Research & Literature

Urinary β2-Microglobulin Testing in Pediatric Uveitis: A Case Report of a 9-Year-Old Boy with Renal and Ocular Sarcoidosis.

Pepple KL, Lam DL, Finn LS, Van Gelder R

Case reports in ophthalmology 2015; (6(1)):101-5 doi:10.1159/000381092.

Tubulointerstitial nephritis: diagnosis, treatment, and monitoring.

Joyce E, Glasner P, Ranganathan S, Swiatecka-Urban A

Pediatric nephrology (Berlin, Germany) 2017; (32(4)):577-587 doi:10.1007/s00467-016-3394-5.

Clinicopathologic characteristics, treatment, and outcomes of tubulointerstitial nephritis and uveitis syndrome in adults: A national retrospective strobe-compliant study.

Legendre M, Devilliers H, Perard L, et al.

Medicine 2016; (95(26)):e3964 doi:10.1097/MD.0000000000003964.

Three cases of tubulointerstitial nephritis and uveitis syndrome with different clinical manifestations.

Nagashima T, Ishihara M, Shibuya E, et al.

International ophthalmology 2017; (37(3)):753-759 doi:10.1007/s10792-016-0321-5.

A Rare Case of Tubulointerstitial Nephritis and Uveitis Syndrome Treated with a Multi-Specialty Approach.

Purt B, Hiremath S, Smith S, et al.

The American journal of case reports 2016; (17()):869-873 doi:10.12659/ajcr.900701.

Long-term Follow-up of Patients with Tubulointerstitial Nephritis and Uveitis (TINU) Syndrome.

Sobolewska B, Bayyoud T, Deuter C, et al.

Ocular immunology and inflammation 2018; (26(4)):601-607 doi:10.1080/09273948.2016.1247872.

Successful treatment of tubulointerstitial nephritis and uveitis with steroid and azathioprine in a 12-year-old boy.

Kim JE, Park SJ, Oh JY, et al.

Korean journal of pediatrics 2016; (59(Suppl 1)):S99-S102 doi:10.3345/kjp.2016.59.11.S99.

Tubulointerstitial nephritis and uveitis (TINU) syndrome: a systematic review of its epidemiology, demographics and risk factors.

Okafor LO, Hewins P, Murray PI, Denniston AK

Orphanet journal of rare diseases 2017; (12(1)):128 doi:10.1186/s13023-017-0677-2.

Tubulointerstitial nephritis and uveitis.

Pakzad-Vaezi K, Pepple KL

Current opinion in ophthalmology 2017; (28(6)):629-635 doi:10.1097/ICU.0000000000000421.

Clinical Profile, Ultra-Wide-Field Fluorescence Angiography Findings, and Long-Term Prognosis of Uveitis in Tubulointerstitial Nephritis and Uveitis Syndrome at One Tertiary Medical Institute in China.

Yang M, Chi Y, Guo C, et al.

Ocular immunology and inflammation 2019; (27(3)):371-379 doi:10.1080/09273948.2017.1394469.

A child with tubulointerstitial nephritis and uveitis (TINU) syndrome.

Pereira C, Costa-Reis P, Esteves da Silva J, Stone R

BMJ case reports 2018; (2018()) doi:10.1136/bcr-2017-222766.

Pediatric Uveitis.

Chan NS, Choi J, Cheung CMG

Asia-Pacific journal of ophthalmology (Philadelphia, Pa.) 2018; (7(3)):192-199 doi:10.22608/APO.2018116.

Clinical and Genetic Features of Tubulointerstitial Nephritis and Uveitis Syndrome with Long-Term Follow-Up.

Kanno H, Ishida K, Yamada W, et al.

Journal of ophthalmology 2018; (2018()):4586532 doi:10.1155/2018/4586532.

HLA-DQA1, -DQB1, and -DRB1 Alleles Associated with Acute Tubulointerstitial Nephritis in a Chinese Population: A Single-Center Cohort Study.

Jia Y, Su T, Gu Y, et al.

Journal of immunology (Baltimore, Md. : 1950) 2018; (201(2)):423-431 doi:10.4049/jimmunol.1800237.

Urinary β2-microglobulin and disease activity in patients with tubulointerstitial nephritis and uveitis syndrome.

Provencher LM, Fairbanks AM, Abramoff MD, Syed NA

Journal of ophthalmic inflammation and infection 2018; (8(1)):24 doi:10.1186/s12348-018-0166-3.

Real-world evidence of treatment for relapse of noninfectious uveitis in tertiary centers in Japan: A multicenter study.

