Research & Literature

Long-term outcome of patients with acquired chronic pure red cell aplasia (PRCA) following immunosuppressive therapy: a final report of the nationwide cohort study in 2004/2006 by the Japan PRCA collaborative study group.

Hirokawa M, Sawada K, Fujishima N, et al.

British journal of haematology 2015; (169(6)):879-86 doi:10.1111/bjh.13376.

[Diagnosis and management of pure red cell aplasia].

Hirokawa M

[Rinsho ketsueki] The Japanese journal of clinical hematology 2015; (56(10)):1922-31 doi:10.11406/rinketsu.56.1922.

Clinicopathological associations of acquired erythroblastopenia.

Gunes G, Malkan UY, Yasar HA, et al.

International journal of clinical and experimental medicine 2015; (8(12)):22515-9.

Cyclosporine restores hematopoietic function by compensating for decreased Tregs in patients with pure red cell aplasia and acquired aplastic anemia.

Dao AT, Yamazaki H, Takamatsu H, et al.

Annals of hematology 2016; (95(5)):771-81 doi:10.1007/s00277-016-2629-7.

Parvovirus B19.

Landry ML

Microbiology spectrum 2016; (4(3)) doi:10.1128/microbiolspec.DMIH2-0008-2015.

Pure red cell aplasia.

Means RT

Hematology. American Society of Hematology. Education Program 2016; (2016(1)):51-56 doi:10.1182/asheducation-2016.1.51.

Refractory anemia in human immunodeficiency virus: Expect the unexpected.

Mirgh SP, Mishra VA, Shah VD, Sorabjee JS

Journal of family medicine and primary care 2016; (5(3)):727-729 doi:10.4103/2249-4863.197288.

Acquired amegakaryocytic thrombocytopenia and red cell aplasia in a patient with thymoma progressing to aplastic anemia successfully treated with allogenic stem cell transplantation.

Simkins A, Maiti A, Short NJ, et al.

Hematology/oncology and stem cell therapy 2019; (12(2)):115-118 doi:10.1016/j.hemonc.2017.09.001.

Parvovirus B19-triggered Acute Hemolytic Anemia and Thrombocytopenia in a Child with Evans Syndrome.

Zikidou P, Grapsa A, Bezirgiannidou Z, et al.

Mediterranean journal of hematology and infectious diseases 2018; (10(1)):e2018018 doi:10.4084/MJHID.2018.018.

The clinical characteristics and therapy response of patients with acquired pure red cell aplasia.

Fu R, Zhang T, Liu B, et al.

Hematology (Amsterdam, Netherlands) 2018; (23(9)):639-645 doi:10.1080/10245332.2018.1470068.

Pure red cell aplasia associated with thymoma: a report of a single-center experience.

Moriyama S, Yano M, Haneda H, et al.

Journal of thoracic disease 2018; (10(8)):5066-5072 doi:10.21037/jtd.2018.07.14.

Frequent STAT3 mutations in CD8+ T cells from patients with pure red cell aplasia.

Kawakami T, Sekiguchi N, Kobayashi J, et al.

Blood advances 2018; (2(20)):2704-2712 doi:10.1182/bloodadvances.2018022723.

Pure Red Cell Aplasia Associated with Thymolipoma: Complete Anaemia Resolution following Thymectomy.

Ferreira D, Ponraj R, Yeung A, de Malmanche J

Case reports in hematology 2018; (2018()):8627145 doi:10.1155/2018/8627145.

Strategies for managing transfusional iron overload: conventional treatments and novel strategies.

Sheth S

Current opinion in hematology 2019; (26(3)):139-144 doi:10.1097/MOH.0000000000000499.

Induced complete remission faster in adult patients with acquired pure red cell aplasia by combining cyclosporine A with corticosteroids.

Wu X, Yang Y, Lu X, et al.

Medicine 2019; (98(41)):e17425 doi:10.1097/MD.0000000000017425.

Successful sirolimus treatment of patients with pure red cell aplasia complicated with renal insufficiency.

Chen Z, Liu X, Chen M, et al.

Annals of hematology 2020; (99(4)):737-741 doi:10.1007/s00277-020-03946-2.

Etiologies and Treatment Burden in Adult Patients with Pure Red Cell Aplasia: A Single-Center Experience and Review of Literature.

