Research & Literature
Explore the leading researchers and institutions driving advances in this area, and dive into the full body of literature that informs this resource.
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University of Pisa
Pisa, Italy
Johannes Gutenberg University Mainz
Mainz, Germany
Sun Yat-sen University
Guangzhou, China
University of Miami
Coral Gables, United States
Essen University Hospital
Essen, Germany
Shanghai Jiao Tong University
Shanghai, China
Institute for Health Metrics and Evaluation
Seattle, United States
Shanghai Ninth People's Hospital
Shanghai, China
University of Tennessee Health Science Center
Memphis, United States
Cliniques Universitaires Saint-Luc
Brussels, Belgium
References
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Ophthalmic plastic and reconstructive surgery 2018; (34(4S Suppl 1)):S52-S55 doi:10.1097/IOP.0000000000001137.
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Functional and structural evaluation of the meibomian gland using a LipiView interferometer in thyroid eye disease.
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Canadian journal of ophthalmology. Journal canadien d'ophtalmologie 2018; (53(4)):373-379 doi:10.1016/j.jcjo.2017.11.006.
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Predominant Contribution of Superior Rectus-Levator Complex Enlargement to Optic Neuropathy and Inferior Visual Field Defects in Thyroid Eye Disease.
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Ophthalmic plastic and reconstructive surgery 2019; (35(3)):262-265 doi:10.1097/IOP.0000000000001224.
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Orbital decompression surgery for the treatment of Graves' ophthalmopathy: comparison of different techniques and long-term results.
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Definition and Diagnostic Criteria of Dry Eye Disease: Historical Overview and Future Directions.
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The Effect of Smoking on Mitochondrial Biogenesis in Patients With Graves Ophthalmopathy.
Yuksel N, Yaman D, Tugce Pasaoglu O, Pasaoglu H
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The New England journal of medicine 2020; (382(4)):341-352 doi:10.1056/NEJMoa1910434.
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Critical care research and practice 2020; (2020()):6267432 doi:10.1155/2020/6267432.
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Ocular Hypertension, Glaucoma or Compressive Neuropathy in Patient with Active TED.
Stoyanova NS, Konareva-Kostianeva MI, Mitkova-Hristova VT
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Treatment with Intravenous Methylprednisolone in Patients with Graves' Orbitopathy Significantly Affects Adrenal Function: Assessment of Serum, Salivary Cortisol and Serum Dehydroepiandrosterone Sulfate.
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Journal of clinical medicine 2020; (9(10)) doi:10.3390/jcm9103233.
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A retrospective study of pediatric thyroid eye disease: the Asian experience.
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Gender differences in clinical presentation and prognosis of thyroid eye disease.
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Eyelid Surgery in Graves' Orbitopathy.
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Klinische Monatsblatter fur Augenheilkunde 2021; (238(1)):33-40 doi:10.1055/a-1325-9061.
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Risk Factors of Thyroid Eye Disease.
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Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists 2021; (27(3)):245-253 doi:10.1016/j.eprac.2020.11.011.
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New-Onset of Inflammatory Bowel Disease in a Patient Treated With Teprotumumab for Thyroid Associated Ophthalmopathy.
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Predictive Factors for Changes in Quality of Life after Steroid Treatment for Active Moderate-to-Severe Graves' Orbitopathy: A Prospective Trial.
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European thyroid journal 2021; (9(6)):313-320 doi:10.1159/000508071.
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Teprotumumab: The First Approved Biologic for Thyroid Eye Disease.
Hwang CJ, Eftekhari K
International ophthalmology clinics 2021; (61(2)):53-61 doi:10.1097/IIO.0000000000000353.
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Advanced Techniques in Orbital Decompression Surgery: Recent Advances.
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International ophthalmology clinics 2021; (61(2)):89-105 doi:10.1097/IIO.0000000000000346.
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Carotid-Cavernous Sinus Fistula Masquerading as Thyroid Eye Disease.
Azzam DB, Cypen SG, Conger JR, Tao JP
Cureus 2021; (13(4)):e14261 doi:10.7759/cureus.14261.
