Research & Literature

Th1 and Th17 cytokines drive inflammation in Takayasu arteritis.

Saadoun D, Garrido M, Comarmond C, et al.

Arthritis & rheumatology (Hoboken, N.J.) 2015; (67(5)):1353-60 doi:10.1002/art.39037.

Assessment of Patients with Takayasu Arteritis in Routine Practice with Indian Takayasu Clinical Activity Score.

Alibaz-Oner F, Aydin SZ, Akar S, et al.

The Journal of rheumatology 2015; (42(8)):1443-7 doi:10.3899/jrheum.140817.

Current Clinical Features of New Patients With Takayasu Arteritis Observed From Cross-Country Research in Japan: Age and Sex Specificity.

Watanabe Y, Miyata T, Tanemoto K

Circulation 2015; (132(18)):1701-9 doi:10.1161/CIRCULATIONAHA.114.012547.

MRI parametric monitoring of biological therapies in primary large vessel vasculitides: a pilot study.

Spira D, Xenitidis T, Henes J, Horger M

The British journal of radiology 2016; (89(1058)):20150892 doi:10.1259/bjr.20150892.

Retrospective Comparison of Open versus Endovascular Procedures for Takayasu Arteritis.

Labarca C, Makol A, Crowson CS, et al.

The Journal of rheumatology 2016; (43(2)):427-32 doi:10.3899/jrheum.150447.

Anaesthetic Management of Patients with Takayasu's Arteritis for Open Cholecystectomy.

Shrestha GS, Shrestha N, Shrestha BK, Shrestha PS

JNMA; journal of the Nepal Medical Association 2015; (53(198)):144-7.

Prevalence, Incidence, and Disease Characteristics of Takayasu Arteritis by Ethnic Background: Data From a Large, Population-Based Cohort Resident in Southern Norway.

Gudbrandsson B, Molberg Ø, Garen T, Palm Ø

Arthritis care & research 2017; (69(2)):278-285 doi:10.1002/acr.22931.

Standard and biological treatment in large vessel vasculitis: guidelines and current approaches.

Muratore F, Pipitone N, Salvarani C

Expert review of clinical immunology 2017; (13(4)):345-360 doi:10.1080/1744666X.2017.1285699.

Vascular surgery: the main risk factor for mortality in 146 Takayasu arteritis patients.

Rosa Neto NS, Shinjo SK, Levy-Neto M, Pereira RMR

Rheumatology international 2017; (37(7)):1065-1073 doi:10.1007/s00296-017-3656-y.

Outcomes of percutaneous coronary intervention and coronary artery bypass grafting in patients with Takayasu arteritis.

Yang Y, Tian T, Yang K, et al.

International journal of cardiology 2017; (241()):64-69 doi:10.1016/j.ijcard.2017.02.041.

Incidence, prevalence, mortality and causes of death in Takayasu Arteritis in Korea - A nationwide, population-based study.

Park SJ, Kim HJ, Park H, et al.

International journal of cardiology 2017; (235()):100-104 doi:10.1016/j.ijcard.2017.02.086.

Renal Autotransplantation with Autologous Saphenous Vein Graft in a Patient with Takayasu Arteritis and Existing Renal Artery Stent in Her Solitary Kidney.

Haberal HB, Tonyali S, Peynircioğlu B, et al.

Urologia internationalis 2018; (100(2)):181-184 doi:10.1159/000475509.

[Large vessel vasculitis : Giant cell arteritis and Takayasu arteritis].

Villiger PM

Zeitschrift fur Rheumatologie 2017; (76(6)):509-523 doi:10.1007/s00393-017-0331-3.

Epidemiology of Takayasu arteritis.

Onen F, Akkoc N

Presse medicale (Paris, France : 1983) 2017; (46(7-8 Pt 2)):e197-e203 doi:10.1016/j.lpm.2017.05.034.

Classification of large vessel vasculitis: Can we separate giant cell arteritis from Takayasu arteritis?

Koster MJ, Warrington KJ

Presse medicale (Paris, France : 1983) 2017; (46(7-8 Pt 2)):e205-e213 doi:10.1016/j.lpm.2016.11.032.

A case report of Takayasu arteritis with aortic dissection as initial presentation.

