Research & Literature

Additional evidence that rosacea pathogenesis may involve demodex: new information from the topical efficacy of ivermectin and praziquantel.

Abokwidir M, Fleischer AB

Dermatology online journal 2015; (21(9)).

Maintenance of remission following successful treatment of papulopustular rosacea with ivermectin 1% cream vs. metronidazole 0.75% cream: 36-week extension of the ATTRACT randomized study.

Taieb A, Khemis A, Ruzicka T, et al.

Journal of the European Academy of Dermatology and Venereology : JEADV 2016; (30(5)):829-36 doi:10.1111/jdv.13537.

Patients with Rosacea Have Increased Risk of Depression and Anxiety Disorders: A Danish Nationwide Cohort Study.

Egeberg A, Hansen PR, Gislason GH, Thyssen JP

Dermatology (Basel, Switzerland) 2016; (232(2)):208-13 doi:10.1159/000444082.

Updating the diagnosis, classification and assessment of rosacea: recommendations from the global ROSacea COnsensus (ROSCO) panel.

Tan J, Almeida LM, Bewley A, et al.

The British journal of dermatology 2017; (176(2)):431-438 doi:10.1111/bjd.15122.

Ocular acne rosacea in tertiary eye center in Saudi Arabia.

Al-Amry MA, Al-Ghadeer HA

International ophthalmology 2018; (38(1)):59-65 doi:10.1007/s10792-016-0420-3.

Clinical characteristics and epidermal barrier function of papulopustular rosacea: A comparison study with acne vulgaris.

Zhou M, Xie H, Cheng L, Li J

Pakistan journal of medical sciences 2016; (32(6)):1344-1348 doi:10.12669/pjms.326.11236.

Rosacea is associated with Helicobacter pylori: a systematic review and meta-analysis.

Jørgensen AR, Egeberg A, Gideonsson R, et al.

Journal of the European Academy of Dermatology and Venereology : JEADV 2017; (31(12)):2010-2015 doi:10.1111/jdv.14352.

Role of Demodex mite infestation in rosacea: A systematic review and meta-analysis.

Chang YS, Huang YC

Journal of the American Academy of Dermatology 2017; (77(3)):441-447.e6 doi:10.1016/j.jaad.2017.03.040.

The dermatology life quality index (DLQI) and the hospital anxiety and depression (HADS) in Chinese rosacea patients.

Wu Y, Fu C, Zhang W, et al.

Psychology, health & medicine 2018; (23(4)):369-374 doi:10.1080/13548506.2017.1361540.

Role of Topical Oxymetazoline for Management of Erythematotelangiectatic Rosacea.

Hoover RM, Erramouspe J

The Annals of pharmacotherapy 2018; (52(3)):263-267 doi:10.1177/1060028017740139.

Nasal tip schwannoma mimicking rhinophyma.

Geyton T, Henderson AH, Morris J, McDonald S

BMJ case reports 2017; (2017()) doi:10.1136/bcr-2017-223495.

Rosacea: Epidemiology, pathogenesis, and treatment.

Rainer BM, Kang S, Chien AL

Dermato-endocrinology 2017; (9(1)):e1361574 doi:10.1080/19381980.2017.1361574.

Quality of Life in Individuals with Erythematotelangiectatic and Papulopustular Rosacea: Findings From a Web-based Survey.

Zeichner JA, Eichenfield LF, Feldman SR, et al.

The Journal of clinical and aesthetic dermatology 2018; (11(2)):47-52.

Effects of combined oral doxycycline and topical cyclosporine treatment on ocular signs, symptoms, and tear film parameters in rosacea patients.

Bilgin B, Karadag AS

Arquivos brasileiros de oftalmologia 2018; (81(6)):466-470 doi:10.5935/0004-2749.20180093.

Interventions for rosacea based on the phenotype approach: an updated systematic review including GRADE assessments.

van Zuuren EJ, Fedorowicz Z, Tan J, et al.

The British journal of dermatology 2019; (181(1)):65-79 doi:10.1111/bjd.17590.

Recommendations for rosacea diagnosis, classification and management: update from the global ROSacea COnsensus 2019 panel.

Schaller M, Almeida LMC, Bewley A, et al.

The British journal of dermatology 2020; (182(5)):1269-1276 doi:10.1111/bjd.18420.

Real-life experience on effectiveness and tolerability of topical ivermectin in papulopustular rosacea and antiparasitic effect on Demodex mites.

Trave I, Merlo G, Cozzani E, Parodi A

Dermatologic therapy 2019; (32(6)):e13093 doi:10.1111/dth.13093.