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A pathological indicator for dysthyroid optic neuropathy: tritan color vision deficiency.
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Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie 2021; (259(11)):3421-3426 doi:10.1007/s00417-021-05227-8.
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Tocilizumab for the Management of Thyroid-Associated Orbitopathy.
Smith LD, Moscato EE, Seiff SR
Ophthalmic plastic and reconstructive surgery 2022; (38(2)):188-192 doi:10.1097/IOP.0000000000002027.
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Cigarette smoking and nicotine exposure contributes for aberrant insulin signaling and cardiometabolic disorders.
Rehman K, Haider K, Akash MSH
European journal of pharmacology 2021; (909()):174410 doi:10.1016/j.ejphar.2021.174410.
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Quality of Life in Patients with Chronic Thyroid Eye Disease in the United States.
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Inhibition of TSH/IGF-1 Receptor Crosstalk by Teprotumumab as a Treatment Modality of Thyroid Eye Disease.
Krieger CC, Sui X, Kahaly GJ, et al.
The Journal of clinical endocrinology and metabolism 2022; (107(4)):e1653-e1660 doi:10.1210/clinem/dgab824.
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Upper Eyelid Contour Changes After Orbital Decompression in Graves Orbitopathy.
Cruz AAV, Equitério B, Diniz SB, et al.
Ophthalmic plastic and reconstructive surgery 2022; (38(3)):289-293 doi:10.1097/IOP.0000000000002093.
PMID: 34812182 - 54
Efficacy and Safety of Teprotumumab in Thyroid Eye Disease.
Teo HM, Smith TJ, Joseph SS
Therapeutics and clinical risk management 2021; (17()):1219-1230 doi:10.2147/TCRM.S303057.
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Proptosis and Diplopia Response With Teprotumumab and Placebo vs the Recommended Treatment Regimen With Intravenous Methylprednisolone in Moderate to Severe Thyroid Eye Disease: A Meta-analysis and Matching-Adjusted Indirect Comparison.
Douglas RS, Dailey R, Subramanian PS, et al.
JAMA ophthalmology 2022; (140(4)):328-335 doi:10.1001/jamaophthalmol.2021.6284.
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Pathophysiology of thyroid-associated orbitopathy.
Lee ACH, Kahaly GJ
Best practice & research. Clinical endocrinology & metabolism 2023; (37(2)):101620 doi:10.1016/j.beem.2022.101620.
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Insights into Current Management Strategies for Dysthyroid Optic Neuropathy: A Review.
Tagami M, Honda S, Azumi A
Clinical ophthalmology (Auckland, N.Z.) 2022; (16()):841-850 doi:10.2147/OPTH.S284609.
PMID: 35330749 - 58
Thyroid-Stimulating Antibody/Thyroid-Stimulating Hormone Receptor Antibody Ratio as a Sensitive Screening Test for Active Graves' Orbitopathy.
Nakano M, Konishi H, Koshiba M
Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists 2022; (28(10)):1050-1054 doi:10.1016/j.eprac.2022.07.007.
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Reduced choroidal peripapillary capillaries in thyroid-associated ophthalmopathy with early stage of dysthyroid optic neuropathy.
Wu JH, Luo LY, Zhou H, et al.
International journal of ophthalmology 2022; (15(7)):1135-1141 doi:10.18240/ijo.2022.07.14.
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Decrease in Bone Formation and Bone Resorption during Intravenous Methylprednisolone Pulse Therapy in Patients with Graves' Orbitopathy.
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Journal of clinical medicine 2022; (11(17)) doi:10.3390/jcm11175005.
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Dysthyroid optic neuropathy: Demographics, risk factors, investigations, and management outcomes.
Poonam NS, Alam MS, Oberoi P, Mukherjee B
Indian journal of ophthalmology 2022; (70(12)):4419-4426 doi:10.4103/ijo.IJO_719_22.
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Role of teprotumumab in the treatment of active moderate-to-severe Graves' orbitopathy.
Bartalena L
European thyroid journal 2022; (11(6)).
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Management of thyroid eye disease: a Consensus Statement by the American Thyroid Association and the European Thyroid Association.
