Research & Literature

Intrasphenoidal Rathke's cleft cyst.

Kasliwal MK, Dua SG, Harbhajanka A, et al.

Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 2015; (22(10)):1678-82.

A Case for Conservative Management: Characterizing the Natural History of Radiographically Diagnosed Rathke Cleft Cysts.

Culver SA, Grober Y, Ornan DA, et al.

The Journal of clinical endocrinology and metabolism 2015; (100(10)):3943-8 doi:10.1210/jc.2015-2604.

Endoscopic Endonasal Approach in the Management of Rathke's Cleft Cysts.

Solari D, Cavallo LM, Somma T, et al.

PloS one 2015; (10(10)):e0139609 doi:10.1371/journal.pone.0139609.

Rapid De Novo Aneurysm Formation after Rathke Cleft Cyst Rupture.

Jimbo H, Ichikawa M, Fukami S, et al.

World neurosurgery 2016; (88()):690.e11-690.e16 doi:10.1016/j.wneu.2015.11.032.

Diagnosis and Treatment of Primary Adrenal Insufficiency: An Endocrine Society Clinical Practice Guideline.

Bornstein SR, Allolio B, Arlt W, et al.

The Journal of clinical endocrinology and metabolism 2016; (101(2)):364-89 doi:10.1210/jc.2015-1710.

Acute Adrenal Insufficiency Associated with Rathke's Cleft Cyst.

Hirayama Y, Kudo T, Kasai N

Internal medicine (Tokyo, Japan) 2016; (55(6)):639-42 doi:10.2169/internalmedicine.55.4803.

Significant Improvement in Chronic Persistent Headaches Caused by Small Rathke Cleft Cysts After Transsphenoidal Surgery.

Fukui I, Hayashi Y, Kita D, et al.

World neurosurgery 2017; (99()):362-368 doi:10.1016/j.wneu.2016.12.111.

SFE/SFEDP adrenal insufficiency French consensus: Introduction and handbook.

Reznik Y, Barat P, Bertherat J, et al.

Annales d'endocrinologie 2018; (79(1)):1-22 doi:10.1016/j.ando.2017.12.001.

Factors Affecting Visual Field Outcome Post-Surgery in Sellar Region Tumors: Retrospective Study.

Sriram PR, Sellamuthu P, Ghani ARI

The Malaysian journal of medical sciences : MJMS 2017; (24(6)):58-67 doi:10.21315/mjms2017.24.6.7.

Outcome of diabetes insipidus in patients with Rathke's cleft cysts.

Oishi M, Hayashi Y, Sasagawa Y, et al.

Clinical neurology and neurosurgery 2018; (167()):141-146 doi:10.1016/j.clineuro.2018.02.031.

Lymphocytic Hypophysitis Secondary to Ruptured Rathke Cleft Cyst: Case Report and Literature Review.

Yang C, Wu H, Bao X, Wang R

World neurosurgery 2018; (114()):172-177 doi:10.1016/j.wneu.2018.03.086.

Natural history of Rathke's cleft cysts: A retrospective analysis of a two centres experience.

Sala E, Moore JM, Amorin A, et al.

Clinical endocrinology 2018; (89(2)):178-186 doi:10.1111/cen.13744.

[Intrasellar xanthogranuloma with abscess formation in a patient with Rathke's cleft cyst].

Tsuda Y, Oguri T, Sakurai K, et al.

Rinsho shinkeigaku = Clinical neurology 2018; (58(6)):411-413 doi:10.5692/clinicalneurol.cn-001163.

Symptomatic Rathke cleft cyst in paediatric patients - clinical presentations, surgical treatment and postoperative outcomes - an analysis of 38 cases.

Prokop-Piotrkowska M, Moszczyńska E, Daszkiewicz P, et al.

Journal of pediatric endocrinology & metabolism : JPEM 2018; (31(8)):903-910 doi:10.1515/jpem-2017-0540.

