Research & Literature

Dendritic Cell Autophagy Contributes to Herpes Simplex Virus-Driven Stromal Keratitis and Immunopathology.

Jiang Y, Yin X, Stuart PM, Leib DA

mBio 2015; (6(6)):e01426-15.

Confocal Microscopic Analysis of a Rabbit Eye Model of High-Incidence Recurrent Herpes Stromal Keratitis.

Jester JV, Morishige N, BenMohamed L, et al.

Cornea 2016; (35(1)):81-8 doi:10.1097/ICO.0000000000000666.

The Basic Domain of Herpes Simplex Virus 1 pUS9 Recruits Kinesin-1 To Facilitate Egress from Neurons.

Diefenbach RJ, Davis A, Miranda-Saksena M, et al.

Journal of virology 2016; (90(4)):2102-11 doi:10.1128/JVI.03041-15.

Dendritiform Keratopathy Associated with Exposure to Polyquarternium-1, a Common Ophthalmic Preservative.

Matoba AY, Peterson JR, Wilhelmus KR

Ophthalmology 2016; (123(3)):451-6.

Long-Term Outcomes of Deep Anterior Lamellar Keratoplasty Treating Posterior Stroma-Implicated Herpetic Corneal Opacities.

Ren Y, Wang H, Zheng Q, et al.

Cornea 2016; (35(3)):299-304 doi:10.1097/ICO.0000000000000742.

Corneal infection in Shandong peninsula of China: a 10-year retrospective study on 578 cases.

Pan XJ, Jiang T, Zhu H, et al.

International journal of ophthalmology 2016; (9(1)):53-7 doi:10.18240/ijo.2016.01.09.

Clinical efficacy of oral and topical acyclovir in herpes simplex virus stromal necrotizing keratitis.

Dutt S, Acharya M, Gour A, et al.

Indian journal of ophthalmology 2016; (64(4)):292-5 doi:10.4103/0301-4738.182940.

Real-time polymerase chain reaction for the diagnosis of necrotizing herpes stromal keratitis.

Ma JX, Wang LN, Zhou RX, et al.

International journal of ophthalmology 2016; (9(5)):682-6 doi:10.18240/ijo.2016.05.07.

The Characteristics of Herpes Simplex Virus Type 1 Infection in Rhesus Macaques and the Associated Pathological Features.

Fan S, Cai H, Xu X, et al.

Viruses 2017; (9(2)) doi:10.3390/v9020026.

Herpes simplex keratitis: challenges in diagnosis and clinical management.

Azher TN, Yin XT, Tajfirouz D, et al.

Clinical ophthalmology (Auckland, N.Z.) 2017; (11()):185-191 doi:10.2147/OPTH.S80475.

Observation of Retrocorneal Plaques in Patients With Infectious Keratitis Using Anterior Segment Optical Coherence Tomography.

Takezawa Y, Suzuki T, Shiraishi A

Cornea 2017; (36(10)):1237-1242 doi:10.1097/ICO.0000000000001286.

Update on the Management of Infectious Keratitis.

Austin A, Lietman T, Rose-Nussbaumer J

Ophthalmology 2017; (124(11)):1678-1689 doi:10.1016/j.ophtha.2017.05.012.

Herpes Labialis: An Update.

Leung AKC, Barankin B

Recent patents on inflammation & allergy drug discovery 2017; (11(2)):107-113 doi:10.2174/1872213X11666171003151717.

Impact of herpetic stromal immune keratitis in corneal biomechanics and innervation.

Marcos-Fernández MÁ, Tabernero SS, Herreras JM, Galarreta DJ

Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie 2018; (256(1)):155-161 doi:10.1007/s00417-017-3826-3.

Diagnostic Evaluation of Co-Occurrence of Acanthamoeba and Fungi in Keratitis: A Preliminary Report.

Raghavan A, Baidwal S, Vijayaraghavan P, et al.

Cornea 2018; (37(2)):227-234 doi:10.1097/ICO.0000000000001441.

Dendritic cells in the cornea during Herpes simplex viral infection and inflammation.

Kwon MS, Carnt NA, Truong NR, et al.

Survey of ophthalmology 2018; (63(4)):565-578 doi:10.1016/j.survophthal.2017.11.001.

Association between Concomitant Use of Acyclovir or Valacyclovir with NSAIDs and an Increased Risk of Acute Kidney Injury: Data Mining of FDA Adverse Event Reporting System.

