Research & Literature

Comorbidities frequency in Takotsubo syndrome: an international collaborative systematic review including 1109 patients.

Pelliccia F, Parodi G, Greco C, et al.

The American journal of medicine 2015; (128(6)):654.e11-9.

Recurrent takotsubo cardiomyopathy in a child.

Srivastava NT, Parent JJ, Hurwitz RA

Cardiology in the young 2016; (26(2)):410-2 doi:10.1017/S1047951115001377.

Clinical Features and Outcomes of Takotsubo (Stress) Cardiomyopathy.

Templin C, Ghadri JR, Diekmann J, et al.

The New England journal of medicine 2015; (373(10)):929-38 doi:10.1056/NEJMoa1406761.

Biventricular Takotsubo Cardiomyopathy Associated with Epilepsy.

Koo N, Yoon BW, Song Y, et al.

Journal of cardiovascular ultrasound 2015; (23(4)):262-5 doi:10.4250/jcu.2015.23.4.262.

Trends in hospitalization for takotsubo cardiomyopathy in the United States.

Khera R, Light-McGroary K, Zahr F, et al.

American heart journal 2016; (172()):53-63.

Takotsubo Syndrome: Underdiagnosed, Underestimated, but Understood?

Templin C, Napp LC, Ghadri JR

Journal of the American College of Cardiology 2016; (67(16)):1937-40.

A handicap in Takotsubo cardiomyopathy: dynamic outflow obstruction.

Keskin M, Tanık VO, Gümüşdağ A, Yıldırımtürk Ö

Turk Kardiyoloji Dernegi arsivi : Turk Kardiyoloji Derneginin yayin organidir 2016; (44(2)):161-5 doi:10.5543/tkda.2015.32762.

Recurrent Takotsubo Cardiomyopathy Related to Recurrent Thyrotoxicosis.

Patel K, Griffing GT, Hauptman PJ, Stolker JM

Texas Heart Institute journal 2016; (43(2)):152-5 doi:10.14503/THIJ-15-5046.

Psychosocial and psychoneuroendocrinal aspects of Takotsubo syndrome.

Kastaun S, Gerriets T, Tschernatsch M, et al.

Nature reviews. Cardiology 2016; (13(11)):688-694 doi:10.1038/nrcardio.2016.108.

Differences in the Clinical Profile and Outcomes of Typical and Atypical Takotsubo Syndrome: Data From the International Takotsubo Registry.

Ghadri JR, Cammann VL, Napp LC, et al.

JAMA cardiology 2016; (1(3)):335-40 doi:10.1001/jamacardio.2016.0225.

Takotsubo Syndrome as a Cause of False Acute Abdomen in the Early Postoperative Period After Bariatric Surgery-a Report of Two Cases.

Viegas F, Viegas C, França E, et al.

Obesity surgery 2016; (26(10)):2547-51 doi:10.1007/s11695-016-2326-6.

A novel clinical score (InterTAK Diagnostic Score) to differentiate takotsubo syndrome from acute coronary syndrome: results from the International Takotsubo Registry.

Ghadri JR, Cammann VL, Jurisic S, et al.

European journal of heart failure 2017; (19(8)):1036-1042 doi:10.1002/ejhf.683.

Exploring the Pathophysiology of Takotsubo Cardiomyopathy.

Chen W, Dilsizian V

Current cardiology reports 2017; (19(6)):53 doi:10.1007/s11886-017-0865-7.

Pathophysiology of Takotsubo Syndrome.

Pelliccia F, Kaski JC, Crea F, Camici PG

Circulation 2017; (135(24)):2426-2441 doi:10.1161/CIRCULATIONAHA.116.027121.

Takotsubo Syndrome Associated With Structural Brain Alterations of the Limbic System.

Hiestand T, Hänggi J, Klein C, et al.

Journal of the American College of Cardiology 2018; (71(7)):809-811 doi:10.1016/j.jacc.2017.12.022.

Takotsubo syndrome.

Gupta S, Gupta MM

Indian heart journal 2018; (70(1)):165-174 doi:10.1016/j.ihj.2017.09.005.

Novel Understanding of Takotsubo Syndrome.

