Research & Literature
Explore the leading researchers and institutions driving advances in this area, and dive into the full body of literature that informs this resource.
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Humboldt-Universität zu Berlin
Berlin, Germany
Universitat Pompeu Fabra
Barcelona, Spain
Novartis (Switzerland)
Basel, Switzerland
Johns Hopkins University
Baltimore, United States
Johannes Gutenberg University Mainz
Mainz, Germany
Siriraj Hospital
Bangkok, Thailand
Medizinische Hochschule Hannover
Hanover, Germany
University of Cincinnati
Cincinnati, United States
Regeneron (United States)
Tarrytown, United States
Bahçeşehir University
Istanbul, Türkiye
References
References (84)
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Positive impact of omalizumab on angioedema and quality of life in patients with refractory chronic idiopathic/spontaneous urticaria: analyses according to the presence or absence of angioedema.
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Clinical efficacy of omalizumab in chronic spontaneous urticaria is associated with a reduction of FcεRI-positive cells in the skin.
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Omalizumab substantially improves dermatology-related quality of life in patients with chronic spontaneous urticaria.
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Chronic urticaria and the metabolic syndrome: a cross-sectional community-based study of 11 261 patients.
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Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology 2017; (13()):38 doi:10.1186/s13223-017-0210-0.
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Expert opinion: defining response to omalizumab in patients with chronic spontaneous urticaria.
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Cost-effectiveness of omalizumab for the treatment of chronic spontaneous urticaria.
Kanters TA, Thio HB, Hakkaart L
The British journal of dermatology 2018; (179(3)):702-708 doi:10.1111/bjd.16476.
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Evaluating and managing chronic idiopathic urticaria in adults.
Webster L, Rider NL, Archambault ME
JAAPA : official journal of the American Academy of Physician Assistants 2018; (31(7)):22-26 doi:10.1097/01.JAA.0000534976.46365.11.
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Omalizumab in patients with chronic spontaneous urticaria nonresponsive to H1-antihistamine treatment: results of the phase IV open-label SUNRISE study.
Bérard F, Ferrier Le Bouedec MC, Bouillet L, et al.
The British journal of dermatology 2019; (180(1)):56-66 doi:10.1111/bjd.16904.
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Chronic Spontaneous Urticaria: The Devil's Itch.
Saini SS, Kaplan AP
The journal of allergy and clinical immunology. In practice 2018; (6(4)):1097-1106 doi:10.1016/j.jaip.2018.04.013.
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Effective treatment with omalizumab of a patient with spontaneous chronic urticaria and eosinophilic esophagitis.
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The Journal of dermatological treatment 2018; (29(sup4)):5-7 doi:10.1080/09546634.2018.1527992.
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The role of patient-reported outcomes in the management of chronic spontaneous urticaria.
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A retrospective analysis omalizumab treatment patterns in patients with chronic spontaneous urticaria: a real-world study in Belgium.
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Case Report: Resolution of chronic urticaria following treatment of odontogenic infection.
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Allergy 2019; (74(12)):2427-2436 doi:10.1111/all.13949.
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Evidence for bradykinin release in chronic spontaneous urticaria.
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Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2020; (50(3)):343-351 doi:10.1111/cea.13558.
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Chronic urticaria and thyroid pathology.
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The World Allergy Organization journal 2020; (13(3)):100101 doi:10.1016/j.waojou.2020.100101.
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Chronic urticaria in the real-life clinical practice setting in the UK: results from the noninterventional multicentre AWARE study.
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Clinical and experimental dermatology 2020; (45(8)):1003-1010 doi:10.1111/ced.14230.
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Health-Related Utility of EQ-5D in Korean Adults With Chronic Urticaria: Mapping From Urticaria Outcome Measures.
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Allergy, asthma & immunology research 2020; (12(4)):599-607 doi:10.4168/aair.2020.12.4.599.
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Anxiety, depression, and stress in Korean patients with chronic urticaria.
Choi GS, Nam YH, Park CS, et al.
The Korean journal of internal medicine 2020; (35(6)):1507-1516 doi:10.3904/kjim.2019.320.
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The Arabic Urticaria Activity Score and Chronic Urticaria Quality of Life Questionnaire: validation and correlations.
Tawil S, Irani C, Kfoury R, et al.
International journal of dermatology 2020; (59(8)):893-901 doi:10.1111/ijd.15006.
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Efficacy of omalizumab treatment for pediatric chronic spontaneous urticaria: A multi-center retrospective case series.
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Pediatric dermatology 2020; (37(6)):1051-1054 doi:10.1111/pde.14360.
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Chronic inducible urticaria: classification and prominent features of physical and non-physical types.
Pozderac I, Lugović-Mihić L, Artuković M, et al.
