Gynecology

Understanding Müllerian Aplasia (MRKH Syndrome)

At a Glance

Müllerian Aplasia (MRKH syndrome) is a congenital condition where the uterus and vagina are underdeveloped, but the ovaries function normally. Care involves a multidisciplinary team, and biological family building is possible through IVF with a surrogate or uterine transplantation.

Receiving a diagnosis of Müllerian Aplasia, commonly known as MRKH syndrome (Mayer-Rokitansky-Küster-Hauser syndrome), can feel overwhelming. This guide is designed to help you, your family, and your support system navigate what this diagnosis means, how it impacts your body, and what choices you have moving forward.

Our goal is to provide clear, evidence-based information so that you can feel empowered to make the best decisions for your health and your future.

How to Use This Guide

This resource is broken down into specific topics. We recommend starting with the basics, but you can explore whichever section feels most relevant to your current stage in your care journey:

Müllerian Aplasia (MRKH Syndrome): The Basics

Learn the basics of Müllerian Aplasia (MRKH Syndrome). Understand why it happens, the difference between Type I and II, and what it means for your body.

Subtypes and Anatomy: Type I vs. Type II MRKH

Learn the differences between Type I and Type II MRKH syndrome. Understand MURCS association, kidney and spine screening, and functional uterine remnants.

Diagnosis and Building Your Care Team

Learn about the MRKH syndrome diagnosis process, including pelvic MRIs and karyotype tests. Discover which specialists you need for a complete MRKH care team.

Creating a Vagina: Dilation and Surgical Options

Learn about creating a neovagina for MRKH syndrome. Explore non-surgical dilation, the Frank's method, and surgical options like the Davydov procedure.

Fertility and Family Building with MRKH

Learn about fertility and family-building options with MRKH syndrome. Understand how IVF, surrogacy, uterine transplants and adoption make parenthood possible.

The Emotional Journey and Mental Health

Learn about the emotional journey of an MRKH syndrome diagnosis. Discover how therapy, peer support, and counseling can help you navigate intimacy and identity.

Remember, outside of checking your kidneys and spine, there is no medical emergency to make any treatment decisions right now. Take your time, lean on your support network, and work with your medical team when you feel ready.

Common questions in this guide

What is Müllerian Aplasia or MRKH syndrome?

MRKH syndrome is a congenital condition that affects the development of the female reproductive system. While the ovaries and external anatomy develop normally, the uterus and vagina may be underdeveloped or absent.

What is the difference between Type I and Type II MRKH?

Type I MRKH primarily involves the underdevelopment of the uterus and vagina. Type II, also known as MURCS, includes these reproductive changes along with additional differences in the kidneys or spine, which is why your doctor will recommend checking those areas.

Can I still have biological children if I have MRKH syndrome?

Yes, having biological children is possible for many people with MRKH. Because your ovaries are unaffected and produce eggs, you can explore options like IVF with a gestational surrogate or uterine transplantation when you are ready to build a family.

What kind of doctors should be on my MRKH care team?

Your care should be managed by a multidisciplinary team, ideally at a Center of Excellence for Müllerian anomalies. This team often includes a specialized gynecologist, a urologist, a reproductive endocrinologist, and a mental health professional.

Do I need to make treatment decisions right away?

Aside from evaluating your kidneys and spine for related anomalies, there is no medical emergency to start treatments for creating a vagina or planning for fertility. You can take your time to process the diagnosis and make decisions when you feel ready.

Curated prompts to bring to your next appointment.

1.Who will be the primary doctor coordinating my MRKH care moving forward?
2.Are you part of a specialized team or Center of Excellence for Müllerian anomalies?
3.How can we securely share my medical records with the other specialists (like a urologist or psychologist) that I need to see?

Tap a prompt to share your answer — we'll use it plus this page's context to start a tailored conversation.

This guide provides educational information about Müllerian Aplasia (MRKH syndrome). It is not a substitute for professional medical advice. Always work with your specialized care team to determine the best treatment and fertility options for your specific anatomy.

Get notified when new evidence is published on Müllerian aplasia.

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Guide Contents