Research & Literature

[Clinical examination of cases of radiation proctitis after intensity-modulated radiation therapy for prostate cancer].

Suko S, Eguchi H, Yoshida K, et al.

Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology 2015; (112(7)):1299-308 doi:10.11405/nisshoshi.112.1299.

Validity and Reliability of the US National Cancer Institute's Patient-Reported Outcomes Version of the Common Terminology Criteria for Adverse Events (PRO-CTCAE).

Dueck AC, Mendoza TR, Mitchell SA, et al.

JAMA oncology 2015; (1(8)):1051-9 doi:10.1001/jamaoncol.2015.2639.

[Follow-up after radiation therapy for cervical cancer].

Cao KI, Mazeron R, Barillot I

Cancer radiotherapie : journal de la Societe francaise de radiotherapie oncologique 2015; (19(6-7)):590-6.

Robotic repair of a vesicovaginal fistula in an irradiated field using a dehydrated amniotic allograft as an interposition patch.

Price DT, Price TC

Journal of robotic surgery 2016; (10(1)):77-80 doi:10.1007/s11701-015-0546-8.

Chronic radiation proctopathy: A practical review of endoscopic treatment.

Lenz L, Rohr R, Nakao F, et al.

World journal of gastrointestinal surgery 2016; (8(2)):151-60 doi:10.4240/wjgs.v8.i2.151.

Complication and remission rates after endoscopic argon plasma coagulation in the treatment of haemorrhagic radiation proctitis.

Siow SL, Mahendran HA, Seo CJ

International journal of colorectal disease 2017; (32(1)):131-134 doi:10.1007/s00384-016-2635-1.

Long-term results on the efficacy of argon plasma coagulation for patients with chronic radiation proctitis after conventionally fractionated, dose-escalated radiation therapy for prostate cancer.

Weiner J, Schwartz D, Martinez M, et al.

Practical radiation oncology 2017; (7(1)):e35-e42 doi:10.1016/j.prro.2016.07.009.

Restorative resection of radiation rectovaginal fistula can better relieve anorectal symptoms than colostomy only.

Zhong Q, Yuan Z, Ma T, et al.

World journal of surgical oncology 2017; (15(1)):37 doi:10.1186/s12957-017-1100-0.

Efficacy of hyperbaric oxygen therapy in patients with radiation-induced rectal ulcers: Report of five cases.

Yoshimizu S, Chino A, Miyamoto Y, et al.

Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society 2017; (29(6)):718-722 doi:10.1111/den.12880.

Radiofrequency ablation for gastric antral vascular ectasia and radiation proctitis.

Markos P, Bilic B, Ivekovic H, Rustemovic N

Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology 2017; (36(2)):145-148 doi:10.1007/s12664-017-0748-2.

Successful Treatment of Acute Radiation Proctitis with Aloe Vera: A Preliminary Randomized Controlled Clinical Trial.

Sahebnasagh A, Ghasemi A, Akbari J, et al.

Journal of alternative and complementary medicine (New York, N.Y.) 2017; (23(11)):858-865 doi:10.1089/acm.2017.0047.

Efficacy and safety of argon plasma coagulation in the management of extensive chronic radiation proctitis after pelvic radiotherapy for cervical carcinoma.

Sudha SP, Kadambari D

International journal of colorectal disease 2017; (32(9)):1285-1288 doi:10.1007/s00384-017-2859-8.

Pelvic Radiation and Normal Tissue Toxicity.

Nicholas S, Chen L, Choflet A, et al.

Seminars in radiation oncology 2017; (27(4)):358-369 doi:10.1016/j.semradonc.2017.04.010.

Expression of vascular endothelial growth factor and its correlation with clinical symptoms and endoscopic findings in patients with chronic radiation proctitis.

Trzcinski R, Dziki A, Brys M, et al.

Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland 2018; (20(4)):321-330 doi:10.1111/codi.13902.

Role of Angiogenesis in Chronic Radiation Proctitis: New Evidence Favoring Inhibition of Angiogenesis Ex Vivo.

Wu P, Li L, Wang H, et al.

Digestive diseases and sciences 2018; (63(1)):113-125 doi:10.1007/s10620-017-4818-1.