Takeuchi M, Kanda T, Kaburaki T, et al.

Medicine 2019; (98(9)):e14668 doi:10.1097/MD.0000000000014668.

Bilateral decompression retinopathy after deep sclerectomy with mitomycin C in a child with tubulointerstitial nephritis and uveitis syndrome.

Muñoz-Negrete FJ, Díez-Álvarez L, Garcia CF, Rebolleda G

European journal of ophthalmology 2020; (30(3)):NP1-NP6 doi:10.1177/1120672119832177.

Tubulointerstitial nephritis and uveitis syndrome.

Vikse J, Johnsen SJA, Rønning B, et al.

Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke 2019; (139(8)) doi:10.4045/tidsskr.18.0840.

Ultra-widefield Fluorescein Angiography and OCT Findings in Tubulointerstitial Nephritis and Uveitis Syndrome.

Cao JL, Srivastava SK, Venkat A, et al.

Ophthalmology. Retina 2020; (4(2)):189-197 doi:10.1016/j.oret.2019.08.012.

Tubulointerstitial nephritis and uveitis (TINU) syndrome and recent Streptococcus infection in a 9-year-old girl.

Moreton RB, Fleck BW, Davidson J, Hughes D

BMJ case reports 2020; (13(2)) doi:10.1136/bcr-2019-232077.

Tubulointerstitial Nephritis and Uveitis Syndrome: Characterization of Clinical Features.

Koreishi AF, Zhou M, Goldstein DA

Ocular immunology and inflammation 2021; (29(7-8)):1312-1317 doi:10.1080/09273948.2020.1736311.

Comprehensive Assessment of Quality of Life, Functioning, and Mental Health in Children With Juvenile Idiopathic Arthritis and Noninfectious Uveitis.

McDonald J, Cassedy A, Altaye M, et al.

Arthritis care & research 2022; (74(8)):1311-1320 doi:10.1002/acr.24551.

Long-term clinical characteristics and renal prognosis of children with tubulointerstitial nephritis and uveitis syndrome.

Hayashi A, Takahashi T, Ueda Y, et al.

Pediatric nephrology (Berlin, Germany) 2021; (36(8)):2319-2325 doi:10.1007/s00467-021-04956-6.

Tubulointerstitial nephritis and uveitis syndrome: a systematic review.

Regusci A, Lava SAG, Milani GP, et al.

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2022; (37(5)):876-886 doi:10.1093/ndt/gfab030.

Classification Criteria for Tubulointerstitial Nephritis With Uveitis Syndrome.

American journal of ophthalmology 2021; (228()):255-261 doi:10.1016/j.ajo.2021.03.041.

Long-term outcome of biopsy-proven idiopathic tubulointersitial nephritis with or without uveitis in children-a nationwide follow-up study.

Rytkönen S, Tainio J, Saarela V, et al.

Pediatric nephrology (Berlin, Germany) 2021; (36(11)):3663-3671 doi:10.1007/s00467-021-05060-5.

Pediatric uveitis: A comprehensive review.

Maleki A, Anesi SD, Look-Why S, et al.

Survey of ophthalmology 2022; (67(2)):510-529 doi:10.1016/j.survophthal.2021.06.006.

Tubulointerstitial nephritis and uveitis in Northern Ireland.

Heaney A, McLoone E, Williams M, et al.

Eye (London, England) 2022; (36(8)):1645-1650 doi:10.1038/s41433-021-01677-w.

Tubulointerstitial nephritis and uveitis syndrome following meningitis and systemic lymphadenopathy with persistent Toxoplasma immunoglobulin M: a case report.

Oya Y, Futami H, Nakazawa T, et al.

Journal of medical case reports 2021; (15(1)):482 doi:10.1186/s13256-021-02909-z.

Immunomodulation and TNF-α inhibition for tubulointerstitial nephritis and uveitis syndrome: a case series.

Tirelli F, Shafer BM, Davidson SL, Lerman MA

Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus 2021; (25(5)):267.e1-267.e6 doi:10.1016/j.jaapos.2021.03.017.

Characteristics of renal sarcoidosis and tubulointerstitial nephritis and uveitis syndrome in Slovenia: An analysis of the national renal biopsy registry and patient datasets in the last decade.

Frelih M, Piko N, Večerić-Haler Ž, et al.

Clinical nephrology 2021; (96(1)):6-15 doi:10.5414/CNP96S02.

Renal Prognosis in Children With Tubulointerstitial Nephritis and Uveitis Syndrome.

Chevalier A, Duflos C, Clave S, et al.

