Research & Literature

Update on Multicystic Dysplastic Kidney.

Cardona-Grau D, Kogan BA

Current urology reports 2015; (16(10)):67 doi:10.1007/s11934-015-0541-7.

Conservative Management of Segmental Multicystic Dysplastic Kidney in Children.

Han JH, Lee YS, Kim MJ, et al.

Urology 2015; (86(5)):1013-8.

Association between renal cystic lesions and bilateral Wilms' tumours.

Simanovsky N, Revel-Vilk S, Weintraub M, Hiller N

European radiology 2016; (26(6)):1665-9 doi:10.1007/s00330-015-3976-9.

Outcome of Multi-Cystic Dysplastic Kidneys in Children.

Mashat SD, El-Desoky SM, Abdulaziz Kari J

Iranian journal of pediatrics 2015; (25(5)):e2991 doi:10.5812/ijp.2991.

Multicystic dysplastic kidney (MCDK) in the neonate: The role of the urologist.

Psooy K,

Canadian Urological Association journal = Journal de l'Association des urologues du Canada 2016; (10(1-2)):18-24 doi:10.5489/cuaj.3520.

Diagnostic accuracy of midtrimester antenatal ultrasound for multicystic dysplastic kidneys.

Scala C, McDonnell S, Murphy F, et al.

Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology 2017; (50(4)):464-469 doi:10.1002/uog.17305.

Evolution of blood pressure in children with congenital and acquired solitary functioning kidney.

Lubrano R, Gentile I, Falsaperla R, et al.

Italian journal of pediatrics 2017; (43(1)):43 doi:10.1186/s13052-017-0359-7.

Natural History of Contralateral Hypertrophy in Patients with Multicystic Dysplastic Kidneys.

Gaither TW, Patel A, Patel C, et al.

The Journal of urology 2018; (199(1)):280-286 doi:10.1016/j.juro.2017.06.075.

Chronic kidney disease and sports participation by children and adolescents.

Master Sankar Raj V, Patel DR, Ramachandran L

Translational pediatrics 2017; (6(3)):207-214 doi:10.21037/tp.2017.06.03.

Three New PAX2 Gene Mutations in Patients with Papillorenal Syndrome.

Galvez-Ruiz A, Lehner AJ, Galindo-Ferreiro A, Schatz P

Neuro-ophthalmology (Aeolus Press) 2017; (41(5)):271-278 doi:10.1080/01658107.2017.1307995.

[SOLITARY KIDNEY - IS IT TOO LITTLE?]

Cleper R

Harefuah 2018; (157(1)):58-62.

Screening for Mullerian anomalies in patients with unilateral renal agenesis: Leveraging early detection to prevent complications.

Friedman MA, Aguilar L, Heyward Q, et al.

Journal of pediatric urology 2018; (14(2)):144-149 doi:10.1016/j.jpurol.2018.01.011.

New insights into the role of HNF-1β in kidney (patho)physiology.

Ferrè S, Igarashi P

Pediatric nephrology (Berlin, Germany) 2019; (34(8)):1325-1335 doi:10.1007/s00467-018-3990-7.

Retrospective study to identify risk factors for chronic kidney disease in children with congenital solitary functioning kidney detected by neonatal renal ultrasound screening.

Urisarri A, Gil M, Mandiá N, et al.

Medicine 2018; (97(32)):e11819 doi:10.1097/MD.0000000000011819.

Advanced Imaging for the Diagnosis and Treatment of Coexistent Renal and Müllerian Abnormalities.

Coleman AD, Arbuckle JL

Current urology reports 2018; (19(11)):89 doi:10.1007/s11934-018-0840-x.

Necessity of performing voiding cystourethrography for children with unilateral multicystic dysplastic kidney.

Yamamoto K, Kamei K, Sato M, et al.

Pediatric nephrology (Berlin, Germany) 2019; (34(2)):295-299 doi:10.1007/s00467-018-4079-z.

A meta-analysis of the incidence and fate of contralateral vesicoureteral reflux in unilateral multicystic dysplastic kidney.

Erlich T, Lipsky AM, Braga LH

Journal of pediatric urology 2019; (15(1)):77.e1-77.e7 doi:10.1016/j.jpurol.2018.10.023.

Whole-Exome Sequencing Enables a Precision Medicine Approach for Kidney Transplant Recipients.

Mann N, Braun DA, Amann K, et al.

Journal of the American Society of Nephrology : JASN 2019; (30(2)):201-215 doi:10.1681/ASN.2018060575.

The clinical characteristics of Chinese patients with unilateral renal agenesis.

Xu Q, Wu H, Zhou L, et al.

