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PubMed This is a summary of 11 peer-reviewed journal articles Updated
Ophthalmology

Symptoms and "Sneaky" Sources of Steroid Exposure

At a Glance

Steroid-induced glaucoma is often completely asymptomatic in its early stages, earning it the name "silent thief of sight." High eye pressure can be triggered not just by eye drops, but by hidden steroid sources like nasal sprays, asthma inhalers, skin creams, and joint injections.

Steroid-induced glaucoma is often referred to as a silent thief of sight [1]. This is because high pressure inside the eye typically does not cause pain, redness, or immediate vision changes [2]. By the time a person notices a problem, significant damage may have already occurred. Understanding the subtle signs and identifying “hidden” sources of steroids is the first step in protecting your vision.

The Lack of Symptoms

In its early and moderate stages, steroid-induced glaucoma is almost always asymptomatic, meaning you will not feel anything unusual [1]. The eye does not have “pressure sensors” that notify you when the internal fluid is building up.

If the condition advances without treatment, you may experience:

  • Peripheral Vision Loss: The edges of your vision begin to fade, a process so gradual it often goes unnoticed [3].
  • Tunnel Vision: In advanced stages, it may feel as though you are looking through a narrow tube as your side vision disappears completely [2].
  • Blurred Vision: If eye pressure spikes very high very quickly, the cornea (the clear front window of the eye) can swell, causing vision to become hazy or blurry [3].

“Sneaky” Sources of Steroids

Many patients are surprised to learn that medications used far away from the eyes can still affect eye pressure. Steroids can be absorbed into your bloodstream and travel to the eye’s drainage system [4]. Common sources include:

  • Dermatological Creams: Over-the-counter or prescription creams for eczema, psoriasis, or rashes [5].
  • Nasal Sprays: Medications used daily for seasonal allergies or hay fever [4].
  • Inhalers: Standard treatments for asthma or COPD (Chronic Obstructive Pulmonary Disease) [6].
  • Joint Injections: Cortisone shots given by an orthopedist for knee, hip, or shoulder pain [7].
  • Oral Medications: Pills like prednisone used for autoimmune flares or severe allergic reactions [8].

The Challenge of Intravitreal Implants

A specific type of treatment called an intravitreal implant (such as Ozurdex) presents a unique situation [9]. These are small devices injected directly into the vitreous (the gel-like center of the eye) to treat retinal conditions.

Unlike eye drops, which you can stop using if your pressure rises, an implant is designed to stay in the eye and release medication slowly over several months [10]. Pressure spikes from these implants usually peak between 30 and 90 days after the injection [9]. If you have an implant, your doctor will need to monitor your pressure closely for several months, as the “source” of the steroid cannot be easily removed [11].

Common questions in this guide

What are the early symptoms of steroid-induced glaucoma?
In its early and moderate stages, steroid-induced glaucoma is almost always completely asymptomatic. The eye does not have internal pressure sensors, so rising pressure does not cause pain, redness, or immediate vision changes.
Can eczema cream or nasal sprays affect my eye pressure?
Yes, steroids from skin creams, nasal sprays, or asthma inhalers can be absorbed into your bloodstream. Once in the body, these medications can travel to the eye's drainage system and cause your eye pressure to rise.
What happens to my vision if steroid-induced glaucoma gets worse?
If the condition advances without treatment, you may slowly lose your peripheral or side vision. As it worsens, this can progress to tunnel vision or blurred vision caused by swelling in the cornea.
How do intravitreal steroid implants affect eye pressure?
Implants like Ozurdex release steroid medication slowly over several months and cannot be easily removed. Because of this, your eye pressure usually peaks between 30 and 90 days after the injection and requires close monitoring by your doctor.

Questions to Ask Your Doctor

Curated prompts to bring to your next appointment.

  1. 1.Which of my current medications (including sprays, creams, or inhalers) contain steroids?
  2. 2.Is the dose I am taking high enough to be concerned about my eye pressure?
  3. 3.If I received an injection like Ozurdex, when should my peak pressure window be, and how often will you check it?
  4. 4.Are there non-steroidal alternatives for my asthma, allergies, or skin condition that we should consider?