Watanabe M, Izumo M, Akashi YJ

International heart journal 2018; (59(2)):250-255 doi:10.1536/ihj.17-586.

International Expert Consensus Document on Takotsubo Syndrome (Part II): Diagnostic Workup, Outcome, and Management.

Ghadri JR, Wittstein IS, Prasad A, et al.

European heart journal 2018; (39(22)):2047-2062 doi:10.1093/eurheartj/ehy077.

Temporarily increased stroke rate after Takotsubo syndrome: need for an anticoagulation?

Abanador-Kamper N, Kamper L, Wolfertz J, et al.

BMC cardiovascular disorders 2018; (18(1)):117 doi:10.1186/s12872-018-0842-0.

Acute Appendicitis as an Unexpected Cause of Inverted Takotsubo Cardiomyopathy.

Mihalcea-Danciu M, Zupan M, Le Borgne P, Bilbault P

Journal of emergencies, trauma, and shock 2018; (11(2)):143-145 doi:10.4103/JETS.JETS_13_17.

Misconceptions and Facts About Takotsubo Syndrome.

Rodríguez M, Rzechorzek W, Herzog E, Lüscher TF

The American journal of medicine 2019; (132(1)):25-31 doi:10.1016/j.amjmed.2018.07.007.

Long-Term Prognosis of Patients With Takotsubo Syndrome.

Ghadri JR, Kato K, Cammann VL, et al.

Journal of the American College of Cardiology 2018; (72(8)):874-882 doi:10.1016/j.jacc.2018.06.016.

Cardiac Magnetic Resonance in Takotsubo Syndrome.

Bratis K

European cardiology 2017; (12(1)):58-62 doi:10.15420/ecr.2017:7:2.

Clinical management in the takotsubo syndrome.

Jha S, Zeijlon R, Shekka Espinosa A, et al.

Expert review of cardiovascular therapy 2019; (17(2)):83-93 doi:10.1080/14779072.2019.1556098.

Outcomes Associated With Cardiogenic Shock in Takotsubo Syndrome.

Di Vece D, Citro R, Cammann VL, et al.

Circulation 2019; (139(3)):413-415 doi:10.1161/CIRCULATIONAHA.118.036164.

Long-Term Prognosis and Outcome Predictors in Takotsubo Syndrome: A Systematic Review and Meta-Regression Study.

Pelliccia F, Pasceri V, Patti G, et al.

JACC. Heart failure 2019; (7(2)):143-154 doi:10.1016/j.jchf.2018.10.009.

Mechanical Circulatory Support With Impella Percutaneous Ventricular Assist Device as a Bridge to Recovery in Takotsubo Syndrome Complicated by Cardiogenic Shock and Left Ventricular Outflow Tract Obstruction.

Beneduce A, Fausta Bertoldi L, Melillo F, et al.

JACC. Cardiovascular interventions 2019; (12(4)):e31-e32 doi:10.1016/j.jcin.2018.10.046.

49-Year-Old Woman With a Broken Heart.

Hernández-Rivera H, Rodríguez-Monserrate C, Escabí-Mendoza J

Federal practitioner : for the health care professionals of the VA, DoD, and PHS 2015; (32(1)):28-33.

Is the spiked helmet sign the manifestation of long QT syndrome?

Simon A, Járai Z

Journal of electrocardiology 2019; (55()):16-19 doi:10.1016/j.jelectrocard.2019.04.011.

Cardiac arrest in takotsubo syndrome: results from the InterTAK Registry.

Gili S, Cammann VL, Schlossbauer SA, et al.

European heart journal 2019; (40(26)):2142-2151 doi:10.1093/eurheartj/ehz170.

Assessment of the German and Italian Stress Cardiomyopathy Score for Risk Stratification for In-hospital Complications in Patients With Takotsubo Syndrome.

Santoro F, Núñez Gil IJ, Stiermaier T, et al.

JAMA cardiology 2019; (4(9)):892-899 doi:10.1001/jamacardio.2019.2597.

Takotsubo cardiomyopathy following ultrasound-guided renal cyst aspiration.