Recurrent Rathke's Cleft Cysts: Incidence and Surgical Management in a Tertiary Pituitary Center over 2 Decades.

Wedemeyer MA, Lin M, Fredrickson VL, et al.

Operative neurosurgery (Hagerstown, Md.) 2019; (16(6)):675-684 doi:10.1093/ons/opy258.

CHANGE OF CENTRAL AND PERIPHERAL VISION IN PATIENT WITH SYMPTOMATIC CYST OF RATHKE'S CLEFT FOLLOWING TRANSSPHENOIDAL RESECTION.

Halička J, Haličková T, Vargončíková L, et al.

Ceska a slovenska oftalmologie : casopis Ceske oftalmologicke spolecnosti a Slovenske oftalmologicke spolecnosti 2018; (74(2)):73-78 doi:10.31348/2018/1/5-2-2018.

Emergency management of adrenal insufficiency in children: advocating for treatment options in outpatient and field settings.

Miller BS, Spencer SP, Geffner ME, et al.

Journal of investigative medicine : the official publication of the American Federation for Clinical Research 2020; (68(1)):16-25 doi:10.1136/jim-2019-000999.

Entirely Suprasellar Rathke Cleft Cysts: Clinical Features and Surgical Efficacy of Endoscopic Endonasal Transtuberculum Sellae Approach.

Hayashi Y, Kobayashi M, Sasagawa Y, et al.

World neurosurgery 2019; (126()):e921-e929 doi:10.1016/j.wneu.2019.03.011.

Recurrence of Rathke's cleft cysts based on gross total resection of cyst wall: a meta-analysis.

Lu VM, Ravindran K, Perry A, et al.

Neurosurgical review 2020; (43(3)):957-966 doi:10.1007/s10143-019-01107-2.

Adrenal crisis: prevention and management in adult patients.

Dineen R, Thompson CJ, Sherlock M

Therapeutic advances in endocrinology and metabolism 2019; (10()):2042018819848218 doi:10.1177/2042018819848218.

Prevalence of pituitary cysts in children using modern magnetic resonance imaging techniques.

Mahdi ES, Webb RL, Whitehead MT

Pediatric radiology 2019; (49(13)):1781-1787 doi:10.1007/s00247-019-04479-1.

Rathke's Cleft Cyst Apoplexy in Two Teenage Sisters.

Martinez Santos J, Hannay M, Olar A, Eskandari R

Pediatric neurosurgery 2019; (54(6)):428-435 doi:10.1159/000503112.

[Magnetic resonance imaging characteristics and differential diagnosis of common sellar cystic lesions].

Liu H, Lu X, Hang W, Liu G

Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery 2019; (54(11)):819-825 doi:10.3760/cma.j.issn.1673-0860.2019.11.004.

Usefulness of Contrast-Enhanced 3D-FLAIR MR Imaging for Differentiating Rathke Cleft Cyst from Cystic Craniopharyngioma.

Azuma M, Khant ZA, Kitajima M, et al.

AJNR. American journal of neuroradiology 2020; (41(1)):106-110 doi:10.3174/ajnr.A6359.

Prevalence of Rathke cleft cysts in children on magnetic resonance imaging.

Schmidt B, Cattin F, Aubry S

Diagnostic and interventional imaging 2020; (101(4)):209-215 doi:10.1016/j.diii.2019.12.005.

Endonasal Endoscopic Surgery for Pediatric Sellar and Suprasellar Lesions: A Systematic Review and Meta-analysis.

Lee JA, Cooper RL, Nguyen SA, et al.

Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery 2020; (163(2)):284-292 doi:10.1177/0194599820913637.

Ophthalmic Manifestations of Rathke's Cleft Cyst and Its Association to Radiological Characteristics.

Jeon H, Suh HB, Chung W, Choi HY

Current eye research 2021; (46(8)):1227-1231 doi:10.1080/02713683.2020.1863430.