Clinical and experimental nephrology 2019; (23(6)):792-798 doi:10.1007/s10157-019-01704-x.

The Incidence and Durability of Compensatory Hypertrophy in Pediatric Patients with Solitary Kidneys.

Wang MK, Gaither T, Phelps A, et al.

Urology 2019; (129()):188-193 doi:10.1016/j.urology.2019.04.003.

Knowledge of vesicoureteral reflux obtained by screening voiding cystourethrogram in children with multicystic dysplastic kidney does not change patient management or prevent febrile urinary tract infection.

Brown C, McLeod D, Ching C

Journal of pediatric urology 2019; (15(3)):267.e1-267.e5 doi:10.1016/j.jpurol.2019.03.013.

Importance of Genetic Diagnostics in Adult-Onset Focal Segmental Glomerulosclerosis.

Snoek R, Nguyen TQ, van der Zwaag B, et al.

Nephron 2019; (142(4)):351-358 doi:10.1159/000499937.

Multicystic dysplastic kidney - treat each case on its merits.

Faruque A, Narayanan S, Marley I, et al.

Journal of pediatric surgery 2020; (55(11)):2497-2503 doi:10.1016/j.jpedsurg.2019.12.008.

Voiding Cystourethrogram in Children With Unilateral Multicystic Dysplastic Kidney: Is It Still necessary?

Blachman-Braun R, Camp MM, Becerra MF, et al.

Urology 2020; (139()):156-160 doi:10.1016/j.urology.2020.02.005.

Hypoparathyroidism, deafness, and renal dysplasia syndrome: 20 Years after the identification of the first GATA3 mutations.

Lemos MC, Thakker RV

Human mutation 2020; (41(8)):1341-1350 doi:10.1002/humu.24052.

Predicting outcomes and improving care in children with congenital kidney anomalies.

Matsell DG, Catapang M

Pediatric nephrology (Berlin, Germany) 2020; (35(10)):1811-1814 doi:10.1007/s00467-020-04677-2.

Physiology and Pathophysiology of Compensatory Adaptations of a Solitary Functioning Kidney.

McArdle Z, Schreuder MF, Moritz KM, et al.

Frontiers in physiology 2020; (11()):725 doi:10.3389/fphys.2020.00725.

"Watch and Wait" Strategy for Multicystic Dysplastic Kidney (MCDK): Status Survey of Perceptions, Attitudes, and Treatment Selection in Chinese Pediatric Urologists and Pediatric Surgeons.

Wang Q, Shi Z, Jiang D

Frontiers in pediatrics 2020; (8()):423 doi:10.3389/fped.2020.00423.

High Activation of the AKT Pathway in Human Multicystic Renal Dysplasia.

Apostolou A, Poreau B, Delrieu L, et al.

Pathobiology : journal of immunopathology, molecular and cellular biology 2020; (87(5)):302-310 doi:10.1159/000509152.

Clinical impact of genomic testing in patients with suspected monogenic kidney disease.

Jayasinghe K, Stark Z, Kerr PG, et al.

Genetics in medicine : official journal of the American College of Medical Genetics 2021; (23(1)):183-191 doi:10.1038/s41436-020-00963-4.

EARLY ONSET OF MODY5 DUE TO HAPLOINSUFFICIENCY OF HNF1B.

Bustamante C, Sanchez J, Seeherunvong T, Ukarapong S

AACE clinical case reports 2020; (6(5)):e243-e246 doi:10.4158/ACCR-2020-0161.

Renal cystic diseases during the perinatal and neonatal period.

Raina R, DeCoy M, Chakraborty R, et al.

Journal of neonatal-perinatal medicine 2021; (14(2)):163-176 doi:10.3233/NPM-200520.

Multicystic Dysplastic Kidney: Prenatal Compensatory Renal Growth Pattern.

Gilad N, Weissmann-Brenner A, Gilboa Y, et al.

Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine 2021; (40(10)):2165-2171 doi:10.1002/jum.15605.

Prenatal diagnosis and outcome of unilateral multicystic kidney.

Turkyilmaz G, Cetin B, Erturk E, et al.

Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology 2021; (41(7)):1071-1075 doi:10.1080/01443615.2020.1845631.

Do children with solitary or hypofunctioning kidney have the same prevalence for masked hypertension?

Yel S, Günay N, Pınarbaşı AS, et al.

Pediatric nephrology (Berlin, Germany) 2021; (36(7)):1833-1841 doi:10.1007/s00467-020-04896-7.

Retrospective evaluation of children with unilateral renal agenesis.

Güngör T, Yazılıtaş F, Çakıcı EK, et al.