Gursahaney DL, Wiktor DM, Lindquist J

BJR case reports 2019; (5(2)):20180101 doi:10.1259/bjrcr.20180101.

Prognostic relevance of GRACE risk score in Takotsubo syndrome.

Scudiero F, Arcari L, Cacciotti L, et al.

European heart journal. Acute cardiovascular care 2020; (9(7)):721-728 doi:10.1177/2048872619882363.

Catecholamine-induced reverse takotsubo cardiomyopathy.

Bhat S, Gazi H, Mwansa V, Chhabra L

Proceedings (Baylor University. Medical Center) 2019; (32(4)):567-569 doi:10.1080/08998280.2019.1634229.

Coexistence of acute takotsubo syndrome and acute coronary syndrome.

Sharkey SW, Kalra A, Henry TD, et al.

Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions 2020; (96(4)):825-829 doi:10.1002/ccd.28595.

Takotsubo Cardiomyopathy in a Case of Intracerebral Hemorrhage: A Case Report.

Nagpal RR, Dhabhar JB, Ghanekar J

Cureus 2019; (11(9)):e5711 doi:10.7759/cureus.5711.

Impella in Takotsubo syndrome complicated by left ventricular outflow tract obstruction and severe mitral regurgitation.

Attisano T, Silverio A, Prota C, et al.

ESC heart failure 2020; (7(1)):306-310 doi:10.1002/ehf2.12546.

Takotsubo cardiomyopathy: Review of broken heart syndrome.

Boyd B, Solh T

JAAPA : official journal of the American Academy of Physician Assistants 2020; (33(3)):24-29 doi:10.1097/01.JAA.0000654368.35241.fc.

Factors Associated with Recurrence in Takotsubo Syndrome: A Systematic Review.

Campos FAD, Ritt LEF, Costa JPS, et al.

Arquivos brasileiros de cardiologia 2020; (114(3)):477-483 doi:10.36660/abc.20180377.

[Takotsubo cardiomyopathy].

Dujardin JJ, Belle L, Yayehd K, Georges JL

La Revue du praticien 2019; (69(8)):877-880.

[Takotsubo syndrome. Clinical and pathogenetic aspects. Basics of diagnosis and treatment].

Suspitsyna IN, Sukmanova IA

Kardiologiia 2019; (60(2)):96-103 doi:10.18087/cardio.2020.2.n521.

Recurrent Takotsubo Cardiomyopathy: Getting to the Root of the Problem.

Tunzi MA, Dinkha L, Sharp AJ, Gore RS

The American journal of case reports 2020; (21()):e923067 doi:10.12659/AJCR.923067.

A rare long-term undetected pheochromocytoma leading to Takotsubo syndrome in an older male patient: a case report.

Chen M, Zhao T, Chen G, Hu S

BMC endocrine disorders 2020; (20(1)):93 doi:10.1186/s12902-020-00578-5.

Takotsubo Cardiomyopathy and QTc Prolongation with Subsequent Improvement of QTc Interval and Resolution of Apical Ballooning: A Case Report.

Alvarez Retamales V, Lara Garcia OE, Ranjha S, et al.

Cureus 2020; (12(7)):e9143 doi:10.7759/cureus.9143.

Variants of Takotsubo syndrome in the perioperative period: A review of potential mechanisms and anaesthetic implications.

Gibson LE, Klinker MR, Wood MJ

Anaesthesia, critical care & pain medicine 2020; (39(5)):647-654 doi:10.1016/j.accpm.2020.01.010.

Role of Depression and Anxiety Disorders in Takotsubo Syndrome: The Psychiatric Side of Broken Heart.

Oliveri F, Goud HK, Mohammed L, et al.

Cureus 2020; (12(9)):e10400 doi:10.7759/cureus.10400.

Recurrent Takotsubo cardiomyopathy triggered by emotionally stressful events: A case report.

Wu HY, Cheng G, Liang L, Cao YW

World journal of clinical cases 2021; (9(3)):677-684 doi:10.12998/wjcc.v9.i3.677.

Is modulation (desensitization) of the beta-adrenergic receptors a cause or an epiphenomenon of takotsubo syndrome?

