemia: Case Series and Recommendations for Early Diagnosis.

Papneja K, Bhatt MD, Kirby-Allen M, et al.

Pediatric blood & cancer 2016; (63(8)):1480-3 doi:10.1002/pbc.25995.

Efficacy and Safety of Long-Term Sirolimus Therapy for Asian Patients with Lymphangioleiomyomatosis.

Takada T, Mikami A, Kitamura N, et al.

Annals of the American Thoracic Society 2016; (13(11)):1912-1922 doi:10.1513/AnnalsATS.201605-335OC.

One-year results from a prospective randomized trial comparing phlebotomy with deferasirox for the treatment of iron overload in pediatric patients with thalassemia major following curative stem cell transplantation.

Inati A, Kahale M, Sbeiti N, et al.

Pediatric blood & cancer 2017; (64(1)):188-196 doi:10.1002/pbc.26213.

Pure red cell aplasia.

Means RT

Hematology. American Society of Hematology. Education Program 2016; (2016(1)):51-56 doi:10.1182/asheducation-2016.1.51.

Refractory anemia in human immunodeficiency virus: Expect the unexpected.

Mirgh SP, Mishra VA, Shah VD, Sorabjee JS

Journal of family medicine and primary care 2016; (5(3)):727-729 doi:10.4103/2249-4863.197288.

Parvovirus B19: A Rare Cause of Post-renal Transplant Anemia.

Ahmed W, Dogar RUH, Acharya S

Journal of the College of Physicians and Surgeons--Pakistan : JCPSP 2017; (27(12)):785-787 doi:2775.

Rational management approach to pure red cell aplasia.

Balasubramanian SK, Sadaps M, Thota S, et al.

Haematologica 2018; (103(2)):221-230 doi:10.3324/haematol.2017.175810.

Acquired amegakaryocytic thrombocytopenia and red cell aplasia in a patient with thymoma progressing to aplastic anemia successfully treated with allogenic stem cell transplantation.

Simkins A, Maiti A, Short NJ, et al.

Hematology/oncology and stem cell therapy 2019; (12(2)):115-118 doi:10.1016/j.hemonc.2017.09.001.

Magnetic resonance imaging during management of patients with transfusion-dependent thalassemia: a single-center experience.

Karakas Z, Yilmaz Y, Bayramoglu Z, et al.

La Radiologia medica 2018; (123(8)):572-576 doi:10.1007/s11547-018-0889-0.

Assessment of liver and cardiac iron overload using MRI in patients with chronic anemias in Latin American countries: results from ASIMILA study.

Cancado R, Watman NP, Lobo C, et al.

Hematology (Amsterdam, Netherlands) 2018; (23(9)):676-682 doi:10.1080/10245332.2018.1461292.

Successful treatment of refractory/relapsed acquired pure red cell aplasia with sirolimus.

Long Z, Yu F, Du Y, et al.

Annals of hematology 2018; (97(11)):2047-2054 doi:10.1007/s00277-018-3431-5.

Critical Issues in Diamond-Blackfan Anemia and Prospects for Novel Treatment.

Li H, Lodish HF, Sieff CA

Hematology/oncology clinics of North America 2018; (32(4)):701-712 doi:10.1016/j.hoc.2018.04.005.

Pure Red Cell Aplasia Caused by Azathioprine.

Kounatidis D, Vallianou N, Daskalaki V, et al.

Cardiovascular & hematological disorders drug targets 2020; (20(2)):164-165 doi:10.2174/1871529X18666180828145818.

Pure red cell aplasia associated with thymoma: a report of a single-center experience.

Moriyama S, Yano M, Haneda H, et al.

Journal of thoracic disease 2018; (10(8)):5066-5072 doi:10.21037/jtd.2018.07.14.

Frequent STAT3 mutations in CD8+ T cells from patients with pure red cell aplasia.

Kawakami T, Sekiguchi N, Kobayashi J, et al.

Blood advances 2018; (2(20)):2704-2712 doi:10.1182/bloodadvances.2018022723.

The Genetic Landscape of Diamond-Blackfan Anemia.

Ulirsch JC, Verboon JM, Kazerounian S, et al.

American journal of human genetics 2018; (103(6)):930-947 doi:10.1016/j.ajhg.2018.10.027.

Diamond Blackfan Anemia: Genetics, Pathogenesis, Diagnosis and Treatment.

Engidaye G, Melku M, Enawgaw B

EJIFCC 2019; (30(1)):67-81.

