Research & Literature

High-Frequency Targetable EGFR Mutations in Sinonasal Squamous Cell Carcinomas Arising from Inverted Sinonasal Papilloma.

Udager AM, Rolland DCM, McHugh JB, et al.

Cancer research 2015; (75(13)):2600-2606 doi:10.1158/0008-5472.CAN-15-0340.

Survival Outcome of Squamous Cell Carcinoma Arising from Sinonasal Inverted Papilloma.

Liang QZ, Li DZ, Wang XL, et al.

Chinese medical journal 2015; (128(18)):2457-61 doi:10.4103/0366-6999.164929.

Surgical risk factors for recurrence of inverted papilloma.

Healy DY, Chhabra N, Metson R, et al.

The Laryngoscope 2016; (126(4)):796-801 doi:10.1002/lary.25663.

Prediction of the originating site of sinonasal inverted papilloma by preoperative magnetic resonance imaging and computed tomography.

Fang G, Lou H, Yu W, et al.

International forum of allergy & rhinology 2016; (6(12)):1221-1228 doi:10.1002/alr.21836.

The clinical behavior of sinonasal inverted papilloma with cellular dysplasia: case series and review of the literature.

Safadi A, Yafit D, Abu-Ghanem S, et al.

European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery 2017; (274(9)):3375-3382 doi:10.1007/s00405-017-4629-1.

Association of Krouse Classification for Sinonasal Inverted Papilloma With Recurrence: A Systematic Review and Meta-analysis.

Lisan Q, Moya-Plana A, Bonfils P

JAMA otolaryngology-- head & neck surgery 2017; (143(11)):1104-1110 doi:10.1001/jamaoto.2017.1686.

Clinical features of nasal and sinonasal inverted papilloma associated with malignancy.

Miyazaki T, Haku Y, Yoshizawa A, et al.

Auris, nasus, larynx 2018; (45(5)):1014-1019 doi:10.1016/j.anl.2018.02.009.

Better surgical outcome by image-guided navigation system in endoscopic removal of sinonasal inverted papilloma.

Ahn SH, Lee EJ, Kim JW, et al.

Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery 2018; (46(6)):937-941 doi:10.1016/j.jcms.2018.03.012.

Comprehensive analysis of HPV infection, EGFR exon 20 mutations and LINE1 hypomethylation as risk factors for malignant transformation of sinonasal-inverted papilloma to squamous cell carcinoma.

Sahnane N, Ottini G, Turri-Zanoni M, et al.

International journal of cancer 2019; (144(6)):1313-1320 doi:10.1002/ijc.31971.

Imaging predictors for malignant transformation of inverted papilloma.

Yan CH, Tong CCL, Penta M, et al.

The Laryngoscope 2019; (129(4)):777-782 doi:10.1002/lary.27582.

Sinonasal inverted papilloma associated with small cell neuroendocrine carcinoma: A case report and literature review of rare malignancies associated with inverted papilloma.

Nakamura Y, Suzuki M, Ozaki S, et al.

Auris, nasus, larynx 2019; (46(4)):641-650 doi:10.1016/j.anl.2018.10.009.

Outcomes of sinonasal inverted papilloma resection by surgical approach: an updated systematic review and meta-analysis.

Peng R, Thamboo A, Choby G, et al.

International forum of allergy & rhinology 2019; (9(6)):573-581 doi:10.1002/alr.22305.

Attachment-oriented endoscopic surgical management for inverted papillomas in the nasal cavity and paranasal sinuses.

Makihara S, Kariya S, Naito T, et al.

Auris, nasus, larynx 2019; (46(5)):748-753 doi:10.1016/j.anl.2019.02.007.

Sinonasal inverted papilloma: rate of recurrence and malignant transformation in 44 operated patients.

Sbrana MF, Borges RFR, Pinna FR, et al.

Brazilian journal of otorhinolaryngology 2021; (87(1)):80-84 doi:10.1016/j.bjorl.2019.07.003.

Clinical Implications of Carcinoma In Situ in Sinonasal Inverted Papilloma.

Maina IW, Tong CCL, Baranov E, et al.

Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery 2019; (161(6)):1036-1042 doi:10.1177/0194599819883298.

Sinonasal Inverted Papilloma: Efficacy of Demucosation to Reduce Recurrence After Surgical Managements.

Ohki M, Kikuchi S

Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India 2019; (71(Suppl 3)):2186-2193 doi:10.1007/s12070-019-01625-x.

Endoscopic Resection of Sinonasal Inverted Papilloma: A Multivariate Retrospective Analysis of Factors Affecting Recurrence and Persistence.

Minni A, Gera R, Bulgheroni C, et al.