Madias JE

Journal of cardiology 2021; (77(5)):552 doi:10.1016/j.jjcc.2021.01.008.

Takotsubo Cardiomyopathy: Current Treatment.

Madias JE

Journal of clinical medicine 2021; (10(15)) doi:10.3390/jcm10153440.

Pathophysiology of Takotsubo Syndrome as A Bridge to Personalized Treatment.

Budnik M, Piątkowski R, Ochijewicz D, et al.

Journal of personalized medicine 2021; (11(9)) doi:10.3390/jpm11090879.

Reverse Takotsubo cardiomyopathy with left bundle branch block after anesthesia induction in a patient with subarachnoid hemorrhage: a case report.

Choi EK, Kim JH, Kim M

Journal of Yeungnam medical science 2022; (39(2)):172-178 doi:10.12701/yujm.2021.01354.

Type of Stressor and Medium-Term Outcomes After Takotsubo Syndrome: What Becomes of the Broken Hearted? (ANZACS-QI 59).

Looi JL, Verryt T, McLeod P, et al.

Heart, lung & circulation 2022; (31(4)):499-507 doi:10.1016/j.hlc.2021.09.021.

The role of central autonomic nervous system dysfunction in Takotsubo syndrome: a systematic review.

Brazdil V, Kala P, Hudec M, et al.

Clinical autonomic research : official journal of the Clinical Autonomic Research Society 2022; (32(1)):9-17 doi:10.1007/s10286-021-00844-z.

A True Case of a Broken Heart With Takotsubo Cardiomyopathy.

Wallen M, Kupsaw GE, Ganti L

Cureus 2022; (14(1)):e21337 doi:10.7759/cureus.21337.

Reverse Takotsubo Cardiomyopathy After Casirivimab-Imdevimab Therapy in a Patient with COVID-19: A Case Report.

Salehin S, Abu Jazar D, Hasan SM, et al.

The American journal of case reports 2022; (23()):e936886 doi:10.12659/AJCR.936886.

A Broken Heart After Witnessing a Dying Heart: A Case of Takotsubo Cardiomyopathy.

To M, Zhang Y, Tompkins A, et al.

Cureus 2022; (14(9)):e28752 doi:10.7759/cureus.28752.

Manganese-Enhanced Magnetic Resonance Imaging in Takotsubo Syndrome.

Singh T, Joshi S, Kershaw LE, et al.

Circulation 2022; (146(24)):1823-1835 doi:10.1161/CIRCULATIONAHA.122.060375.

QT Prolongation and In-Hospital Ventricular Arrhythmic Complications in Patients With Apical Ballooning Takotsubo Syndrome.

Del Buono MG, Damonte JI, Moroni F, et al.

JACC. Clinical electrophysiology 2022; (8(12)):1500-1510 doi:10.1016/j.jacep.2022.08.010.

Epidemiology, Pathophysiology, Diagnosis, and Principles of Management of Takotsubo Cardiomyopathy: A Review.

Matta AG, Carrié D

Medical science monitor : international medical journal of experimental and clinical research 2023; (29()):e939020 doi:10.12659/MSM.939020.

Takotsubo syndrome: more frequent in women, more dangerous in men.

Natale E, Mistrulli R

European heart journal supplements : journal of the European Society of Cardiology 2023; (25(Suppl B)):B119-B122 doi:10.1093/eurheartjsupp/suad089.

Takotsubo syndrome: getting closer to its causes.

Akhtar MM, Cammann VL, Templin C, et al.

Cardiovascular research 2023; (119(7)):1480-1494 doi:10.1093/cvr/cvad053.

NT-proBNP/cardiac troponin T ratio >7.5 on the second day of admission can differentiate Takotsubo from acute coronary syndrome with good accuracy.

Rallidis LS, Iordanidis D, Papathanasiou KA, et al.

Hellenic journal of cardiology : HJC = Hellenike kardiologike epitheorese 2024; (76()):22-30 doi:10.1016/j.hjc.2023.05.010.

Takotsubo Syndrome, Stressful Triggers, and Risk of Recurrence.

Fernández-Cordón C, Núñez-Gil IJ, Martín de Miguel I, et al.