A Novel Deletion in the RPL5 Gene in a Lebanese Child With Diamond Blackfan Anemia Unresponsive to Steroid Treatment.

Farah RA, Kamel L, Roy N, et al.

Journal of pediatric hematology/oncology 2020; (42(4)):e235-e237 doi:10.1097/MPH.0000000000001435.

Human parvovirus B19 in solid organ transplantation: Guidelines from the American society of transplantation infectious diseases community of practice.

Eid AJ, Ardura MI,

Clinical transplantation 2019; (33(9)):e13535 doi:10.1111/ctr.13535.

Induced complete remission faster in adult patients with acquired pure red cell aplasia by combining cyclosporine A with corticosteroids.

Wu X, Yang Y, Lu X, et al.

Medicine 2019; (98(41)):e17425 doi:10.1097/MD.0000000000017425.

Thymoma and pure red cell aplasia with hypoplasia of megakaryocytopoiesis: A rare and life-treating condition.

Lo Iacono G, Gigli F, Gherzi L, et al.

Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis 2020; (59(2)):102656 doi:10.1016/j.transci.2019.09.009.

Emtricitabine-induced pure red cell aplasia.

Manickchund N, du Plessis C, John MA, et al.

Southern African journal of HIV medicine 2019; (20(1)):983 doi:10.4102/sajhivmed.v20i1.983.

Cardiac and hepatic siderosis in myelodysplastic syndrome, thalassemia and diverse causes of transfusion-dependent anemia: the TIMES study.

Ho PJ, Hiwase D, Ramakrishna R, et al.

HemaSphere 2019; (3(3)):e224 doi:10.1097/HS9.0000000000000224.

Outcome of allogeneic Hematopoietic Stem Cell Transplantation on Diamond-Blackfan anemia using busulfan-based myeloablative regimen.

Behfar M, Koochakzadeh L, Yazdanian N, et al.

The Turkish journal of pediatrics 2019; (61(3)):407-412.

Successful sirolimus treatment of patients with pure red cell aplasia complicated with renal insufficiency.

Chen Z, Liu X, Chen M, et al.

Annals of hematology 2020; (99(4)):737-741 doi:10.1007/s00277-020-03946-2.

Etiologies and Treatment Burden in Adult Patients with Pure Red Cell Aplasia: A Single-Center Experience and Review of Literature.

Niparuck P, Kanoksil W, Wacharapornin P, et al.

Anemia 2020; (2020()):4812759 doi:10.1155/2020/4812759.

Isoniazid Induced Pure Red Blood Cell Aplasia.

Azhar W, Zaidi F, Hannan A

Cureus 2020; (12(2)):e7112 doi:10.7759/cureus.7112.

Favorable outcomes of hematopoietic stem cell transplantation in children and adolescents with Diamond-Blackfan anemia.

Strahm B, Loewecke F, Niemeyer CM, et al.

Blood advances 2020; (4(8)):1760-1769 doi:10.1182/bloodadvances.2019001210.

Immunosuppression therapy is effective for both acquired tumor-associated and primary pure red cell aplasia: a match pair case-control study.

Chen Z, Chen M, Yang C, Han B

Annals of hematology 2020; (99(7)):1485-1491 doi:10.1007/s00277-020-04105-3.

Moxibustion with deferasirox results in safe, accelerated, and sustained cardiac iron chelation for a young Diamond Blackfan Anemia patient: An integrative case report.

Marie EF

Explore (New York, N.Y.) 2021; (17(3)):239-246 doi:10.1016/j.explore.2020.05.011.

Nonsense Suppression Therapy: New Hypothesis for the Treatment of Inherited Bone Marrow Failure Syndromes.

Bezzerri V, Api M, Allegri M, et al.

International journal of molecular sciences 2020; (21(13)) doi:10.3390/ijms21134672.

[Clinical analysis of 67 cases of pure red cell aplastic anemia].

Wang Q, Ma JX, Li BH, et al.

Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi 2020; (41(6)):506-510 doi:10.3760/cma.j.issn.0253-2727.2020.06.013.

Pure red cell aplasia and seronegative myasthenia gravis in association with thymoma.

Lee SY, Gill A, Jung SM

Journal of community hospital internal medicine perspectives 2020; (10(3)):238-241 doi:10.1080/20009666.2020.1770019.

Development of pure red cell aplasia by transmission and persistent infection of parvovirus B19 through a kidney allograft.

Inoue D, Oda T, Iwama S, et al.

Transplant infectious disease : an official journal of the Transplantation Society 2021; (23(1)):e13462 doi:10.1111/tid.13462.