Acta dermatovenerologica Alpina, Pannonica, et Adriatica 2020; (29(3)):141-148.
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Autologous serum skin test reactions in chronic spontaneous urticaria differ from heterologous cell reactions.
Baumann K, Marcelino J, Skov PS, et al.
Journal of the European Academy of Dermatology and Venereology : JEADV 2021; (35(6)):1338-1345 doi:10.1111/jdv.17131.
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Histopathology of chronic spontaneous urticaria with occasional bruising lesions is not significantly different from urticaria with typical wheals.
Batista M, Calado R, Gil F, et al.
Journal of cutaneous pathology 2021; (48(8)):1020-1026 doi:10.1111/cup.13985.
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Use of biologics in chronic spontaneous urticaria - beyond omalizumab therapy?
Metz M, Maurer M
Allergologie select 2021; (5()):89-95 doi:10.5414/ALX02204E.
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Comparison of immunoglobulin E anti-thyroid peroxidase antibodies in patients with Hashimoto thyroiditis and chronic spontaneous urticaria.
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Medicine and pharmacy reports 2021; (94(1)):53-57 doi:10.15386/mpr-1598.
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The Diagnostic Workup in Chronic Spontaneous Urticaria-What to Test and Why.
Metz M, Altrichter S, Buttgereit T, et al.
The journal of allergy and clinical immunology. In practice 2021; (9(6)):2274-2283 doi:10.1016/j.jaip.2021.03.049.
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A novel histopathological scoring system to distinguish urticarial vasculitis from chronic spontaneous urticaria.
Puhl V, Bonnekoh H, Scheffel J, et al.
Clinical and translational allergy 2021; (11(2)):e12031 doi:10.1002/clt2.12031.
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Autoimmune Diseases Are Linked to Type IIb Autoimmune Chronic Spontaneous Urticaria.
Kolkhir P, Altrichter S, Asero R, et al.
Allergy, asthma & immunology research 2021; (13(4)):545-559 doi:10.4168/aair.2021.13.4.545.
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The Classification, Pathogenesis, Diagnostic Workup, and Management of Urticaria: An Update.
Maurer M, Zuberbier T, Metz M
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The international EAACI/GA²LEN/EuroGuiDerm/APAAACI guideline for the definition, classification, diagnosis, and management of urticaria.
Zuberbier T, Abdul Latiff AH, Abuzakouk M, et al.
Allergy 2022; (77(3)):734-766 doi:10.1111/all.15090.
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Relationships between quality of life, sleep problems, and sleep quality in patients with chronic idiopathic urticaria.
Ates H, Firat S, Buhari GK, et al.
Journal of cosmetic dermatology 2022; (21(9)):4072-4079 doi:10.1111/jocd.14851.
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Biomarkers associated with chronic spontaneous urticaria severity in 108 children.
Zhang L, Le M, Gabrielli S, et al.
Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology 2022; (33(2)):e13727 doi:10.1111/pai.13727.
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Pathobiology of Second-Generation Antihistamines Related to Sleep in Urticaria Patients.
Mann C, Wegner J, Weeß HG, Staubach P
Biology 2022; (11(3)) doi:10.3390/biology11030433.
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Autoimmune chronic spontaneous urticaria.
Kolkhir P, Muñoz M, Asero R, et al.
The Journal of allergy and clinical immunology 2022; (149(6)):1819-1831 doi:10.1016/j.jaci.2022.04.010.
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Association of Chronic Urticaria with Psychological Distress: A Multicentre Cross-sectional Study.
Tawil S, Irani C, Kfoury R, et al.
Acta dermato-venereologica 2023; (103()):adv00865 doi:10.2340/actadv.v102.2939.
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A case of chronic spontaneous urticaria unresponsive to ligelizumab successfully treated with omalizumab.
Russo F, Cortonesi G, Lazzeri L, et al.
Dermatologic therapy 2022; (35(11)):e15859 doi:10.1111/dth.15859.
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Efficacy and Safety of Up-dosed Second-generation Antihistamines in Uncontrolled Chronic Spontaneous Urticaria: A Review.
Podder I, Dhabal A, Chakraborty SS
The Journal of clinical and aesthetic dermatology 2023; (16(3)):44-50.
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Chronic Urticaria and Angioedema: Masqueraders and Misdiagnoses.
Bernstein JA, Ziaie N, Criado R, et al.
The journal of allergy and clinical immunology. In practice 2023; (11(8)):2251-2263 doi:10.1016/j.jaip.2023.06.033.
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Circulating Pentraxin-3 and its association with C-reactive protein levels and disease activity in patients with chronic spontaneous urticaria.
