Research & Literature

Survival after somatostatin based radiopeptide therapy with (90)Y-DOTATOC vs. (90)Y-DOTATOC plus (177)Lu-DOTATOC in metastasized gastrinoma.

Dumont RA, Seiler D, Marincek N, et al.

American journal of nuclear medicine and molecular imaging 2015; (5(1)):46-55.

Somatostatin receptor imaging with 68Ga DOTATATE PET/CT: clinical utility, normal patterns, pearls, and pitfalls in interpretation.

Hofman MS, Lau WF, Hicks RJ

Radiographics : a review publication of the Radiological Society of North America, Inc 2015; (35(2)):500-16 doi:10.1148/rg.352140164.

Hypomagnesemia Induced by Long-Term Treatment with Proton-Pump Inhibitors.

Janett S, Camozzi P, Peeters GG, et al.

Gastroenterology research and practice 2015; (2015()):951768 doi:10.1155/2015/951768.

Comparison of Three Ki-67 Index Quantification Methods and Clinical Significance in Pancreatic Neuroendocrine Tumors.

Kroneman TN, Voss JS, Lohse CM, et al.

Endocrine pathology 2015; (26(3)):255-62 doi:10.1007/s12022-015-9379-2.

Weight Gain in Zollinger-Ellison Syndrome After Acid Suppression.

Riff BP, Leiman DA, Bennett B, et al.

Pancreas 2016; (45(2)):193-7 doi:10.1097/MPA.0000000000000376.

Diagnostic and Treatment Approaches for Refractory Peptic Ulcers.

Kim HU

Clinical endoscopy 2015; (48(4)):285-90 doi:10.5946/ce.2015.48.4.285.

Biochemical Testing in Patients with Neuroendocrine Tumors.

Granberg D

Frontiers of hormone research 2015; (44()):24-39 doi:10.1159/000381981.

Gastric Hypersecretory States: Investigation and Management.

Phan J, Benhammou JN, Pisegna JR

Current treatment options in gastroenterology 2015; (13(4)):386-97 doi:10.1007/s11938-015-0065-8.

(68)Ga-DOTATOC-PET/CT for effective diagnosis and treatment of pancreatic tail gastrinoma with multiple liver metastases: a case report.

Matsumura S, Okuyama Y, Doi R, et al.

Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology 2016; (113(1)):86-93 doi:10.11405/nisshoshi.113.86.

Impact of Delay in Diagnosis in Outcomes in MEN1: Results From the Dutch MEN1 Study Group.

van Leeuwaarde RS, van Nesselrooij BP, Hermus AR, et al.

The Journal of clinical endocrinology and metabolism 2016; (101(3)):1159-65 doi:10.1210/jc.2015-3766.

Proton-pump inhibitors adverse effects: a review of the evidence and position statement by the Sociedad Española de Patología Digestiva.

de la Coba Ortiz C, Argüelles Arias F, Martín de Argila de Prados C, et al.

Revista espanola de enfermedades digestivas 2016; (108(4)):207-24 doi:10.17235/reed.2016.4232/2016.

Assessing for Multiple Endocrine Neoplasia Type 1 in Patients Evaluated for Zollinger-Ellison Syndrome-Clues to a Safer Diagnostic Process.

Singh Ospina N, Donegan D, Rodriguez-Gutierrez R, et al.

The American journal of medicine 2017; (130(5)):603-605 doi:10.1016/j.amjmed.2016.11.035.

The Risks and Benefits of Long-term Use of Proton Pump Inhibitors: Expert Review and Best Practice Advice From the American Gastroenterological Association.

Freedberg DE, Kim LS, Yang YX

Gastroenterology 2017; (152(4)):706-715 doi:10.1053/j.gastro.2017.01.031.

A Perplexing Case of Abdominal Pain That Led to the Diagnosis of Zollinger-Ellison Syndrome.

Lenhart A, Hassan M, Meighani A, et al.

Case reports in gastrointestinal medicine 2017; (2017()):7636952 doi:10.1155/2017/7636952.

Natural History of MEN1 GEP-NET: Single-Center Experience After a Long Follow-Up.