A Rare Presentation of Parvovirus Induced Pure Red Cell Aplasia in Elderly Male With Inclusion Body Myositis.

Mandal S, Shah R, Lowry P

Cureus 2020; (12(12)):e12095 doi:10.7759/cureus.12095.

Pure red-cell aplasia secondary to pregnancy: Case report and review of the literature.

Herrera-Quintana JF, Rojas-Figueroa AC, Aragón-Mendoza RL, et al.

Revista colombiana de obstetricia y ginecologia 2020; (71(4)):365-373 doi:10.18597/rcog.3543.

Deferasirox-associated Fanconi syndrome in adult patients with transfusional iron overload.

Yui JC, Geara A, Sayani F

Vox sanguinis 2021; (116(7)):793-797 doi:10.1111/vox.13064.

Stem Cell Transplantation for Diamond-Blackfan Anemia. A Retrospective Study on Behalf of the Severe Aplastic Anemia Working Party of the European Blood and Marrow Transplantation Group (EBMT).

Miano M, Eikema DJ, de la Fuente J, et al.

Transplantation and cellular therapy 2021; (27(3)):274.e1-274.e5 doi:10.1016/j.jtct.2020.12.024.

Management of thymoma associated autoimmune pure red cell aplasia: Case report and systematic review of the literature.

Lesire B, Durieux V, Grigoriu B, et al.

Lung cancer (Amsterdam, Netherlands) 2021; (157()):131-146 doi:10.1016/j.lungcan.2021.05.010.

Colorectal cancer screening and surveillance strategy for patients with Diamond Blackfan anemia: Preliminary recommendations from the Diamond Blackfan Anemia Registry.

Lipton JM, Molmenti CLS, Hussain M, et al.

Pediatric blood & cancer 2021; (68(8)):e28984 doi:10.1002/pbc.28984.

Low- and intermediate-risk myelodysplastic syndrome with pure red cell aplasia.

Wang H, Niu H, Zhang T, et al.

Hematology (Amsterdam, Netherlands) 2021; (26(1)):444-446 doi:10.1080/16078454.2021.1929694.

Recommendations on hematopoietic stem cell transplantation for patients with Diamond-Blackfan anemia. On behalf of the Pediatric Diseases and Severe Aplastic Anemia Working Parties of the EBMT.

Diaz-de-Heredia C, Bresters D, Faulkner L, et al.

Bone marrow transplantation 2021; (56(12)):2956-2963 doi:10.1038/s41409-021-01449-w.

Short Stature in Patients with Diamond-Blackfan Anemia: A Cross-Sectional Study.

Wan Y, Gong X, Cheng S, et al.

The Journal of pediatrics 2022; (240()):177-185 doi:10.1016/j.jpeds.2021.09.015.

[Research Progress on Pathogenesis of Congenital Pure Red Cell Aplasia---Review].

Liu WY, Wang HQ, Shao ZH

Zhongguo shi yan xue ye xue za zhi 2021; (29(5)):1654-1657 doi:10.19746/j.cnki.issn.1009-2137.2021.05.045.

Pure Red Cell Aplasia and Other Haematological Diseases Associated With Thymoma: A Case Series and Systematic Review.

Yen CC, Huang WL, Li SS, et al.

Frontiers in medicine 2021; (8()):759914 doi:10.3389/fmed.2021.759914.

Successful Treatment of Antibody-mediated Pure Red Cell Aplasia Induced by Continuous Erythropoietin Receptor Activator with Prednisolone.

Okahashi N, Kubo M, Hoshino E, et al.

Internal medicine (Tokyo, Japan) 2022; (61(14)):2209-2213 doi:10.2169/internalmedicine.8823-21.

Early Onset Colorectal Cancer: An Emerging Cancer Risk in Patients with Diamond Blackfan Anemia.

Lipton JM, Molmenti CLS, Desai P, et al.

Genes 2021; (13(1)) doi:10.3390/genes13010056.

Sirolimus is effective for refractory/relapsed/intolerant acquired pure red cell aplasia: results of a prospective single-institutional trial.

Huang Y, Chen M, Yang C, et al.

Leukemia 2022; (36(5)):1351-1360 doi:10.1038/s41375-022-01532-1.

T cell clonal expansion and STAT3 mutations: a characteristic feature of acquired chronic T cell-mediated pure red cell aplasia.

Kawakami F, Kawakami T, Yamane T, et al.

International journal of hematology 2022; (115(6)):816-825 doi:10.1007/s12185-022-03310-2.

