Research & Literature

High prevalence of gluten sensitivity in a cohort of patients with undifferentiated connective tissue disease.

Conti V, Leone MC, Casato M, et al.

European annals of allergy and clinical immunology 2015; (47(2)):54-7.

Recommendations on Screening for Chloroquine and Hydroxychloroquine Retinopathy (2016 Revision).

Marmor MF, Kellner U, Lai TY, et al.

Ophthalmology 2016; (123(6)):1386-94.

Estimating the incidence of connective tissue diseases and vasculitides in a defined population in Northern Savo area in 2010.

Elfving P, Marjoniemi O, Niinisalo H, et al.

Rheumatology international 2016; (36(7)):917-24 doi:10.1007/s00296-016-3474-7.

Fibromyalgia.

Häuser W, Ablin J, Fitzcharles MA, et al.

Nature reviews. Disease primers 2015; (1()):15022 doi:10.1038/nrdp.2015.22.

Autoantibodies Against DFS70/LEDGF Exclusion Markers for Systemic Autoimmune Rheumatic Diseases (SARD).

Seelig CA, Bauer O, Seelig HP

Clinical laboratory 2016; (62(4)):499-517 doi:10.7754/clin.lab.2015.150905.

Undifferentiated vasculitis or an evolving systemic autoimmune rheumatic disease?

Fatimah N, Ussaid A, Rasheed A

Oxford medical case reports 2016; (2016(8)):omw066 doi:10.1093/omcr/omw066.

Application of SLICC classification criteria in undifferentiated connective tissue disease and evolution in systemic lupus erythematosus: analysis of a large monocentric cohort with a long-term follow-up.

Bortoluzzi A, Furini F, Campanaro F, Govoni M

Lupus 2017; (26(6)):616-622 doi:10.1177/0961203316671814.

Undifferentiated connective tissue disease and interstitial lung disease: Trying to define patterns.

Alberti ML, Paulin F, Toledo HM, et al.

Reumatologia clinica 2018; (14(2)):75-80 doi:10.1016/j.reuma.2016.10.007.

Longitudinal analysis of quality of life in patients with undifferentiated connective tissue diseases.

Iudici M, Irace R, Riccardi A, et al.

Patient related outcome measures 2017; (8()):7-13 doi:10.2147/PROM.S117767.

Hydroxychloroquine retinopathy.

Yusuf IH, Sharma S, Luqmani R, Downes SM

Eye (London, England) 2017; (31(6)):828-845 doi:10.1038/eye.2016.298.

Intracranial lesion as onset symptom in a patient with early undifferentiated connective tissue disease: a case report.

Du Y, Li C, Zhao DD, et al.

BMC neurology 2017; (17(1)):85 doi:10.1186/s12883-017-0868-4.

Lung involvement in "stable" undifferentiated connective tissue diseases: a rheumatology perspective.

Riccardi A, Irace R, Di Stefano I, et al.

Clinical rheumatology 2017; (36(8)):1833-1837 doi:10.1007/s10067-017-3704-8.

Undifferentiated connective tissue disease: predictors of evolution into definite disease.

García-González M, Rodríguez-Lozano B, Bustabad S, Ferraz-Amaro I

Clinical and experimental rheumatology 2017; (35(5)):739-745.

Undifferentiated connective tissue diseases and adverse pregnancy outcomes. An undervalued association?

Spinillo A, Beneventi F, Caporali R, et al.

American journal of reproductive immunology (New York, N.Y. : 1989) 2017; (78(6)) doi:10.1111/aji.12762.

Hydroxychloroquine-induced autophagic vacuolar myopathy with mitochondrial abnormalities.

Khosa S, Khanlou N, Khosa GS, Mishra SK

Neuropathology : official journal of the Japanese Society of Neuropathology 2018; (38(6)):646-652 doi:10.1111/neup.12520.

The presence of anti-nuclear antibodies alone is associated with changes in B cell activation and T follicular helper cells similar to those in systemic autoimmune rheumatic disease.

Baglaenko Y, Chang NH, Johnson SR, et al.

Arthritis research & therapy 2018; (20(1)):264 doi:10.1186/s13075-018-1752-3.