Guo J, Zhang G, Tang D, Zhang J

Medicine 2017; (96(45)):e8610 doi:10.1097/MD.0000000000008610.

Takayasu arteritis in paediatrics.

Di Santo M, Stelmaszewski EV, Villa A

Cardiology in the young 2018; (28(3)):354-361 doi:10.1017/S1047951117001998.

Imaging modalities for the diagnosis and disease activity assessment of Takayasu's arteritis: A systematic review and meta-analysis.

Barra L, Kanji T, Malette J, et al.

Autoimmunity reviews 2018; (17(2)):175-187 doi:10.1016/j.autrev.2017.11.021.

EULAR recommendations for the use of imaging in large vessel vasculitis in clinical practice.

Dejaco C, Ramiro S, Duftner C, et al.

Annals of the rheumatic diseases 2018; (77(5)):636-643 doi:10.1136/annrheumdis-2017-212649.

Revascularization of Concurrent Renal and Cerebral Artery Stenosis in a 14-Year-Old Girl with Takayasu Arteritis and Moyamoya Syndrome.

Lee ML, Chang MY, Chang TM, et al.

Journal of Korean medical science 2018; (33(10)):e76 doi:10.3346/jkms.2018.33.e76.

Analysis of predictive factors for treatment resistance and disease relapse in Takayasu's arteritis.

Sun Y, Ma L, Chen H, et al.

Clinical rheumatology 2018; (37(10)):2789-2795 doi:10.1007/s10067-018-4094-2.

Treatment of Takayasu arteritis with the IL-6R antibody tocilizumab vs. cyclophosphamide.

Kong X, Zhang X, Lv P, et al.

International journal of cardiology 2018; (266()):222-228 doi:10.1016/j.ijcard.2017.12.066.

Overall survival and mortality risk factors in Takayasu's arteritis: A multicenter study of 318 patients.

Mirouse A, Biard L, Comarmond C, et al.

Journal of autoimmunity 2019; (96()):35-39 doi:10.1016/j.jaut.2018.08.001.

Diagnosis and differential diagnosis of large-vessel vasculitides.

Keser G, Aksu K

Rheumatology international 2019; (39(2)):169-185 doi:10.1007/s00296-018-4157-3.

Takayasu Arteritis.

Russo RAG, Katsicas MM

Frontiers in pediatrics 2018; (6()):265 doi:10.3389/fped.2018.00265.

Takayasu Arteritis Presenting as Renovascular Hypertension and Renal Failure in a Patient with Factor VII Deficiency.

Ozkok S, Aslan A, Gulseren Y, et al.

The Eurasian journal of medicine 2018; (50(3)):210-212 doi:10.5152/eurasianjmed.2018.17324.

Surgical intervention and its role in Takayasu arteritis.

Mason JC

Best practice & research. Clinical rheumatology 2018; (32(1)):112-124 doi:10.1016/j.berh.2018.07.008.

Demographic, Clinical, and Radiologic Characteristics of a Cohort of Patients with Takayasu Arteritis.

Sanchez-Alvarez C, Mertz LE, Thomas CS, et al.

The American journal of medicine 2019; (132(5)):647-651 doi:10.1016/j.amjmed.2018.12.017.

Clinical course and prognostic factors of childhood Takayasu's arteritis: over 15-year comprehensive analysis of 101 patients.

Fan L, Zhang H, Cai J, et al.

Arthritis research & therapy 2019; (21(1)):31 doi:10.1186/s13075-018-1790-x.

Contrast-enhanced Ultrasonography for Monitoring Arterial Inflammation in Takayasu Arteritis.

Li Z, Zheng Z, Ding J, et al.

The Journal of rheumatology 2019; (46(6)):616-622 doi:10.3899/jrheum.180701.

Evolution into Takayasu arteritis in a patient presenting with acute pulmonary oedema due to severe aortic regurgitation; a case report.

de Silva NL, Withana M, Weeratunga P, et al.

BMC rheumatology 2018; (2()):20 doi:10.1186/s41927-018-0028-5.

Comparative study of 18F-FDG PET/CT and CT angiography in detection of large vessel vasculitis.

Moragas Solanes M, Andreu Magarolas M, Martín Miramon JC, et al.

Revista espanola de medicina nuclear e imagen molecular 2019; (38(5)):280-289 doi:10.1016/j.remn.2019.03.002.