Pediatric nephrology (Berlin, Germany) 2021; (36(9)):2847-2855 doi:10.1007/s00467-021-05027-6.

Hnf1b haploinsufficiency differentially affects developmental target genes in a new renal cysts and diabetes mouse model.

Niborski LL, Paces-Fessy M, Ricci P, et al.

Disease models & mechanisms 2021; (14(5)) doi:10.1242/dmm.047498.

New PAX2 Mutation Associated with Polycystic Kidney Disease: A Case Report.

Forero-Delgadillo JM, Ochoa V, Duque N, et al.

Clinical medicine insights. Pediatrics 2021; (15()):1179556521992354 doi:10.1177/1179556521992354.

Renal function in children with a congenital solitary functioning kidney: A systematic review.

Hutchinson KA, Halili L, Guerra A, et al.

Journal of pediatric urology 2021; (17(4)):556-565 doi:10.1016/j.jpurol.2021.03.001.

Predictors of poor neonatal outcomes in fetuses diagnosed with congenital urinary tract anomalie.

Pop-Trajkovic Dinic S, Zivadinovic R, Stefanovic M, et al.

Ginekologia polska 2021; doi:10.5603/GP.a2021.0032.

Evaluation of renal injury in children with a solitary functioning kidney.

Balkı HG, Turhan P, Candan C

Turkish archives of pediatrics 2021; (56(3)):219-223 doi:10.5152/TurkArchPediatr.2021.20095.

Prevalence of reflux nephropathy in Iranian children with solitary kidney: results of a multi-center study.

Esteghamati M, Sorkhi H, Mohammadjafari H, et al.

BMC nephrology 2022; (23(1)):70 doi:10.1186/s12882-022-02703-z.

A case of right hypodysplastic kidney and ectopic ureter associated with bicornuate uterus in a prepubertal girl.

Nakamura M, Kanda S, Kajiho Y, et al.

CEN case reports 2023; (12(1)):122-129 doi:10.1007/s13730-022-00730-1.

Uncovering risk factors for kidney injury in children with a solitary functioning kidney.

Groen In 't Woud S, Roeleveld N, Westland R, et al.

Kidney international 2023; (103(1)):156-165 doi:10.1016/j.kint.2022.09.028.

Unilateral multicystic dysplastic kidney disease associated with ipsilateral ureteric bud remnant and contralateral duplex collecting system.

Nugraha HG, Adibrata ASP

Radiology case reports 2023; (18(6)):2289-2292 doi:10.1016/j.radcr.2023.03.048.

The Outcome of Multicystic Dysplastic Kidney Disease Patients at King Abdulaziz Medical City in Riyadh.

Alamir A, Al Rasheed SA, Al Qahtani AT, et al.

Cureus 2023; (15(4)):e37994 doi:10.7759/cureus.37994.

New insights from trio whole-exome sequencing in the children with kidney disease: A single-center retrospective cohort study.

Chen Y, Zhang Y, Huang J, et al.

Molecular genetics & genomic medicine 2023; (11(7)):e2163 doi:10.1002/mgg3.2163.

PAX2 Gene Mutation in Pediatric Renal Disorders-A Narrative Review.

Muntean C, Chirtes C, Baczoni B, Banescu C

International journal of molecular sciences 2023; (24(16)) doi:10.3390/ijms241612737.

Müllerian anomalies in girls with congenital solitary kidney.

Walawender L, Santhanam N, Davies B, et al.

Pediatric nephrology (Berlin, Germany) 2024; (39(6)):1783-1789 doi:10.1007/s00467-023-06266-5.

A Narrative Review of Contact Sports Participation in Children and Young Athletes With a Solitary (Functioning) Kidney.

Coghlan K, McDermott J, Molloy M, et al.

The American journal of sports medicine 2024; (52(11)):2939-2947 doi:10.1177/03635465231216341.

Multicystic renal dysplasia, a histomorphological spectrum: Seven years experience from a tertiary care hospital.

Gupta K, Mandal S, Mallya V, et al.

Indian journal of pathology & microbiology 2024; (67(2)):385-389 doi:10.4103/ijpm.ijpm_202_23.

Single-Center Experience of Pediatric Cystic Kidney Disease and Literature Review.

Grlić S, Gregurović V, Martinić M, et al.

Children (Basel, Switzerland) 2024; (11(4)) doi:10.3390/children11040392.

Practical Approach to Congenital Anomalies of the Kidneys: Focus on Anomalies With Insufficient or Abnormal Nephron Development: Renal Dysplasia, Renal Hypoplasia, and Renal Tubular Dysgenesis.