Yue Z, Shi J, Li H, Li H

Biological & pharmaceutical bulletin 2018; (41(2)):158-162 doi:10.1248/bpb.b17-00547.

Application of our understanding of pathogenesis of herpetic stromal keratitis for novel therapy.

Rajasagi NK, Rouse BT

Microbes and infection 2018; (20(9-10)):526-530 doi:10.1016/j.micinf.2017.12.014.

Acanthamoeba keratitis - Clinical signs, differential diagnosis and treatment.

Szentmáry N, Daas L, Shi L, et al.

Journal of current ophthalmology 2019; (31(1)):16-23 doi:10.1016/j.joco.2018.09.008.

Corneal Sub-Basal Nerve Changes in Patients with Herpetic Keratitis During Acute Phase and after 6 Months.

Danileviciene V, Zemaitiene R, Gintauskiene VM, et al.

Medicina (Kaunas, Lithuania) 2019; (55(5)) doi:10.3390/medicina55050214.

Systemic IL-1β production as a consequence of corneal HSV-1 infection-contribution to the development of herpes simplex keratitis.

Ní Gabhann-Dromgoole J, de Chaumont C, Shahnazaryan D, et al.

International journal of ophthalmology 2019; (12(9)):1493-1497 doi:10.18240/ijo.2019.09.19.

Clinical Pattern And Visual Impairment Associated With Herpes Simplex Keratitis.

Shah A, Joshi P, Bhusal B, Subedi P

Clinical ophthalmology (Auckland, N.Z.) 2019; (13()):2211-2215 doi:10.2147/OPTH.S219184.

Stromal Keratitis After Varicella in Children.

Denier M, Gabison E, Sahyoun M, et al.

Cornea 2020; (39(6)):680-684 doi:10.1097/ICO.0000000000002281.

Amniotic Membrane as a Main Component in Treatments Supporting Healing and Patch Grafts in Corneal Melting and Perforations.

Krysik K, Dobrowolski D, Wylegala E, Lyssek-Boron A

Journal of ophthalmology 2020; (2020()):4238919 doi:10.1155/2020/4238919.

Herpetic Eye Disease Study: A Controlled Trial of Topical Corticosteroids for Herpes Simplex Stromal Keratitis.

Wilhelmus KR, Gee L, Hauck WW, et al.

Ophthalmology 2020; (127(4S)):S5-S18 doi:10.1016/j.ophtha.2020.01.037.

Pathogenesis of Herpes Stromal Keratitis: Immune Inflammatory Response Mediated by Inflammatory Regulators.

Wang L, Wang R, Xu C, Zhou H

Frontiers in immunology 2020; (11()):766 doi:10.3389/fimmu.2020.00766.

Case series: Delayed diagnoses of Acanthamoeba keratitis.

Lee MJ, Srikumaran D, Zafar S, et al.

American journal of ophthalmology case reports 2020; (19()):100778 doi:10.1016/j.ajoc.2020.100778.

Adoption of Innovation in Herpes Simplex Virus Keratitis.

Chodosh J, Ung L

Cornea 2020; (39 Suppl 1()):S7-S18 doi:10.1097/ICO.0000000000002425.

Characterization of Resident Corneal Plasmacytoid Dendritic Cells and Their Pivotal Role in Herpes Simplex Keratitis.

Jamali A, Hu K, Sendra VG, et al.

Cell reports 2020; (32(9)):108099 doi:10.1016/j.celrep.2020.108099.

Ocular surgery after herpes simplex and herpes zoster keratitis.

Kanclerz P, Alio JL

International ophthalmology 2020; (40(12)):3599-3612 doi:10.1007/s10792-020-01539-6.

Impact of Adherence (Compliance) to Oral Acyclovir Prophylaxis in the Recurrence of Herpetic Keratitis: Long-Term Results From a Pediatric Cohort.

Luccarelli SV, Lucentini S, Martellucci CA, et al.

Cornea 2021; (40(9)):1126-1131 doi:10.1097/ICO.0000000000002578.

Corneal Graft Success Rates in HSV Keratitis: A Systematic Review.

Skarentzos K, Chatzimichael E, Panagiotopoulou EK, et al.

Acta medica (Hradec Kralove) 2020; (63(4)):150-158 doi:10.14712/18059694.2020.57.

Potential Role and Significance of Ocular Demodicosis in Patients with Concomitant Refractory Herpetic Keratitis.

Hung KH, Lan YH, Lin JY, et al.