[Rathke's cleft cyst in a middle-aged man with chief complaint of depression : A case report and literature review].

Liu Y, Yang J

Zhonghua nan ke xue = National journal of andrology 2020; (26(8)):736-739.

Surgery versus conservative care for Rathke's cleft cyst.

Truong LUF, Bazin C, Gomis P, et al.

Neuro-Chirurgie 2021; (67(2)):104-111 doi:10.1016/j.neuchi.2020.12.010.

Anterior pituitary function in Rathke's cleft cysts versus nonfunctioning pituitary adenomas.

Fujii M, Nakagawa A, Tachibana O, et al.

Endocrine journal 2021; (68(8)):943-952 doi:10.1507/endocrj.EJ21-0050.

Endoscopic Endonasal Resection of Symptomatic Rathke Cleft Cysts: Total Resection or Partial Resection.

Zhang X, Yang J, Huang Y, et al.

Frontiers in neurology 2021; (12()):701177 doi:10.3389/fneur.2021.701177.

Pituitary incidentaloma.

Constantinescu SM, Maiter D

Presse medicale (Paris, France : 1983) 2021; (50(4)):104081 doi:10.1016/j.lpm.2021.104081.

Imaging of Sella and Parasellar Region.

Kirsch CFE

Neuroimaging clinics of North America 2021; (31(4)):541-552 doi:10.1016/j.nic.2021.05.010.

Natural history and surgical outcome of Rathke's cleft cysts-A study from the Swedish Pituitary Registry.

Petersson M, Berinder K, Eden Engström B, et al.

Clinical endocrinology 2022; (96(1)):54-61 doi:10.1111/cen.14622.

Presenting symptoms and endocrine dysfunction in Rathke cleft cysts - a two-centre experience.

Dadej D, Skraba K, Matyjaszek-Matuszek B, et al.

Endokrynologia Polska 2021; (72(5)):505-511 doi:10.5603/EP.a2021.0091.

Diagnosis and Management of Central Diabetes Insipidus in Adults.

Tomkins M, Lawless S, Martin-Grace J, et al.

The Journal of clinical endocrinology and metabolism 2022; (107(10)):2701-2715 doi:10.1210/clinem/dgac381.

Conservative management of complicated Rathke's cleft cyst mimicking pituitary apoplexy.

Constantinescu SM, Wilms G, Furnica RM, et al.

Endocrinology, diabetes & metabolism case reports 2022; (2022()).

Natural course of Rathke's cleft cysts and risk factors for progression.

Kinoshita Y, Taguchi A, Yamasaki F, et al.

Journal of neurosurgery 2023; (138(5)):1426-1432 doi:10.3171/2022.7.JNS22716.

An Overview of Pituitary Incidentalomas: Diagnosis, Clinical Features, and Management.

Tahara S, Hattori Y, Suzuki K, et al.

Cancers 2022; (14(17)) doi:10.3390/cancers14174324.

Endoscopic Treatment of Rathke's Cleft Cysts: The Case for Simple Fenestration.

Millesi M, Lai C, Lau R, et al.

Brain sciences 2022; (12(11)) doi:10.3390/brainsci12111482.

Incidence and factors associated with the recurrence of Rathke's cleft cyst after surgery: A systematic review and meta-analysis.

Qian A, Zhou J, Zhang X, et al.

Frontiers in surgery 2022; (9()):1065316 doi:10.3389/fsurg.2022.1065316.

Differentiation of pure cystic sellar lesions on magnetic resonance imaging.

Altintas Taslicay C, Dervisoglu E, Cam I, et al.

The neuroradiology journal 2023; (36(5)):533-540 doi:10.1177/19714009221147223.

Clinical features and surgical outcomes of Rathke cleft cysts with suprasellar components: a single-center experience of 157 cases.

Qian A, Li R, Zhou J, et al.

Acta neurochirurgica 2023; (165(8)):2267-2276 doi:10.1007/s00701-023-05617-3.