Gazeu A, Collardeau-Frachon S

Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society 2024; (27(5)):459-493 doi:10.1177/10935266241239241.

Heterozygous variants in the teashirt zinc finger homeobox 3 (TSHZ3) gene in human congenital anomalies of the kidney and urinary tract.

Kesdiren E, Martens H, Brand F, et al.

European journal of human genetics : EJHG 2025; (33(1)):44-55 doi:10.1038/s41431-024-01710-y.

Supporting Infants with Multicystic Dysplastic Kidney Disease: A Comprehensive Approach.

Baker HM, Jnah AJ

Neonatal network : NN 2024; (43(5)):286-294 doi:10.1891/NN-2024-0007.

Subclinical target organ damage in a sample of children and adolescents with solitary functioning kidney. A pilot study.

Tagetti A, Cattazzo F, Marcon D, et al.

Journal of hypertension 2025; (43(2)):221-227 doi:10.1097/HJH.0000000000003857.

Renal dysplasia development and chronic kidney disease.

Zhang L, Yang C, Liu X, et al.

Pediatric research 2025; (98(4)):1212-1222 doi:10.1038/s41390-025-03950-0.

Clinical Characteristics and Outcomes of Children with Unilateral Multicystic Dysplastic Kidney: A Cohort Study.

Vandana G, Karunakar P, Krishnasamy S, et al.

Indian pediatrics 2025; (62(3)):203-209 doi:10.1007/s13312-025-00006-8.

A Novel Synonymous Variant of PAX2 in Monochorionic Diamniotic Twins With Bilateral Renal Agenesis: A Case Report and Literature Review.

Yao W, Xu B, Wang H, et al.

Molecular genetics & genomic medicine 2025; (13(6)):e70113 doi:10.1002/mgg3.70113.

Clinical outcome of children with prenatally diagnosed isolated unilateral multicystic dysplastic kidney.

Huettinger M, Bogner G, Fischer T, et al.

European journal of obstetrics, gynecology, and reproductive biology 2025; (312()):114112 doi:10.1016/j.ejogrb.2025.114112.

Kidney Agenesis and Müllerian Duct Anomalies: A Report of Two Cases and Literature Review.

Donielaitė-Anisė K, Marozas R, Bumbulienė Ž, Jankauskienė A

Acta medica Lituanica 2025; (32(1)):229-235 doi:10.15388/Amed.2025.32.1.7.

From Intermittent Knee Pain to End-Stage Kidney Disease: An Atypical Presentation of Bilateral Kidney Dysplasia in an 11-Year-Old Girl.

Kim K, Araya C, Brogan R

Case reports in pediatrics 2025; (2025()):8856638 doi:10.1155/crpe/8856638.

Association Between Multicystic Dysplastic Kidney and the Local Renin-Angiotensin-Aldosterone System: A Pilot Study of a New Biomarker.

Ishimori S, Ishiko S, Fujimura J, et al.

Nephrology (Carlton, Vic.) 2025; (30(10)):e70132 doi:10.1111/nep.70132.

Multicystic dysplastic kidneys (MCDK) during prenatal life and postnatal outcome.

Reinhardt CJM, Henrich W, Verlohren S, et al.

Archives of gynecology and obstetrics 2025; (312(6)):2131-2146 doi:10.1007/s00404-025-08197-y.

Bilateral multicystic dysplastic kidney disease in a Fetus: A rare case with a fatal outcome.

Pedun B, Pitua I, Bongomin F, Tumusiime C

Urology case reports 2025; (63()):103259 doi:10.1016/j.eucr.2025.103259.

Prenatal diagnosis to postnatal outcomes in multicystic dysplastic kidney: experience of a tertiary center in the Black Sea region.

Ünver G, Serin S, Tosun M, et al.

Revista da Associacao Medica Brasileira (1992) 2025; (71(12)):e20251175 doi:10.1590/1806-9282.20251175.

Presence And Laterality Of Endometriosis In Adolescent Patients With Obstructed Müllerian Duct Anomalies, A Twenty-Three Year Retrospective Cohort Analysis Between 2002 - 2025 At An Australian Quaternary Paediatric And Adolescent Gynaecology Service.

Skalecki SL, Ballard EL, Baartz DL, Kimble RMN

Journal of pediatric and adolescent gynecology 2026; doi:10.1016/j.jpag.2026.01.002.

From Pelvis to Groin: Non-Communicating Rudimentary Uterine Horn and Endometriosis Presenting as an Inguinal Hernia in a Woman with a Solitary Pelvic Kidney.

Xu G, Li W, Qu J

International journal of women's health 2026; (18()):581854 doi:10.2147/IJWH.S581854.