Giudici F, Cavalli T, Giusti F, et al.

World journal of surgery 2017; (41(9)):2312-2323 doi:10.1007/s00268-017-4019-2.

Catching the Zebra: Clinical Pearls and Pitfalls for the Successful Diagnosis of Zollinger-Ellison Syndrome.

Mendelson AH, Donowitz M

Digestive diseases and sciences 2017; (62(9)):2258-2265 doi:10.1007/s10620-017-4695-7.

The future: diagnostic and imaging advances in MEN1 therapeutic approaches and management strategies.

Manoharan J, Albers MB, Bartsch DK

Endocrine-related cancer 2017; (24(10)):T209-T225 doi:10.1530/ERC-17-0231.

Current Concepts in 68Ga-DOTATATE Imaging of Neuroendocrine Neoplasms: Interpretation, Biodistribution, Dosimetry, and Molecular Strategies.

Bodei L, Ambrosini V, Herrmann K, Modlin I

Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2017; (58(11)):1718-1726 doi:10.2967/jnumed.116.186361.

Diagnosis and management of Zollinger-Ellison syndrome in 2018.

De Angelis C, Cortegoso Valdivia P, Venezia L, et al.

Minerva endocrinologica 2018; (43(2)):212-220 doi:10.23736/S0391-1977.17.02745-6.

The Zollinger-Ellison syndrome: is there a role for somatostatin analogues in the treatment of the gastrinoma?

Guarnotta V, Martini C, Davì MV, et al.

Endocrine 2018; (60(1)):15-27 doi:10.1007/s12020-017-1420-4.

Diagnosis of Zollinger-Ellison syndrome in the era of PPIs, faulty gastrin assays, sensitive imaging and limited access to acid secretory testing.

Metz DC, Cadiot G, Poitras P, et al.

International journal of endocrine oncology 2017; (4(4)):167-185 doi:10.2217/ije-2017-0018.

Grading Using Ki-67 Index and Mitotic Rate Increases the Prognostic Accuracy of Pancreatic Neuroendocrine Tumors.

Philips P, Kooby DA, Maithel S, et al.

Pancreas 2018; (47(3)):326-331 doi:10.1097/MPA.0000000000000990.

Management of functional neuroendocrine tumors of the pancreas.

Öberg K

Gland surgery 2018; (7(1)):20-27 doi:10.21037/gs.2017.10.08.

Gastrinomas: Medical or Surgical Treatment.

Norton JA, Foster DS, Ito T, Jensen RT

Endocrinology and metabolism clinics of North America 2018; (47(3)):577-601 doi:10.1016/j.ecl.2018.04.009.

Results of Duodenopancreatic Reoperations in Multiple Endocrine Neoplasia Type 1.

Albers MB, Manoharan J, Bollmann C, et al.

World journal of surgery 2019; (43(2)):552-558 doi:10.1007/s00268-018-4809-1.

Clinicopathological characteristics and risk factors for recurrence of well-differentiated pancreatic neuroendocrine tumors after radical surgery: a case-control study.

Zhang P, Li YL, Qiu XD, et al.

World journal of surgical oncology 2019; (17(1)):66 doi:10.1186/s12957-019-1606-8.

Resection of pancreatic neuroendocrine tumors: defining patterns and time course of recurrence.

Dong DH, Zhang XF, Lopez-Aguiar AG, et al.

HPB : the official journal of the International Hepato Pancreato Biliary Association 2020; (22(2)):215-223 doi:10.1016/j.hpb.2019.05.020.

Time-trend and recurrence analysis of pancreatic neuroendocrine tumors.

Kim H, Song KB, Hwang DW, et al.

Endocrine connections 2019; (8(7)):1052-1060.

Zollinger Ellison Syndrome in a Patient with Multiple Endocrine Neoplasia Type 1: A Classic Presentation.

Shah I, Vyas N, Kadkhodayan KS

Case reports in gastrointestinal medicine 2019; (2019()):9605769 doi:10.1155/2019/9605769.

Prognostic factors and survival in MEN1 patients with gastrinomas: Results from the DutchMEN study group (DMSG).

van Beek DJ, Nell S, Pieterman CRC, et al.