Undifferentiated connective tissue disease: state of the art on clinical practice guidelines.

Antunes M, Scirè CA, Talarico R, et al.

RMD open 2018; (4(Suppl 1)):e000786 doi:10.1136/rmdopen-2018-000786.

Fatigue severity in anti-nuclear antibody-positive individuals does not correlate with pro-inflammatory cytokine levels or predict imminent progression to symptomatic disease.

Hafiz W, Nori R, Bregasi A, et al.

Arthritis research & therapy 2019; (21(1)):223 doi:10.1186/s13075-019-2013-9.

A multicentre study of 244 pregnancies in undifferentiated connective tissue disease: maternal/fetal outcomes and disease evolution.

Radin M, Schreiber K, Cecchi I, et al.

Rheumatology (Oxford, England) 2020; (59(9)):2412-2418 doi:10.1093/rheumatology/kez620.

Impact of the 2019 European Alliance of Associations for Rheumatology/American College of Rheumatology Classification Criteria for Systemic Lupus Erythematosus in a Multicenter Cohort Study of 133 Women With Undifferentiated Connective Tissue Disease.

Radin M, Schreiber K, Cecchi I, et al.

Arthritis care & research 2021; (73(12)):1804-1808 doi:10.1002/acr.24391.

The prevalence of thyroid autoantibodies in autoimmune connective tissue diseases: a systematic review and meta-analysis.

Wang Q, Shangguan J, Zhang Y, et al.

Expert review of clinical immunology 2020; (16(9)):923-930 doi:10.1080/1744666X.2020.1811089.

American College of Rheumatology, American Academy of Dermatology, Rheumatologic Dermatology Society, and American Academy of Ophthalmology 2020 Joint Statement on Hydroxychloroquine Use With Respect to Retinal Toxicity.

Rosenbaum JT, Costenbader KH, Desmarais J, et al.

Arthritis & rheumatology (Hoboken, N.J.) 2021; (73(6)):908-911 doi:10.1002/art.41683.

The Psychosocial Impact of Undifferentiated Connective Tissue Disease on Patient Health and Well-Being: A Qualitative Study.

Siegel CH, Kleinman J, Barbhaiya M, et al.

Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases 2022; (28(2)):e340-e347 doi:10.1097/RHU.0000000000001714.

The impact of various entities of antiphospholipid antibodies positivity on adverse pregnancy outcome. An epidemiological perspective.

Spinillo A, Bellingeri C, De Maggio I, et al.

Journal of reproductive immunology 2021; (145()):103304 doi:10.1016/j.jri.2021.103304.

[Undifferentiated connective tissue disease : what is it ?]

Brulhart L

Revue medicale suisse 2021; (17(729)):498-500.

Occult primary Sjögren Syndrome in patients with interstitial pneumonia with autoimmune features.

Auteri S, Alberti ML, Fernández ME, et al.

Respiratory medicine 2021; (182()):106405 doi:10.1016/j.rmed.2021.106405.

Undifferentiated connective tissue disease presenting with optic neuritis and concomitant axial spondyloarthritis: A rare case report.

Mansız-Kaplan B, Nacır B, Mülkoğlu C, et al.

Turkish journal of physical medicine and rehabilitation 2021; (67(1)):111-114 doi:10.5606/tftrd.2021.4909.

Serological abnormalities that predict progression to systemic autoimmune rheumatic diseases in antinuclear antibody-positive individuals.

Muñoz-Grajales C, Prokopec SD, Johnson SR, et al.

Rheumatology (Oxford, England) 2022; (61(3)):1092-1105 doi:10.1093/rheumatology/keab501.

Disease evolution in a long-term follow-up of 104 undifferentiated connective tissue disease patients.

Radin M, Rubini E, Cecchi I, et al.

Clinical and experimental rheumatology 2022; (40(3)):575-580 doi:10.55563/clinexprheumatol/7vp1bo.

Diagnosis of Undifferentiated Connective Tissue Disease in a Patient With Digital Gangrene and Positive Antinuclear Antibodies.

Ravi P, Thabah MM, Verghese RJ, et al.

Cureus 2021; (13(6)):e15883 doi:10.7759/cureus.15883.