Incidence of acquired pure red cell aplasia: a nationwide epidemiologic analysis with 2 registry databases in Japan.

Nakazawa H, Sakai K, Ohta A, et al.

Blood advances 2022; (6(24)):6282-6290 doi:10.1182/bloodadvances.2021006486.

[Clinical and pathophysiological features of acquired pure red cell aplasia: based on the concept of T-cell dysregulations].

Ishida F

[Rinsho ketsueki] The Japanese journal of clinical hematology 2022; (63(8)):893-898 doi:10.11406/rinketsu.63.893.

Adult pure red cell aplasia at Universitas Academic Hospital, Bloemfontein, South Africa: A 9-year review.

Thibile S, Barrett C, Potgieter S, et al.

South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde 2022; (112(9)):753-759 doi:10.7196/SAMJ.2022.v112i9.16416.

Parvovirus B19-Associated Severe Anemia in Adult Liver Transplant Recipients: A Case Series and Review of the Literature.

Cheng P, Jian Q, Fu Z, Ma Y

Surgical infections 2022; (23(9)):848-856 doi:10.1089/sur.2022.186.

[Pure red cell aplasia: Diagnosis, classification and treatment].

Lobbes H

La Revue de medecine interne 2023; (44(1)):19-26 doi:10.1016/j.revmed.2022.10.385.

Transfusion burden in early childhood plays an important role in iron overload in Diamond-Blackfan anaemia.

de Wilde JRA, van Dooijeweert B, van Vuren AJ, et al.

EJHaem 2022; (3(4)):1300-1304 doi:10.1002/jha2.524.

Case report: Dynamic antibody monitoring in a case of anti-recombinant human erythropoietin-mediated pure red cell aplasia with prolonged course after kidney transplantation.

Chen XM, Li H, Wu Y, et al.

Frontiers in immunology 2022; (13()):1049444 doi:10.3389/fimmu.2022.1049444.

Hepatitis C Infection Associated with Acquired Pure Red Cell Aplasia.

Teague D, Gurnari C, Awada H, et al.

Tropical medicine and infectious disease 2022; (8(1)) doi:10.3390/tropicalmed8010008.

Quantification of Liver Iron Overload with MRI: Review and Guidelines from the ESGAR and SAR.

Reeder SB, Yokoo T, França M, et al.

Radiology 2023; (307(1)):e221856 doi:10.1148/radiol.221856.

Exacerbation of autoimmune hemolytic anemia associated with pure red cell aplasia after COVID-19: A case report.

Kimura H, Furukawa M, Shiga Y, et al.

Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 2023; (29(8)):787-791 doi:10.1016/j.jiac.2023.04.002.

Pure Red Cell Aplasia Encountered in a Tertiary Care Hematology Laboratory: A Series of Nine Distinctive Cases.

Kala M, Das K, Baveja A, et al.

Journal of laboratory physicians 2023; (15(2)):316-320 doi:10.1055/s-0042-1757584.

Pure red cell aplasia: The second hundred years.

Means RT

The American journal of the medical sciences 2023; (366(3)):160-166 doi:10.1016/j.amjms.2023.06.009.

[Comparison of Cyclosporine A and Cyclosporine A Combined with Corticosteroid in the Treatment of Acquired Pure Red Cell Aplasia].

Zhang RX, Huang YZ, Han B

Zhongguo shi yan xue ye xue za zhi 2023; (31(4)):1138-1142 doi:10.19746/j.cnki.issn.1009-2137.2023.04.032.

Treatment strategy for acquired pure red cell aplasia: a systematic review and meta-analysis.

Lobbes H, Lega JC, Le Guenno G, et al.

Blood advances 2023; (7(21)):6451-6465 doi:10.1182/bloodadvances.2023010587.

Hematopoietic cell transplantation and gene therapy for Diamond-Blackfan anemia: state of the art and science.

Bhoopalan SV, Suryaprakash S, Sharma A, Wlodarski MW

Frontiers in oncology 2023; (13()):1236038 doi:10.3389/fonc.2023.1236038.

Deficiency of Adenosine Deaminase 2: Clinical Manifestations, Diagnosis, and Treatment.

Grim A, Veiga KR, Saad N

Rheumatic diseases clinics of North America 2023; (49(4)):773-787 doi:10.1016/j.rdc.2023.06.004.

The Diverse Genomic Landscape of Diamond-Blackfan Anemia: Two Novel Variants and a Mini-Review.

Pelagiadis I, Kyriakidis I, Katzilakis N, et al.

Children (Basel, Switzerland) 2023; (10(11)) doi:10.3390/children10111812.