Dermoscopy in the differential diagnosis between malar rash of systemic lupus erythematosus and erythematotelangiectatic rosacea: an observational study.

Errichetti E, Lallas A, De Marchi G, et al.

Lupus 2019; (28(13)):1583-1588 doi:10.1177/0961203319882493.

ADAMDEC1 promotes skin inflammation in rosacea via modulating the polarization of M1 macrophages.

Liu T, Deng Z, Xie H, et al.

Biochemical and biophysical research communications 2020; (521(1)):64-71 doi:10.1016/j.bbrc.2019.10.073.

Pediatric Ocular Acne Rosacea: Clinical Features and Long Term Follow-Up of Sixteen Cases.

Donmez O, Akova YA

Ocular immunology and inflammation 2021; (29(1)):57-65 doi:10.1080/09273948.2019.1668951.

Efficacy and safety results of micellar water, cream and serum for rosacea in comparison to a control group.

Guertler A, Jøntvedt NM, Clanner-Engelshofen BM, et al.

Journal of cosmetic dermatology 2020; (19(10)):2627-2633 doi:10.1111/jocd.13591.

Ocular Symptoms of Rosacea.

Beran D, Stepanov A, Studnička J, Jirásková N

Ceska a slovenska oftalmologie : casopis Ceske oftalmologicke spolecnosti a Slovenske oftalmologicke spolecnosti 2020; (75(6)):329-333 doi:10.31348/2019/6/6.

COVID-19 related masks increase severity of both acne (maskne) and rosacea (mask rosacea): Multi-center, real-life, telemedical, and observational prospective study.

Damiani G, Gironi LC, Grada A, et al.

Dermatologic therapy 2021; (34(2)):e14848 doi:10.1111/dth.14848.

A randomized, controlled, split-face study of topical timolol maleate 0.5% eye drops for the treatment of erythematotelangiectatic rosacea.

Wei D, Hamblin MR, Wen X

Journal of cosmetic dermatology 2021; (20(12)):3968-3973 doi:10.1111/jocd.14347.

Association of rosacea with depression and anxiety: A systematic review and meta-analysis.

Chang HC, Huang YC, Lien YJ, Chang YS

Journal of affective disorders 2022; (299()):239-245 doi:10.1016/j.jad.2021.12.008.

Rosacea and Dry Eye Disease.

Sobolewska B, Schaller M, Zierhut M

Ocular immunology and inflammation 2022; (30(3)):570-579 doi:10.1080/09273948.2021.2025251.

Aging-Conferred SIRT7 Decline Inhibits Rosacea-Like Skin Inflammation by Modulating Toll-Like Receptor 2‒NF-κB Signaling.

Li G, Tang X, Zhang S, et al.

The Journal of investigative dermatology 2022; (142(10)):2580-2590.e6 doi:10.1016/j.jid.2022.03.026.

A cream containing the sap of oat plantlets and mandarin extract soothes the symptoms of rosacea and improves the quality of life of patients.

Fabbrocini G, Monteil CB, Carballido F

Journal of the European Academy of Dermatology and Venereology : JEADV 2022; (36 Suppl 8()):3-11 doi:10.1111/jdv.18201.

Paediatric ocular rosacea: diagnosis and management with an eyelid-warming device and topical azithromycin 1.5.

Brémond-Gignac D, Navel V, Doan S, Chiambaretta F

Journal francais d'ophtalmologie 2022; (45(10)):1150-1159 doi:10.1016/j.jfo.2022.01.003.

Papulopustular Rosacea Treated With Ivermectin 1% Cream: Remission of the Demodex Mite Infestation Over Time and Evaluation of Clinical Relapses.

Trave I, Micalizzi C, Cozzani E, et al.

Dermatology practical & conceptual 2022; (12(4)):e2022201 doi:10.5826/dpc.1204a201.

A Review of the Challenges and Nuances in Treating Rosacea in Asian Skin Types Using Cleansers and Moisturizers as Adjuncts.

Kulthanan K, Andriessen A, Jiang X, et al.

Journal of drugs in dermatology : JDD 2023; (22(1)):45-53 doi:10.36849/JDD.7021.

The Psychosocial Impact of Chronic Facial Dermatoses in Adults.

Ozcan Y, Sungur MA, Ozcan BY, et al.

Dermatology practical & conceptual 2023; (13(1)) doi:10.5826/dpc.1301a29.

Preferred practice patterns and review on rosacea.

Patel NV, Gupta N, Shetty R

Indian journal of ophthalmology 2023; (71(4)):1382-1390 doi:10.4103/IJO.IJO_2983_22.