Emerging role of thalidomide in the treatment of gastrointestinal bleeding.

McFarlane M, O'Flynn L, Ventre R, Disney BR

Frontline gastroenterology 2018; (9(2)):98-104 doi:10.1136/flgastro-2017-100870.

Management of Radiation Proctitis.

Tabaja L, Sidani SM

Digestive diseases and sciences 2018; (63(9)):2180-2188 doi:10.1007/s10620-018-5163-8.

Mesalazine suppository for the treatment of refractory ulcerative chronic radiation proctitis.

Wu C, Guan L, Yao L, Huang J

Experimental and therapeutic medicine 2018; (16(3)):2319-2324 doi:10.3892/etm.2018.6464.

The role of endoscopic evaluation for radiation proctitis in patients receiving intermediate-dose postoperative radiotherapy for rectal cancer.

Lee J, Han HJ, Min BS, et al.

Japanese journal of clinical oncology 2018; (48(11)):988-994 doi:10.1093/jjco/hyy126.

[Chinese consensus on diagnosis and treatment of radiation proctitis (2018)].

Wang L, Wang J

Zhonghua wei chang wai ke za zhi = Chinese journal of gastrointestinal surgery 2018; (21(12)):1321-1336.

Rubber Band Ligation of Hemorrhoids is often a Necessary Complement in the Management of Hemorrhagic Radiation Proctitis.

De Robles MS, Young CJ

Scandinavian journal of surgery : SJS : official organ for the Finnish Surgical Society and the Scandinavian Surgical Society 2020; (109(2)):108-114 doi:10.1177/1457496918822619.

Feasibility Assessment of Using the Complete Patient-Reported Outcomes Version of the Common Terminology Criteria for Adverse Events (PRO-CTCAE) Item Library.

Shepshelovich D, McDonald K, Spreafico A, et al.

The oncologist 2019; (24(4)):e146-e148 doi:10.1634/theoncologist.2018-0332.

Four percent formalin application for the management of radiation proctitis in carcinoma cervix patients: An effective, safe, and economical practice.

Sharma B, Gupta M, Sharma R, et al.

Journal of cancer research and therapeutics 2019; (15(1)):92-95 doi:10.4103/jcrt.JCRT_393_17.

Efficacy and complications of argon plasma coagulation for hemorrhagic chronic radiation proctitis.

Zhong QH, Liu ZZ, Yuan ZX, et al.

World journal of gastroenterology 2019; (25(13)):1618-1627 doi:10.3748/wjg.v25.i13.1618.

Assessment of chronic radiation proctopathy and radiofrequency ablation treatment follow-up with optical coherence tomography angiography: A pilot study.

Ahsen OO, Liang K, Lee HC, et al.

World journal of gastroenterology 2019; (25(16)):1997-2009 doi:10.3748/wjg.v25.i16.1997.

Expanded validation of the EPIC bowel and urinary domains for use in women with gynecologic cancer undergoing postoperative radiotherapy.

Gil KM, Pugh SL, Klopp AH, et al.

Gynecologic oncology 2019; (154(1)):183-188 doi:10.1016/j.ygyno.2019.04.682.

Efficacy and safety of radiofrequency ablation for treatment of chronic radiation proctitis: A systematic review and meta-analysis.

McCarty TR, Garg R, Rustagi T

Journal of gastroenterology and hepatology 2019; (34(9)):1479-1485 doi:10.1111/jgh.14729.

ASGE guideline on the role of endoscopy for bleeding from chronic radiation proctopathy.

Lee JK, Agrawal D, Thosani N, et al.

Gastrointestinal endoscopy 2019; (90(2)):171-182.e1 doi:10.1016/j.gie.2019.04.234.

Understanding the mechanism of radiation induced fibrosis and therapy options.

Ejaz A, Greenberger JS, Rubin PJ

Pharmacology & therapeutics 2019; (204()):107399 doi:10.1016/j.pharmthera.2019.107399.

Effect of interval between preoperative radiotherapy and surgery on clinical outcome and radiation proctitis in rectal cancer from FOWARC trial.

Cheng YK, Qin QY, Huang XY, et al.

Cancer medicine 2020; (9(3)):912-919 doi:10.1002/cam4.2755.