Burch HB, Perros P, Bednarczuk T, et al.
European thyroid journal 2022; (11(6)).
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Machine learning-assisted system using digital facial images to predict the clinical activity score in thyroid-associated orbitopathy.
Moon JH, Shin K, Lee GM, et al.
Scientific reports 2022; (12(1)):22085 doi:10.1038/s41598-022-25887-8.
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Thyroid Eye Disease.
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Life (Basel, Switzerland) 2022; (12(12)) doi:10.3390/life12122084.
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Evaluation of Depression and Anxiety in a Diverse Population With Thyroid Eye Disease Using the Nationwide NIH All of Us Database.
Lee TC, Radha-Saseendrakumar B, Delavar A, et al.
Ophthalmic plastic and reconstructive surgery 2023; (39(3)):281-287 doi:10.1097/IOP.0000000000002318.
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Graves' Eye Disease: Clinical and Radiological Diagnosis.
Hutchings KR, Fritzhand SJ, Esmaeli B, et al.
Biomedicines 2023; (11(2)) doi:10.3390/biomedicines11020312.
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Prospective Assessment of Otologic Adverse Events due to Teprotumumab: Preliminary Results.
Kay-Rivest E, Belinsky I, Kozlova A, et al.
Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery 2023; (168(5)):1164-1169 doi:10.1002/ohn.174.
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Ocular Surface Changes in Treatment-Naive Thyroid Eye Disease.
Liao X, Lai KKH, Aljufairi FMAA, et al.
Journal of clinical medicine 2023; (12(9)) doi:10.3390/jcm12093066.
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[Complications of transnasal endoscopic orbital decompression in thyroid eye disease].
Grusha YO, Kochetkov PA, Danilov SS, et al.
Vestnik oftalmologii 2023; (139(3)):63-68 doi:10.17116/oftalma202313903163.
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The effect of previous orbital decompression on outcomes of rectus muscle recession surgery in patients with thyroid ophthalmopathy.
Hou X, Tu Y, Min X, et al.
Journal francais d'ophtalmologie 2024; (47(1)):103924 doi:10.1016/j.jfo.2023.01.045.
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The effect of acromegaly on thyroid disease.
Mo C, Zhong L
Endocrine journal 2023; (70(11)):1051-1060 doi:10.1507/endocrj.EJ23-0356.
PMID: 37880078 - 73
Teprotumumab and Orbital Decompression for the Management of Proptosis in Patients With Thyroid Eye Disease.
Hubschman S, Sojitra B, Ghiam S, et al.
Ophthalmic plastic and reconstructive surgery 2024; (40(3)):270-275 doi:10.1097/IOP.0000000000002563.
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Current and promising therapies based on the pathogenesis of Graves' ophthalmopathy.
Zhang X, Zhao Q, Li B
Frontiers in pharmacology 2023; (14()):1217253 doi:10.3389/fphar.2023.1217253.
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Dysthyroid Optic Neuropathy.
Potvin ARGG, Pakdel F, Saeed P
Ophthalmic plastic and reconstructive surgery 2023; (39(6S)):S65-S80 doi:10.1097/IOP.0000000000002555.
PMID: 38054987 - 76
Orbital Decompression: Conceptual Approach for Orbital Volume Expansion.
Goldberg RA, Gout T
Ophthalmic plastic and reconstructive surgery 2023; (39(6S)):S105-S111 doi:10.1097/IOP.0000000000002556.
PMID: 38054990 - 77
Surgical Outcomes of Standardized Endoscopical Deep Medial Orbital Decompression in Dysthyroid Optic Neuropathy.
Li C, Gao Y, Zhang Z, et al.
Ophthalmic research 2024; (67(1)):39-50 doi:10.1159/000535330.
PMID: 38109861 - 78
The Role of Thermal Camera in the Assessment of Thyroid Eye Disease Activity.
Prpic A, Kasumovic A, Guarro IG, et al.
Acta informatica medica : AIM : journal of the Society for Medical Informatics of Bosnia & Herzegovina : casopis Drustva za medicinsku informatiku BiH 2023; (31(4)):260-264 doi:10.5455/aim.2023.31.260-264.