Beyaz Ş, Belkaya S, Öztop N
Allergologia et immunopathologia 2023; (51(4)):87-93 doi:10.15586/aei.v51i4.894.
PMID: 37422784 - 52
Clinical Response to Low-dose Omalizumab Treatment in Chronic Spontaneous Urticaria: A Retrospective Study of 179 Patients.
Kim MJ, Kim BR, Kim SH, et al.
Acta dermato-venereologica 2023; (103()):adv11627 doi:10.2340/actadv.v103.11627.
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A comparative analysis of chronic inducible urticaria in 423 patients: Clinical and laboratory features and comorbid conditions.
Ornek Ozdemir S, Kuteyla Can P, Degirmentepe EN, et al.
Journal of the European Academy of Dermatology and Venereology : JEADV 2024; (38(3)):513-520 doi:10.1111/jdv.19637.
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Comorbid Inducible Urticaria Is Linked to Non-Autoimmune Chronic Spontaneous Urticaria: CURE Insights.
Kovalkova E, Fomina D, Borzova E, et al.
The journal of allergy and clinical immunology. In practice 2024; (12(2)):482-490.e1 doi:10.1016/j.jaip.2023.11.029.
PMID: 38008357 - 55
Does chronic urticaria affect quality of sleep and quality of life?
Abdel-Meguid AM, Awad SM, Noaman M, et al.
Journal of public health research 2024; (13(2)):22799036241243268 doi:10.1177/22799036241243268.
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Efficacy and Safety of Systemic Corticosteroids for Urticaria: A Systematic Review and Meta-Analysis of Randomized Clinical Trials.
Chu X, Wang J, Ologundudu L, et al.
The journal of allergy and clinical immunology. In practice 2024; (12(7)):1879-1889.e8 doi:10.1016/j.jaip.2024.04.016.
PMID: 38642709 - 57
Non-Skin Related Symptoms Are Common in Chronic Spontaneous Urticaria and Linked to Active and Uncontrolled Disease: Results From the Chronic Urticaria Registry.
Pyatilova P, Hackler Y, Aulenbacher F, et al.
The journal of allergy and clinical immunology. In practice 2024; (12(7)):1890-1899.e3 doi:10.1016/j.jaip.2024.04.027.
PMID: 38670260 - 58
A Practical Approach to Diagnosing and Managing Chronic Spontaneous Urticaria.
Friedman A, Kwatra SG, Yosipovitch G
Dermatology and therapy 2024; (14(6)):1371-1387 doi:10.1007/s13555-024-01173-5.
PMID: 38758422 - 59
The future of targeted therapy in chronic spontaneous urticaria.
Min TK, Saini SS
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 2024; (133(4)):367-373 doi:10.1016/j.anai.2024.05.020.
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A Retrospective Cohort Study on the Comorbidity in 19,264 Chinese Patients of Different Ages with Urticaria.
Xiao M, Zhang X, Guo A, et al.
Acta dermato-venereologica 2024; (104()):adv24050 doi:10.2340/actadv.v104.24050.
PMID: 38932592 - 61
Chronic Spontaneous Urticaria: Quality of Life and Economic Impacts.
Keller L, Stitt J
Immunology and allergy clinics of North America 2024; (44(3)):453-467 doi:10.1016/j.iac.2024.03.004.
PMID: 38937009 - 62
Chronic Spontaneous Urticaria: An Update on the Evaluation and Management.
Joshi SR, Anstey KM, Khan DA
Immunology and allergy clinics of North America 2024; (44(3)):503-515 doi:10.1016/j.iac.2024.03.007.
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Chronic Spontaneous Urticaria: A Review.
Kolkhir P, Bonnekoh H, Metz M, Maurer M
JAMA 2024; (332(17)):1464-1477 doi:10.1001/jama.2024.15568.
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Key differences between chronic inducible and spontaneous urticaria.
Bizjak M, Košnik M
Frontiers in allergy 2024; (5()):1487831 doi:10.3389/falgy.2024.1487831.
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Sexual Dysfunction in Chronic Urticaria: A Systematic Review.
Park SE, Ma E, Dagenet C, et al.
Dermatology and therapy 2025; (15(1)):31-44 doi:10.1007/s13555-024-01319-5.
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Cost-effective omalizumab dosage for chronic urticaria: a systematic review and network meta-analysis.
Tajerian A, Pourvali A, Khoshkhui M, et al.
Archives of dermatological research.. 2024; (317(1)):131 doi:10.1007/s00403-024-03629-2.
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Remibrutinib in Chronic Spontaneous Urticaria.
Metz M, Giménez-Arnau A, Hide M, et al.
The New England journal of medicine 2025; (392(10)):984-994 doi:10.1056/NEJMoa2408792.