2018 Update of the EULAR recommendations for the management of large vessel vasculitis.

Hellmich B, Agueda A, Monti S, et al.

Annals of the rheumatic diseases 2020; (79(1)):19-30 doi:10.1136/annrheumdis-2019-215672.

Current Treatment Options in Acute Limb Ischemia.

Fluck F, Augustin AM, Bley T, Kickuth R

RoFo : Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin 2020; (192(4)):319-326 doi:10.1055/a-0998-4204.

Risk of rupture of an aortorenal vein graft aneurysm after the surgical repair of Takayasu arteritis-induced right renal artery stenosis: A case report and a literature review.

Chen X, Huang B, Yuan D, et al.

Medicine 2019; (98(48)):e17889 doi:10.1097/MD.0000000000017889.

Advancements in medical and surgical treatments of Takayasu arteritis-induced renal arteritis: a systematic review.

Dai XM, Yin MM, Liu Y, et al.

Chinese medical journal 2020; (133(8)):975-981 doi:10.1097/CM9.0000000000000704.

Biologic therapy in supra-aortic Takayasu arteritis can improve symptoms of cerebral ischaemia without surgical intervention.

Porter A, Youngstein T, Tombetti E, Mason JC

Rheumatology (Oxford, England) 2020; (59(Suppl 3)):iii28-iii32 doi:10.1093/rheumatology/kez616.

[Treatment of Takayasu arteritis].

Hellmich B

Zeitschrift fur Rheumatologie 2020; (79(6)):532-544 doi:10.1007/s00393-020-00806-2.

Coronary artery involvements in Takayasu arteritis: systematic review of reports.

Yuan SM, Lin HZ

General thoracic and cardiovascular surgery 2020; (68(9)):883-904 doi:10.1007/s11748-020-01378-3.

Pathogenesis of Giant Cell Arteritis and Takayasu Arteritis-Similarities and Differences.

Watanabe R, Berry GJ, Liang DH, et al.

Current rheumatology reports 2020; (22(10)):68 doi:10.1007/s11926-020-00948-x.

Imaging for Diagnosis, Monitoring, and Outcome Prediction of Large Vessel Vasculitides.

Schäfer VS, Jin L, Schmidt WA

Current rheumatology reports 2020; (22(11)):76 doi:10.1007/s11926-020-00955-y.

Cardiovascular and Renal Morbidity in Takayasu Arteritis: A Population-Based Retrospective Cohort Study From the United Kingdom.

Goel R, Chandan JS, Thayakaran R, et al.

Arthritis & rheumatology (Hoboken, N.J.) 2021; (73(3)):504-511 doi:10.1002/art.41529.

Takayasu arteritis: a cohort of Italian patients and recent pathogenetic and therapeutic advances.

Dammacco F, Cirulli A, Simeone A, et al.

Clinical and experimental medicine 2021; (21(1)):49-62 doi:10.1007/s10238-020-00668-7.

Aortitis and aortic aneurysm in systemic vasculitis.

Tyagi S, Safal S, Tyagi D

Indian journal of thoracic and cardiovascular surgery 2019; (35(Suppl 2)):47-56 doi:10.1007/s12055-019-00832-z.

Assessment of inflammatory activity in Takayasu's arteritis: performance of clinical scores and common biomarkers versus 18F-FDG PET/CT.

Jiménez D, Soto ME, Martínez-Martínez LA, et al.

Clinical and experimental rheumatology 2021; (39(5)):1011-1020 doi:10.55563/clinexprheumatol/a71bzh.

Factors associated with event-free survival in Chinese patients with Takayasu's arteritis.

Wei Y, Zhao C, Liang J, et al.

Clinical rheumatology 2021; (40(5)):1941-1948 doi:10.1007/s10067-020-05481-x.

Medium- and Large-Vessel Vasculitis.

Saadoun D, Vautier M, Cacoub P

Circulation 2021; (143(3)):267-282 doi:10.1161/CIRCULATIONAHA.120.046657.

Risk factors for cerebral infarction in Takayasu arteritis: a single-centre case-control study.

Kong F, Huang X, Su L, et al.

Rheumatology (Oxford, England) 2021; (61(1)):281-290 doi:10.1093/rheumatology/keab308.