Ear, nose, & throat journal 2021; (100(5_suppl)):542S-548S doi:10.1177/0145561319890454.

[Inverted papilloma: a study of 13 cases in the Oto-Rhino-Laryngology at the National University Hospital of Fann].

Ndiaye M, Ndiaye C, Diouf MS, et al.

The Pan African medical journal 2019; (34()):71 doi:10.11604/pamj.2019.34.71.19888.

How aggressive should resection of inverted papilloma be? Refinement of surgical planning based on the 25-year experience of a single tertiary center.

Ferrari M, Schreiber A, Mattavelli D, et al.

International forum of allergy & rhinology 2020; (10(5)):619-628 doi:10.1002/alr.22541.

Clinical evidence based review and systematic scientific review in the identification of malignant transformation of inverted papilloma.

Long C, Jabarin B, Harvey A, et al.

Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale 2020; (49(1)):25 doi:10.1186/s40463-020-00420-x.

Squamous Cell Carcinoma Arising from Sinonasal Inverted Papilloma.

Ginat DT, Trzcinska A, Horowitz P

AJNR. American journal of neuroradiology 2020; (41(7)):1156-1159 doi:10.3174/ajnr.A6583.

A multimodal diagnostic approach to inverted papilloma: Proposal of a novel diagnostic flow-chart.

Russo C, Elefante A, Romano A, et al.

Current problems in diagnostic radiology 2021; (50(4)):499-504 doi:10.1067/j.cpradiol.2020.04.009.

Comparison of Current Staging Systems for Sinonasal Inverted Papilloma.

Nakayama T, Tsunemi Y, Kashiwagi T, et al.

American journal of rhinology & allergy 2021; (35(1)):64-71 doi:10.1177/1945892420933178.

Sinonasal inverted schneiderian papilloma presenting as a large intraoral lesion.

Nilesh K, Mukherji S, Kanetkar SR, Vande A

BMJ case reports 2020; (13(7)) doi:10.1136/bcr-2020-234985.

Can Computed Tomography Findings Predict the Recurrence of Sinonasal Inverted Papilloma?

Glikson E, Dragonetti A, Soudry E, et al.

Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery 2021; (164(5)):1116-1121 doi:10.1177/0194599820964798.

Need for long-term follow-up in sinonasal inverted papilloma: A Single-institution experience.

Binz GHA, Soyka MB, Holzmann D, Meerwein CM

Head & neck 2021; (43(2)):630-638 doi:10.1002/hed.26523.

Endoscopic Denker's Approach for the Treatment of Extensive Sinonasal Tumors: Our Experience.

Stavrakas M, Karkos PD, Tsinaslanidou Z, Constantinidis J

The Laryngoscope 2021; (131(7)):1458-1462 doi:10.1002/lary.29235.

TP53 mutations and CDKN2A mutations/deletions are highly recurrent molecular alterations in the malignant progression of sinonasal papillomas.

Brown NA, Plouffe KR, Yilmaz O, et al.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2021; (34(6)):1133-1142 doi:10.1038/s41379-020-00716-3.

Clinical characteristics of sinonasal inverted papilloma associated with recurrence and malignant transformation.

He X, Wang Y

Auris, nasus, larynx 2021; (48(6)):1105-1108 doi:10.1016/j.anl.2021.04.008.

Endoscopic Modified Medial Maxillectomy for Inverted Papilloma of the Maxillary Sinus.

Liu Q, Weng C, Zheng H, et al.

The Journal of craniofacial surgery 2022; (33(1)):e71-e73 doi:10.1097/SCS.0000000000007989.

[Risk factors of malignant transformation of sinonasal inverted papilloma].

Wang M, Hou L, Zhou B, et al.

Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery 2021; (35(7)):627-632 doi:10.13201/j.issn.2096-7993.2021.07.011.

Computed Tomography as a Predictor of Sinonasal Inverted Papilloma Origin, Skull Base Involvement, and Stage.

Lee JJ, Orlowski HLP, Schneider JS, et al.

Journal of neurological surgery. Part B, Skull base 2021; (82(Suppl 3)):e335-e341 doi:10.1055/s-0040-1701677.

Endoscopic Modified Danker's Approach for Management of Sinonasal Inverted Papilloma: Our Experience.

Baser B, Mishra A, Chaubey P

Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India 2021; (73(3)):282-289 doi:10.1007/s12070-020-02090-7.

A Systematic Review of Definitive Treatment for Inverted Papilloma Attachment Site and Associations With Recurrence.

Trent MS, Goshtasbi K, Hui L, et al.

Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery 2022; (167(3)):425-433 doi:10.1177/01945998211051975.

Surgical treatment of sinonasal inverted papilloma.