The American journal of cardiology 2023; (205()):58-62 doi:10.1016/j.amjcard.2023.07.155.

Beta-blockers and renin-angiotensin system inhibitors for Takotsubo syndrome recurrence: a network meta-analysis.

Santoro F, Sharkey S, Citro R, et al.

Heart (British Cardiac Society) 2024; (110(7)):476-481 doi:10.1136/heartjnl-2023-322980.

A Case Report on Takotsubo Cardiomyopathy.

Chauhan R, Brown B, Ahmed A, et al.

Cureus 2023; (15(9)):e45285 doi:10.7759/cureus.45285.

Comprehensive invasive evaluation of coronary microcirculation in patients with Takotsubo syndrome.

Belmonte M, Gallinoro E, Bermpeis K, et al.

Atherosclerosis 2023; (385()):117332 doi:10.1016/j.atherosclerosis.2023.117332.

Mechanical Circulatory Support Strategies in Takotsubo Syndrome with Cardiogenic Shock: A Systematic Review.

von Mackensen JKR, Zwaans VIT, El Shazly A, et al.

Journal of clinical medicine 2024; (13(2)) doi:10.3390/jcm13020473.

Comparison of troponin and natriuretic peptides in Takotsubo syndrome and acute coronary syndrome: a meta-analysis.

Couch LS, Garrard JW, Henry JA, et al.

Open heart 2024; (11(1)) doi:10.1136/openhrt-2024-002607.

Norepinephrine and Dobutamine-Induced Dynamic Left Ventricular Outflow Tract Obstruction Caused by Systolic Anterior Motion.

Hung TD, Ha PVT, Chien DV

Journal of medical cases 2024; (15(4-5)):67-71 doi:10.14740/jmc4204.

A Rare Case of Recurrent Takotsubo Cardiomyopathy Complicated by Thromboemboli.

Javed N, Ashraf S, Singh A, Kamalakkannan G

Journal of investigative medicine high impact case reports 2024; (12()):23247096241257394 doi:10.1177/23247096241257394.

Cardiac rupture as a life-threatening outcome of Takotsubo syndrome: A systematic review.

Denicolai M, Morello M, Del Buono MG, et al.

International journal of cardiology 2024; (412()):132336 doi:10.1016/j.ijcard.2024.132336.

An Extensive Review on Imaging Diagnosis Methods in Takotsubo Syndrome.

Paraschiv C, Paduraru L, Balanescu S

Reviews in cardiovascular medicine 2023; (24(10)):300 doi:10.31083/j.rcm2410300.

Incidence of Takotsubo cardiomyopathy in patients with acute coronary syndrome: a single center retrospective analysis.

Poruban T, Studencan M, Kirsch P, Novotny R

The Egyptian heart journal : (EHJ) : official bulletin of the Egyptian Society of Cardiology 2024; (76(1)):112 doi:10.1186/s43044-024-00542-x.

Clinical perspectives: Takotsubo cardiomyopathy.

Ravindran J, Brieger D

Internal medicine journal 2024; (54(11)):1785-1795 doi:10.1111/imj.16493.

Recurrent Takotsubo Syndrome Resulting From Different Emotional Triggers as Broken and Happy Heart Syndrome.

Maher W, Byrne L, Powell C, et al.

JACC. Case reports 2024; (29(18)):102535 doi:10.1016/j.jaccas.2024.102535.

Thromboembolic Complications in Takotsubo Cardiomyopathy.

Habib M, Aronson D

Seminars in thrombosis and hemostasis 2025; (51(4)):423-429 doi:10.1055/s-0044-1791511.

Tailored Therapies for Cardiogenic Shock in Hypertrophic Cardiomyopathy: Navigating Emerging Strategies.

Zakynthinos GE, Gialamas I, Tsolaki V, et al.

Journal of cardiovascular development and disease 2024; (11(12)) doi:10.3390/jcdd11120401.

Myocardial microvascular function assessed by cardiovascular magnetic resonance first-pass perfusion in patients with Takotsubo syndrome.

Cau R, Pitzalis C, Pisu F, et al.