Diagnostic value of [18F]FDG-PET/CT for treatment monitoring in large vessel vasculitis: a systematic review and meta-analysis.

van der Geest KSM, Treglia G, Glaudemans AWJM, et al.

European journal of nuclear medicine and molecular imaging 2021; (48(12)):3886-3902 doi:10.1007/s00259-021-05362-8.

A systematic review and meta-analysis of the incidence rate of Takayasu arteritis.

Rutter M, Bowley J, Lanyon PC, et al.

Rheumatology (Oxford, England) 2021; (60(11)):4982-4990 doi:10.1093/rheumatology/keab406.

Diagnostic Approaches for Large Vessel Vasculitides.

Betrains A, Blockmans D

Open access rheumatology : research and reviews 2021; (13()):153-165 doi:10.2147/OARRR.S282605.

2021 American College of Rheumatology/Vasculitis Foundation Guideline for the Management of Giant Cell Arteritis and Takayasu Arteritis.

Maz M, Chung SA, Abril A, et al.

Arthritis care & research 2021; (73(8)):1071-1087 doi:10.1002/acr.24632.

Epidemiology of Takayasu arteritis in Shanghai: A hospital-based study and systematic review.

Sun Y, Yin MM, Ma LL, et al.

International journal of rheumatic diseases 2021; (24(10)):1247-1256 doi:10.1111/1756-185X.14183.

Takayasu arteritis - epidemiology, pathogenesis, diagnosis and treatment.

Podgorska D, Podgorski R, Aebisher D, Dabrowski P

Journal of applied biomedicine 2019; (17(1)):20 doi:10.32725/jab.2018.005.

Large-vessel vasculitis.

Pugh D, Karabayas M, Basu N, et al.

Nature reviews. Disease primers 2022; (7(1)):93 doi:10.1038/s41572-021-00327-5.

Novel Therapies in Takayasu Arteritis.

Regola F, Uzzo M, Toniati P, et al.

Frontiers in medicine 2021; (8()):814075 doi:10.3389/fmed.2021.814075.

Mimickers of Large Vessel Giant Cell Arteritis.

Ramon A, Greigert H, Ornetti P, et al.

Journal of clinical medicine 2022; (11(3)) doi:10.3390/jcm11030495.

Novel Th17 Lymphocyte Populations, Th17.1 and PD1+Th17, are Increased in Takayasu Arteritis, and Both Th17 and Th17.1 Sub-Populations Associate with Active Disease.

Singh K, Rathore U, Rai MK, et al.

Journal of inflammation research 2022; (15()):1521-1541 doi:10.2147/JIR.S355881.

Large-Vessel Vasculitis in Ophthalmology: Giant Cell Arteritis and Takayasu Arteritis.

Dhanani U, Zhao MY, Charoenkijkajorn C, et al.

Asia-Pacific journal of ophthalmology (Philadelphia, Pa.) 2022; (11(2)):177-183 doi:10.1097/APO.0000000000000514.

[Large Vessel Vasculitides: Giant Cell Arteritis and Takayasu Arteritis - Similarities and Differences].

Gloor AD, Christ L

Therapeutische Umschau. Revue therapeutique 2022; (79(5)):221-228 doi:10.1024/0040-5930/a001353.

Ocular Manifestations in an Italian Cohort of Patients with Takayasu Arteritis.

Dammacco R, Cimino L, De Simone L, et al.

Ocular immunology and inflammation 2023; (31(5)):945-954 doi:10.1080/09273948.2022.2072348.

Recent advances in the diagnosis and therapy of large vessel vasculitis.

Keser G, Atagunduz P, Soy M

Polish archives of internal medicine 2022; (132(6)) doi:10.20452/pamw.16272.

Characteristics of four-limb blood pressure and brachial-ankle pulse wave velocity in Chinese patients with Takayasu arteritis.

Chen Y, Dong H, Li HW, et al.

Blood pressure 2022; (31(1)):146-154 doi:10.1080/08037051.2022.2091513.

Derivation and Validation of a New Disease Activity Assessment Tool With Higher Accuracy for Takayasu Arteritis.

Kwon OC, Park MC

Frontiers in immunology 2022; (13()):925341 doi:10.3389/fimmu.2022.925341.

Takayasu's Arteritis With Acute Severe Aortic Regurgitation Requiring a Bio-Bentall Procedure.