Niparuck P, Kanoksil W, Wacharapornin P, et al.

Anemia 2020; (2020()):4812759 doi:10.1155/2020/4812759.

Isoniazid Induced Pure Red Blood Cell Aplasia.

Azhar W, Zaidi F, Hannan A

Cureus 2020; (12(2)):e7112 doi:10.7759/cureus.7112.

[Clinical analysis of 67 cases of pure red cell aplastic anemia].

Wang Q, Ma JX, Li BH, et al.

Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi 2020; (41(6)):506-510 doi:10.3760/cma.j.issn.0253-2727.2020.06.013.

Pure red cell aplasia and seronegative myasthenia gravis in association with thymoma.

Lee SY, Gill A, Jung SM

Journal of community hospital internal medicine perspectives 2020; (10(3)):238-241 doi:10.1080/20009666.2020.1770019.

Pure red cell aplasia in systemic lupus erythematosus, a nationwide retrospective cohort and review of the literature.

Lobbes H, Mahévas M, Alviset S, et al.

Rheumatology (Oxford, England) 2021; (61(1)):355-366 doi:10.1093/rheumatology/keab363.

Treatment for CD57-negative γδ T-cell large granular lymphocytic leukemia with pure red cell aplasia: A case report.

Xiao PP, Chen XY, Dong ZG, et al.

World journal of clinical cases 2021; (9(26)):7818-7824 doi:10.12998/wjcc.v9.i26.7818.

True thymic hyperplasia causing pure red cell aplasia: a case report.

Mohammad A, Dawson AG, Bajaj A, Rathinam S

Interactive cardiovascular and thoracic surgery 2022; (34(4)):697-699 doi:10.1093/icvts/ivab301.

Pure red cell aplasia secondary to rheumatoid arthritis: a case report.

Weerasinghe S, Karunathilake P, Ralapanawa U, et al.

Journal of medical case reports 2021; (15(1)):578 doi:10.1186/s13256-021-03141-5.

A case of synchronous triple autoimmune disorders secondary to thymoma: Pure red cell aplasia, Good's syndrome, and thymoma-associated multi-organ autoimmunity.

Nakagawa Y, Matsumoto K, Yamamoto M, et al.

Respiratory medicine case reports 2022; (36()):101619 doi:10.1016/j.rmcr.2022.101619.

Sirolimus is effective for refractory/relapsed/intolerant acquired pure red cell aplasia: results of a prospective single-institutional trial.

Huang Y, Chen M, Yang C, et al.

Leukemia 2022; (36(5)):1351-1360 doi:10.1038/s41375-022-01532-1.

Case Report: Pure Red Cell Aplasia Caused by Refractory Parvovirus B19 Infection After Pancreas Transplantation Alone.

Lindahl JP, Barlinn R, Abrahamsen IW, et al.

Frontiers in medicine 2022; (9()):849783 doi:10.3389/fmed.2022.849783.

Pure Red Cell Aplasia in a Renal Transplant Recipient: Case Report and Review of the Literature.

Nagib AM, Gheith OA, Zahab MA, et al.

Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation 2022; (20(Suppl 1)):136-139 doi:10.6002/ect.MESOT2021.P66.

Incidence of acquired pure red cell aplasia: a nationwide epidemiologic analysis with 2 registry databases in Japan.

Nakazawa H, Sakai K, Ohta A, et al.

Blood advances 2022; (6(24)):6282-6290 doi:10.1182/bloodadvances.2021006486.

Isolated Anemia in a 69-Year-Old Man with HIV-1: Features of Pure Red Cell Aplasia Mediated by Chronic Parvovirus-B19 Infection.

Wylde J, Berneri MA, Malherbe JAJ, Davel S

The American journal of case reports 2022; (23()):e936445 doi:10.12659/AJCR.936445.

[Pure red cell aplasia: Diagnosis, classification and treatment].

Lobbes H

La Revue de medecine interne 2023; (44(1)):19-26 doi:10.1016/j.revmed.2022.10.385.

Hepatitis C Infection Associated with Acquired Pure Red Cell Aplasia.

Teague D, Gurnari C, Awada H, et al.

Tropical medicine and infectious disease 2022; (8(1)) doi:10.3390/tropicalmed8010008.