Rathke's cleft cyst classification and outcomes after endoscopic endonasal approach.

Wang HK, Lee CC, Wang YC, et al.

Clinical neurology and neurosurgery 2023; (233()):107882 doi:10.1016/j.clineuro.2023.107882.

Nuclear translocation of beta catenin in patients with Rathke cleft cysts-clinical and imaging characteristics and risk of recurrence.

Schmutzer M, Thorsteinsdottir J, Weller J, et al.

Acta neurochirurgica 2023; (165(9)):2435-2444 doi:10.1007/s00701-023-05733-0.

Surgical indication of pediatric Rathke's cleft cyst based on a 20-year retrospective cohort.

Lee JS, Kim YH, Koh EJ, et al.

Journal of neurosurgery. Pediatrics 2023; (32(6)):729-738 doi:10.3171/2023.7.PEDS23181.

Intrasellar Dermoid Cyst: Case Report of a Rare Lesion and Systematic Literature Review Comparing Intrasellar, Suprasellar, and Parasellar Locations.

Donofrio CA, Bertazzoni G, Riccio L, et al.

World neurosurgery 2024; (182()):83-90 doi:10.1016/j.wneu.2023.11.057.

Endoscopic endonasal resection of Rathke cleft cysts: a single-institution analysis of 148 consecutive patients.

Algattas HN, Gersey ZC, Fernandes Cabral D, et al.

Journal of neurosurgery 2024; (141(5)):1352-1362 doi:10.3171/2024.3.JNS232740.

Natural history and surgical outcomes of Rathke's cleft cysts: a Spanish multicenter study.

Menéndez-Torre EL, Gutiérrez-Hurtado A, Ollero MD, et al.

Frontiers in endocrinology 2024; (15()):1413810 doi:10.3389/fendo.2024.1413810.

Central diabetes insipidus (vasopressin deficiency) after surgery for pituitary tumours: a systematic review and meta-analysis.

Fountas A, Coulden A, Fernández-García S, et al.

European journal of endocrinology 2024; (191(1)):S1-S13 doi:10.1093/ejendo/lvae084.

Spontaneous regression of Rathke's cleft cysts with conservative management: patient series.

Fixman B, Peterson R, Shiroishi M, et al.

Journal of neurosurgery. Case lessons 2024; (8(13)).

Treatment and Prevention of Adrenal Crisis and Family Education

Çamtosun E, Sangün Ö

Journal of clinical research in pediatric endocrinology 2025; (17(Suppl 1)):80-92 doi:10.4274/jcrpe.galenos.2024.2024-6-12-S.

Efficacy and safety of surgical management for Rathke's cleft cysts in pediatric patients: a systematic review and meta-analysis.

Punukollu A, Franklin BA, Pineda FG, et al.

Neurosurgical review 2024; (48(1)):13.

Challenges in intraoperative differentiation of craniopharyngioma and Rathke cleft cyst on endoscopic visualization.

Cherem-Kibrit M, Spektor S, Kaye AH, et al.

Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 2025; (133()):111015 doi:10.1016/j.jocn.2024.111015.

Rathke's cleft cyst: From history to molecular genetics.

Hacioglu A, Tekiner H, Altinoz MA, et al.

Reviews in endocrine & metabolic disorders 2025; (26(2)):229-260 doi:10.1007/s11154-025-09949-6.

Clinical features of Rathke's cleft cyst with secondary hypophysitis and outcomes of endoscopic transnasal surgery versus features of common Rathke's cleft cysts: a single-center retrospective cohort study.

Ehara T, Fukuhara N, Ito S, et al.

Journal of neurosurgery 2025; (143(2)):423-430 doi:10.3171/2025.1.JNS24892.

Rathke Cleft Cyst Presenting as Panhypopituitarism in an Adolescent.

Bano T, Alghamdi NN, Altwijri AJ

JCEM case reports 2025; (3(7)):luaf129 doi:10.1210/jcemcr/luaf129.