Journal of surgical oncology 2019; (120(6)):966-975 doi:10.1002/jso.25667.

Surgical management of Zollinger-Ellison syndrome: Classical considerations and current controversies.

Shao QQ, Zhao BB, Dong LB, et al.

World journal of gastroenterology 2019; (25(32)):4673-4681 doi:10.3748/wjg.v25.i32.4673.

Novel scoring system for recurrence risk classification of surgically resected G1/2 pancreatic neuroendocrine tumors - Retrospective cohort study.

Zou S, Jiang Y, Wang W, et al.

International journal of surgery (London, England) 2020; (74()):86-91 doi:10.1016/j.ijsu.2019.12.034.

De novo Gastrinoma: A Case Report.

Barbosa A, Gomes F, Fonseca L, et al.

GE Portuguese journal of gastroenterology 2020; (27(3)):192-196 doi:10.1159/000503073.

Delayed Management of Zollinger-Ellison Syndrome in a Noncompliant Patient.

Klimko A, Plotogea O, Constantinescu A, Constantinescu G

Cureus 2020; (12(6)):e8471 doi:10.7759/cureus.8471.

Diagnosis and Management of Gastrointestinal Neuroendocrine Neoplasms.

Gonzalez RS

Surgical pathology clinics 2020; (13(3)):377-397 doi:10.1016/j.path.2020.04.002.

Risk Factors for Recurrence in Pancreatic Neuroendocrine Tumor and Size as a Surrogate in Determining the Treatment Strategy: A Korean Nationwide Study.

Kwon W, Jang JY, Song KB, et al.

Neuroendocrinology 2021; (111(8)):794-804 doi:10.1159/000511875.

Prognosis after surgery for multiple endocrine neoplasia type 1-related pancreatic neuroendocrine tumors: Functionality matters.

van Beek DJ, Nell S, Verkooijen HM, et al.

Surgery 2021; (169(4)):963-973 doi:10.1016/j.surg.2020.09.037.

Role of PET/CT and Therapy Management of Pancreatic Neuroendocrine Tumors.

Calabrò D, Argalia G, Ambrosini V

Diagnostics (Basel, Switzerland) 2020; (10(12)) doi:10.3390/diagnostics10121059.

Total gastrectomy for severe proton pump inhibitor-induced hypomagnesemia in a MEN1/Zollinger Ellison syndrome patient.

Perrier M, Delemer B, Deguelte S, et al.

Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] 2021; (21(1)):236-239 doi:10.1016/j.pan.2020.12.002.

Gastric enterochromaffin-like cell changes in multiple endocrine neoplasia type 1.

Manoharan J, Anlauf M, Albers MB, et al.

Clinical endocrinology 2021; (95(3)):439-446 doi:10.1111/cen.14430.

Imaging of Pancreatic Neuroendocrine Neoplasms.

Chiti G, Grazzini G, Cozzi D, et al.

International journal of environmental research and public health 2021; (18(17)) doi:10.3390/ijerph18178895.

Validity of Secretin Stimulation Testing on Proton Pump Inhibitor Therapy for Diagnosis of Zollinger-Ellison Syndrome.

Bhattacharya S, Blau JE, Cochran C, et al.

The American journal of gastroenterology 2021; (116(11)):2216-2221 doi:10.14309/ajg.0000000000001487.

Gastrinoma and Zollinger Ellison syndrome: A roadmap for the management between new and old therapies.

Rossi RE, Elvevi A, Citterio D, et al.

World journal of gastroenterology 2021; (27(35)):5890-5907 doi:10.3748/wjg.v27.i35.5890.

[Comparison of clinical characteristics between sporadic gastrinoma and multiple endocrine neoplasia type 1-related gastrinoma].

Guo Y, Chen LH, Liu M, et al.

Zhonghua wei chang wai ke za zhi = Chinese journal of gastrointestinal surgery 2021; (24(10)):875-882 doi:10.3760/cma.j.cn.441530-20210719-00291.

Somatostatin analogs in patients with Zollinger Ellison syndrome (ZES): an observational study.