STAT1 overexpression triggers aplastic anemia: a pilot study unravelling novel pathogenetic insights in bone marrow failure.

Solimando AG, Desantis V, Palumbo C, et al.

Clinical and experimental medicine 2023; (23(6)):2687-2694 doi:10.1007/s10238-023-01017-0.

High TOX expression on CD8+ T cells in pure red cell aplasia.

Niu H, Yan L, Yang L, et al.

Annals of hematology 2023; (102(5)):1247-1255 doi:10.1007/s00277-023-05174-w.

Large granular lymphocyte leukemia: An indolent clonal proliferative disease associated with an array of various immunologic disorders.

Drillet G, Pastoret C, Moignet A, et al.

La Revue de medecine interne 2023; (44(6)):295-306 doi:10.1016/j.revmed.2023.03.014.

A case report of T-LGL leukemia-associated pure red cell aplasia harboring STAT3, TNFAIP3, and KMT2D mutation.

Shen M

Translational cancer research 2023; (12(4)):1054-1059 doi:10.21037/tcr-23-326.

Pure red cell aplasia: The second hundred years.

Means RT

The American journal of the medical sciences 2023; (366(3)):160-166 doi:10.1016/j.amjms.2023.06.009.

Pure Red Cell Aplasia Associated With Thymoma.

Thangatorai R

Cureus 2023; (15(5)):e39387 doi:10.7759/cureus.39387.

Pure red cell aplasia occurring during ibrutinib therapy for chronic lymphocytic leukemia.

Wang L, Wu S, Yu G, et al.

Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners 2023; (29(8)):2031-2036 doi:10.1177/10781552231189192.

[Comparison of Cyclosporine A and Cyclosporine A Combined with Corticosteroid in the Treatment of Acquired Pure Red Cell Aplasia].

Zhang RX, Huang YZ, Han B

Zhongguo shi yan xue ye xue za zhi 2023; (31(4)):1138-1142 doi:10.19746/j.cnki.issn.1009-2137.2023.04.032.

Treatment strategy for acquired pure red cell aplasia: a systematic review and meta-analysis.

Lobbes H, Lega JC, Le Guenno G, et al.

Blood advances 2023; (7(21)):6451-6465 doi:10.1182/bloodadvances.2023010587.

[A man in his forties with anaemia requiring transfusion].

Sandnes M, Helgeland L, Johansen S, Reikvam H

Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke 2023; (143(15)) doi:10.4045/tidsskr.23.0022.

Pure Red Cell Aplasia Induced by Atezolizumab in a Patient with Small-Cell Lung Cancer Successfully Treated with Steroid Therapy: A Case Report.

Kawakado K, Ito S, Kono K, et al.

Case reports in oncology 2023; (16(1)):1592-1597 doi:10.1159/000535468.

A nomogram model for predicting the efficacy of cyclosporine in patients with pure red cell aplasia.

Yang L, Niu H, Zhang T, et al.

Annals of hematology 2024; (103(6)):1877-1885 doi:10.1007/s00277-024-05636-9.

Umbilical Cord Blood and UC-MSCs Combined with Low-Dose Immunosuppressant in the Treatment of Elderly Patients with Pure Red Cell Aplastic: A Case Series.

Zhu WW, Zhuang S, Yu Z, et al.

Current stem cell research & therapy 2025; (20(3)):350-355 doi:10.2174/011574888X290378240424075002.

Phase 1 Study of CK0801 in Treatment of Bone Marrow Failure Syndromes.

Kadia TM, Huang M, Pemmaraju N, et al.

NEJM evidence 2024; (3(6)):EVIDoa2300362 doi:10.1056/EVIDoa2300362.

Neuromyelitis Optica spectrum disorder complicated with pure red cell aplasia: a case report.

Jiang W, Wang J, Feng Y, et al.

BMC neurology 2024; (24(1)):241 doi:10.1186/s12883-024-03749-2.

[Pure white cell aplasia combined with thymoma and lung cancer: a case report and literature review].

Chen XL, Cai ZJ, Zheng R, Lin WQ

Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi 2024; (45(8)):789-793 doi:10.3760/cma.j.cn121090-20240113-00018.

[Efficacy of rituximab for idiopathic acquired pure red cell aplasia].