Questions For You

Tap a prompt to share your answer — we'll use it plus this page's context to start a tailored conversation.

References

References (11)
  1. 1

    Steroid-induced Glaucoma: An Avoidable Irreversible Blindness.

    Phulke S, Kaushik S, Kaur S, Pandav SS

    Journal of current glaucoma practice 2017; (11(2)):67-72 doi:10.5005/jp-journals-l0028-1226.

    PMID: 28924342
  2. 2

    Managing Bilateral Vernal Keratoconjunctivitis, Keratoconus, and Steroid-Induced Glaucoma: A Threefold Struggle.

    Maffar NH, Azhany Y, Mohd Ghazali NAS, Muhammed J

    Cureus 2025; (17(1)):e77901 doi:10.7759/cureus.77901.

    PMID: 39991424
  3. 3

    Steroid-induced glaucoma: an avoidable cause of irreversible blindness.

    Teo BHK, Au Eong JTW, Au Eong KG

    BMJ case reports 2023; (16(9)) doi:10.1136/bcr-2023-254709.

    PMID: 37666571
  4. 4

    The short-term effects of intranasal steroids on intraocular pressure in pediatric population.

    Ozturk T, Durmaz Engin C, Koksaldi S, Arikan G

    International ophthalmology 2022; (42(12)):3821-3827 doi:10.1007/s10792-022-02402-6.

    PMID: 35819739
  5. 5

    Risk of ocular hypertension in children treated with systemic glucocorticoid.

    Krag S, Larsen D, Albertsen BK, Glerup M

    Acta ophthalmologica 2021; (99(8)):e1430-e1434 doi:10.1111/aos.14820.

    PMID: 33629533
  6. 6

    Effect of Long-term Oral Steroids on Intraocular Pressure in Children With Autoimmune Hepatitis: a Prospective Cohort Study.

    Prasad D, Poddar U, Kanaujia V, et al.

    Journal of glaucoma 2019; (28(10)):929-933 doi:10.1097/IJG.0000000000001352.

    PMID: 31453897
  7. 7

    Intra-articular spine injections of steroid as a contributing factor to glaucoma.

    Qin Q, Casson RJ, Myers D, Cugati S

    Clinical & experimental ophthalmology 2020; (48(5)):703-705 doi:10.1111/ceo.13735.

    PMID: 32083765
  8. 8

    Steroid-induced glaucoma in the pediatric population.

    Nuyen B, Weinreb RN, Robbins SL

    Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus 2017; (21(1)):1-6 doi:10.1016/j.jaapos.2016.09.026.

    PMID: 28087345
  9. 9

    Incidence and risk factors of ocular hypertension following ıntravitreal dexamethasone implantation: the role of baseline intraocular pressure.

    Ertan E, Çelen İ, Gül C

    International ophthalmology 2025; (45(1)):233 doi:10.1007/s10792-025-03605-3.

    PMID: 40478293
  10. 10

    Effects of Repeated Intravitreal Injections of Dexamethasone Implants on Intraocular Pressure: A 4-Year Study.

    Pacella E, Loffredo L, Malvasi M, et al.

    Clinical ophthalmology (Auckland, N.Z.) 2020; (14()):3611-3617 doi:10.2147/OPTH.S265691.

    PMID: 33154620
  11. 11

    Secondary ocular hypertension post intravitreal dexamethasone implant (OZURDEX) managed by pars plana implant removal along with trabeculectomy in a young patient.

    David RL, Sen P

    Oman journal of ophthalmology 2020; (13(2)):92-94 doi:10.4103/ojo.OJO_40_2018.

    PMID: 32792805

This page provides educational information about the symptoms and hidden sources of steroid-induced glaucoma. Always consult your ophthalmologist or healthcare provider before starting, stopping, or changing any prescribed medications.

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