Massironi S, Cavalcoli F, Elvevi A, et al.

Endocrine 2022; (75(3)):942-948 doi:10.1007/s12020-021-02915-7.

Secretin Stimulation Test and Early Diagnosis of Gastrinoma in MEN1 Syndrome: Survey on the MEN1 Florentine Database.

Giusti F, Cioppi F, Fossi C, et al.

The Journal of clinical endocrinology and metabolism 2022; (107(5)):e2110-e2123 doi:10.1210/clinem/dgab903.

Surgery in Patients with Gastro-Entero-Pancreatic Neuroendocrine Carcinomas, Neuroendocrine Tumors G3 and High Grade Mixed Neuroendocrine-Non-Neuroendocrine Neoplasms.

Holmager P, Langer SW, Kjaer A, et al.

Current treatment options in oncology 2022; (23(6)):806-817 doi:10.1007/s11864-022-00969-x.

Endoscopic ultrasound-guided side-fenestrated needle biopsy sampling is sensitive for pancreatic neuroendocrine tumors but inadequate for tumor grading: a prospective study.

Appelstrand A, Bergstedt F, Elf AK, et al.

Scientific reports 2022; (12(1)):5971 doi:10.1038/s41598-022-09923-1.

Pancreaticoduodenectomy Is the Best Surgical Procedure for Zollinger-Ellison Syndrome Associated with Multiple Endocrine Neoplasia Type 1.

Kong W, Albers MB, Manoharan J, et al.

Cancers 2022; (14(8)) doi:10.3390/cancers14081928.

Iron deficiency anemia from iron malabsorption caused by proton pump inhibitors.

Boxer M

EJHaem 2020; (1(2)):548-551 doi:10.1002/jha2.96.

Radiological Features of Zollinger-Ellison Syndrome: A Report of Two Cases.

Pratap T, Jalal MJA, Jacob D, et al.

The Indian journal of radiology & imaging 2022; (32(3)):395-402 doi:10.1055/s-0042-1750725.

How to treat gastrinomas in patients with multiple endocrine neoplasia type1: surgery or long-term proton pump inhibitors?

Imamura M, Komoto I, Taki Y

Surgery today 2023; (53(12)):1325-1334 doi:10.1007/s00595-022-02627-z.

The Effects of Proton Pump Inhibitors in Acid Hypersecretion-Induced Vitamin B12 Deficiency: A Systematic Review (2022).

Swarnakari KM, Bai M, Manoharan MP, et al.

Cureus 2022; (14(11)):e31672 doi:10.7759/cureus.31672.

Recurrence after surgical resection of nonmetastatic sporadic gastrinoma: Which prognostic factors and surgical procedure?

Robin L, Sauvanet A, Walter T, et al.

Surgery 2023; (173(5)):1144-1152 doi:10.1016/j.surg.2022.12.030.

Advances in the pharmacotherapeutic management of refractory peptic ulcers.

Borao Laguna C, Lanas A

Expert opinion on pharmacotherapy 2023; (24(7)):825-833 doi:10.1080/14656566.2023.2199922.

All you need to know about gastrinoma today | Gastrinoma and Zollinger-Ellison syndrome: A thorough update.

Chatzipanagiotou O, Schizas D, Vailas M, et al.

Journal of neuroendocrinology 2023; (35(4)):e13267 doi:10.1111/jne.13267.

MENIN-mediated regulation of gastrin gene expression and its role in gastrinoma development.

Elvis-Offiah UB, Duan S, Merchant JL

FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023; (37(5)):e22913 doi:10.1096/fj.202201809RR.

Adverse Effects Associated with Long-Term Use of Proton Pump Inhibitors.

Maideen NMP

Chonnam medical journal 2023; (59(2)):115-127 doi:10.4068/cmj.2023.59.2.115.

Clinically Defined Mutations in MEN1 Alter Its Tumor-suppressive Function Through Increased Menin Turnover.

Duan S, Sheriff S, Elvis-Offiah UB, et al.

Cancer research communications 2023; (3(7)):1318-1334 doi:10.1158/2767-9764.CRC-22-0522.