Efficacy and safety of antibiotic agents in the treatment of rosacea: a systemic network meta-analysis.

Xiao W, Chen M, Wang B, et al.

Frontiers in pharmacology 2023; (14()):1169916 doi:10.3389/fphar.2023.1169916.

Patient Education with New Media Integration Self-Management Support Model Improves Therapeutic Outcomes of Rosacea Patients.

Liu X, Kim MK, Du D, et al.

Patient preference and adherence 2023; (17()):2395-2400 doi:10.2147/PPA.S431955.

Increased risk of sleep disturbances in patients with rosacea: A nationwide population-based cohort study.

Chae K, Cho M, Kim S, Woo YR

The Journal of dermatology 2024; (51(1)):70-75 doi:10.1111/1346-8138.17012.

Spontaneous bilateral corneal perforation in ocular Rosacea.

Pellegrini F, Vincigiuerra A, Maria A

European journal of ophthalmology 2024; (34(3)):NP5-NP7 doi:10.1177/11206721231212087.

Rosacea: Practical Guidance and Challenges for Clinical Management.

Nguyen C, Kuceki G, Birdsall M, et al.

Clinical, cosmetic and investigational dermatology 2024; (17()):175-190 doi:10.2147/CCID.S391705.

Ocular Rosacea: Don't Forget Eyelids and Skin in the Assessment of This Stubborn Ocular Surface Disease.

Khadamy J

Cureus 2024; (16(1)):e51439 doi:10.7759/cureus.51439.

S100A9 Exacerbates the Inflammation in Rosacea through Toll-Like Receptor 4/MyD88/NF-κB Signaling Pathway.

Le Y, Zhang J, Lin Y, et al.

The Journal of investigative dermatology 2024; (144(9)):1985-1993.e1 doi:10.1016/j.jid.2024.02.012.

A Review of Intense Pulsed Light in the Treatment of Ocular Rosacea.

Shergill M, Khaslavsky S, Avraham S, et al.

Journal of cutaneous medicine and surgery 2024; (28(4)):370-374 doi:10.1177/12034754241254051.

Health-related Quality of Life of Patients with Rosacea: A Systematic Review and Meta-analysis of Real-world Data.

Chiu CW, Tsai J, Huang YC

Acta dermato-venereologica 2024; (104()):adv40053 doi:10.2340/actadv.v104.40053.

Genetic analyses reveal association between rosacea and cardiovascular diseases.

Gao Y, Xu C, Yan Q

Scientific reports 2025; (15(1)):6657 doi:10.1038/s41598-025-91240-4.

Efficacy and safety of non-fractional ablative carbon dioxide laser resurfacing for the treatment of rhinophyma - a retrospective cohort and questionnaires-based study.

Noyman Y, Friedman HO, Lapidoth M, et al.

Lasers in medical science 2025; (40(1)):261 doi:10.1007/s10103-025-04442-7.

[Prevalence and risk of small intestinal bacterial overgrowth in patients with rosacea: A systematic review and meta-analysis].

Khurmatullina АR, Kucheryavyy YA, Andreev DN, et al.

Terapevticheskii arkhiv 2025; (97(7)):580-586 doi:10.26442/00403660.2025.07.203297.

Treatment management for rosacea: current pharmacological and non-pharmacological options.

Volk K, Ulfers A, Yi RC, et al.

Expert review of clinical pharmacology 2025; (18(8)):589-605 doi:10.1080/17512433.2025.2550727.

No Causal Relationship Between Helicobacter Pylori Infection and Rosacea: A 2-Sample Mendelian Randomization Study.

Qiu Y, Shen S, Zhang Y

Clinical, cosmetic and investigational dermatology 2025; (18()):2359-2365 doi:10.2147/CCID.S543236.

The exposomal imprint on rosacea: More than skin deep.

Grafanaki K, Bakoli Sgourou D, Maniatis A, Pasmatzi E

Journal of the European Academy of Dermatology and Venereology : JEADV 2026; (40(3)):387-403 doi:10.1111/jdv.70112.

Exploring New Dimensions in Longitudinal Rosacea Management.

Schaller M, Welsh B, Micali G, et al.

Dermatology and therapy 2026; (16(2)):741-761 doi:10.1007/s13555-025-01612-x.

Evaluating the Efficacy of Five-Blades Scratcher Surgery in Rhinophyma Treatment: A 3D Reconstruction Approach.

He XF, Wang DM, Bai Y, et al.

The Journal of craniofacial surgery 2026; (37(3-4)):e260-e263 doi:10.1097/SCS.0000000000012214.