Sato S, Tsunoda S, Tamai Y

[Rinsho ketsueki] The Japanese journal of clinical hematology 2024; (65(11)):1393-1399 doi:10.11406/rinketsu.65.1393.

Aberrant Hematopoiesis and CD8+ T-Cell Activation in Thymoma-Associated Pure Red Cell Aplasia.

Liu M, He X, Zhang H, et al.

Thoracic cancer 2025; (16(6)):e70046 doi:10.1111/1759-7714.70046.

Spectrum of Pure Red Cell Aplasia in a Tertiary Care Hospital in Northeast India.

Dey B, Raphael V, Shangpliang DM, et al.

Cureus 2025; (17(2)):e79364 doi:10.7759/cureus.79364.

Treatment-free survival to bortezomib combined with dexamethasone in patients with refractory/relapsed pure red cell aplasia: a prospective clinical study.

Zhang L, Shen Y, Li R, et al.

Annals of medicine 2025; (57(1)):2540016 doi:10.1080/07853890.2025.2540016.

Pure Red Cell Aplasia That Developed 13 Years After Thymoma Treatment: A Case Report and Literature Review.

Kono K, Nakashima K, Tsubata Y, et al.

Thoracic cancer 2025; (16(17)):e70157 doi:10.1111/1759-7714.70157.

Pure Red Cell Aplasia Associated With Thymic Tumors, a Nationwide Retrospective Study.

Hemmer M, Moinard S, Lambotte O, et al.

American journal of hematology 2025; (100(12)):2230-2237 doi:10.1002/ajh.70068.

[Acquired pure red cell aplasia].

Nakazawa H

[Rinsho ketsueki] The Japanese journal of clinical hematology 2025; (66(9)):926-935 doi:10.11406/rinketsu.66.926.

Outcomes of allogeneic hematopoietic stem cell transplantation for acquired pure red cell aplasia.

Noguchi Y, Mori T, Onishi Y, et al.

International journal of hematology 2026; (123(4)):600-606 doi:10.1007/s12185-025-04137-3.

Phagocytosis of Lymphocytes and Erythrocytes by B-Cell Lymphoma in a Patient With a Clinical Suspicion of Pure Red Cell Aplasia.

Cao T, Li Y, Peng X

Clinical case reports 2026; (14(1)):e71750 doi:10.1002/ccr3.71750.

Disseminated human parvovirus B19 encephalitis and pure red cell aplasia unmasking immune dysregulation in angioimmunoblastic T-cell lymphoma.

Savetamornkul C, Niparuck P, Chotiprasitsakul D

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases 2026; (164()):108390 doi:10.1016/j.ijid.2026.108390.

[Pure red cell aplasia in a patient with cold agglutinin disease-associated lymphoproliferative disorder].

Ogawa M, Osada Y, Tomori A, et al.

[Rinsho ketsueki] The Japanese journal of clinical hematology 2026; (67(2)):118-123 doi:10.11406/rinketsu.67.118.

Somatic Mutations and Mutation Burden Predict Treatment Response and Survival in Adult Acquired Pure Red Cell Aplasia.

Yang L, Zhang H, Wei Y, et al.

American journal of hematology 2026; (101(7)):1443-1450 doi:10.1002/ajh.70311.

Rheumatoid arthritis flare mimicry by parvovirus B19.

Patil P, War GA, Sahoo DP, et al.

Modern rheumatology case reports 2026; (10(1)) doi:10.1093/mrcr/rxag031.

Clinical heterogeneity and outcome of acquired PRCA: a multicenter European study.

Versino F, Michel M, Vidler J, et al.

Blood advances 2026; (10(15)):5285-5292 doi:10.1182/bloodadvances.2025019525.

Pure red cell aplasia in a patient with rheumatoid arthritis after JAK inhibitor exposure-diagnostic challenges.

Rajnarinesingh S, Georgiou M, Prasannan N, Sriskandarajah P

Oxford medical case reports 2026; (2026(7)):omag125 doi:10.1093/omcr/omag125.

ESA-induced pure red cell aplasia presenting as a precipitous hemoglobin drop in end-stage renal disease.

Mui JSK

Archive of clinical cases 2026; (13(2)):38-42 doi:10.22551/2026.51.1302.10339.