Kamel RH, Khaled A, Abdelfattah AF, Awad AG

Current opinion in otolaryngology & head and neck surgery 2022; (30(1)):26-32 doi:10.1097/MOO.0000000000000781.

Long-term outcomes in sinonasal squamous cell carcinoma arising from inverted papilloma: Systematic review.

Birkenbeuel JL, Pang JC, Lee A, et al.

Head & neck 2022; (44(4)):1014-1029 doi:10.1002/hed.26995.

Sinonasal Inverted Papilloma Showing a Misleading Finding on Magnetic Resonance Imaging.

Numano Y, Nomura K, Sugawara M, et al.

Ear, nose, & throat journal 2025; (104(2)):NP59-NP62 doi:10.1177/01455613221095614.

Keeping in Mind Its Synchronous Features, Is Sinonasal Inverted Papilloma Always Benign?

Sultan Abdul Kader MI, Prahaspathiji UJ, Ahmad AR, Zahedi FD

Cureus 2022; (14(7)):e27498 doi:10.7759/cureus.27498.

Association between human papillomavirus infection and malignant transformation of sinonasal inverted papilloma: A systematic review and meta-analysis.

Ferreli F, Di Bari M, Moya-Plana A, et al.

American journal of otolaryngology 2022; (43(6)):103614 doi:10.1016/j.amjoto.2022.103614.

Development and Validation of a Clinical Prediction Model to Diagnose Sinonasal Inverted Papilloma Based on Computed Tomography Features and Clinical Characteristics.

Zhang Z, Yu L, Jiang J, et al.

Ear, nose, & throat journal 2025; (104(8)):NP540-NP549 doi:10.1177/01455613221134421.

Sinonasal Inverted Papilloma: A Narrative Review.

Upadhya IB, Rao K

Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India 2022; (74(Suppl 2)):1017-1022 doi:10.1007/s12070-020-02089-0.

The choice of endoscopic surgical approach and four steps of operation of inverted papilloma of the maxillary sinus.

Lou Z

BMC surgery 2023; (23(1)):7 doi:10.1186/s12893-023-01908-9.

Preoperative Prediction of Sinonasal Inverted Papilloma-associated Squamous Cell Carcinoma (IP-SCC).

Park MJ, Cho W, Kim JH, et al.

The Laryngoscope 2023; (133(10)):2502-2510 doi:10.1002/lary.30583.

Evaluation of inverted papilloma recurrence rates and factors associated recurrence after endoscopic surgical resection: a retrospective review.

Yu S, Grose E, Lee DJ, et al.

Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale 2023; (52(1)):34 doi:10.1186/s40463-023-00638-5.

[Inverted papilloma of the nose and paranasal sinuses : Diagnosis, treatment, and malignant transformation].

Hildenbrand T, Weber RK

HNO 2024; (72(4)):257-264 doi:10.1007/s00106-023-01406-7.

Treatment outcome and prognostic factors of inverted papilloma involving the frontal sinus.

Cho SW, Kim SG, Han DH, et al.

Laryngoscope investigative otolaryngology 2024; (9(1)):e1206 doi:10.1002/lio2.1206.

Assessment of TP53 and CDKN2A status as predictive markers of malignant transformation of sinonasal inverted papilloma.

Kwon S, Kim JW, Kim ES, et al.

Scientific reports 2024; (14(1)):14286 doi:10.1038/s41598-024-64901-z.

Challenging Nasal Pathologies: An Inverted Nasal Papilloma Case Series Illustrating Diagnostic Challenges and Management Strategies.

Buali HF, Alrayyes H, Habib H, Ansari S

Cureus 2024; (16(8)):e66577 doi:10.7759/cureus.66577.

Management of frontal sinus and frontal recess inverted papilloma: our experience and systematic review.

Gaudioso P, Vinciguerra A, Verillaud B, Herman P

Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale 2024; (44(4)):252-260 doi:10.14639/0392-100X-N2331.

Impact of fast-track on recurrence and malignant transformation of patients with inverted papilloma.

Gydesen K, Bülow R, Aanaes K, et al.

Acta oto-laryngologica 2024; (144(11-12)):631-634 doi:10.1080/00016489.2024.2408741.

Treatments in sinonasal inverted papilloma malignancy invading the pterygopalatine fossa: A case report.

Jiang L, Wang L, Gao S, et al.

Science progress 2024; (107(4)):368504241306895 doi:10.1177/00368504241306895.

Bilateral inverted papilloma: Case report and literature review.

Rabhi MA, Sbai AA, Benfadil D, et al.

Radiology case reports 2025; (20(3)):1499-1503 doi:10.1016/j.radcr.2024.11.053.

Development of a Clinical Prediction Model to Predict Malignant Transformation of Sinonasal Inverted Papilloma Based on Hematological Indices and Clinical Features.