American College of Rheumatology White Paper on Antimalarial Cardiac Toxicity.

Desmarais J, Rosenbaum JT, Costenbader KH, et al.

Arthritis & rheumatology (Hoboken, N.J.) 2021; (73(12)):2151-2160 doi:10.1002/art.41934.

Performance of the systemic lupus erythematosus risk probability index in a cohort of undifferentiated connective tissue disease.

Erden A, Apaydın H, Fanouriakis A, et al.

Rheumatology (Oxford, England) 2022; (61(9)):3606-3613 doi:10.1093/rheumatology/keac005.

Undifferentiated Connective Tissue Disease in Pregnancy: A Topic Yet to be Explored.

Serena C, Clemenza S, Simeone S, et al.

Frontiers in pharmacology 2022; (13()):820760 doi:10.3389/fphar.2022.820760.

Nailfold capillaroscopy for the early diagnosis of the scleroderma spectrum of diseases in patients without Raynaud's phenomenon.

Hong C, Xiang L, Saffari SE, Low AH

Journal of scleroderma and related disorders 2022; (7(2)):144-150 doi:10.1177/23971983221088460.

Predicting progression from undifferentiated connective tissue disease to definite connective tissue disease: A systematic review and meta-analysis.

Dyball S, Rodziewicz M, Mendoza-Pinto C, et al.

Autoimmunity reviews 2022; (21(11)):103184 doi:10.1016/j.autrev.2022.103184.

Frequency of ANA/DFS70 autoantibodies in Colombian patients with undifferentiated connective tissue disease.

Rincón-Riaño D, Fernández-Ávila DG, Acero-Molina D, et al.

Reumatismo 2022; (74(2)) doi:10.4081/reumatismo.2022.1420.

Review of Hydroxychloroquine Cardiotoxicity: Lessons From the COVID-19 Pandemic.

Gagnon LR, Sadasivan C, Yogasundaram H, Oudit GY

Current heart failure reports 2022; (19(6)):458-466 doi:10.1007/s11897-022-00581-y.

Progression and prognosis of interstitial pneumonia with autoimmune features: a longitudinal, prospective, multi-centre study.

Sambataro G, Sambataro D, Spicuzza L, et al.

Clinical and experimental rheumatology 2023; (41(5)):1140-1148 doi:10.55563/clinexprheumatol/lycdca.

Undifferentiated Connective Tissue Disease: Comprehensive Review.

Rubio J, Kyttaris VC

Current rheumatology reports 2023; (25(5)):98-106 doi:10.1007/s11926-023-01099-5.

Undifferentiated Connective Tissue Disease With Isolated Diaphragmatic Dysfunction.

Purohit R, Shahu Khal R, Gokalp G, et al.

Cureus 2023; (15(6)):e40515 doi:10.7759/cureus.40515.

Towards Early Diagnosis of Mixed Connective Tissue Disease: Updated Perspectives.

Ferrara CA, La Rocca G, Ielo G, et al.

ImmunoTargets and therapy 2023; (12()):79-89 doi:10.2147/ITT.S390023.

[Analysis of adverse neonatal outcomes in pregnant women with positive anti-Ro/SSA and anti-La/SSB antibodies].

Zhang MY, Sun X

Zhonghua fu chan ke za zhi 2023; (58(11)):804-810 doi:10.3760/cma.j.cn112141-20230805-00037.

Progression of patients with Raynaud's phenomenon to systemic sclerosis: a five-year analysis of the European Scleroderma Trial and Research group multicentre, longitudinal registry study for Very Early Diagnosis of Systemic Sclerosis (VEDOSS).

Bellando-Randone S, Del Galdo F, Lepri G, et al.

The Lancet. Rheumatology 2021; (3(12)):e834-e843 doi:10.1016/S2665-9913(21)00244-7.

A Case Report: Unveiling the Underlying Cause of Recurrent Pericarditis in a Patient With Undifferentiated Connective Tissue Disease.

Boever S, Bannis K

Cureus 2024; (16(2)):e54113 doi:10.7759/cureus.54113.

Disease evolution and organ damage accrual in patients with stable UCTD: a long-term monocentric inception cohort.