Jules P, Valencia O, Valencia D, et al.

Cureus 2022; (14(7)):e26969 doi:10.7759/cureus.26969.

Outcome Measures and Biomarkers for Disease Assessment in Takayasu Arteritis.

Misra DP, Jain N, Ora M, et al.

Diagnostics (Basel, Switzerland) 2022; (12(10)) doi:10.3390/diagnostics12102565.

2022 American College of Rheumatology/EULAR Classification Criteria for Takayasu Arteritis.

Grayson PC, Ponte C, Suppiah R, et al.

Arthritis & rheumatology (Hoboken, N.J.) 2022; (74(12)):1872-1880 doi:10.1002/art.42324.

2022 American College of Rheumatology/EULAR classification criteria for Takayasu arteritis.

Grayson PC, Ponte C, Suppiah R, et al.

Annals of the rheumatic diseases 2022; (81(12)):1654-1660 doi:10.1136/ard-2022-223482.

Cardiovascular Disease in Large Vessel Vasculitis: Risks, Controversies, and Management Strategies.

Clifford AH

Rheumatic diseases clinics of North America 2023; (49(1)):81-96 doi:10.1016/j.rdc.2022.08.004.

Augmented PFKFB3-mediated glycolysis by interferon-γ promotes inflammatory M1 polarization through the JAK2/STAT1 pathway in local vascular inflammation in Takayasu arteritis.

Chen R, Wang J, Dai X, et al.

Arthritis research & therapy 2022; (24(1)):266 doi:10.1186/s13075-022-02960-1.

Takayasu Arteritis: JACC Focus Seminar 3/4.

Joseph G, Goel R, Thomson VS, et al.

Journal of the American College of Cardiology 2022; doi:10.1016/j.jacc.2022.09.051.

The effectiveness of tocilizumab and its comparison with tumor necrosis factor alpha inhibitors for Takayasu Arteritis: A systematic review and meta-analysis.

Misra DP, Singh K, Rathore U, et al.

Autoimmunity reviews 2023; (22(3)):103275 doi:10.1016/j.autrev.2023.103275.

Clinical and vascular lesion characteristics of the patients with takayasu arteritis manifested firstly as acute myocardial infarction at onset.

Liu R, Xu F, Zhou Y, et al.

Heliyon 2023; (9(2)):e13099 doi:10.1016/j.heliyon.2023.e13099.

Validation of the 2022 American College of Rheumatology/EULAR classification criteria for Takayasu arteritis.

Tomelleri A, Padoan R, Kavadichanda CG, et al.

Rheumatology (Oxford, England) 2023; (62(10)):3427-3432 doi:10.1093/rheumatology/kead161.

The Epidemiology of Takayasu Arteritis in Rio de Janeiro, Brazil: A Large Population-Based Study.

Vieira M, Ochtrop MLG, Sztajnbok F, et al.

Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases 2023; (29(5)):e100-e103 doi:10.1097/RHU.0000000000001964.

Sudden death due to Takayasu arteritis complication associated with situs inversus totalis: A case discovered at autopsy.

Ben Jomaa S, El Aini I, Chebbi E, et al.

Journal of forensic and legal medicine 2023; (96()):102527 doi:10.1016/j.jflm.2023.102527.

Management of Takayasu arteritis.

Misra DP, Singh K, Rathore U, et al.

Best practice & research. Clinical rheumatology 2023; (37(1)):101826 doi:10.1016/j.berh.2023.101826.

An unusual case of Takayasu arteritis presenting as isolated severe aortic regurgitation: A case report.

Simkhada A, Acharya P, Tiwari SB, K C B

International journal of surgery case reports 2023; (108()):108407 doi:10.1016/j.ijscr.2023.108407.

A patient with Takayasu arteritis presenting with malignant hypertension: a case report.

Sierra LV, Binzenhöfer L, Schulze-Koops H, et al.

European heart journal. Case reports 2023; (7(6)):ytad263 doi:10.1093/ehjcr/ytad263.

Current Diagnosis and Management of Takayasu Arteritis.

As C, Danda D

International heart journal 2023; (64(4)):519-534 doi:10.1536/ihj.23-195.

Takayasu arteritis, an atypical presentation as chronic kidney disease.