The Role of VEGF and TNF-Alpha on Epithelialization of Diabetic Foot Ulcers after Hyperbaric Oxygen Therapy.

Semadi NI

Open access Macedonian journal of medical sciences 2019; (7(19)):3177-3183 doi:10.3889/oamjms.2019.297.

Locally-advanced vaginal cancer with complete utero-vaginal prolapse.

Buda A, Yaprak E, MIlani R, et al.

International journal of gynecological cancer : official journal of the International Gynecological Cancer Society 2020; (30(5)):705-708 doi:10.1136/ijgc-2020-001326.

Pravastatin Alleviates Radiation Proctitis by Regulating Thrombomodulin in Irradiated Endothelial Cells.

Jang H, Kwak SY, Park S, et al.

International journal of molecular sciences 2020; (21(5)) doi:10.3390/ijms21051897.

DNA double-strand breaks of human peripheral blood lymphocyte induced by CT examination of oral and maxillofacial region.

Yang P, Wang S, Liu D, et al.

Clinical oral investigations 2020; (24(12)):4617-4624 doi:10.1007/s00784-020-03331-3.

Dietary Oat Bran Reduces Systemic Inflammation in Mice Subjected to Pelvic Irradiation.

Patel P, Malipatlolla DK, Devarakonda S, et al.

Nutrients 2020; (12(8)) doi:10.3390/nu12082172.

The effect of hyperbaric oxygen therapy combined with hair transplantation surgery for the treatment of alopecia.

Fan ZX, Gan Y, Qu Q, et al.

Journal of cosmetic dermatology 2021; (20(3)):917-921 doi:10.1111/jocd.13665.

Radiation enteritis: Diagnostic and therapeutic issues.

Loge L, Florescu C, Alves A, Menahem B

Journal of visceral surgery 2020; (157(6)):475-485 doi:10.1016/j.jviscsurg.2020.08.012.

Ulcerative Colitis: Making the Diagnosis.

Kaenkumchorn T, Wahbeh G

Gastroenterology clinics of North America 2020; (49(4)):655-669 doi:10.1016/j.gtc.2020.07.001.

Efficacy of sucralfate ointment in the prevention of acute proctitis in cancer patients: A randomized controlled clinical trial.

Saei S, Sahebnasagh A, Ghasemi A, et al.

Caspian journal of internal medicine 2020; (11(4)):410-418 doi:10.22088/cjim.11.4.410.

Association of bowel radiation dose-volume with skeletal muscle loss during pelvic intensity-modulated radiotherapy in cervical cancer.

Lee J, Lin JB, Wu MH, et al.

Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 2021; (29(9)):5497-5505 doi:10.1007/s00520-021-06131-x.

Amelanotic anorectal malignant melanoma in an ulcerative colitis patient: a rare coincidence or a rare association.

Kuriakose Kuzhiyanjal AJ, Nigam GB, Afzal M

BMJ case reports 2021; (14(3)) doi:10.1136/bcr-2020-240398.

Screening of chronic radiation proctitis and colorectal cancer using periodic total colonoscopy after external beam radiation therapy for prostate cancer.

Nakamura Y, Soma T, Izumi K, et al.

Japanese journal of clinical oncology 2021; (51(8)):1298-1302 doi:10.1093/jjco/hyab056.

A Ten-year-long Update on Radiation Proctitis Among Prostate Cancer Patients Treated With Curative External Beam Radiotherapy.

Ferini G, Pergolizzi S

In vivo (Athens, Greece) 2021; (35(3)):1379-1391 doi:10.21873/invivo.12390.

Role of dietary fiber in safeguarding intestinal health after pelvic radiotherapy.

Bull C, Devarakonda S, Ahlin R

Current opinion in supportive and palliative care 2021; (15(3)):180-187 doi:10.1097/SPC.0000000000000559.

Hyperbaric oxygen therapy as a complementary treatment for radiation proctitis: Useless or useful? - A literature review.

Alpuim Costa D, Amaro CE, Nunes A, et al.

World journal of gastroenterology 2021; (27(27)):4413-4428 doi:10.3748/wjg.v27.i27.4413.

DNA Repair Inhibition Leads to Active Export of Repetitive Sequences to the Cytoplasm Triggering an Inflammatory Response.