European Neuroendocrine Tumor Society 2023 guidance paper for functioning pancreatic neuroendocrine tumour syndromes.

Hofland J, Falconi M, Christ E, et al.

Journal of neuroendocrinology 2023; (35(8)):e13318 doi:10.1111/jne.13318.

Esophageal Perforation Unveiling the Diagnosis of Zollinger-Ellison Syndrome.

Shaik MR, Shaik NA, Kunarathnam V, et al.

Journal of community hospital internal medicine perspectives 2023; (13(5)):77-81 doi:10.55729/2000-9666.1228.

Sporadic Zollinger-Ellison syndrome in a patient with isolated mesenteric gastrinoma.

Efared B, Tassiou EIM, Bako ABA, et al.

International journal of surgery case reports 2024; (116()):109474 doi:10.1016/j.ijscr.2024.109474.

Proton pump inhibitors, bone and phosphocalcic metabolism.

Philippoteaux C, Paccou J, Chazard E, Cortet B

Joint bone spine 2024; (91(5)):105714 doi:10.1016/j.jbspin.2024.105714.

Digital image analysis of Ki67 hotspot detection and index counting in gastroenteropancreatic neuroendocrine neoplasms.

Saetiew K, Angkathunyakul N, Hunnangkul S, Pongpaibul A

Annals of diagnostic pathology 2024; (71()):152295 doi:10.1016/j.anndiagpath.2024.152295.

Severe Hypomagnesemia Caused by Proton-Pump Inhibitors in a Patient With an Ostomy.

Ali K, Ali AA, Jaikaransingh V

Cureus 2024; (16(3)):e55856 doi:10.7759/cureus.55856.

Long-Term Proton Pump Inhibitor-Acid Suppressive Treatment Can Cause Vitamin B12 Deficiency in Zollinger-Ellison Syndrome (ZES) Patients.

Ito T, Ramos-Alvarez I, Jensen RT

International journal of molecular sciences 2024; (25(13)) doi:10.3390/ijms25137286.

A Reassessment of the Clinical Utility of 68Ga-DOTATATE PET/CT in Patients With Gastroenteropancreatic Neuroendocrine Tumors.

Prela O, Caveney B, Strawderman M, et al.

Journal of surgical oncology 2025; (131(7)):1336-1342 doi:10.1002/jso.28061.

Autoimmune Pancreatitis Mimicking a Pancreatic Neuroendocrine Tumor: A Case Report with a Literature Review.

Franchina M, Dell'Oro L, Massironi S

International journal of molecular sciences 2025; (26(4)) doi:10.3390/ijms26041536.

Case Report: PRRT in a patient with Zollinger-Ellison syndrome. The management of gastrointestinal complications.

Di Franco M, Durmo R, Di Paolo ML, et al.

Frontiers in oncology 2025; (15()):1590478 doi:10.3389/fonc.2025.1590478.

Diarrhea, Weight Loss, and an Elevated Gastrin: A Case Report.

Alexander RG, Cheville JC, Thompson GB, Alexander GL

Case reports in gastroenterology 2025; (19(1)):428-433 doi:10.1159/000545714.

Zollinger-Ellison Syndrome Unmasked during Hiatal Hernia Evaluation: A Case Report.

Vasireddy R, Gaddipati G, Bilalaga MM, et al.

Case reports in gastroenterology 2025; (19(1)):219-224 doi:10.1159/000544940.

Severe Recurrent Gastrointestinal Bleeding and Diagnostic Dilemmas in Zollinger-Ellison Syndrome: A Case Report.

Bragança S, Figueiredo LM, Oliveira AM, et al.

GE Portuguese journal of gastroenterology 2025; doi:10.1159/000550071.

Surgical Management of Zollinger-Ellison Syndrome in Multiple Endocrine Neoplasia Type 1 an AFCE and GTE Cohort Study. (Association Francophone de Chirurgie Endocrinienne and Groupe d'étude des Tumeurs Endocrines).

Gaujoux S, Pattou F, Cadiot G, et al.

World journal of surgery 2026; (50(5)):1300-1311 doi:10.1002/wjs.70303.