Clinical ophthalmology (Auckland, N.Z.) 2020; (14()):4469-4482 doi:10.2147/OPTH.S282059.

20 years since the Herpetic Eye Disease Study: Lessons, developments and applications to clinical practice.

Arshad S, Petsoglou C, Lee T, et al.

Clinical & experimental optometry 2021; (104(3)):396-405 doi:10.1080/08164622.2021.1877531.

Role of Intravenous Acyclovir in Treatment of Herpes Simplex Virus Stromal Keratitis with Ulceration: A Review of 2 Cases.

Pisitpayat P, Jongkhajornpong P, Lekhanont K, Nonpassopon M

The American journal of case reports 2021; (22()):e930467 doi:10.12659/AJCR.930467.

Syphilitic interstitial keratitis treated with topical tacrolimus.

Martin J, Kopplin L, Costakos D

American journal of ophthalmology case reports 2021; (23()):101175 doi:10.1016/j.ajoc.2021.101175.

Pathogenesis and virulence of herpes simplex virus.

Zhu S, Viejo-Borbolla A

Virulence 2021; (12(1)):2670-2702 doi:10.1080/21505594.2021.1982373.

Anti-glaucoma agents-induced pseudodendritic keratitis presumed to be herpetic simplex keratitis: a clinical case series.

Chang HL, Kuo BI, Wu JH, et al.

Scientific reports 2021; (11(1)):21443 doi:10.1038/s41598-021-01073-0.

Recurrence of Herpetic Keratitis after COVID-19 Vaccination: A Report of Two Cases.

Fard AM, Desilets J, Patel S

Case reports in ophthalmological medicine 2022; (2022()):7094893 doi:10.1155/2022/7094893.

Infectious keratitis: A review.

Cabrera-Aguas M, Khoo P, Watson SL

Clinical & experimental ophthalmology 2022; (50(5)):543-562 doi:10.1111/ceo.14113.

Hypopyon after Periocular Corticosteroid Injection: A Case Series.

Li F, Zhang Q

Ocular immunology and inflammation 2023; (31(5)):955-960 doi:10.1080/09273948.2022.2073237.

Neuroimmune crosstalk in the cornea: The role of immune cells in corneal nerve maintenance during homeostasis and inflammation.

Wu M, Hill LJ, Downie LE, Chinnery HR

Progress in retinal and eye research 2022; (91()):101105 doi:10.1016/j.preteyeres.2022.101105.

Clinical course and treatment of archipelago keratitis: a Herpesviridae keratitis subtype.

Guindolet D, Gemahling A, Rousseau A, et al.

The British journal of ophthalmology 2022; doi:10.1136/bjo-2021-320847.

A Patient With Recurrent Immune Stromal Keratitis and Adherence Challenges.

Glickman A, Hunter A, Greenberg PB, et al.

Federal practitioner : for the health care professionals of the VA, DoD, and PHS 2022; (39(10)):403-405 doi:10.12788/fp.0323.

Full-length transcriptome sequencing of lymphocytes respond to IFN-γ reveals a Th1-skewed immune response in flounder (Paralichthys olivaceus).

He Z, Tian H, Xing J, et al.

Fish & shellfish immunology 2023; (134()):108636 doi:10.1016/j.fsi.2023.108636.

Wessely corneal ring phenomenon: An unsolved pathophysiological dilemma.

Ruiz-Lozano RE, Salan-Gomez M, Rodriguez-Garcia A, et al.

Survey of ophthalmology 2023; (68(4)):713-727 doi:10.1016/j.survophthal.2023.02.009.

Clinical Features of Pediatric Age Herpes Simplex Virus Keratitis.

Ulman EA, Selver OB, Biler ED, Palamar M

Cornea 2023; (42(9)):1099-1103 doi:10.1097/ICO.0000000000003264.

Antiviral and Anti-Inflammatory Therapeutic Interventions for Treating Herpes Stromal Keratitis: A Systematic Review.

Li X, Nayeni M, Malvankar-Mehta MS

Ophthalmic epidemiology 2024; (31(3)):191-209 doi:10.1080/09286586.2023.2213324.

Amniotic Membrane Transplantation in the Management of Corneal Ulceration Following Infectious Keratitis.

Lamas-Francis D, Navarro D, Moreno C, et al.

Ocular immunology and inflammation 2024; (32(7)):1261-1267 doi:10.1080/09273948.2023.2228901.

Herpes simplex virus keratitis: electronic medical records driven big data analytics report from a tertiary eye institute of South India.