Kidney international reports 2021; (6(12)):3045-3053 doi:10.1016/j.ekir.2021.09.017.

Renal replacement therapy-requiring acute kidney injury due to tubulointerstitial nephritis and uveitis syndrome: case report.

Marahrens B, Amann K, Asmus K, et al.

Journal of medical case reports 2021; (15(1)):629 doi:10.1186/s13256-021-03147-z.

A non-immunocompromised host with nontuberculous mycobacteria-associated tubulointerstitial nephritis.

Hattori S, Fujisaki K, Nakamata Y, et al.

CEN case reports 2022; (11(4)):442-447 doi:10.1007/s13730-022-00690-6.

A Young Man With Acute Kidney Injury and Uveitis: An Unusual Presentation and Case Report.

Iqbal J, Alassafi MT, Alashaikh FM, et al.

Cureus 2022; (14(6)):e25927 doi:10.7759/cureus.25927.

Renal outcomes in tubulointerstitial nephritis and uveitis (TINU) syndrome: a systematic review and meta-analysis.

Southgate G, Clarke P, Harmer MJ

Journal of nephrology 2023; (36(2)):507-519 doi:10.1007/s40620-022-01478-8.

RARE COMPLICATION OF COVID -19 DISEASE TINU SYNDROME IN A 11-YEAR-OLD BOY, FEATURES AND MANAGMENT.

Bilak VM, Ilko AV, Ignatko YY, Ignatko LV

Wiadomosci lekarskie (Warsaw, Poland : 1960) 2022; (75(10)):2541-2543 doi:10.36740/WLek202210142.

TUBULOINTERSTITIAL NEPHRITIS WITH UVEITIS (TINU SYNDROME). A CASE REPORT.

Kurašová E, Orság J, Klementa V, et al.

Ceska a slovenska oftalmologie : casopis Ceske oftalmologicke spolecnosti a Slovenske oftalmologicke spolecnosti 2022; (78(6)):315-318 doi:10.31348/2022/31.

Genome-Wide Association Study in Acute Tubulointerstitial Nephritis.

Zhou XJ, Su T, Xie J, et al.

Journal of the American Society of Nephrology : JASN 2023; (34(5)):895-908 doi:10.1681/ASN.0000000000000091.

Tubulointerstitial nephritis and uveitis in children during the COVID-19 pandemic: report of four cases.

Sakhinia F, Brice V, Ollerenshaw R, et al.

Journal of nephrology 2023; (36(5)):1451-1455 doi:10.1007/s40620-022-01564-x.

An Overview of Pediatric Uveitis.

Tuğal-Tutkun İ

Turkish archives of pediatrics 2023; (58(4)):363-370 doi:10.5152/TurkArchPediatr.2023.23086.

Tubulointerstitial Nephritis and Uveitis Syndrome: A Report of 6 Cases with Renal Biopsy and Electron Microscopy Evaluation.

Palamaris K, Stylianou K, Destouni M, et al.

Nephron 2024; (148(4)):204-214 doi:10.1159/000533402.

Ocular manifestations and clinical outcomes in Tubulointerstitial Nephritis and Uveitis Syndrome (TINU).

Uludag Kirimli G, Hassan M, Onghanseng N, et al.

Eye (London, England) 2024; (38(2)):349-356 doi:10.1038/s41433-023-02695-6.

Diagnostic and Management Strategies of Tubulointerstitial Nephritis and Uveitis Syndrome (TINU): Current Perspectives.

Sanchez-Quiros J, Giralt L, Fonollosa A, et al.

Clinical ophthalmology (Auckland, N.Z.) 2023; (17()):2625-2630 doi:10.2147/OPTH.S404644.

Comprehensive evaluation of functional vision, quality of life, and cognitive ability in pediatric uveitis.

Wan W, Chen Z, Xun Y, et al.

BMC ophthalmology 2023; (23(1)):381 doi:10.1186/s12886-023-03117-7.

Clinical outcomes in paediatric tubulointerstitial nephritis and uveitis syndrome (TINU).

Mandel M, Elhusseiny AM, Davidson SL, et al.

Eye (London, England) 2024; (38(17)):3318-3324 doi:10.1038/s41433-024-03286-9.

Pediatric uveitis.

Furtado JM, Smith JR

Journal of family medicine and primary care 2024; (13(11)):4815-4818 doi:10.4103/jfmpc.jfmpc_923_24.

A Case of Tubulointerstitial Nephritis With Uveitis Diagnosed From Isolated Glucosuria Detected During School Urinary Screening.