Neeraja V, Nakka V, Mahadev M, et al.

African health sciences 2023; (23(1)):781-784 doi:10.4314/ahs.v23i1.82.

EULAR recommendations for the use of imaging in large vessel vasculitis in clinical practice: 2023 update.

Dejaco C, Ramiro S, Bond M, et al.

Annals of the rheumatic diseases 2024; (83(6)):741-751 doi:10.1136/ard-2023-224543.

Common Autoantibody among Takayasu Arteritis and Ulcerative Colitis: A Possible Pathophysiology That Includes Gut-Vessel Connection in Vascular Inflammation.

Shirai T

JMA journal 2023; (6(3)):265-273 doi:10.31662/jmaj.2023-0038.

Impact of non-immunosuppressive medical therapy on disease progression and complications of Takayasu arteritis: A narrative review.

Terribili R, Conticini E, Grazzini S, et al.

Autoimmunity reviews 2024; (23(12)):103656 doi:10.1016/j.autrev.2024.103656.

Perioperative Management of Takayasu Arteritis for Cardiac Surgery　- Review and Single-Center Experience.

Arita Y, Asano R, Ueda J, et al.

Circulation journal : official journal of the Japanese Circulation Society 2025; (89(12)):1849-1856 doi:10.1253/circj.CJ-24-0496.

Update in imaging for large vessel vasculitis.

Nielsen BD, Seitz L, Schmidt WA

Best practice & research. Clinical rheumatology 2025; (39(3)):102060 doi:10.1016/j.berh.2025.102060.

Efficacy of Tofacitinib in Takayasu Arteritis Refractory to Biologic DMARDs-A Multicentre Study in Indian Patients.

Vasanth P, Aithala R, Ganapati A, et al.

International journal of rheumatic diseases 2025; (28(6)):e70293 doi:10.1111/1756-185X.70293.

Association of PET vascular activity score with Takayasu's arteritis angiographic progression.

Wu S, Wu B, Ma L, et al.

European journal of nuclear medicine and molecular imaging 2025; (52(11)):4268-4280 doi:10.1007/s00259-025-07348-2.

Validation and clinical application of 2022 ACR/EULAR criteria for Takayasu arteritis in a large Chinese cohort.

Gao J, He S, Liu Y, et al.

Rheumatology (Oxford, England) 2025; (64(11)):5826-5833 doi:10.1093/rheumatology/keaf372.

Mycophenolate mofetil plus methotrexate versus cyclophosphamide with sequential azathioprine for treatment of Takayasu arteritis.

Sun X, Li J, Duan X, et al.

Annals of the rheumatic diseases 2025; (84(10)):1733-1742 doi:10.1016/j.ard.2025.07.018.

Advances in the pathophysiology, diagnosis and treatment of Takayasu arteritis.

Sawalha AH, Misra DP, Goel R, et al.

Nature reviews. Rheumatology 2025; (21(12)):737-751 doi:10.1038/s41584-025-01309-7.

The Role of Imaging in Monitoring Large Vessel Vasculitis: A Comprehensive Review.

Sopa I, Pereira da Costa R, Martins Martinho J, Ponte C

Biomolecules 2025; (15(11)) doi:10.3390/biom15111505.

Acute limb ischemia secondary to left brachial artery occlusion in a 45-year-old woman: A case report.

Zada O, Patel T, Syed S, et al.

Medicine 2025; (104(50)):e46515 doi:10.1097/MD.0000000000046515.

Case report: A rare case of catastrophic Takayasu arteritis: acute ischemic stroke and anterior ischemic optic neuropathy.

Olalusi OV, Yaria J, Makanjuola A, et al.

Frontiers in stroke 2024; (3()):1481940 doi:10.3389/fstro.2024.1481940.

Takayasu Arteritis Presenting With Cardiac Arrest: An Intravascular Imaging Triggered Diagnosis.

Sivapalan K, Lal V, Lakshmanan A, et al.

JACC. Case reports 2026; (31(11)):106944 doi:10.1016/j.jaccas.2026.106944.

The role of CD34-high endothelial cells and FGF2 in vasa vasorum angiogenesis of Takayasu arteritis.

Li T, Wang C, Zhu J, et al.

Clinical rheumatology 2026; (45(6)):3621-3633 doi:10.1007/s10067-026-08140-9.