Song X, Aw JTM, Ma F, et al.

The Journal of neuroscience : the official journal of the Society for Neuroscience 2021; (41(45)):9286-9307 doi:10.1523/JNEUROSCI.0845-21.2021.

Pentoxifylline and tocopherol (vitamin E) with/without clodronate for the management of osteoradionecrosis: A scoping review.

Banjar A, Patel V, Abed H

Oral diseases 2023; (29(1)):29-39 doi:10.1111/odi.14058.

Rectal irrigation as rescue therapy for refractory and severe hemorrhagic radiation proctitis: A case report.

Pattarajierapan S, Amornwichet N, Khomvilai S

Clinical case reports 2021; (9(10)):e04985 doi:10.1002/ccr3.4985.

[Chinese expert consensus on multidisciplinary diagnosis and treatment of radiation rectal injury (2021 edition)].

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Zhonghua wei chang wai ke za zhi = Chinese journal of gastrointestinal surgery 2021; (24(11)):937-949 doi:10.3760/cma.j.cn441530-20210927-00387.

[Questionnaire investigation of radiation rectal injury with anxiety, depression and somatic disorder].

Lian B, Cao XP, Deng HJ, et al.

Zhonghua wei chang wai ke za zhi = Chinese journal of gastrointestinal surgery 2021; (24(11)):984-990 doi:10.3760/cma.j.cn441530-20210804-00308.

A Combination of Iohexol Treatment and Ionizing Radiation Exposure Enhances Kidney Injury in Contrast-Induced Nephropathy by Increasing DNA Damage.

Fujino S, Sun J, Nakayama S, et al.

Radiation research 2022; (197(4)):384-395 doi:10.1667/RADE-21-00178.1.

A Mixed Neuroendocrine/Non-Neuroendocrine Neoplasm Arising in the Background of Ulcerative Colitis: A Case Report and Review of the Literature.

Al Buthi SA, Bin Gheshayan SF, Al Samaani I, et al.

The American journal of case reports 2022; (23()):e934396 doi:10.12659/AJCR.934396.

Comment on "The Effect of Hyperbaric Oxygen Therapy on Rectal Ulcers after Argon Plasma Coagulation".

Cunha Neves JA, Roseira J, Queirós P, Tavares de Sousa H

GE Portuguese journal of gastroenterology 2022; (29(2)):80-81 doi:10.1159/000520227.

Interventions for Radiation-Induced Fibrosis in Patients With Breast Cancer: Systematic Review and Meta-analyses.

Nogueira RMP, Vital FMR, Bernabé DG, Carvalho MB

Advances in radiation oncology 2022; (7(3)):100912 doi:10.1016/j.adro.2022.100912.

To evaluate the use of tandem and cylinder as an intracavitary brachytherapy device for carcinoma of the cervix with regard to local control and toxicities.

Gadda IR, Khan NA, Wani SQ, Baba MH

Journal of cancer research and therapeutics 2022; (18(3)):740-746 doi:10.4103/jcrt.jcrt_243_21.

Patient- and physician-reported radiation-induced toxicity of short-course radiotherapy with a prolonged interval to surgery for rectal cancer.

Verweij ME, Hoendervangers S, von Hebel CM, et al.

Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland 2023; (25(1)):24-30 doi:10.1111/codi.16315.

[Exploration of Indole Compounds as Candidate for Radiation Mitigators].

Sugawara K, Ishikawa J

Nihon Hoshasen Gijutsu Gakkai zasshi 2022; (78(11)):1295-1305 doi:10.6009/jjrt.2022-1283.

Risk factors associated to argon plasma coagulation treatment failure in patients with chronic radiation proctopathy.

Amaya-Fragoso E, Hernández Guerrero AI, Beltrán-Galindo LG

Revista espanola de enfermedades digestivas 2023; (115(9)):480-487 doi:10.17235/reed.2023.9258/2022.

Effects of Mesenchymal Stem Cells Treatment on Radiation-Induced Proctitis in Rats.

Kim WH, Yoo JH, Yoo IK, et al.

Yonsei medical journal 2023; (64(3)):167-174 doi:10.3349/ymj.2022.0342.