PMID: 38379681 - 79
Tocilizumab use for optic nerve compression in thyroid eye disease: a prospective longitudinal cohort.
Habroosh FA, Albrashdi SS, Alsaadi AH, Eatamadi H
International ophthalmology 2024; (44(1)):222 doi:10.1007/s10792-024-03143-4.
PMID: 38717530 - 80
A Review of Novel Medical Treatments for Thyroid Eye Disease.
Park JW, Yoon JS
Korean journal of ophthalmology : KJO 2024; (38(3)):249-259 doi:10.3341/kjo.2024.0031.
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Plasma exosomes from patients with active thyroid-associated orbitopathy induce inflammation and fibrosis in orbital fibroblasts.
Wei L, Huang Q, Tu Y, et al.
Journal of translational medicine 2024; (22(1)):546 doi:10.1186/s12967-024-05263-y.
PMID: 38849907 - 82
Systematic review of ocular surface treatments in the setting of thyroid eye disease.
Wong AS, Chelnis JG
Frontiers in ophthalmology 2024; (4()):1352355 doi:10.3389/fopht.2024.1352355.
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Thyroid Eye Disease: Advancements in Orbital and Ocular Pathology Management.
Scarabosio A, Surico PL, Singh RB, et al.
Journal of personalized medicine 2024; (14(7)) doi:10.3390/jpm14070776.
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Quality of life in patients with Graves' orbitopathy submitted to orbital decompression: comparison between balanced and inferomedial techniques.
Leite CA, Pereira TS, Chiang J, et al.
Arquivos brasileiros de oftalmologia 2024; (87(5)):e20230296 doi:10.5935/0004-2749.2023-0296.
PMID: 39109703 - 85
Role of Lysyl Oxidase-Like Protein 3 in the Pathogenesis of Graves' Orbitopathy in Orbital Fibroblasts.
Park SH, Choi SH, Park HY, et al.
Investigative ophthalmology & visual science 2024; (65(13)):33 doi:10.1167/iovs.65.13.33.
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Risk of audiologic side effects with teprotumumab treatment for thyroid eye disease: propensity matched analysis.
Markle JC, Johanis A, Shaia JK, et al.
Eye (London, England) 2025; (39(6)):1107-1114 doi:10.1038/s41433-024-03531-1.
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Efficacy and Safety of Teprotumumab in Thyroid Eye Disease: A Systematic Review and Meta-Analysis.
Huang W, Ou X, Lin S, et al.
Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists 2025; (31(5)):640-649 doi:10.1016/j.eprac.2025.01.012.
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S-phase kinase-associated protein 1 inhibits orbital fibroblasts adipogenesis to improve thyroid-associated ophthalmopathy (TAO).
Lu S, Xiong W, Yi J, et al.
Biochimica et biophysica acta. Molecular cell research 2025; (1872(5)):119937 doi:10.1016/j.bbamcr.2025.119937.
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Teprotumumab Improves Quality of Life in Thyroid Eye Disease: Meta-analysis and Matching-adjusted Indirect Comparison.
Kahaly GJ, Xi A, Barretto N, et al.
Journal of the Endocrine Society 2025; (9(6)):bvaf063 doi:10.1210/jendso/bvaf063.
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Thyroid eye disease (Graves' orbitopathy): clinical presentation, epidemiology, pathogenesis, and management.
Wiersinga WM, Eckstein AK, Žarković M
The lancet. Diabetes & endocrinology 2025; (13(7)):600-614 doi:10.1016/S2213-8587(25)00066-X.
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Quantification of Conjunctival Dendritiform Cells under In Vivo Confocal Microscopy for Clinical Activity Evaluation in Thyroid Eye Disease.
Cai J, Zheng T, Ng TK, et al.
Current eye research 2025; (50(10)):1003-1009 doi:10.1080/02713683.2025.2521865.
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Teprotumumab for treating active thyroid eye disease: A meta-analysis.
Cong X, Pei L, Hu H
Medicine 2025; (104(26)):e42966 doi:10.1097/MD.0000000000042966.
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