Das AV, Satyashree G, Joseph J, Bagga B

International ophthalmology 2023; (43(12)):4669-4676 doi:10.1007/s10792-023-02866-0.

Diagnostic performance of real-time quantitative PCR in tear samples in various subtypes of herpes simplex keratitis.

Hoarau G, Haigh O, Vauloup-Fellous C, et al.

Journal of clinical microbiology 2023; (61(12)):e0088523 doi:10.1128/jcm.00885-23.

Steroids in the Management of Infectious Keratitis.

Keenan JD

Cornea 2023; (42(11)):1333-1339 doi:10.1097/ICO.0000000000003340.

Atopic Disease as a Risk Factor for Recurrent Herpetic Keratitis.

Safir M, Mimouni M

Microorganisms 2024; (12(1)) doi:10.3390/microorganisms12010220.

Analysis of clinical characteristics and factors influencing herpes simplex virus keratitis.

Zhang S, Mi J, Ge S, et al.

Frontiers in medicine 2023; (10()):1267783 doi:10.3389/fmed.2023.1267783.

Effect of atopic conditions on development and recurrences of infectious keratitis.

Omatsu Y, Shimizu Y, Haruki T, et al.

Allergology international : official journal of the Japanese Society of Allergology 2024; (73(3)):445-452 doi:10.1016/j.alit.2024.01.008.

Differentiation of acanthamoeba keratitis from other non-acanthamoeba keratitis: Risk factors and clinical features.

Alreshidi SO, Vargas JM, Ahmad K, et al.

PloS one 2024; (19(3)):e0299492 doi:10.1371/journal.pone.0299492.

The immunobiology of corneal HSV-1 infection and herpetic stromal keratitis.

Antony F, Kinha D, Nowińska A, et al.

Clinical microbiology reviews 2024; (37(3)):e0000624 doi:10.1128/cmr.00006-24.

Physiological oxygen concentration during sympathetic primary neuron culture improves neuronal health and reduces HSV-1 reactivation.

Dochnal SA, Krakowiak PA, Whitford AL, Cliffe AR

bioRxiv : the preprint server for biology 2024; doi:10.1101/2024.08.09.607366.

Clinical and surgical outcomes of tectonic corneal patch grafts : insights from a tertiary referral hospital.

Asfuroğlu Y, Karaca EE, Orman C, Evren Kemer Ö

BMC ophthalmology 2024; (24(1)):516 doi:10.1186/s12886-024-03782-2.

Valacyclovir Versus Acyclovir for Herpes Simplex Virus Suppression Following Neonatal Infection.

Olkiewicz HA, Mitchell ML, Ray KM, et al.

WMJ : official publication of the State Medical Society of Wisconsin 2024; (123(6)):589-592.

The need for prolonged antiviral use to prevent recurrences of herpes simplex virus ocular disease: A systematic review.

Ruiz Sifre L, Bort Martí S, Ruiz García V, Bort Martí ÁR

Farmacia hospitalaria : organo oficial de expresion cientifica de la Sociedad Espanola de Farmacia Hospitalaria 2025; (49(4)):235-242 doi:10.1016/j.farma.2025.02.005.

Herpes simplex keratitis in central India: Clinical types, treatment patterns, and outcome measures.

Chatterjee S, Agrawal D, Malik M

Indian journal of ophthalmology 2025; (73(7)):1050-1054 doi:10.4103/IJO.IJO_2233_24.

Clinical manifestations and outcomes of HSK following corneal transplantation.

Wu D, Huang H, Zheng M, et al.

Frontiers in medicine 2025; (12()):1654643 doi:10.3389/fmed.2025.1654643.

Neurotoxicity from acyclovir and valacyclovir in patients undergoing peritoneal dialysis: Still rare, but still present.

Moyses Neto M, Nakagawa B, Chiozi SZ, et al.

Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis 2026; 8968608261415988 doi:10.1177/08968608261415988.

Case Report: Conservative management of herpes simplex keratitis with corneal perforation and anterior chamber collapse.

Xie W, Tian T, Ying L

Frontiers in medicine 2026; (13()):1749225 doi:10.3389/fmed.2026.1749225.

Evaluation of safety and efficacy of cyclosporine-A eye drops in herpetic stromal keratitis: a prospective randomized clinical trial.

Lotfy NM, Alshatti H, Khachaba RY, Hagras SM

Journal of ophthalmic inflammation and infection 2026; (16(1)).