Sun K, Wu C, Zhang Z, et al.

Laryngoscope investigative otolaryngology 2025; (10(1)):e70075 doi:10.1002/lio2.70075.

Radial intralesional linear calcifications and focal hyperostosis: key points for diagnosis, extension and point of origin identification of sinonasal inverted papilloma.

Granell E, Cardesin A, Pallares D, et al.

Rhinology 2025; (63(2)):250-252 doi:10.4193/Rhin24.379.

Endoscopic Sinus Surgery in Frontal Sinus Inverted Papilloma: A Systematic Review.

Fieux M, Favier V, Sousa Machado A, et al.

Journal of personalized medicine 2025; (15(5)) doi:10.3390/jpm15050183.

Risk Factors for Malignant Transformation in Inverted Sinonasal Papilloma: A Systematic Review and Meta-Analysis.

Ambrosini-Spaltro A, Querzoli G, Leucci AC, et al.

Cancers 2025; (17(11)) doi:10.3390/cancers17111798.

Differences in Imaging and Histology Between Sinonasal Inverted Papilloma with and Without Squamous Cell Carcinoma.

Kuusisto N, Hagström J, Kurdo G, et al.

Diagnostics (Basel, Switzerland) 2025; (15(13)) doi:10.3390/diagnostics15131645.

Patterns of Recurrence and Malignant Transformation in Sinonasal Papilloma: Implications for Long-term Follow-up.

Kimura T, Koike S, Tamaki H, et al.

In vivo (Athens, Greece) 2025; (39(6)):3461-3467 doi:10.21873/invivo.14144.

Sinonasal Inverted Papilloma and Clinical Significance of Dysplasia: A Multi-Institutional Study.

Kim AH, Tham T, Giannaris PS, et al.

The Laryngoscope 2026; (136(4)):1656-1664 doi:10.1002/lary.70263.

Diagnostic Accuracy of Office Biopsy for Inverted Papilloma.

Yu AJ, Tapescu I, Venkatesh S, et al.

American journal of rhinology & allergy 2026; (40(3)):239-244 doi:10.1177/19458924251414779.

Clinical and Epidemiological Profile of Patients with Sinonasal Papilloma in a University Hospital.

Leão SEG, Brasil MQA, Coêlho Neto J, et al.

International archives of otorhinolaryngology 2026; (30(1)):1-6 doi:10.1055/s-0045-1811638.

Imaging of sinonasal inverted papillomas: A literature review.

Bouatay R, Koubaa J

La Tunisie medicale 2025; (103(8)):982-987 doi:10.62438/tunismed.v103i8.5970.

Sinonasal Inverted Papillomas: Predictors of Recurrence and Malignant Transformation.

Tanase I, Ciolofan MS, Sarafoleanu CC, et al.

Life (Basel, Switzerland) 2026; (16(3)) doi:10.3390/life16030442.

Malignant Transformation of Sinonasal Papilloma: Assessment of Clinicopathologic Features, p16 and p53 Expression, Transcriptionally Active HPV Status and Underlying Molecular Alterations.

Amin SE, Sono R, Al-Jumaili ZI, et al.

Head and neck pathology 2026; (20(1)).

Impact of Dysplasia on Inverted Papilloma Recurrence: A Systematic Review and Meta-Analysis.

Giannaris P, Tham T, Giannaris E, et al.

International forum of allergy & rhinology 2026; (16(8)):841-851 doi:10.1002/alr.70215.

Sinonasal squamous cell carcinoma: REFCOR guidelines for diagnosis, treatment and follow-up.

Vérillaud B, Chatelet F, Baglin AC, et al.

European annals of otorhinolaryngology, head and neck diseases 2026; (143(4)):319-324 doi:10.1016/j.anorl.2026.06.001.

scRNA-seq and genomics analyses reveal key mechanisms of inverted papilloma-associated sinonasal squamous cell carcinoma malignant transformation.

Olonisakin TF, Zamuner FT, Vu K, et al.

bioRxiv : the preprint server for biology 2026; doi:10.64898/2026.06.01.729345.

Epithelial Markers in Sinonasal Inverted Papilloma with Malignant Transformation: A Scoping Review and Proposal for an Integrative Model of Malignant Risk Stratification.

Oanca RC, Paun LA, Dumitru M, et al.

Diagnostics (Basel, Switzerland) 2026; (16(15)) doi:10.3390/diagnostics16152347.

Inverted Papilloma Presenting as Orbital Cellulitis and Dacryocystitis.

Ho MC, Mei ES, Gregerson CH, Lelli G

Ophthalmic plastic and reconstructive surgery 2026; doi:10.1097/IOP.0000000000003300.