A Retrospective Single-Arm Cohort Study in a Single Center of Radiofrequency Ablation in Treatment of Chronic Radiation Proctitis.

Tang CE, Cheng KC, Wu KL, et al.

Life (Basel, Switzerland) 2023; (13(2)) doi:10.3390/life13020566.

[Clincal practice of pelvic exenteration for late complications of pelvic radiation injury].

Ma TH, He YJ, Zhou ZL

Zhonghua wei chang wai ke za zhi = Chinese journal of gastrointestinal surgery 2023; (26(3)):235-240 doi:10.3760/cma.j.cn441530-20221206-00510.

Impact of radiation therapy on healthy tissues.

Chargari C, Rassy E, Helissey C, et al.

International review of cell and molecular biology 2023; (376()):69-98 doi:10.1016/bs.ircmb.2022.11.006.

Pentoxifylline Inhibits TNF-α/TGF-β1-Induced Epithelial-Mesenchymal Transition via Suppressing the NF-κB Pathway and SERPINE1 Expression in CaSki Cells.

Palafox-Mariscal LA, Ortiz-Lazareno PC, Jave-Suárez LF, et al.

International journal of molecular sciences 2023; (24(13)) doi:10.3390/ijms241310592.

Racecadotril Versus Loperamide in Acute Radiation Enteritis: A Randomized, Double-Masked, Phase 3, Noninferiority Trial.

P B A, Sudha SP, Mohan P, et al.

International journal of radiation oncology, biology, physics 2024; (118(3)):616-625 doi:10.1016/j.ijrobp.2023.09.021.

Single-cell map of dynamic cellular microenvironment of radiation-induced intestinal injury.

Lu H, Yan H, Li X, et al.

Communications biology 2023; (6(1)):1248 doi:10.1038/s42003-023-05645-w.

[Progressive radiation-induced rectal injury: is there an opportunity to get out of a vicious circle? A clinical case].

Skvortsova TE, Oganezova IA, Medvedeva OI

Terapevticheskii arkhiv 2023; (95(10)):870-875 doi:10.26442/00403660.2023.10.202453.

Secondary bladder and colorectal cancer after treatments for prostate cancer: A population based study.

Bárcena PGQ, Aprikian AG, Dragomir A

Cancer medicine 2024; (13(3)):e6922 doi:10.1002/cam4.6922.

Evaluation of therapeutic use of a combination of pentoxifylline and vitamin E in radiation-induced renal fibrosis.

Demircan V, Guzel C, Sarıbas GS, et al.

Scientific reports 2024; (14(1)):6977 doi:10.1038/s41598-024-57850-0.

Radiation Proctitis in Patients With Locally Advanced Cervical Cancer Treated by Chemoradiation: Analysis and Predictive Factors From a Retrospective Cohort.

Sauvage LM, Bentahila R, Tran Y, et al.

American journal of clinical oncology 2024; (47(7)):311-316 doi:10.1097/COC.0000000000001092.

Pelvic Floor Rehabilitation After Rectal Cancer Surgery One-year follow-up of a Multicenter Randomized Clinical Trial (FORCE trial).

Bosch NM, Kalkdijk-Dijkstra AJ, van Westreenen HL, et al.

Annals of surgery 2024; doi:10.1097/SLA.0000000000006402.

Pelvic Radiation Therapy Increases Risk of Pouch Failure in Patients with Inflammatory Bowel Disease and Ileal Pouch.

Gnanapandithan K, Stuessel LG, Shen B, et al.

Digestive diseases and sciences 2024; (69(9)):3392-3401 doi:10.1007/s10620-024-08576-6.

Radiation-Induced Intestinal Injury: Molecular Mechanisms and Therapeutic Status.

Gao D, Zhang H, Sun W, et al.

DNA and cell biology 2024; (43(11)):537-548 doi:10.1089/dna.2024.0105.

Rectal Epithelial Stem Cell Kinetics in Acute Radiation Proctitis.

Ghosh S, Morita A, Nishiyama Y, et al.

International journal of molecular sciences 2024; (25(20)) doi:10.3390/ijms252011252.

Radiation Proctitis: A Review of Pathophysiology and Treatment Strategies.

Bhatia M, Suliman H, Ahmed R, et al.