Kumagai N, Akamatsu M, Kawamura Y, et al.

Cureus 2025; (17(1)):e77447 doi:10.7759/cureus.77447.

Acute tubulointerstitial nephritis (ATIN) including drug-induced, tubulointerstitial nephritis and uveitis (TINU), ANCA-associated vasculitis (AAV), kidney- limited sarcoidosis, and hemolysis: a case series from Syria.

Alsultan M, Kliea M, Hassan Q

BMC nephrology 2025; (26(1)):97 doi:10.1186/s12882-025-04030-5.

Drug-induced tubulointerstitial nephritis and uveitis syndrome in a nationwide surveillance.

Ali A, Downes DG, Eleiwa TK, et al.

Eye (London, England) 2025; (39(10)):2036-2041 doi:10.1038/s41433-025-03808-z.

Yersiniosis complicated by tubulointerstitial nephropathy necessitating peritoneal dialysis in a young child.

Dutilloy M, Ferrand J, Martinez-Casado E, Petat H

BMJ case reports 2025; (18(4)) doi:10.1136/bcr-2025-265446.

Ocular complications in pediatric non-infectious anterior uveitis in long-term follow-up: population-based cohort study.

Siiskonen M, Pesälä R, Ohtonen P, et al.

Journal of ophthalmic inflammation and infection 2025; (15(1)):42 doi:10.1186/s12348-025-00499-1.

Tubulointerstitial nephritis and uveitis (TINU) syndrome: a case series.

Farnan R, Stokes J, Casey R, et al.

Journal of ophthalmic inflammation and infection 2025; (15(1)):55 doi:10.1186/s12348-025-00500-x.

Fatigue, Polyuria, and Hidden Uveitis: A Case of Tubulointerstitial Nephritis and Uveitis Syndrome Diagnosed in Primary Care.

Kerner M, Todoroff J, von Schnakenburg C, et al.

Cureus 2025; (17(8)):e89245 doi:10.7759/cureus.89245.

Adalimumab in refractory pediatric tubulointerstitial nephritis and uveitis syndrome: a case report of sustained renal-ocular remission and literature review.

Yang D, Xi W, Liu W, et al.

BMC nephrology 2025; (26(1)):609 doi:10.1186/s12882-025-04535-z.

Successful long-term treatment of tubulointerstitial nephritis and uveitis with mycophenolate.

Qi L, Chandler S, Puri P, Hepburn K

BMJ case reports 2025; (18(11)) doi:10.1136/bcr-2025-266877.

Early Initiation of TNF Inhibitors for Tubulointerstitial Nephritis and Uveitis (TINU).

Song BM, VanDevoorde R, Graham TB, Gangaputra S

Ocular immunology and inflammation 2025; 1-5 doi:10.1080/09273948.2025.2592067.

Tubulointerstitial nephritis and uveitis syndrome in children: What to keep an eye on.

Hendrikse J, Simon ASP, Kalinina Ayuso V, et al.

Acta ophthalmologica 2026; (104(4)):e443-e452 doi:10.1111/aos.70042.

Cross-Cultural Adaptation and Validation of the Pediatric Eye Questionnaire in Chinese Children with Uveitis: A Rasch Analysis.

Linghu W, Sun X, Zhang M, et al.

Patient preference and adherence 2025; (19()):4167-4177 doi:10.2147/PPA.S556321.

Tubulointerstitial nephritis with uveitis (TINU) syndrome following COVID-19 vaccination in an elderly patient: a case report.

Takahashi S, Nagao N, Yoshida K, et al.

CEN case reports 2026; (15(1)):28 doi:10.1007/s13730-025-01047-5.

Clinical Features and Treatment Outcomes of Patients with Tubulointerstitial Nephritis and Uveitis Syndrome: A Case Series.

Ruiz-Lozano RE, Liberman P, Zhao AT, et al.

Ocular immunology and inflammation 2026; (34(3)):464-472 doi:10.1080/09273948.2026.2621958.

Tubulointerstitial Nephritis With Uveitis (TINU) Syndrome: A Case Series and Review of Literature.

Ali W, Agrawal N, Sinha S, et al.

Nephrology (Carlton, Vic.) 2026; (31(9)):e70271 doi:10.1111/nep.70271.

[Clinical analysis of 4 children with tubulointerstitial nephritis and uveitis syndrome].

Wang NN, Tu J, Chen CY

Zhonghua er ke za zhi = Chinese journal of pediatrics 2026; (64(11)):1274-1278 doi:10.3760/cma.j.cn112140-20260711-00547.