Tani C, Trentin F, Parma A, et al.

RMD open 2024; (10(2)) doi:10.1136/rmdopen-2023-003967.

Risk Factors for Hydroxychloroquine Retinopathy and Its Subtypes.

Jorge AM, Melles RB, Marmor MF, et al.

JAMA network open 2024; (7(5)):e2410677 doi:10.1001/jamanetworkopen.2024.10677.

Clinical trial eligibility of a real-world connective tissue disease cohort: Results from the LEAP cohort.

Dyball S, Madenidou AV, Rodziewicz M, et al.

Seminars in arthritis and rheumatism 2024; (67()):152463 doi:10.1016/j.semarthrit.2024.152463.

Placental Pathologic Features and Perinatal Outcomes in Pregnant Woman With Autoimmune Connective Tissue Disease.

Zheng A, Zheng Y, Li D, et al.

American journal of reproductive immunology (New York, N.Y. : 1989) 2024; (92(2)):e13914 doi:10.1111/aji.13914.

Undifferentiated connective tissue disease: the diagnoses critically revised-experience of a single center.

Cavazzana I, Semeraro P, Tomasi C, et al.

Clinical and experimental medicine 2025; (25(1)):100 doi:10.1007/s10238-025-01614-1.

Evolutionary trajectory of undifferentiated connective tissue disease and impact of 2019 EULAR/ACR systemic lupus erythematosus classification criteria: insights from a longitudinal study.

Ciancarella C, Ceccarelli F, Picciariello L, et al.

Clinical and experimental medicine 2025; (25(1)):134 doi:10.1007/s10238-025-01668-1.

A Case of Undifferentiated Connective Tissue Disease with Bilateral Auricular Polychondritis Manifestations: A Rare Clinical Association.

Nigro A, Santarcangelo P, Bonelli A, et al.

The American journal of case reports 2025; (26()):e946827 doi:10.12659/AJCR.946827.

Special AAO Report: Recommendations on Screening for Hydroxychloroquine Retinopathy (2025 Revision).

Marmor MF, Ahn SJ, Ehlers JP, et al.

Ophthalmology 2026; (133(4)):439-450 doi:10.1016/j.ophtha.2025.11.001.

Exostosin 1/exostosin 2-associated membranous nephropathy in undifferentiated connective tissue disease: a case report and literature review.

Ye H, Jiang X, Wu B, et al.

BMC nephrology 2025; (26(1)):665 doi:10.1186/s12882-025-04596-0.

From antinuclear antibody testing to undifferentiated connective tissue disease diagnosis: a three-year median follow-up of 119 patients.

Yarkan Tuğsal H, Sezer S, Türker O, et al.

Postgraduate medicine 2025; 1-11 doi:10.1080/00325481.2025.2602233.

Can baseline features predict progression to defined connective tissue disease? Insights from a minimum 5-year follow-up study of 504 patients with undifferentiated connective tissue disease: A retrospective study.

Apaydin H, Sağirkaya ŞÇ, Polat B, et al.

Modern rheumatology 2026; (36(4)):619-626 doi:10.1093/mr/roag006.

Unravelling Fibromyalgia in Psoriatic Arthritis.

Findeisen KE, Guymer EK, Littlejohn GO

Rheumatology and therapy 2026; (13(2)):299-311 doi:10.1007/s40744-026-00825-6.

Hydroxychloroquine-Induced Hypoglycemia in a Non-Diabetic Patient with Chronic Kidney Disease and Rheumatoid Arthritis.

English K

Current health sciences journal 2025; (51(4)):560-563 doi:10.12865/CHSJ.51.04.15.

Axial spondyloarthritis patients with comorbid fibromyalgia feel worse, work less and more often try multiple biological therapies: results from a population-based, cross-sectional study investigating the discriminative capacity of pressure algometry.

Brink A, Mogard E, Lindqvist E, et al.

Rheumatology international 2026; (46(6)).

Diplopia as the herald of fulminant myocarditis in undifferentiated connective tissue disease: a case report.

Chen Y, Li Y, Zhang R, et al.

Frontiers in cardiovascular medicine 2026; (13()):1848981 doi:10.3389/fcvm.2026.1848981.