European radiology 2025; (35(7)):3917-3926 doi:10.1007/s00330-024-11340-z.

Beta-Blockers and Long-Term Mortality in Takotsubo Syndrome: Results of the Multicenter GEIST Registry.

Raposeiras-Roubin S, Santoro F, Arcari L, et al.

JACC. Heart failure 2025; (13(5)):815-825 doi:10.1016/j.jchf.2024.11.015.

Reverse Takotsubo cardiomyopathy at caesarean section following administration of glycopyrrolate for bradycardia secondary to high spinal block.

Mannolini K, Flanagan N, Brushett K, McCartney B

BMJ case reports 2025; (18(6)) doi:10.1136/bcr-2025-265777.

Refractory Acute Myocardial Infarction Cardiogenic Shock Due to Left Ventricular Outflow Tract Obstruction.

Akinmolayemi O, Beerkens FJ, Hu V, et al.

JACC. Case reports 2025; (30(23)):104452 doi:10.1016/j.jaccas.2025.104452.

Global Microvascular Dysfunction and Incomplete Recovery in Takotsubo Syndrome: Insights From Serial PET Imaging.

Kadoya Y, Chong AY, Small GR, et al.

Circulation. Cardiovascular imaging 2025; (18(10)):e018266 doi:10.1161/CIRCIMAGING.125.018266.

Long-Term Prognosis, Risk Assessment, and Management of Patients Diagnosed with Takotsubo Syndrome: A Narrative Review.

Kosek-Nikołajczuk M, Borowiak E, Piatkowski R, et al.

Journal of personalized medicine 2025; (15(9)) doi:10.3390/jpm15090425.

Takotsubo syndrome: pathophysiological insights and innovations in patient care.

Omerovic E, Redfors B

Nature reviews. Cardiology 2026; (23(4)):239-254 doi:10.1038/s41569-025-01211-5.

Validation of the InterTAK Diagnostic Score for Differentiating Takotsubo Syndrome from Acute Coronary Syndrome in a Middle Eastern Population.

Jamil G, Al Shamisi A, AlShamsi F, Agha A

Journal of clinical medicine 2025; (14(21)) doi:10.3390/jcm14217806.

Left anterior descending artery stenosis coexisting with Takotsubo cardiomyopathy: Innocent bystander or underlying culprit?

Jabri M, Ismaili N, Ouafi NE

Radiology case reports 2026; (21(2)):669-675 doi:10.1016/j.radcr.2025.10.036.

Severe reverse Takotsubo cardiomyopathy and cardiogenic shock during Caesarean section surgery under epidural anaesthesia: a case report.

Alkadi AM, Alkaf FA, Shah MA, Qattea MB

European heart journal. Case reports 2025; (9(12)):ytaf619 doi:10.1093/ehjcr/ytaf619.

Perioperative Takotsubo Cardiomyopathy Revealed by Ventricular Arrhythmia After a Minor Surgery in a Young Woman.

Hafid S, Lebbar S, Bennis G, et al.

Cureus 2026; (18(1)):e101699 doi:10.7759/cureus.101699.

Takotsubo: a systematic review of the neurological and psychological implications of a broken heart.

Cappadona I, Pagano M, Cardile D, et al.

Future cardiology 2026; (22(3)):309-317 doi:10.1080/14796678.2026.2635981.

Late Gadolinium Enhancement on Cardiac MRI in Patients With Takotsubo Syndrome: Insights From the Multicenter EVOLUTION Registry.

Cau R, Arcari L, Pontone G, et al.

AJR. American journal of roentgenology 2026; doi:10.2214/AJR.26.34546.

Diagnostic challenges of Takotsubo syndrome in the context of hypertrophic obstructive cardiomyopathy phenocopy.

Bánfi-Bacsárdi F, Forrai Z, Piróth Z, Muk B

BMJ case reports 2026; (19(2)) doi:10.1136/bcr-2025-270318.

Fuzzy boundaries between physical and emotional triggers in Takotsubo syndrome: a scoping review.

Scalzeri M, Mastrangelo A, Andreini D, et al.

BMC cardiovascular disorders 2026; (26(1)).