Cureus 2024; (16(9)):e70581 doi:10.7759/cureus.70581.

Relationship Between Radiation Therapy and Fecal Incontinence in Patients Treated for Localized Prostate Cancer: Results of the French ICONES Study.

Belkacemi Y, Coraggio G, Debbi K, et al.

The Prostate 2025; (85(5)):492-501 doi:10.1002/pros.24852.

Radiation-induced recto-urinary fistula: A dreaded complication with devastating consequences.

Yu KR, Keller-Biehl L, Smith-Harrison L, et al.

Surgery in practice and science 2023; (15()):100216 doi:10.1016/j.sipas.2023.100216.

Hyperbaric Oxygen Therapy: An Evidence-Based Primer for Emergency Physicians.

Samson M, Gottlieb M, Logue C, Popa D

The Journal of emergency medicine 2025; (70()):35-44 doi:10.1016/j.jemermed.2024.09.009.

The Impact of Radiation Proctopathy on Secondary-Primary Colorectal Cancer in Patients with Prostate Cancer.

Ahmad AI, Ansari Z, Jamal Al-Din T, et al.

Journal of gastrointestinal cancer 2025; (56(1)):66 doi:10.1007/s12029-025-01193-0.

Radiation proctitis as a differential of lower GIT bleeding in Nigeria: A case series.

Chukwudike ES, David NP, Obasi E, et al.

Nigerian medical journal : journal of the Nigeria Medical Association 2025; (66(1)):370-378 doi:10.71480/nmj.v66i1.556.

Chinese clinical practice guidelines for the prevention and treatment of radiation-induced rectal injury.

Zhang H, Zhang Z, Yuan S

Precision radiation oncology 2023; (7(4)):237-255 doi:10.1002/pro6.1217.

Radiofrequency ablation: Solution for a long-time therapeutic dilemma of chronic radiation proctitis?

Esswein K, Ninkovic M, Kröpfl V, et al.

Endoscopy international open 2025; (13()):a26051079 doi:10.1055/a-2605-1079.

Oat bran fiber protects against radiation-induced disruption of gut barrier dynamics and mucosal damage.

Patel P, Jin C, Nookaew I, et al.

NPJ biofilms and microbiomes 2025; (11(1)):128 doi:10.1038/s41522-025-00759-x.

Severe and Long-Term Side Effects of Radiotherapy for Nasopharyngeal Cancer: A Case Report.

Nafaa M, Lahlou M, Miqdadi A, et al.

Cureus 2025; (17(7)):e88993 doi:10.7759/cureus.88993.

Anal Canal Squamous Cell Carcinoma Following Low-Dose-Rate Prostate Brachytherapy: A Report of Two Cases and Literature Review.

Shibuya N, Fukagai T, Tsunokawa Y, et al.

Cureus 2025; (17(9)):e92602 doi:10.7759/cureus.92602.

Management of radiation-induced gynecological toxicities: AFSOS-SFCE-GFRCP clinical practice guidelines.

Bruand M, Kanoun D, Le Tinier F, et al.

International journal of gynecological cancer : official journal of the International Gynecological Cancer Society 2026; (36(2)):102817 doi:10.1016/j.ijgc.2025.102817.

Radiation-Induced Brachial Plexopathy: Current Understanding, Diagnosis, and Treatment Options.

Lambi AG, Holy T, Tomlinson RE, Barbe MF

Journal of hand surgery global online 2026; (8(1)):100896 doi:10.1016/j.jhsg.2025.100896.

Post-radiation levator ani atrophy is associated with worse Low Anterior Resection Syndrome score after nonoperative management for locally advanced rectal cancer: a potential MRI biomarker.

Thomas RJ, Derasari S, Palmquist SM, et al.

Frontiers in oncology 2025; (15()):1656898 doi:10.3389/fonc.2025.1656898.

Magnetic Resonance Imaging-Directed Stereotactic Body Radiation Therapy Microboost in Concert With Pelvic Nodal Irradiation for Prostate Cancer in the Higher-Risk Spectrum: Toxicity.

Musthafa M, Wells M, Kearney T, et al.

Advances in radiation oncology 2026; (11(4)):101997 doi:10.1016/j.adro.2026.101997.