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[Spectrum of morphological changes in chronic spontaneous urticaria and urticarial vasculitis].
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Arkhiv patologii 2025; (87(2)):30-36 doi:10.17116/patol20258702130.
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Sleep Disturbance and Chronic Urticaria: A Narrative Review of Its Relationship, Treatment and Evolving Literature.
Wasim AU, Miriyala SA, Haward R, et al.
Health science reports 2025; (8(5)):e70777 doi:10.1002/hsr2.70777.
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Chronic spontaneous urticaria and chronic inducible urticaria.
Lee R, Bernstein JA
The Journal of allergy and clinical immunology 2025; (156(3)):546-556 doi:10.1016/j.jaci.2025.05.019.
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Diagnostic testing for chronic spontaneous urticaria with or without angioedema: The do's, don't and maybe's.
Bernstein JA, Ansotegui I, Asero R, et al.
The World Allergy Organization journal 2025; (18(7)):101068 doi:10.1016/j.waojou.2025.101068.
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Differential Diagnosis of Chronic Spontaneous Urticaria.
Gialama D, Bonnekoh H, Rothermel ND, et al.
The journal of allergy and clinical immunology. In practice 2025; (13(9)):2242-2250 doi:10.1016/j.jaip.2025.06.019.
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Delayed pressure urticaria successfully treated with omalizumab: A tertiary-level health-care center experience.
Cakmak ME, Oztop N
Allergy and asthma proceedings 2025; (46(4)):323-327 doi:10.2500/aap.2025.46.250031.
PMID: 40624787 - 74
Comparative efficacy and safety of biologics and systemic immunomodulatory treatments for chronic urticaria: Systematic review and network meta-analysis.
Chu AWL, Oykhman P, Chu X, et al.
The Journal of allergy and clinical immunology 2025; (156(4)):1008-1023 doi:10.1016/j.jaci.2025.06.004.
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Clinical Evaluation and Outcome Measures of Chronic Spontaneous Urticaria and Chronic Inducible Urticaria.
Weller K, Podder I, Salman A, et al.
The journal of allergy and clinical immunology. In practice 2025; (13(9)):2229-2241 doi:10.1016/j.jaip.2025.07.008.
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Concomitant Chronic Urticaria in Children: A Distinct Severe Phenotype.
Alrafiaah AS, Khalaf R, Sillcox C, et al.
International archives of allergy and immunology 2026; (187(6)):599-604 doi:10.1159/000548050.
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Comparative efficacy of omalizumab, dupilumab, and remibrutinib in chronic spontaneous urticaria: a network meta-analysis of randomized control trials.
Xiong G, Rayner DG, Kim L, et al.
The Journal of dermatological treatment 2025; (36(1)):2580374 doi:10.1080/09546634.2025.2580374.
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Can the Control of Chronic Spontaneous Urticaria Symptoms Depend on the Stress-Coping Styles?
Pluta-Kubicz M, Jura-Szołtys E, Gawlik R, et al.
Diagnostics (Basel, Switzerland) 2025; (15(23)) doi:10.3390/diagnostics15232965.
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The International Guideline for the Definition, Classification, Diagnosis and Management of Urticaria.
Zuberbier T, Ansari ZA, Abdul Latiff AH, et al.
Allergy 2026; (81(8)):2582-2632 doi:10.1111/all.70210.
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Remibrutinib Showed a Favorable Safety Profile and Sustained Efficacy in Japanese Patients with Chronic Spontaneous Urticaria Over 52 Weeks.
Hayama K, Chinuki Y, Yagami A, et al.
Dermatology and therapy 2026; (16(3)):1707-1721 doi:10.1007/s13555-026-01666-5.
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Disease Control, Activity and Quality of Life in Chronic Spontaneous Urticaria: A Cross-Sectional Study from Kazakhstan.
Batyrbayeva A, Ispayeva Z, Pashimov M, et al.
Diagnostics (Basel, Switzerland) 2026; (16(5)) doi:10.3390/diagnostics16050672.
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Bruton protein-tyrosine kinase (BTK) FDA-approved small molecule inhibitors used for the management of neoplastic and inflammatory disorders.
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Pharmacological research 2026; (227()):108187 doi:10.1016/j.phrs.2026.108187.
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Global Real-World Validation of First-Day Urticaria Activity Score (UAS1).
Su LH, Sousa Pinto B, Ramanauskaite A, et al.
The journal of allergy and clinical immunology. In practice 2026; (14(7)):1663-1670.e7 doi:10.1016/j.jaip.2026.04.011.
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[Treatment of mast cell-mediated angioedema].
Smola A, Lochbaum R
Dermatologie (Heidelberg, Germany) 2026; doi:10.1007/s00105-026-05753-8.
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