Posttransplant complications in patients with marrow failure syndromes: are we improving long-term outcomes?

Hudda Z, Myers KC

Hematology. American Society of Hematology. Education Program 2023; (2023(1)):141-148 doi:10.1182/hematology.2023000471.

A nomogram model for predicting the efficacy of cyclosporine in patients with pure red cell aplasia.

Yang L, Niu H, Zhang T, et al.

Annals of hematology 2024; (103(6)):1877-1885 doi:10.1007/s00277-024-05636-9.

Pure Red Cell Aplasia Secondary to Parvovirus B19 Infection as a Rare Cause of Anemia in a Dialysis Patient.

Shi Y, Shi X, Wang H, et al.

Internal medicine (Tokyo, Japan) 2024; (63(19)):2647-2650 doi:10.2169/internalmedicine.2631-23.

Treatment of refractory/relapsed Diamond-Blackfan anaemia with eltrombopag.

Duncan BB, Lotter JL, Superata J, et al.

British journal of haematology 2024; (204(5)):2077-2085 doi:10.1111/bjh.19357.

Diagnosis, treatment, and surveillance of Diamond-Blackfan anaemia syndrome: international consensus statement.

Wlodarski MW, Vlachos A, Farrar JE, et al.

The Lancet. Haematology 2024; (11(5)):e368-e382 doi:10.1016/S2352-3026(24)00063-2.

Infantile Pure Red Cell Aplasia Secondary to Deficiency of Adenosine Deaminase2 (DADA2) Syndrome-Time to Think Beyond Diamond Blackfan Anemia.

Nayak AR, Dass J, Parikh H, et al.

Pediatric blood & cancer 2025; (72(6)):e31656 doi:10.1002/pbc.31656.

Clinical features and outcomes in large granular lymphocyte leukemia - associated pure red cell aplasia with STAT3 mutation.

Liu X, Chai X, Yu Q, et al.

Annals of hematology 2025; (104(4)):2351-2360 doi:10.1007/s00277-025-06371-5.

Pure Red Cell Aplasia Associated With Thymic Tumors, a Nationwide Retrospective Study.

Hemmer M, Moinard S, Lambotte O, et al.

American journal of hematology 2025; (100(12)):2230-2237 doi:10.1002/ajh.70068.

Parvovirus B19 Infection in Kidney Transplant Recipients: Clinical Spectrum, Management, and Outcomes in a Large Multicentered Indian Cohort.

Meena P, Bukka V, Bhargava V, et al.

Transplant infectious disease : an official journal of the Transplantation Society 2026; (28(3)):e70174 doi:10.1111/tid.70174.

Sustained Drug-Drug Interaction Between Cyclosporine and Apalutamide in a Patient With Metastatic Hormone-Sensitive Prostate Cancer: A Case Report and Evaluation of CYP3A4 Induction via Pregnane X Receptor Activation by Apalutamide.

Mimura Y, Sanda T, Unno R, et al.

Case reports in oncological medicine 2026; (2026()):3539500 doi:10.1155/crom/3539500.

[Pure red cell aplasia in a patient with cold agglutinin disease-associated lymphoproliferative disorder].

Ogawa M, Osada Y, Tomori A, et al.

[Rinsho ketsueki] The Japanese journal of clinical hematology 2026; (67(2)):118-123 doi:10.11406/rinketsu.67.118.

Steroid Responsiveness and Clinical Outcomes in Diamond-Blackfan Anemia: Analysis From the Canadian Inherited Marrow Failure Registry.

Choi YB, Mathew R, Li H, et al.

European journal of haematology 2026; (117(1)):267-273 doi:10.1111/ejh.70187.

Pediatric diamond-blackfan anemia after hematopoietic stem cell transplantation complicated by bronchiolitis obliterans and air-leak syndrome leading to lung transplantation: a case report with multimodal follow-up.

Zhang W, Zhao Y, Ge N, et al.

Frontiers in immunology 2026; (17()):1782188 doi:10.3389/fimmu.2026.1782188.

Clinical heterogeneity and outcome of acquired PRCA: a multicenter European study.

Versino F, Michel M, Vidler J, et al.

Blood advances 2026; (10(15)):5285-5292 doi:10.1182/bloodadvances.2025019525.

Pure Red Cell Aplasia as an Isolated Paraneoplastic Manifestation of Thymoma: A Case Report and Literature Review.

Amer H, Alajlani M, Jamle MR, et al.

Clinical case reports 2026; (14(6)):e72888 doi:10.1002/ccr3.72888.