Adrenal Insufficiency in Adults: A Review.

Vaidya A, Findling J, Bancos I

JAMA 2025; (334(8)):714-725 doi:10.1001/jama.2025.5485.

Recovery of Pituitary and Visual Function After Rathke's Cleft Cyst Decompression: An 80-case Institutional Experience.

Yoshimoto H, Kato M, Ishida A, et al.

Journal of the Endocrine Society 2025; (9(8)):bvaf093 doi:10.1210/jendso/bvaf093.

The clinical picture of symptomatic Rathke cleft cysts in children.

Cebeci AN, Marx M, Trollmann R, et al.

Journal of pediatric endocrinology & metabolism : JPEM 2025; (38(12)):1317-1323 doi:10.1515/jpem-2025-0407.

Radiological Differentiation of Pituitary Adenomas From Other Sellar Masses: A Systematic Review.

Goyal R, Khaing I, Madhusuthanan AK, et al.

Cureus 2025; (17(11)):e96793 doi:10.7759/cureus.96793.

Clinical characteristics and long-term outcome in patients with Rathke's cleft cysts associated with headache.

Sasagawa Y, Nakajima R, Ichinose T, et al.

Neurosurgical review 2026; (49(1)):213 doi:10.1007/s10143-026-04141-z.

Pituitary apoplexy presenting as refractory hyponatremia.

Chandra S, Banh T, Thumma S, et al.

JCEM case reports 2026; (4(5)):luag052 doi:10.1210/jcemcr/luag052.

Development and Internal Validation of an MRI-Based Diagnostic Prediction Model for Differentiating Cystic Pituitary Adenoma and Rathke's Cleft Cyst.

Kerter EK, Unal O, Ozcan ANS

Medicina (Kaunas, Lithuania) 2026; (62(4)) doi:10.3390/medicina62040659.

Central Adrenal Insufficiency Unmasked After Pneumonia-Associated Asthma Exacerbation Leading to the Diagnosis of Rathke's Cleft Cyst in an Elderly Woman: A Case Report.

Yamamoto N, Ohta R, Yamasaki A, Sano C

Cureus 2026; (18(4)):e107114 doi:10.7759/cureus.107114.

A rare case report of panhypopituitarism and suspected pituitary apoplexy secondary to Rathke cleft cyst.

Ashchi T, Charnvitayapong P, Khan M, et al.

SAGE open medical case reports 2026; (14()):2050313X261458654 doi:10.1177/2050313X261458654.

Surgical outcomes and predictors of recurrence following endoscopic endonasal marsupialization of Rathke's cleft cysts.

Noiphithak R, Subenja S, Pongsukvechkul B, Nimmannitya P

Acta neurochirurgica 2026; (168(1)).

Visual field loss in pituitary and hypothalamic disorders.

Batra R, Alvarez LM

Best practice & research. Clinical endocrinology & metabolism 2026; (40(5)):102152 doi:10.1016/j.beem.2026.102152.

Hyponatremia as the Initial Presentation of Rathke's Cleft Cyst-Related Hypopituitarism.

Htun NL, Thinzar AN, Win HT, Thottacherry DJ

Cureus 2026; (18(8)):e114171 doi:10.7759/cureus.114171.

Hemorrhagic sellar lesion mimicking pituitary adenoma apoplexy: MRI follow-up suggesting Rathke cleft cyst.

Dier C, Sidani C, Abrams KJ, Freitas LF

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology 2026; (47(10)).

Persistent SIADH-like Hyponatremia Requiring Tolvaptan Despite Glucocorticoid Replacement in Rathke's Cleft Cyst-Associated Hypophysitis: A Therapeutic Dilemma.

Shimizu Y, Ishii R, Tanaka K, et al.

Internal medicine (Tokyo, Japan) 2026; doi:10.2169/internalmedicine.7951-26.